Loperamide (hydrochloride)_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Loperamide (hydrochloride) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Loperamide (hydrochloride)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0929684
FAM13A family with sequence similarity 13, member A 0.0840869
STC1 stanniocalcin 1 0.0624111
VIM vimentin 0.0619959
ELL2 elongation factor, RNA polymerase II, 2 0.0597861
SPAG9 sperm associated antigen 9 0.0575679
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0568777
FTL ferritin, light polypeptide 0.0552209
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0540056
GOLGA4 golgin A4 0.0504777
CAVIN1 caveolae associated protein 1 0.0453374
NAMPT nicotinamide phosphoribosyltransferase 0.0437006
ARHGAP21 Rho GTPase activating protein 21 0.0414208
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0383244
KDM3A lysine (K)-specific demethylase 3A 0.0371288
PTMA prothymosin, alpha 0.0349487
HILPDA hypoxia inducible lipid droplet-associated 0.0329326
EIF1 eukaryotic translation initiation factor 1 0.0327317
MT2A metallothionein 2A 0.0323884
PDE4D phosphodiesterase 4D, cAMP-specific 0.0323343
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0317151
ADM adrenomedullin 0.0304104
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0287499
OGA O-GlcNAcase 0.0286517
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0277802
LCORL ligand dependent nuclear receptor corepressor-like 0.0274402
MXI1 MAX interactor 1, dimerization protein 0.0274228
ZNF292 zinc finger protein 292 0.0260297
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0256159
NUP58 nucleoporin 58 0.0252766
RPS6 ribosomal protein S6 0.0249616
SUCO SUN domain containing ossification factor 0.024071
RPL23 ribosomal protein L23 0.0239662
HMGB2 high mobility group box 2 0.0237142
USP3 ubiquitin specific peptidase 3 0.023528
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0232547
RPS12 ribosomal protein S12 0.0226417
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0225181
CANX calnexin 0.0224955
TTC3 tetratricopeptide repeat domain 3 0.0222675
RPLP1 ribosomal protein, large, P1 0.0218407
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0217242
NGLY1 N-glycanase 1 0.0216353
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0215924
RLF rearranged L-myc fusion 0.0214898
CLINT1 clathrin interactor 1 0.0214421
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0211981
DDIT4 DNA-damage-inducible transcript 4 0.0207794
SRP54 signal recognition particle 54kDa 0.0204934
SOD2 superoxide dismutase 2, mitochondrial 0.0204819
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0203824
NPEPPS aminopeptidase puromycin sensitive 0.0203424
HELZ helicase with zinc finger 0.02007
ARRDC3 arrestin domain containing 3 0.0196994
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0194854
RAB8B RAB8B, member RAS oncogene family 0.0194474
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0192392
FMNL2 formin-like 2 0.0192347
NAP1L1 nucleosome assembly protein 1-like 1 0.0192193
FOXO3 forkhead box O3 0.0191976
RPL26 ribosomal protein L26 0.0189288
DSCAM Down syndrome cell adhesion molecule 0.0188239
PNISR PNN-interacting serine/arginine-rich protein 0.018797
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0187944
LMAN1 lectin, mannose-binding, 1 0.0185314
YBX3 Y box binding protein 3 0.0184089
MATR3 matrin 3 0.0180901
SQSTM1 sequestosome 1 0.0179166
ESYT2 extended synaptotagmin-like protein 2 0.0176638
BZW1 basic leucine zipper and W2 domains 1 0.0175249
CCDC47 coiled-coil domain containing 47 0.0174774
CENPF centromere protein F, 350/400kDa 0.0174572
RPL12 ribosomal protein L12 0.0174538
RB1CC1 RB1-inducible coiled-coil 1 0.0173908
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0172692
RAI1 retinoic acid induced 1 0.0171903
NDRG1 N-myc downstream regulated 1 0.017024
WDR45B WD repeat domain 45B 0.0170137
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0164045
KMT2E lysine (K)-specific methyltransferase 2E 0.0163977
UBA6 ubiquitin-like modifier activating enzyme 6 0.0163866
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0161968
AMPD3 adenosine monophosphate deaminase 3 0.0161723
IER3 immediate early response 3 0.0161461
WSB1 WD repeat and SOCS box containing 1 0.016061
TNPO1 transportin 1 0.0158848
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0156825
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0156045
BHLHE40 basic helix-loop-helix family, member e40 0.0154708
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0154428
DUSP10 dual specificity phosphatase 10 0.0153715
NOP58 NOP58 ribonucleoprotein 0.015328
YTHDC1 YTH domain containing 1 0.015299
RNF145 ring finger protein 145 0.0152913
CEP350 centrosomal protein 350kDa 0.0151461
AKAP9 A kinase (PRKA) anchor protein 9 0.0149023
TOP2B topoisomerase (DNA) II beta 180kDa 0.0148206
KIF5B kinesin family member 5B 0.0147942
CALU calumenin 0.014786
YME1L1 YME1-like 1 ATPase 0.0147105

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.263346
NALF1 NALCN channel auxiliary factor 1 -0.231803
COL6A3 collagen, type VI, alpha 3 -0.201641
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.18472
PRKG1 protein kinase, cGMP-dependent, type I -0.157218
HMGA2 high mobility group AT-hook 2 -0.155871
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.133585
MYO10 myosin X -0.124399
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.123195
COL6A1 collagen, type VI, alpha 1 -0.122023
COL1A1 collagen, type I, alpha 1 -0.121416
INHBA inhibin, beta A -0.112622
NAV1 neuron navigator 1 -0.107192
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0996131
COL1A2 collagen, type I, alpha 2 -0.0886361
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0855915
GLIS3 GLIS family zinc finger 3 -0.0823796
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0793558
COL6A2 collagen, type VI, alpha 2 -0.0745452
OXR1 oxidation resistance 1 -0.0722597
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0721657
ADGRB3 adhesion G protein-coupled receptor B3 -0.0717579
TGFBI transforming growth factor, beta-induced, 68kDa -0.0708907
AKAP12 A kinase (PRKA) anchor protein 12 -0.0697258
POTEF POTE ankyrin domain family, member F -0.0675404
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0639677
CD44 CD44 molecule (Indian blood group) -0.0598266
FRMD4A FERM domain containing 4A -0.0567701
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0562457
HLA-B major histocompatibility complex, class I, B -0.0554801
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0553946
VCL vinculin -0.0531993
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0523867
ACTG1 actin gamma 1 -0.0505804
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0500185
CDH13 cadherin 13 -0.0497406
CALD1 caldesmon 1 -0.0490121
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0488684
ASPH aspartate beta-hydroxylase -0.048416
EXT1 exostosin glycosyltransferase 1 -0.0480319
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0479634
EGFR epidermal growth factor receptor -0.0458733
FBN1 fibrillin 1 -0.045169
KIAA1549L KIAA1549-like -0.0439607
TMSB10 thymosin beta 10 -0.0429071
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0428842
ABI3BP ABI family, member 3 (NESH) binding protein -0.0421511
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0416635
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0403027
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0386348
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0378007
EMP1 epithelial membrane protein 1 -0.0372916
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0364952
LTBP1 latent transforming growth factor beta binding protein 1 -0.035798
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.035438
PRSS23 protease, serine, 23 -0.0346118
CLMP CXADR-like membrane protein -0.0345646
EGR1 early growth response 1 -0.0342085
RAI14 retinoic acid induced 14 -0.0332126
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0329744
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0322473
MAP1B microtubule-associated protein 1B -0.0318902
PRRX1 paired related homeobox 1 -0.0317309
WNT5A wingless-type MMTV integration site family, member 5A -0.0316895
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0311173
NOTCH2 notch 2 -0.030814
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0300837
DIAPH2 diaphanous-related formin 2 -0.029942
COL5A1 collagen, type V, alpha 1 -0.0292408
GREM1 gremlin 1, DAN family BMP antagonist -0.0291218
EFCAB13 EF-hand calcium binding domain 13 -0.0289444
PDLIM5 PDZ and LIM domain 5 -0.0289028
MED13L mediator complex subunit 13-like -0.0288284
NCKAP5 NCK-associated protein 5 -0.0286966
PRR16 proline rich 16 -0.0283078
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0282588
LPP LIM domain containing preferred translocation partner in lipoma -0.0277044
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0273956
CREB3L1 cAMP responsive element binding protein 3-like 1 -0.0273653
ARHGAP22 Rho GTPase activating protein 22 -0.0273023
DGKI diacylglycerol kinase, iota -0.0272439
SAMD3 sterile alpha motif domain containing 3 -0.0266621
ENO2 enolase 2 (gamma, neuronal) -0.0266406
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0260024
ITGA11 integrin, alpha 11 -0.0256393
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0255734
FNDC3B fibronectin type III domain containing 3B -0.0254897
CEMIP cell migration inducing protein, hyaluronan binding -0.0253018
COL5A3 collagen, type V, alpha 3 -0.0250663
LYST lysosomal trafficking regulator -0.0246598
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0246533
MAML3 mastermind-like 3 (Drosophila) -0.0244658
VEGFA vascular endothelial growth factor A -0.0243461
MSN moesin -0.0242867
SLC38A2 solute carrier family 38, member 2 -0.0241518
SLIT2 slit homolog 2 (Drosophila) -0.0240958
IGF2 insulin-like growth factor 2 -0.023953
PDGFRB platelet-derived growth factor receptor, beta polypeptide -0.023851
VCAN versican -0.0238185
SASH1 SAM and SH3 domain containing 1 -0.0237781