Loperamide (hydrochloride)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Loperamide (hydrochloride) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Loperamide (hydrochloride)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide 0.228838
PTMA prothymosin, alpha 0.156018
RPS6 ribosomal protein S6 0.0826614
RPL35A ribosomal protein L35a 0.0658512
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0632514
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0571699
RPL12 ribosomal protein L12 0.0564616
RPLP1 ribosomal protein, large, P1 0.0516783
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0472084
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0470352
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0465977
RPL23 ribosomal protein L23 0.0461658
RPS19 ribosomal protein S19 0.0452276
GOLGA4 golgin A4 0.0435937
KRT18 keratin 18, type I 0.0419987
RPL37A ribosomal protein L37a 0.0407491
EIF1 eukaryotic translation initiation factor 1 0.0399909
RPL18 ribosomal protein L18 0.0395649
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0395194
PGK1 phosphoglycerate kinase 1 0.0378635
RPS3 ribosomal protein S3 0.0367176
B2M beta-2-microglobulin 0.0366014
RPLP2 ribosomal protein, large, P2 0.036519
RPS25 ribosomal protein S25 0.0363128
RPLP0 ribosomal protein, large, P0 0.0359304
RPS13 ribosomal protein S13 0.0352279
RPS21 ribosomal protein S21 0.0346005
FTH1 ferritin, heavy polypeptide 1 0.0338492
GSTP1 glutathione S-transferase pi 1 0.0333666
RPL19 ribosomal protein L19 0.0327045
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0324549
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0324348
RPS8 ribosomal protein S8 0.0318428
LDHA lactate dehydrogenase A 0.0312529
RPL27A ribosomal protein L27a 0.0309457
RPL31 ribosomal protein L31 0.0304828
PDIA3 protein disulfide isomerase family A, member 3 0.0299185
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.029751
RPS14 ribosomal protein S14 0.0297003
RPL36 ribosomal protein L36 0.0290199
LOC102724023 ES1 protein homolog, mitochondrial 0.0287031
S100A6 S100 calcium binding protein A6 0.0284692
RPS5 ribosomal protein S5 0.0284269
ESYT2 extended synaptotagmin-like protein 2 0.0280125
RPS12 ribosomal protein S12 0.0272836
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0263076
TPT1 tumor protein, translationally-controlled 1 0.025807
TMSB4X thymosin beta 4, X-linked 0.0256424
RPL32 ribosomal protein L32 0.0252399
RPL36A ribosomal protein L36a 0.0249011
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0246451
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.024494
RPS17 ribosomal protein S17 0.0243711
TMSB10 thymosin beta 10 0.0237815
RACK1 receptor for activated C kinase 1 0.0234881
RPL10A ribosomal protein L10a 0.0234318
RPL7A ribosomal protein L7a 0.0233117
RPL37 ribosomal protein L37 0.0219084
RPS27 ribosomal protein S27 0.0218235
KRT19 keratin 19, type I 0.0212155
CBX3 chromobox homolog 3 0.0211566
RPL26 ribosomal protein L26 0.0206751
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0205554
RPL11 ribosomal protein L11 0.0204317
RPL35 ribosomal protein L35 0.020102
RPL8 ribosomal protein L8 0.0200579
RSL24D1 ribosomal L24 domain containing 1 0.0200391
S100A9 S100 calcium binding protein A9 0.0198807
RPS11 ribosomal protein S11 0.019875
RPL28 ribosomal protein L28 0.0198654
ATP5F1E ATP synthase F1 subunit epsilon 0.019767
RNF145 ring finger protein 145 0.0196698
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0196302
HMGB2 high mobility group box 2 0.019396
EIF5B eukaryotic translation initiation factor 5B 0.0193201
RPS16 ribosomal protein S16 0.0192947
IFITM3 interferon induced transmembrane protein 3 0.0189901
DDIT4 DNA-damage-inducible transcript 4 0.0188068
MTDH metadherin 0.0186823
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0184624
DSTN destrin (actin depolymerizing factor) 0.018418
BHLHE40 basic helix-loop-helix family, member e40 0.0179431
RPL39 ribosomal protein L39 0.0176327
KIF5B kinesin family member 5B 0.017534
CST3 cystatin C 0.0172635
MLEC malectin 0.0172635
RPL21 ribosomal protein L21 0.0171454
ZC3H15 zinc finger CCCH-type containing 15 0.0171385
TTC3 tetratricopeptide repeat domain 3 0.0170934
RPL34 ribosomal protein L34 0.0170705
RPL7 ribosomal protein L7 0.0170047
RPL15 ribosomal protein L15 0.0169944
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0168335
SERF2 small EDRK-rich factor 2 0.0167701
UBE2C ubiquitin-conjugating enzyme E2C 0.0166101
RPS29 ribosomal protein S29 0.0163338
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0161615
KPNB1 karyopherin (importin) beta 1 0.0161222
BZW1 basic leucine zipper and W2 domains 1 0.0161195
PA2G4 proliferation-associated 2G4, 38kDa 0.0161108

decreased expression

Symbol Name Standardized Value
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.112699
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.10541
BCL2L1 BCL2-like 1 -0.103244
VCL vinculin -0.0783879
UBC ubiquitin C -0.0779302
ACTN4 actinin, alpha 4 -0.0721435
AHNAK AHNAK nucleoprotein -0.0660677
KRT8 keratin 8, type II -0.0596466
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0580944
IFRD1 interferon-related developmental regulator 1 -0.0573723
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0563439
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0556154
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0538666
VMP1 vacuole membrane protein 1 -0.0530823
SDK1 sidekick cell adhesion molecule 1 -0.0522995
NCEH1 neutral cholesterol ester hydrolase 1 -0.0511456
MAML2 mastermind-like 2 (Drosophila) -0.0506716
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0499857
NEBL nebulette -0.0488301
OSBPL10 oxysterol binding protein-like 10 -0.0476242
FAT1 FAT atypical cadherin 1 -0.0471368
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0466684
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0461241
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0457929
CEMIP cell migration inducing protein, hyaluronan binding -0.0454348
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0444735
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.044258
SAMD4A sterile alpha motif domain containing 4A -0.0433391
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0428609
FLNA filamin A, alpha -0.0426483
MED13L mediator complex subunit 13-like -0.0416781
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0416097
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0408061
NKD1 naked cuticle homolog 1 (Drosophila) -0.038677
YAP1 Yes-associated protein 1 -0.038657
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0367743
PLEC plectin -0.0366944
ANKRD11 ankyrin repeat domain 11 -0.0363933
EXOC4 exocyst complex component 4 -0.0362619
ZBTB20 zinc finger and BTB domain containing 20 -0.0356634
RUNX1 runt-related transcription factor 1 -0.0354889
USP34 ubiquitin specific peptidase 34 -0.0348199
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0345753
RAB7A RAB7A, member RAS oncogene family -0.034419
JMJD1C jumonji domain containing 1C -0.0343733
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.0337793
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0335302
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0333818
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.033305
PCBP2 poly(rC) binding protein 2 -0.0330425
GMDS GDP-mannose 4,6-dehydratase -0.0329494
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0328536
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0327742
ZNFX1 zinc finger, NFX1-type containing 1 -0.0324633
DOCK4 dedicator of cytokinesis 4 -0.0321992
ETV6 ets variant 6 -0.0321936
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0318547
LPP LIM domain containing preferred translocation partner in lipoma -0.0316014
TOP1 topoisomerase (DNA) I -0.0313914
UBE2H ubiquitin-conjugating enzyme E2H -0.0313348
APP amyloid beta (A4) precursor protein -0.0311209
PICALM phosphatidylinositol binding clathrin assembly protein -0.0309322
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0304582
ARHGAP26 Rho GTPase activating protein 26 -0.0304363
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0302618
RCOR1 REST corepressor 1 -0.029794
FNDC3B fibronectin type III domain containing 3B -0.0297381
TGFA transforming growth factor, alpha -0.029677
GPHN gephyrin -0.0296579
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0294893
CADPS Ca++-dependent secretion activator -0.0293095
PATJ PATJ crumbs cell polarity complex component -0.0291218
FRMD5 FERM domain containing 5 -0.0290555
ARHGAP32 Rho GTPase activating protein 32 -0.0290341
RBM39 RNA binding motif protein 39 -0.0285126
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0284866
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.0284137
FAM3C family with sequence similarity 3, member C -0.0283921
INTS6 integrator complex subunit 6 -0.0283917
MYH9 myosin, heavy chain 9, non-muscle -0.0282008
GLS2 glutaminase 2 (liver, mitochondrial) -0.0281133
PCLO piccolo presynaptic cytomatrix protein -0.0280295
SHB Src homology 2 domain containing adaptor protein B -0.0279525
PRELID2 PRELI domain containing 2 -0.0279309
MYO1E myosin IE -0.0275882
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0275203
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0274525
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0273169
RNF213 ring finger protein 213 -0.0269972
MYO5B myosin VB -0.0268808
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0268724
NCOA3 nuclear receptor coactivator 3 -0.0266295
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0266075
PTPRK protein tyrosine phosphatase, receptor type, K -0.0265679
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0263139
SMYD3 SET and MYND domain containing 3 -0.0261241
UBAP2 ubiquitin associated protein 2 -0.0257579
EZR ezrin -0.0256833
MAPK8 mitogen-activated protein kinase 8 -0.0256121
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0255827