Lopinavir_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lopinavir perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lopinavir_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.207767
PLEC plectin 0.120992
TRIO trio Rho guanine nucleotide exchange factor 0.10966
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0954119
MTSS1 metastasis suppressor 1 0.0943852
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0938087
ASPH aspartate beta-hydroxylase 0.0789016
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0699565
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0646009
MSN moesin 0.0639949
APLP2 amyloid beta (A4) precursor-like protein 2 0.0624689
RPL3 ribosomal protein L3 0.0609998
TPM3 tropomyosin 3 0.0590075
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0571157
ENO1 enolase 1, (alpha) 0.0567602
FLNA filamin A, alpha 0.0566019
SRRM2 serine/arginine repetitive matrix 2 0.0556532
MACF1 microtubule-actin crosslinking factor 1 0.0544123
MBNL1 muscleblind-like splicing regulator 1 0.053225
SMAD3 SMAD family member 3 0.0520223
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0517785
RAI14 retinoic acid induced 14 0.0512776
RPS8 ribosomal protein S8 0.049678
SLC35F3 solute carrier family 35, member F3 0.0483729
SET SET nuclear proto-oncogene 0.0469311
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.0467895
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0462176
CEMIP cell migration inducing protein, hyaluronan binding 0.045964
AKAP13 A kinase (PRKA) anchor protein 13 0.0453985
PDIA3 protein disulfide isomerase family A, member 3 0.0440275
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0431727
MEF2A myocyte enhancer factor 2A 0.0429706
TOP1 topoisomerase (DNA) I 0.0428028
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0427864
RPS12 ribosomal protein S12 0.0417668
CANX calnexin 0.0412972
RPS6 ribosomal protein S6 0.0406612
PKM pyruvate kinase, muscle 0.0396562
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0392344
ANKRD11 ankyrin repeat domain 11 0.0382814
FNDC3B fibronectin type III domain containing 3B 0.0382243
HMGA2 high mobility group AT-hook 2 0.0381832
ANGPTL4 angiopoietin-like 4 0.0372791
SQSTM1 sequestosome 1 0.0370808
NAP1L1 nucleosome assembly protein 1-like 1 0.0368991
AMOTL1 angiomotin like 1 0.0366171
LMO7 LIM domain 7 0.0362692
RPL37A ribosomal protein L37a 0.0358838
RPS2 ribosomal protein S2 0.0351818
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0348245
RPL4 ribosomal protein L4 0.0345859
RNF145 ring finger protein 145 0.0330059
RPL23 ribosomal protein L23 0.0329659
HDGF hepatoma-derived growth factor 0.0323886
CALB1 calbindin 1, 28kDa 0.0319756
RPL21 ribosomal protein L21 0.0318819
RPS15A ribosomal protein S15a 0.0314615
EEF2 eukaryotic translation elongation factor 2 0.0304659
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0301188
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0300489
MEGF6 multiple EGF-like-domains 6 0.0299398
FNIP1 folliculin interacting protein 1 0.0298827
ERRFI1 ERBB receptor feedback inhibitor 1 0.0297221
KRT17 keratin 17, type I 0.0293359
PDE4D phosphodiesterase 4D, cAMP-specific 0.029161
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0291222
TNIP1 TNFAIP3 interacting protein 1 0.0290281
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.028786
KMT2E lysine (K)-specific methyltransferase 2E 0.0287415
HYOU1 hypoxia up-regulated 1 0.0282412
RPL26 ribosomal protein L26 0.0278681
TFG TRK-fused gene 0.0274931
AHNAK AHNAK nucleoprotein 0.0274437
HSPA8 heat shock 70kDa protein 8 0.0272205
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0269366
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0269025
CPNE1 copine I 0.0266392
NACA nascent polypeptide-associated complex alpha subunit 0.0263436
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0263235
TPM2 tropomyosin 2 (beta) 0.0262299
RPL19 ribosomal protein L19 0.0262288
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0261796
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.026106
PCDH1 protocadherin 1 0.0258357
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0257745
RPS3 ribosomal protein S3 0.0253927
ACTN1 actinin, alpha 1 0.0253491
LPP LIM domain containing preferred translocation partner in lipoma 0.0252536
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0246203
PLS3 plastin 3 0.0245496
LDHA lactate dehydrogenase A 0.0242637
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0241711
RPL35 ribosomal protein L35 0.0240982
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0240545
KTN1 kinectin 1 (kinesin receptor) 0.0239109
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0237827
RPSA ribosomal protein SA 0.0236693
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0230816
CALR calreticulin 0.0229897
EGFR epidermal growth factor receptor 0.0228184

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.240562
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.183531
NDRG1 N-myc downstream regulated 1 -0.117893
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.104932
IGF2 insulin-like growth factor 2 -0.101613
EMP1 epithelial membrane protein 1 -0.10055
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0942006
DPYD dihydropyrimidine dehydrogenase -0.0859689
EZR ezrin -0.0814612
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0741291
GNAS GNAS complex locus -0.0739684
ANXA2 annexin A2 -0.0736294
S100A10 S100 calcium binding protein A10 -0.0730258
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0724478
RBM39 RNA binding motif protein 39 -0.0697859
RPS21 ribosomal protein S21 -0.0678365
HLA-B major histocompatibility complex, class I, B -0.0583217
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0582207
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0577678
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0528559
CLU clusterin -0.0525669
PODXL podocalyxin-like -0.0519873
ZNFX1 zinc finger, NFX1-type containing 1 -0.0518543
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0510066
BCL2L1 BCL2-like 1 -0.0507792
B2M beta-2-microglobulin -0.0504956
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -0.0488343
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0482894
RIGI RNA sensor RIG-I -0.0481601
ANKRD33B ankyrin repeat domain 33B -0.0479536
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.046704
RTN4 reticulon 4 -0.0459792
NAMPT nicotinamide phosphoribosyltransferase -0.0443601
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0421137
MT1X metallothionein 1X -0.0417216
STAU1 staufen double-stranded RNA binding protein 1 -0.0408965
ACTN4 actinin, alpha 4 -0.0404602
CAVIN1 caveolae associated protein 1 -0.0400971
VDAC1 voltage-dependent anion channel 1 -0.0393095
TXNIP thioredoxin interacting protein -0.0393084
YBX3 Y box binding protein 3 -0.0390604
MECOM MDS1 and EVI1 complex locus -0.0379001
NF1 neurofibromin 1 -0.036403
FSCN1 fascin actin-bundling protein 1 -0.0363584
PIBF1 progesterone immunomodulatory binding factor 1 -0.0363156
IFITM3 interferon induced transmembrane protein 3 -0.0360072
CD99 CD99 molecule -0.0354
GLG1 golgi glycoprotein 1 -0.0350738
CD44 CD44 molecule (Indian blood group) -0.0350172
NBEAL1 neurobeachin-like 1 -0.0349162
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.034113
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0340234
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0332209
SERINC3 serine incorporator 3 -0.0331823
MEIS2 Meis homeobox 2 -0.0328611
NPEPPS aminopeptidase puromycin sensitive -0.032809
TMEM135 transmembrane protein 135 -0.0327766
TMEM263 transmembrane protein 263 -0.031858
PALLD palladin, cytoskeletal associated protein -0.031408
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0311148
TAOK3 TAO kinase 3 -0.0310678
HIP1 huntingtin interacting protein 1 -0.0310093
IFITM1 interferon induced transmembrane protein 1 -0.0309083
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0308855
WSB1 WD repeat and SOCS box containing 1 -0.0304372
POTEF POTE ankyrin domain family, member F -0.0303781
RASAL2 RAS protein activator like 2 -0.0303374
NRG1 neuregulin 1 -0.0302224
ZMYND8 zinc finger, MYND-type containing 8 -0.0301261
EVI5 ecotropic viral integration site 5 -0.0301221
RRBP1 ribosome binding protein 1 -0.0300534
HSPG2 heparan sulfate proteoglycan 2 -0.0299532
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0294226
RCOR1 REST corepressor 1 -0.0293125
THBD thrombomodulin -0.0293114
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0291308
CAV1 caveolin 1, caveolae protein, 22kDa -0.0290979
MARCHF6 membrane associated ring-CH-type finger 6 -0.0290519
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0287737
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0285286
RIOK3 RIO kinase 3 -0.028444
S100A4 S100 calcium binding protein A4 -0.0282257
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0277188
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0277171
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0275852
WARS1 tryptophanyl-tRNA synthetase 1 -0.0274564
RPS24 ribosomal protein S24 -0.0273064
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0271793
TENT5A terminal nucleotidyltransferase 5A -0.0269102
SULF2 sulfatase 2 -0.0267914
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0267888
S100A11 S100 calcium binding protein A11 -0.0267347
HLA-A major histocompatibility complex, class I, A -0.0266272
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0264658
KPNB1 karyopherin (importin) beta 1 -0.0264383
CAV2 caveolin 2 -0.0261559
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0261027
SKAP2 src kinase associated phosphoprotein 2 -0.0259891
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0256244
XRN1 5'-3' exoribonuclease 1 -0.0255913