| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lopinavir perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lopinavir_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.259864 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0545307 |
| EREG | epiregulin | 0.0508039 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0495366 |
| LMO7 | LIM domain 7 | 0.0481634 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0457975 |
| AHNAK | AHNAK nucleoprotein | 0.0432846 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0426861 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0426453 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0422907 |
| KRT8 | keratin 8, type II | 0.0365135 |
| PLEC | plectin | 0.0326835 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0295152 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0294975 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0290234 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.028357 |
| MYO5B | myosin VB | 0.0281386 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0279324 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0278448 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.027738 |
| HDLBP | high density lipoprotein binding protein | 0.0273129 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0271398 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0261698 |
| TFG | TRK-fused gene | 0.0245919 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0240989 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0239018 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.023857 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0235704 |
| TMSB4X | thymosin beta 4, X-linked | 0.0235608 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0233343 |
| RBM39 | RNA binding motif protein 39 | 0.0232197 |
| OGA | O-GlcNAcase | 0.0231996 |
| RPL4 | ribosomal protein L4 | 0.0227278 |
| USP3 | ubiquitin specific peptidase 3 | 0.0223952 |
| PUM2 | pumilio RNA-binding family member 2 | 0.02233 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0221637 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0218781 |
| RPL3 | ribosomal protein L3 | 0.0217525 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0213105 |
| YME1L1 | YME1-like 1 ATPase | 0.0210954 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0209226 |
| AFDN | afadin, adherens junction formation factor | 0.0209081 |
| MED13L | mediator complex subunit 13-like | 0.0208865 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0208165 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0207689 |
| GDF15 | growth differentiation factor 15 | 0.0207652 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0203815 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0203728 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0203445 |
| ARF1 | ADP-ribosylation factor 1 | 0.0197529 |
| H1-0 | H1.0 linker histone | 0.019683 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0194636 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0193973 |
| NEK7 | NIMA-related kinase 7 | 0.0192503 |
| H1-4 | H1.4 linker histone, cluster member | 0.0191682 |
| RLF | rearranged L-myc fusion | 0.0188455 |
| PRRC1 | proline-rich coiled-coil 1 | 0.0188089 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0184979 |
| UBQLN1 | ubiquilin 1 | 0.0184734 |
| EWSR1 | EWS RNA-binding protein 1 | 0.0182326 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0181964 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0181393 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0180449 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0177994 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0176095 |
| NCKAP1 | NCK-associated protein 1 | 0.0176027 |
| NUP58 | nucleoporin 58 | 0.0174109 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0173602 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0172708 |
| CTBP2 | C-terminal binding protein 2 | 0.0172242 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0171113 |
| COG5 | component of oligomeric golgi complex 5 | 0.0169911 |
| HELZ | helicase with zinc finger | 0.0167774 |
| MARS1 | methionyl-tRNA synthetase 1 | 0.0167149 |
| RPL6 | ribosomal protein L6 | 0.0166942 |
| RNF145 | ring finger protein 145 | 0.0163942 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0162141 |
| PSAT1 | phosphoserine aminotransferase 1 | 0.0160515 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | 0.0160106 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0153243 |
| COPA | coatomer protein complex, subunit alpha | 0.0151944 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0151458 |
| RTN3 | reticulon 3 | 0.0151134 |
| H2AC6 | H2A clustered histone 6 | 0.0151081 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0149238 |
| TES | testin LIM domain protein | 0.0148521 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0147772 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0147266 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0146538 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | 0.0146173 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0145018 |
| SAFB | scaffold attachment factor B | 0.0143525 |
| PREPL | prolyl endopeptidase-like | 0.0143364 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0142833 |
| XPR1 | xenotropic and polytropic retrovirus receptor 1 | 0.0142365 |
| HBP1 | HMG-box transcription factor 1 | 0.0142168 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0141913 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0141742 |
| CANX | calnexin | 0.0140963 |
| SEC24D | SEC24 family member D | 0.0140727 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.235384 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.15985 |
| PTMA | prothymosin, alpha | -0.142295 |
| NPSR1 | neuropeptide S receptor 1 | -0.121971 |
| TMSB10 | thymosin beta 10 | -0.112095 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0999165 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0950096 |
| RPS6 | ribosomal protein S6 | -0.0891858 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0870757 |
| NDRG1 | N-myc downstream regulated 1 | -0.0846649 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0815821 |
| TNS4 | tensin 4 | -0.0752559 |
| ITGA6 | integrin, alpha 6 | -0.0734956 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0690379 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0675763 |
| FTL | ferritin, light polypeptide | -0.0626465 |
| RPS19 | ribosomal protein S19 | -0.0624226 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0608153 |
| EZR | ezrin | -0.0583689 |
| POTEF | POTE ankyrin domain family, member F | -0.0550186 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0547747 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0532594 |
| LDHA | lactate dehydrogenase A | -0.0524246 |
| HMGA1 | high mobility group AT-hook 1 | -0.0519895 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0495195 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0480151 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0472588 |
| MT2A | metallothionein 2A | -0.0464589 |
| S100A6 | S100 calcium binding protein A6 | -0.0463472 |
| RPS8 | ribosomal protein S8 | -0.0463281 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0455086 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0446728 |
| RPL36 | ribosomal protein L36 | -0.0445352 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0420712 |
| RPL35A | ribosomal protein L35a | -0.0418143 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0417137 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0415097 |
| CADPS | Ca++-dependent secretion activator | -0.0406693 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0402604 |
| CALB1 | calbindin 1, 28kDa | -0.0392706 |
| MLEC | malectin | -0.038841 |
| RPL37A | ribosomal protein L37a | -0.0381181 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0379109 |
| EGR1 | early growth response 1 | -0.0373258 |
| RPL9 | ribosomal protein L9 | -0.0371737 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0366291 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | -0.0365944 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0364818 |
| KRT19 | keratin 19, type I | -0.0364768 |
| PTEN | phosphatase and tensin homolog | -0.0364151 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0351536 |
| PCBP2 | poly(rC) binding protein 2 | -0.0344718 |
| RPLP2 | ribosomal protein, large, P2 | -0.0343351 |
| RPS23 | ribosomal protein S23 | -0.0337596 |
| RPL12 | ribosomal protein L12 | -0.0336774 |
| TPM4 | tropomyosin 4 | -0.0336681 |
| RPLP1 | ribosomal protein, large, P1 | -0.033092 |
| PKM | pyruvate kinase, muscle | -0.0329961 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.03247 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0324396 |
| PFN1 | profilin 1 | -0.0318007 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0312883 |
| GPHN | gephyrin | -0.0309899 |
| RBM25 | RNA binding motif protein 25 | -0.0309341 |
| FOSL1 | FOS-like antigen 1 | -0.0306539 |
| RPL5 | ribosomal protein L5 | -0.0304738 |
| ENO1 | enolase 1, (alpha) | -0.0303251 |
| RPS29 | ribosomal protein S29 | -0.0301428 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.030131 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0300051 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | -0.0299073 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0295175 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0293666 |
| RPS3 | ribosomal protein S3 | -0.0292497 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | -0.0290773 |
| VEGFA | vascular endothelial growth factor A | -0.028711 |
| TRIM2 | tripartite motif containing 2 | -0.02809 |
| S100A10 | S100 calcium binding protein A10 | -0.0280652 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0276727 |
| PERP | PERP, TP53 apoptosis effector | -0.0276032 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0275682 |
| RPL31 | ribosomal protein L31 | -0.0273171 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0273153 |
| CLDN4 | claudin 4 | -0.0270308 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0269694 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0266925 |
| RNF217 | ring finger protein 217 | -0.0263627 |
| RPS13 | ribosomal protein S13 | -0.0261466 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0261392 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0260998 |
| CLDN7 | claudin 7 | -0.0259685 |
| BPTF | bromodomain PHD finger transcription factor | -0.0259595 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0258574 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0256782 |
| RPS12 | ribosomal protein S12 | -0.0256441 |
| LAMA4 | laminin, alpha 4 | -0.0254946 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0253713 |
| RBM47 | RNA binding motif protein 47 | -0.0252498 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -0.0252043 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0250142 |
