| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lopinavir perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lopinavir_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.135283 |
| ATP13A3 | ATPase type 13A3 | 0.0461121 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.042603 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0407235 |
| PLEC | plectin | 0.039522 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0366185 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.03489 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.030499 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0281298 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0267868 |
| POSTN | periostin, osteoblast specific factor | 0.0266808 |
| ARRDC3 | arrestin domain containing 3 | 0.0256548 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0231412 |
| RPL3 | ribosomal protein L3 | 0.021181 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0201247 |
| FLNA | filamin A, alpha | 0.0196097 |
| VEGFA | vascular endothelial growth factor A | 0.0195572 |
| YBX1 | Y box binding protein 1 | 0.019096 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0187192 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0185663 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0180699 |
| SQLE | squalene epoxidase | 0.0178528 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0172136 |
| SMAD3 | SMAD family member 3 | 0.0170408 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0163062 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0162618 |
| USP3 | ubiquitin specific peptidase 3 | 0.0157747 |
| H1-4 | H1.4 linker histone, cluster member | 0.0146956 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0143167 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0137828 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.013732 |
| RAD21 | RAD21 homolog (S. pombe) | 0.013697 |
| CADM1 | cell adhesion molecule 1 | 0.0135837 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0135417 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0134576 |
| MT1X | metallothionein 1X | 0.0132215 |
| FOXJ3 | forkhead box J3 | 0.0128987 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0128437 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0127808 |
| ANGPTL4 | angiopoietin-like 4 | 0.0125195 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0120918 |
| TPM2 | tropomyosin 2 (beta) | 0.0118139 |
| RPS15A | ribosomal protein S15a | 0.0117344 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0116882 |
| TFG | TRK-fused gene | 0.0115509 |
| RPSA | ribosomal protein SA | 0.0115432 |
| SEPTIN9 | septin 9 | 0.0113975 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0113881 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0113713 |
| RPL13A | ribosomal protein L13a | 0.0113231 |
| ZNF292 | zinc finger protein 292 | 0.0112788 |
| HYOU1 | hypoxia up-regulated 1 | 0.0112513 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.010983 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0109765 |
| RPL19 | ribosomal protein L19 | 0.0109228 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.0106058 |
| RPL4 | ribosomal protein L4 | 0.0104556 |
| RCN1 | reticulocalbin 1, EF-hand calcium binding domain | 0.0103446 |
| MSMO1 | methylsterol monooxygenase 1 | 0.0103385 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0103094 |
| DRAP1 | DR1-associated protein 1 (negative cofactor 2 alpha) | 0.010201 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0101791 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0101596 |
| PKM | pyruvate kinase, muscle | 0.010141 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.010096 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0100755 |
| APP | amyloid beta (A4) precursor protein | 0.0099526 |
| RNF145 | ring finger protein 145 | 0.00968629 |
| RBM33 | RNA binding motif protein 33 | 0.00962679 |
| IL1B | interleukin 1, beta | 0.00945153 |
| COL12A1 | collagen, type XII, alpha 1 | 0.0092843 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.00915616 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | 0.00912864 |
| RPS2 | ribosomal protein S2 | 0.0090668 |
| SF3A1 | splicing factor 3a, subunit 1, 120kDa | 0.00905917 |
| DENND4C | DENN/MADD domain containing 4C | 0.00894677 |
| PER1 | period circadian clock 1 | 0.00882016 |
| TCP1 | t-complex 1 | 0.00879743 |
| CNOT12 | CCR4-NOT transcription complex subunit 12 | 0.0087472 |
| H1-2 | H1.2 linker histone, cluster member | 0.00847882 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.00843986 |
| PPP2R1A | protein phosphatase 2, regulatory subunit A, alpha | 0.00841836 |
| TPM3 | tropomyosin 3 | 0.0083058 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.00829772 |
| ICAM1 | intercellular adhesion molecule 1 | 0.00825701 |
| FBXO7 | F-box protein 7 | 0.00821155 |
| NUP58 | nucleoporin 58 | 0.00815219 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.00814433 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.00813249 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.00809148 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.00801631 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.00800396 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | 0.00794823 |
| FOSL1 | FOS-like antigen 1 | 0.00788599 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0077554 |
| RPS12 | ribosomal protein S12 | 0.00766166 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.00757596 |
| MYO1B | myosin IB | 0.00751518 |
| KLF10 | Kruppel-like factor 10 | 0.00750946 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.00749907 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.299898 |
| COL1A1 | collagen, type I, alpha 1 | -0.177578 |
| VIM | vimentin | -0.170784 |
| NDRG1 | N-myc downstream regulated 1 | -0.150265 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.139267 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.100297 |
| COL1A2 | collagen, type I, alpha 2 | -0.0931433 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0894358 |
| EXT1 | exostosin glycosyltransferase 1 | -0.086386 |
| TPM4 | tropomyosin 4 | -0.0859174 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0751282 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0742558 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0705143 |
| FN1 | fibronectin 1 | -0.0694645 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0690512 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0621791 |
| FBN1 | fibrillin 1 | -0.0618501 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0579351 |
| LOX | lysyl oxidase | -0.0551429 |
| LOXL2 | lysyl oxidase-like 2 | -0.0545191 |
| IER3 | immediate early response 3 | -0.0543351 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0525993 |
| VCAN | versican | -0.0496 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.048468 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0476546 |
| GLIS3 | GLIS family zinc finger 3 | -0.0455348 |
| CDH13 | cadherin 13 | -0.0452722 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0445594 |
| HLA-B | major histocompatibility complex, class I, B | -0.0443327 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0412944 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0411214 |
| VCL | vinculin | -0.040948 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0391993 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0391619 |
| STC1 | stanniocalcin 1 | -0.0390519 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0384393 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0370826 |
| GOLGB1 | golgin B1 | -0.0366687 |
| ACTG1 | actin gamma 1 | -0.0364141 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0364125 |
| CD44 | CD44 molecule (Indian blood group) | -0.0361569 |
| MAP1B | microtubule-associated protein 1B | -0.0358621 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0338636 |
| TMSB10 | thymosin beta 10 | -0.0331006 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0329809 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0324812 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0323444 |
| FOXP1 | forkhead box P1 | -0.032077 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0318088 |
| DST | dystonin | -0.0316066 |
| RUNX1 | runt-related transcription factor 1 | -0.0314017 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0312896 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0306325 |
| COL5A1 | collagen, type V, alpha 1 | -0.0305505 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0305289 |
| CUX1 | cut-like homeobox 1 | -0.0305249 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0304595 |
| NAV1 | neuron navigator 1 | -0.0301779 |
| CALU | calumenin | -0.0297845 |
| CAVIN1 | caveolae associated protein 1 | -0.0285725 |
| CALD1 | caldesmon 1 | -0.0284036 |
| RPL35A | ribosomal protein L35a | -0.0282385 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0281042 |
| CNTN5 | contactin 5 | -0.0271905 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0271361 |
| CLMP | CXADR-like membrane protein | -0.0271004 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0266386 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0264471 |
| INHBA | inhibin, beta A | -0.0260441 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0260241 |
| RRBP1 | ribosome binding protein 1 | -0.0259245 |
| S100A9 | S100 calcium binding protein A9 | -0.0253071 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0249843 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.024914 |
| PRELID2 | PRELI domain containing 2 | -0.0245181 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0243626 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0243013 |
| MTDH | metadherin | -0.0242044 |
| EGFR | epidermal growth factor receptor | -0.0239635 |
| EGR1 | early growth response 1 | -0.0236867 |
| ASPH | aspartate beta-hydroxylase | -0.023671 |
| PDE10A | phosphodiesterase 10A | -0.0236217 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0233518 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0233318 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0227926 |
| EHD2 | EH-domain containing 2 | -0.0225357 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0225333 |
| MAP4 | microtubule-associated protein 4 | -0.0225104 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0224198 |
| SP100 | SP100 nuclear antigen | -0.0224001 |
| ATXN1 | ataxin 1 | -0.0221889 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0220209 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0219887 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0219379 |
| OSMR | oncostatin M receptor | -0.0217748 |
| PTK2 | protein tyrosine kinase 2 | -0.0217373 |
| HM13 | histocompatibility (minor) 13 | -0.0215383 |
| CANX | calnexin | -0.0213069 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0212746 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0210671 |
