Lopinavir_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lopinavir perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lopinavir_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CDH13 cadherin 13 0.0969581
AHNAK AHNAK nucleoprotein 0.0964837
SLC39A11 solute carrier family 39, member 11 0.0667096
MYH9 myosin, heavy chain 9, non-muscle 0.0631436
ANKRD11 ankyrin repeat domain 11 0.0580989
FLNA filamin A, alpha 0.0467961
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.04562
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0429548
S100A10 S100 calcium binding protein A10 0.0421751
TRIO trio Rho guanine nucleotide exchange factor 0.04129
CSTB cystatin B (stefin B) 0.0403936
MSI2 musashi RNA-binding protein 2 0.0395117
RND3 Rho family GTPase 3 0.0393575
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0385925
MT2A metallothionein 2A 0.0378622
PLEC plectin 0.0375235
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0356376
TMSB10 thymosin beta 10 0.0352188
HDAC9 histone deacetylase 9 0.0344173
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0338677
RPS6 ribosomal protein S6 0.0330913
TPT1 tumor protein, translationally-controlled 1 0.0327475
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0324574
NAV2 neuron navigator 2 0.031673
RPL37A ribosomal protein L37a 0.0314033
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0301799
RPL23 ribosomal protein L23 0.0298902
LMNA lamin A/C 0.0295093
RPLP2 ribosomal protein, large, P2 0.0293416
E2F7 E2F transcription factor 7 0.0287247
BHLHE40 basic helix-loop-helix family, member e40 0.0283111
RPL35 ribosomal protein L35 0.027685
RPLP1 ribosomal protein, large, P1 0.0276611
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0276001
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0274492
RPS8 ribosomal protein S8 0.02717
CALR calreticulin 0.0270013
RPL35A ribosomal protein L35a 0.0267021
LOC112694756 uncharaterized LOC112694756 0.0255521
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0250634
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0241811
RPL28 ribosomal protein L28 0.0239445
RPL19 ribosomal protein L19 0.0238701
LDHA lactate dehydrogenase A 0.0238045
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0231458
MACF1 microtubule-actin crosslinking factor 1 0.0225982
ASPH aspartate beta-hydroxylase 0.0220244
TM4SF19 transmembrane 4 L six family member 19 0.0212644
AHNAK2 AHNAK nucleoprotein 2 0.0209993
FSTL1 follistatin-like 1 0.0205438
RHOBTB3 Rho-related BTB domain containing 3 0.0202289
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0200458
RPS5 ribosomal protein S5 0.0199791
SEC61G Sec61 gamma subunit 0.0197282
RPS27 ribosomal protein S27 0.019565
RPS19 ribosomal protein S19 0.0194784
RPL34 ribosomal protein L34 0.0194411
ANKRD28 ankyrin repeat domain 28 0.0192812
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 0.0191139
ENO1 enolase 1, (alpha) 0.0190691
RPS12 ribosomal protein S12 0.0190144
RPL12 ribosomal protein L12 0.0183785
HILPDA hypoxia inducible lipid droplet-associated 0.0182003
RPS11 ribosomal protein S11 0.0180959
CENPF centromere protein F, 350/400kDa 0.0179894
ULK1 unc-51 like autophagy activating kinase 1 0.0176835
FGFR1 fibroblast growth factor receptor 1 0.0171801
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 0.0171149
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.016915
RPS23 ribosomal protein S23 0.0167794
PTMA prothymosin, alpha 0.0166191
LGALS1 lectin, galactoside-binding, soluble, 1 0.016518
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0162159
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0160962
MEAK7 MTOR associated protein, eak-7 homolog 0.0158919
RPL36 ribosomal protein L36 0.0156013
LENG8 leukocyte receptor cluster (LRC) member 8 0.0155558
RPS2 ribosomal protein S2 0.0154808
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0154263
BCL2L1 BCL2-like 1 0.0153979
EEF2 eukaryotic translation elongation factor 2 0.0153886
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0153633
ANKRD30B ankyrin repeat domain 30B 0.0153407
GLRX glutaredoxin (thioltransferase) 0.0153065
SORBS2 sorbin and SH3 domain containing 2 0.0151452
MIDEAS mitotic deacetylase associated SANT domain protein 0.0150466
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0149809
LIMS1 LIM and senescent cell antigen-like domains 1 0.0148648
DTNA dystrobrevin, alpha 0.0148573
PABPN1 poly(A) binding protein, nuclear 1 0.0148262
RPS13 ribosomal protein S13 0.014789
RPL27 ribosomal protein L27 0.0147763
FOSL2 FOS-like antigen 2 0.0147704
RPS27A ribosomal protein S27a 0.0145536
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 0.0143605
RPS24 ribosomal protein S24 0.0142567
RAB7A RAB7A, member RAS oncogene family 0.0142173
TPM3 tropomyosin 3 0.0142023
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0141663
RPL31 ribosomal protein L31 0.0141638

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.213327
LOX lysyl oxidase -0.183383
FBN1 fibrillin 1 -0.180084
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.151823
COL8A1 collagen, type VIII, alpha 1 -0.14981
ZBTB20 zinc finger and BTB domain containing 20 -0.134344
LOXL2 lysyl oxidase-like 2 -0.115504
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.11065
COL1A2 collagen, type I, alpha 2 -0.110452
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.10038
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0983255
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0937202
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.090686
AKAP12 A kinase (PRKA) anchor protein 12 -0.0896702
MX2 MX dynamin-like GTPase 2 -0.0874003
GLIS3 GLIS family zinc finger 3 -0.0858554
COL3A1 collagen, type III, alpha 1 -0.0850423
PLAT plasminogen activator, tissue -0.0754134
COL5A2 collagen, type V, alpha 2 -0.0748871
DLG1 discs, large homolog 1 (Drosophila) -0.0700757
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0686483
DST dystonin -0.0651461
THBS2 thrombospondin 2 -0.0603919
MAP4 microtubule-associated protein 4 -0.0602027
GPC6 glypican 6 -0.0563382
RIGI RNA sensor RIG-I -0.0552406
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0545849
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0531631
ARL15 ADP-ribosylation factor-like 15 -0.0525682
EHBP1 EH domain binding protein 1 -0.0524142
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0509867
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0506663
MEIS2 Meis homeobox 2 -0.0505615
FRMD5 FERM domain containing 5 -0.0486141
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0485823
NDRG1 N-myc downstream regulated 1 -0.0481044
RNF213 ring finger protein 213 -0.0479312
CD44 CD44 molecule (Indian blood group) -0.0472925
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0472806
TAGLN2 transgelin 2 -0.0469047
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0468627
ANXA2 annexin A2 -0.0460304
B2M beta-2-microglobulin -0.0459996
PSD3 pleckstrin and Sec7 domain containing 3 -0.0454909
MAP1B microtubule-associated protein 1B -0.0436072
JAZF1 JAZF zinc finger 1 -0.0431253
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0427808
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0421567
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0420619
IFIH1 interferon induced with helicase C domain 1 -0.0418855
KLF7 Kruppel-like factor 7 (ubiquitous) -0.04133
UBC ubiquitin C -0.0409446
PARD3 par-3 family cell polarity regulator -0.0407221
STC1 stanniocalcin 1 -0.0405784
PDE4D phosphodiesterase 4D, cAMP-specific -0.040257
SBF2 SET binding factor 2 -0.0399948
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0398144
DPYSL3 dihydropyrimidinase-like 3 -0.0388799
IFI16 interferon, gamma-inducible protein 16 -0.0379446
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0377528
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0375092
TENM3 teneurin transmembrane protein 3 -0.0373993
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0366387
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0358604
KIFAP3 kinesin-associated protein 3 -0.035607
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0351746
SLFN5 schlafen family member 5 -0.035067
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0349432
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.03465
CD99 CD99 molecule -0.0344595
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0343378
MYADM myeloid-associated differentiation marker -0.0343128
SH3KBP1 SH3-domain kinase binding protein 1 -0.0342694
SP100 SP100 nuclear antigen -0.0339435
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0332434
VEGFC vascular endothelial growth factor C -0.0329429
RTN4 reticulon 4 -0.0329308
CCL5 chemokine (C-C motif) ligand 5 -0.0328394
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0327847
TTC3 tetratricopeptide repeat domain 3 -0.0324549
NF1 neurofibromin 1 -0.0324538
SVIL supervillin -0.0319943
WARS1 tryptophanyl-tRNA synthetase 1 -0.0319814
FNDC3A fibronectin type III domain containing 3A -0.0319282
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0316841
TDRD7 tudor domain containing 7 -0.0315784
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0312431
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0309133
PRRX1 paired related homeobox 1 -0.0304186
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0301556
HLA-B major histocompatibility complex, class I, B -0.029716
SP3 Sp3 transcription factor -0.0296305
TCF12 transcription factor 12 -0.0296248
MBD5 methyl-CpG binding domain protein 5 -0.029053
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0290088
SSBP2 single-stranded DNA binding protein 2 -0.0287965
BIRC6 baculoviral IAP repeat containing 6 -0.0287104
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0285634
NEK7 NIMA-related kinase 7 -0.0283533
DSCAM Down syndrome cell adhesion molecule -0.0282314