| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lopinavir perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lopinavir_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.107744 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.10153 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0996954 |
| MMP12 | matrix metallopeptidase 12 | 0.0798639 |
| TPI1 | triosephosphate isomerase 1 | 0.0711295 |
| RPS12 | ribosomal protein S12 | 0.0660972 |
| AREG | amphiregulin | 0.0633675 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.063101 |
| TMSB10 | thymosin beta 10 | 0.0621527 |
| RPL3 | ribosomal protein L3 | 0.0560363 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0507894 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0475619 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0470167 |
| RPSA | ribosomal protein SA | 0.046388 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0459817 |
| ANXA1 | annexin A1 | 0.0455555 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.045436 |
| RAB10 | RAB10, member RAS oncogene family | 0.0450743 |
| RPS27A | ribosomal protein S27a | 0.0449175 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.043674 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0436081 |
| RPL26 | ribosomal protein L26 | 0.0415399 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0414941 |
| RPL4 | ribosomal protein L4 | 0.0413041 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0400498 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0400244 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0399585 |
| RPL19 | ribosomal protein L19 | 0.0398317 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0396484 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0381114 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0358189 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0353828 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0349873 |
| RPS2 | ribosomal protein S2 | 0.0348918 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0343415 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | 0.0341821 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0336271 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0331347 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0328135 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.032486 |
| RPS27 | ribosomal protein S27 | 0.0321732 |
| JMJD1C | jumonji domain containing 1C | 0.032167 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0318111 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0317162 |
| YTHDC1 | YTH domain containing 1 | 0.0312271 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0311049 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0306581 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0302942 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0302735 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.030078 |
| KLC1 | kinesin light chain 1 | 0.0297906 |
| HMGA2 | high mobility group AT-hook 2 | 0.0296003 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0294964 |
| RPL11 | ribosomal protein L11 | 0.0292031 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0289829 |
| XPOT | exportin, tRNA | 0.0289038 |
| ZNF217 | zinc finger protein 217 | 0.0286136 |
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.0283889 |
| NSD2 | nuclear receptor binding SET domain protein 2 | 0.0283157 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0279432 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0276875 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0276352 |
| RPS23 | ribosomal protein S23 | 0.0272675 |
| TRAPPC8 | trafficking protein particle complex 8 | 0.02707 |
| SETD5 | SET domain containing 5 | 0.0270619 |
| SLMAP | sarcolemma associated protein | 0.0270017 |
| LOC112694756 | uncharaterized LOC112694756 | 0.026846 |
| RPS5 | ribosomal protein S5 | 0.0267713 |
| SNX27 | sorting nexin family member 27 | 0.0266067 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0265213 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0261421 |
| PLK2 | polo-like kinase 2 | 0.0261002 |
| RPS18 | ribosomal protein S18 | 0.0260942 |
| PLEC | plectin | 0.025949 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0258745 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.025767 |
| MEMO1 | mediator of cell motility 1 | 0.0253612 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0253436 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0252519 |
| PTMA | prothymosin, alpha | 0.0252192 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0251792 |
| RPL36A | ribosomal protein L36a | 0.0251567 |
| ABI1 | abl-interactor 1 | 0.0250221 |
| RBM39 | RNA binding motif protein 39 | 0.0247463 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0246074 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0246051 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0245791 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0245199 |
| SPAG9 | sperm associated antigen 9 | 0.0244903 |
| RPS8 | ribosomal protein S8 | 0.0244049 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0241271 |
| TMEM41B | transmembrane protein 41B | 0.024097 |
| FAT1 | FAT atypical cadherin 1 | 0.024056 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0239908 |
| CEP192 | centrosomal protein 192kDa | 0.0239592 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0238859 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0238524 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0238412 |
| NCKAP1 | NCK-associated protein 1 | 0.0237746 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0237245 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.281997 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.184877 |
| NLGN1 | neuroligin 1 | -0.150377 |
| PCDH7 | protocadherin 7 | -0.136284 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.116977 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.107895 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.105191 |
| VIM | vimentin | -0.0946588 |
| DST | dystonin | -0.0912718 |
| HMGA1 | high mobility group AT-hook 1 | -0.086161 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0788961 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0741046 |
| PCBP2 | poly(rC) binding protein 2 | -0.0691712 |
| PFN1 | profilin 1 | -0.0684212 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.068091 |
| POTEF | POTE ankyrin domain family, member F | -0.0671154 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0662057 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0580065 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0562418 |
| ZNF804A | zinc finger protein 804A | -0.0534631 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0526554 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | -0.0515963 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0494098 |
| TENM3 | teneurin transmembrane protein 3 | -0.0467896 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0453986 |
| USP34 | ubiquitin specific peptidase 34 | -0.0444468 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.044392 |
| CCND1 | cyclin D1 | -0.0441016 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0440442 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0439068 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0416512 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0406969 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0390851 |
| SEC62 | SEC62 homolog (S. cerevisiae) | -0.0369759 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | -0.0369531 |
| TUBA1B | tubulin, alpha 1b | -0.0366358 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0363818 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0353786 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0350932 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0347864 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0344443 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0344431 |
| SMYD3 | SET and MYND domain containing 3 | -0.0342226 |
| NEGR1 | neuronal growth regulator 1 | -0.0340772 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0339327 |
| HELLS | helicase, lymphoid-specific | -0.0328297 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.0322565 |
| LDHB | lactate dehydrogenase B | -0.0319008 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0314435 |
| CCN2 | cellular communication network factor 2 | -0.0313638 |
| TIGAR | TP53 induced glycolysis regulatory phosphatase | -0.0310563 |
| CBX3 | chromobox homolog 3 | -0.0309373 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0302073 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0301459 |
| RASAL2 | RAS protein activator like 2 | -0.0301282 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0298231 |
| BPTF | bromodomain PHD finger transcription factor | -0.0296061 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0288893 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.028504 |
| FSTL5 | follistatin-like 5 | -0.0284052 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0281258 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0278051 |
| U2SURP | U2 snRNP-associated SURP domain containing | -0.0276785 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | -0.0275927 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0270621 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0269281 |
| PCM1 | pericentriolar material 1 | -0.0267428 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0265002 |
| LDHA | lactate dehydrogenase A | -0.0264677 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0264101 |
| SYT1 | synaptotagmin I | -0.0261386 |
| THSD7A | thrombospondin, type I, domain containing 7A | -0.0260538 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0258552 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0258432 |
| NRXN3 | neurexin 3 | -0.0255648 |
| TXNRD1 | thioredoxin reductase 1 | -0.0254214 |
| ZNF519 | zinc finger protein 519 | -0.0253356 |
| LRRC23 | leucine rich repeat containing 23 | -0.0251432 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0241339 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0241269 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0239914 |
| MPG | N-methylpurine-DNA glycosylase | -0.0238014 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0235714 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0231739 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0230977 |
| CCDC88A | coiled-coil domain containing 88A | -0.0230865 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0229494 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | -0.0226654 |
| CALR | calreticulin | -0.0222811 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0219846 |
| EHBP1 | EH domain binding protein 1 | -0.0219413 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0217657 |
| NBEAL1 | neurobeachin-like 1 | -0.0216842 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.0216024 |
| RAD51AP1 | RAD51 associated protein 1 | -0.0216023 |
| MAP4 | microtubule-associated protein 4 | -0.0215027 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0214716 |
| NHSL1 | NHS-like 1 | -0.0213969 |
| HMGB1 | high mobility group box 1 | -0.021396 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | -0.021271 |
