Loperamide (hydrochloride)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Loperamide (hydrochloride) perturbation in SW48 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Loperamide (hydrochloride)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0995731
ANXA1 annexin A1 0.063457
AREG amphiregulin 0.0467186
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0440699
CD36 CD36 molecule (thrombospondin receptor) 0.0424917
HILPDA hypoxia inducible lipid droplet-associated 0.0395333
ITPRID2 ITPR interacting domain containing 2 0.0362729
PDE4B phosphodiesterase 4B, cAMP-specific 0.0337429
EREG epiregulin 0.0334664
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0330905
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.032247
LMO7 LIM domain 7 0.0311888
NUP58 nucleoporin 58 0.0309456
OXR1 oxidation resistance 1 0.029926
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.029838
KMT2C lysine (K)-specific methyltransferase 2C 0.029779
EZR ezrin 0.0282019
WAC WW domain containing adaptor with coiled-coil 0.02769
TSC22D2 TSC22 domain family, member 2 0.0275558
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0270895
RNF145 ring finger protein 145 0.0260298
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0245657
WDR43 WD repeat domain 43 0.0245614
KDM6A lysine (K)-specific demethylase 6A 0.0236065
GARS1 glycyl-tRNA synthetase 1 0.0217879
UBA6 ubiquitin-like modifier activating enzyme 6 0.0211359
ZNF292 zinc finger protein 292 0.0202888
LAMB3 laminin, beta 3 0.0202485
PLAUR plasminogen activator, urokinase receptor 0.0200083
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0199962
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0195747
DSPP dentin sialophosphoprotein 0.0190748
NCKAP1 NCK-associated protein 1 0.01882
RLF rearranged L-myc fusion 0.0187735
SLMAP sarcolemma associated protein 0.0187183
TOP1 topoisomerase (DNA) I 0.0185697
TOP2B topoisomerase (DNA) II beta 180kDa 0.0185523
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0184535
PDLIM5 PDZ and LIM domain 5 0.0178502
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0177566
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0175464
HDAC2 histone deacetylase 2 0.0175062
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0173219
ZMYM2 zinc finger, MYM-type 2 0.0172192
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0172141
YME1L1 YME1-like 1 ATPase 0.0168343
SRRM1 serine/arginine repetitive matrix 1 0.0167522
KIF5B kinesin family member 5B 0.0166253
FXR1 fragile X mental retardation, autosomal homolog 1 0.0163572
SLTM SAFB-like, transcription modulator 0.015834
GPBP1 GC-rich promoter binding protein 1 0.0153748
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0153422
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0152742
NPEPPS aminopeptidase puromycin sensitive 0.0150624
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0150299
HSPA8 heat shock 70kDa protein 8 0.0149659
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0149457
PPP4R3A protein phosphatase 4 regulatory subunit 3A 0.0147902
PTBP2 polypyrimidine tract binding protein 2 0.0147544
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0147085
KMT2E lysine (K)-specific methyltransferase 2E 0.0145958
PUM2 pumilio RNA-binding family member 2 0.0145455
HMGB2 high mobility group box 2 0.0144771
MT1X metallothionein 1X 0.0144164
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0143163
FAR1 fatty acyl CoA reductase 1 0.0140508
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0139912
CEP152 centrosomal protein 152kDa 0.0139179
GOLGA4 golgin A4 0.0138542
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0137841
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0135196
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 0.0133534
LAMC2 laminin, gamma 2 0.0133382
STRN3 striatin, calmodulin binding protein 3 0.0133149
GTF2I general transcription factor IIi 0.0132703
ECT2 epithelial cell transforming 2 0.0131764
KDM3A lysine (K)-specific demethylase 3A 0.0131076
USP3 ubiquitin specific peptidase 3 0.013082
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0130588
NEK7 NIMA-related kinase 7 0.0129834
CKAP5 cytoskeleton associated protein 5 0.0129099
SET SET nuclear proto-oncogene 0.0128158
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0128123
CDC73 cell division cycle 73 0.0128118
PNISR PNN-interacting serine/arginine-rich protein 0.0128038
MPZL3 myelin protein zero-like 3 0.0127481
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0127055
RAD21 RAD21 homolog (S. pombe) 0.0127025
BIRC3 baculoviral IAP repeat containing 3 0.0126861
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0126452
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0126384
SFXN1 sideroflexin 1 0.0125836
NCEH1 neutral cholesterol ester hydrolase 1 0.0125199
OXSR1 oxidative stress responsive 1 0.0125078
NAMPT nicotinamide phosphoribosyltransferase 0.0124888
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0124524
IWS1 IWS1 homolog (S. cerevisiae) 0.0123892
MTF2 metal response element binding transcription factor 2 0.0123416
MINDY2 MINDY lysine 48 deubiquitinase 2 0.012219
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0120658

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.150107
ACTG1 actin gamma 1 -0.142012
RPL35A ribosomal protein L35a -0.0877861
RPS6 ribosomal protein S6 -0.0817816
TPT1 tumor protein, translationally-controlled 1 -0.0781769
PTMA prothymosin, alpha -0.0706386
EGR1 early growth response 1 -0.0703477
RPS8 ribosomal protein S8 -0.0575532
TMSB10 thymosin beta 10 -0.0559526
RPS29 ribosomal protein S29 -0.0544076
RPLP1 ribosomal protein, large, P1 -0.0491255
RPL34 ribosomal protein L34 -0.0464169
RPL31 ribosomal protein L31 -0.0460114
IER3 immediate early response 3 -0.0451906
RPL37A ribosomal protein L37a -0.0449633
RPS23 ribosomal protein S23 -0.0405114
RPL9 ribosomal protein L9 -0.0404195
RPS13 ribosomal protein S13 -0.0390955
RPS25 ribosomal protein S25 -0.0369759
RPL5 ribosomal protein L5 -0.0368265
HLA-B major histocompatibility complex, class I, B -0.0359288
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0354523
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0349996
RPS24 ribosomal protein S24 -0.0342643
HMGA2 high mobility group AT-hook 2 -0.0335549
FLOT1 flotillin 1 -0.0332327
HLA-A major histocompatibility complex, class I, A -0.0324717
FTL ferritin, light polypeptide -0.0320414
ACTN4 actinin, alpha 4 -0.0319915
RPLP2 ribosomal protein, large, P2 -0.0319323
RPS21 ribosomal protein S21 -0.0313025
RPS27A ribosomal protein S27a -0.0311209
ATP5F1B ATP synthase F1 subunit beta -0.0299258
FHIT fragile histidine triad -0.0297946
EGFR epidermal growth factor receptor -0.0291623
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0289821
LOC102724023 ES1 protein homolog, mitochondrial -0.028681
FTH1 ferritin, heavy polypeptide 1 -0.0283032
RPS17 ribosomal protein S17 -0.0278996
RPS11 ribosomal protein S11 -0.0276238
RPS10 ribosomal protein S10 -0.0269206
VCL vinculin -0.0268568
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0261804
RAD51B RAD51 paralog B -0.0258279
SMYD3 SET and MYND domain containing 3 -0.0252059
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0250271
HMGA1 high mobility group AT-hook 1 -0.0249293
IGFBP3 insulin-like growth factor binding protein 3 -0.0240751
RPS15 ribosomal protein S15 -0.0240351
RPL37 ribosomal protein L37 -0.0238375
RPS14 ribosomal protein S14 -0.0237753
SGPP2 sphingosine-1-phosphate phosphatase 2 -0.0234853
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0233828
RPL8 ribosomal protein L8 -0.023307
RPS12 ribosomal protein S12 -0.0232603
RPL32 ribosomal protein L32 -0.0230944
RPS5 ribosomal protein S5 -0.0226562
NDRG1 N-myc downstream regulated 1 -0.0226049
RPL38 ribosomal protein L38 -0.0225879
UBC ubiquitin C -0.0221193
RPL13A ribosomal protein L13a -0.0218465
RPS19 ribosomal protein S19 -0.0215122
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0214048
CUX1 cut-like homeobox 1 -0.0213899
SEPTIN9 septin 9 -0.0211129
RPL19 ribosomal protein L19 -0.0209369
BPTF bromodomain PHD finger transcription factor -0.0208154
VIM vimentin -0.0208075
RPL12 ribosomal protein L12 -0.0206104
SLC38A2 solute carrier family 38, member 2 -0.0203419
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0200635
RPL7A ribosomal protein L7a -0.0200468
RPL27 ribosomal protein L27 -0.0199603
NTSR1 neurotensin receptor 1 (high affinity) -0.0194896
POTEF POTE ankyrin domain family, member F -0.0194107
EEF2 eukaryotic translation elongation factor 2 -0.019377
ATXN1 ataxin 1 -0.0193634
RPS16 ribosomal protein S16 -0.0190139
RPL11 ribosomal protein L11 -0.0187772
TTC3 tetratricopeptide repeat domain 3 -0.0186969
RPL30 ribosomal protein L30 -0.0186773
ENO2 enolase 2 (gamma, neuronal) -0.0186371
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0186057
CCSER1 coiled-coil serine-rich protein 1 -0.0185945
AHNAK AHNAK nucleoprotein -0.0185776
S100A6 S100 calcium binding protein A6 -0.0184916
FUS FUS RNA binding protein -0.0181317
CMIP c-Maf inducing protein -0.0179482
RPL36 ribosomal protein L36 -0.017541
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0174974
RPL15 ribosomal protein L15 -0.0173599
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.0171017
TRAF3 TNF receptor-associated factor 3 -0.0168743
SETD5 SET domain containing 5 -0.0163565
TUBB4B tubulin, beta 4B class IVb -0.0161705
GPHN gephyrin -0.0160409
TENM3 teneurin transmembrane protein 3 -0.0155745
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0154478
TPM4 tropomyosin 4 -0.0153403
PDE4D phosphodiesterase 4D, cAMP-specific -0.0151865