Lopinavir_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lopinavir perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lopinavir_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 0.106725
FN1 fibronectin 1 0.0829955
GPC3 glypican 3 0.0799612
ASPH aspartate beta-hydroxylase 0.0735326
DSPP dentin sialophosphoprotein 0.0624045
ENO1 enolase 1, (alpha) 0.0616162
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0600375
ERRFI1 ERBB receptor feedback inhibitor 1 0.0551876
VCL vinculin 0.0534577
TM4SF1 transmembrane 4 L six family member 1 0.0530265
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0483241
AKAP12 A kinase (PRKA) anchor protein 12 0.0460675
RPS24 ribosomal protein S24 0.0446382
KDM3A lysine (K)-specific demethylase 3A 0.0412673
FAM107B family with sequence similarity 107, member B 0.0375503
TMSB10 thymosin beta 10 0.0372153
RPL11 ribosomal protein L11 0.0352946
SDC4 syndecan 4 0.0339779
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0328997
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0323901
APOB apolipoprotein B 0.0315141
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0308424
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0303637
RPL26 ribosomal protein L26 0.0303598
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0292991
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0285905
MYH9 myosin, heavy chain 9, non-muscle 0.0277075
PTPRF protein tyrosine phosphatase, receptor type, F 0.0271386
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0264761
SAMD4A sterile alpha motif domain containing 4A 0.0249739
RSL1D1 ribosomal L1 domain containing 1 0.0241264
H1-0 H1.0 linker histone 0.0241159
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0231815
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0229817
ACTG1 actin gamma 1 0.0225351
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0225316
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.021841
LDHA lactate dehydrogenase A 0.0209915
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0209319
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0202367
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0201182
EXT1 exostosin glycosyltransferase 1 0.0200056
STK17A serine/threonine kinase 17a 0.0199822
NAP1L1 nucleosome assembly protein 1-like 1 0.019969
DSCAM Down syndrome cell adhesion molecule 0.0195958
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0194825
AHNAK AHNAK nucleoprotein 0.019017
LAMA4 laminin, alpha 4 0.0189826
SERINC1 serine incorporator 1 0.0186612
BZW1 basic leucine zipper and W2 domains 1 0.0182562
EIF1 eukaryotic translation initiation factor 1 0.0179482
RPS8 ribosomal protein S8 0.0179465
MAPK13 mitogen-activated protein kinase 13 0.0179247
RPS27A ribosomal protein S27a 0.0177306
NACA nascent polypeptide-associated complex alpha subunit 0.0175547
GRB10 growth factor receptor-bound protein 10 0.0173655
KRT23 keratin 23, type I 0.017313
CP ceruloplasmin (ferroxidase) 0.0169507
ARHGAP5 Rho GTPase activating protein 5 0.016917
RPL4 ribosomal protein L4 0.016863
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0168141
HDLBP high density lipoprotein binding protein 0.0163883
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.0163066
STAU1 staufen double-stranded RNA binding protein 1 0.016103
KIF21A kinesin family member 21A 0.0160385
PGK1 phosphoglycerate kinase 1 0.0159484
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0159363
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0154016
JAK1 Janus kinase 1 0.0152491
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 0.0152144
KRT18 keratin 18, type I 0.0151262
ANKLE2 ankyrin repeat and LEM domain containing 2 0.0151101
NPR2 natriuretic peptide receptor 2 0.0149302
WAPL WAPL cohesin release factor 0.0148991
RAB3B RAB3B, member RAS oncogene family 0.0148433
APOA2 apolipoprotein A-II 0.0148351
MIDN midnolin 0.014721
TMEM263 transmembrane protein 263 0.0145494
RPS21 ribosomal protein S21 0.0145098
ARHGAP9 Rho GTPase activating protein 9 0.0144667
IFIH1 interferon induced with helicase C domain 1 0.0141275
RPLP0 ribosomal protein, large, P0 0.014081
ARL5A ADP-ribosylation factor-like 5A 0.01407
HMGA1 high mobility group AT-hook 1 0.01405
EEF1B2 eukaryotic translation elongation factor 1 beta 2 0.0139805
PTCHD4 patched domain containing 4 0.0139415
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0139105
MTSS1 metastasis suppressor 1 0.0138776
RPL12 ribosomal protein L12 0.0138348
CLIC1 chloride intracellular channel 1 0.0138051
EIF4A1 eukaryotic translation initiation factor 4A1 0.0137612
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0136119
DSG2 desmoglein 2 0.0135409
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.0134962
PLEC plectin 0.0133701
GLIPR1 GLI pathogenesis-related 1 0.0132917
OSBPL3 oxysterol binding protein-like 3 0.0131471
IFRD1 interferon-related developmental regulator 1 0.0131349
RPL38 ribosomal protein L38 0.0130303
COTL1 coactosin-like F-actin binding protein 1 0.0129679

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.531355
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.357345
C3 complement component 3 -0.150124
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.11806
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.105257
IGFBP1 insulin-like growth factor binding protein 1 -0.0973304
FNDC3B fibronectin type III domain containing 3B -0.0563353
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0508633
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0502362
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0477944
RPS6 ribosomal protein S6 -0.0446294
PCBP2 poly(rC) binding protein 2 -0.041608
MAML2 mastermind-like 2 (Drosophila) -0.0362481
FBF1 Fas (TNFRSF6) binding factor 1 -0.0313687
DNAH17 dynein, axonemal, heavy chain 17 -0.0298004
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0289399
VMP1 vacuole membrane protein 1 -0.0269916
VEGFA vascular endothelial growth factor A -0.0267236
GK glycerol kinase -0.0263082
ADAM9 ADAM metallopeptidase domain 9 -0.0249818
CCL20 chemokine (C-C motif) ligand 20 -0.024418
PARD3 par-3 family cell polarity regulator -0.0238493
CPE carboxypeptidase E -0.0237229
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0235095
KTN1 kinectin 1 (kinesin receptor) -0.0231346
SOS1 son of sevenless homolog 1 (Drosophila) -0.0231283
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0228488
AHSG alpha-2-HS-glycoprotein -0.0227904
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0221988
PDIA3 protein disulfide isomerase family A, member 3 -0.0220764
JMJD1C jumonji domain containing 1C -0.0211537
KCMF1 potassium channel modulatory factor 1 -0.0205246
YAP1 Yes-associated protein 1 -0.0205024
CCNL1 cyclin L1 -0.0204604
TRAM1 translocation associated membrane protein 1 -0.0202533
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0198107
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0193211
SESTD1 SEC14 and spectrin domains 1 -0.0191972
PKM pyruvate kinase, muscle -0.0191106
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0189461
COL27A1 collagen, type XXVII, alpha 1 -0.0188922
PTBP3 polypyrimidine tract binding protein 3 -0.0186829
RNF213 ring finger protein 213 -0.0186535
ZNF638 zinc finger protein 638 -0.0183517
SNX9 sorting nexin 9 -0.0181667
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0180282
EML4 echinoderm microtubule associated protein like 4 -0.0179773
RBM39 RNA binding motif protein 39 -0.017884
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0177595
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0175102
FTH1 ferritin, heavy polypeptide 1 -0.0174968
ITGAV integrin, alpha V -0.0174965
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0173792
BPTF bromodomain PHD finger transcription factor -0.0173035
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0172544
MYO1B myosin IB -0.0172405
MBNL1 muscleblind-like splicing regulator 1 -0.0171835
ZNF207 zinc finger protein 207 -0.0171831
CYB5R3 cytochrome b5 reductase 3 -0.0167757
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0167203
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0165776
SRPK1 SRSF protein kinase 1 -0.016515
BBX bobby sox homolog (Drosophila) -0.0163614
RBM25 RNA binding motif protein 25 -0.0163321
MATN3 matrilin 3 -0.0163307
PCM1 pericentriolar material 1 -0.0160429
TNS3 tensin 3 -0.0159442
NHSL1 NHS-like 1 -0.0159313
ACYP2 acylphosphatase 2, muscle type -0.0159126
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -0.0157536
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0157477
TPM1 tropomyosin 1 (alpha) -0.0156387
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0155609
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0155469
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0154212
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0151793
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0151599
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0151559
WWTR1 WW domain containing transcription regulator 1 -0.0151517
SETD5 SET domain containing 5 -0.0150756
GMDS GDP-mannose 4,6-dehydratase -0.0150694
USP34 ubiquitin specific peptidase 34 -0.0149976
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0147723
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0147717
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0147287
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0147113
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.014521
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0145104
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0144504
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0143054
ATP10A ATPase, class V, type 10A -0.0142669
WDR43 WD repeat domain 43 -0.0141757
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0141728
SRPK2 SRSF protein kinase 2 -0.0141616
FBXO42 F-box protein 42 -0.0141434
TJP1 tight junction protein 1 -0.0140572
EIF5 eukaryotic translation initiation factor 5 -0.0140279
FABP1 fatty acid binding protein 1, liver -0.0138753
DTNA dystrobrevin, alpha -0.0138747
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0138513