| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lopinavir perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lopinavir_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.148064 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.138983 |
| DST | dystonin | 0.0981259 |
| AHNAK | AHNAK nucleoprotein | 0.0931862 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0753619 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0712767 |
| FMNL2 | formin-like 2 | 0.070481 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0648905 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0615355 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.06002 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0582703 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0575077 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0547071 |
| RPL4 | ribosomal protein L4 | 0.0497406 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0497228 |
| TMSB4X | thymosin beta 4, X-linked | 0.0475323 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.046549 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0452907 |
| RPS12 | ribosomal protein S12 | 0.0444684 |
| PGK1 | phosphoglycerate kinase 1 | 0.0436301 |
| RPL3 | ribosomal protein L3 | 0.0434492 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0425644 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0422927 |
| OGA | O-GlcNAcase | 0.042153 |
| PLEC | plectin | 0.0414563 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0404351 |
| XPO1 | exportin 1 | 0.0397227 |
| RPL23 | ribosomal protein L23 | 0.039456 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0388733 |
| APP | amyloid beta (A4) precursor protein | 0.0388678 |
| TPI1 | triosephosphate isomerase 1 | 0.038615 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0377036 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0374837 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0372809 |
| RPS18 | ribosomal protein S18 | 0.0372412 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0372213 |
| FLNB | filamin B, beta | 0.0367722 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0364732 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0363714 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0362282 |
| KLF6 | Kruppel-like factor 6 | 0.0361164 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0360976 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0356395 |
| ATP13A3 | ATPase type 13A3 | 0.0354011 |
| RPL19 | ribosomal protein L19 | 0.0346914 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0346421 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0344335 |
| EREG | epiregulin | 0.0344271 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0337938 |
| YEATS2 | YEATS domain containing 2 | 0.0336812 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0327851 |
| RPL26 | ribosomal protein L26 | 0.0326475 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0322873 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0319426 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0319225 |
| LRRC49 | leucine rich repeat containing 49 | 0.0315272 |
| IFNGR2 | interferon gamma receptor 2 (interferon gamma transducer 1) | 0.0314712 |
| RPL12 | ribosomal protein L12 | 0.0312732 |
| PYGL | phosphorylase, glycogen, liver | 0.0311962 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0307557 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.030604 |
| RAD51B | RAD51 paralog B | 0.0302853 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0300184 |
| ERBIN | erbb2 interacting protein | 0.0299951 |
| RPS2 | ribosomal protein S2 | 0.0296883 |
| VCL | vinculin | 0.0296406 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0291127 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0288785 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0285252 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | 0.0284803 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.028249 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0281801 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0279999 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0279531 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.027877 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0278621 |
| DENND5A | DENN/MADD domain containing 5A | 0.0276994 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0276277 |
| MYH10 | myosin, heavy chain 10, non-muscle | 0.0274702 |
| ANGPTL4 | angiopoietin-like 4 | 0.0273236 |
| ENO1 | enolase 1, (alpha) | 0.0272547 |
| RAI1 | retinoic acid induced 1 | 0.0271264 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0270874 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0270562 |
| NBAS | neuroblastoma amplified sequence | 0.0267125 |
| SMYD3 | SET and MYND domain containing 3 | 0.0266618 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0261094 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0260127 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0257454 |
| SRPK2 | SRSF protein kinase 2 | 0.0256173 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.025608 |
| RAB10 | RAB10, member RAS oncogene family | 0.0255578 |
| RPL35 | ribosomal protein L35 | 0.0255403 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0251538 |
| TPM3 | tropomyosin 3 | 0.0250823 |
| RPL37A | ribosomal protein L37a | 0.0250588 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0247638 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0244084 |
| KLC1 | kinesin light chain 1 | 0.02436 |
| HMGB2 | high mobility group box 2 | 0.0243332 |
| Symbol | Name | Standardized Value |
|---|---|---|
| POTEF | POTE ankyrin domain family, member F | -0.118333 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.117166 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.100538 |
| EGR1 | early growth response 1 | -0.0859839 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0782062 |
| HMGA1 | high mobility group AT-hook 1 | -0.0769578 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0653792 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0632903 |
| PTMA | prothymosin, alpha | -0.0622907 |
| VIM | vimentin | -0.0540523 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0539662 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0515281 |
| RUNX1 | runt-related transcription factor 1 | -0.049477 |
| CD44 | CD44 molecule (Indian blood group) | -0.0488529 |
| FOSL1 | FOS-like antigen 1 | -0.0452103 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.043832 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0399736 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0394567 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0387702 |
| RIGI | RNA sensor RIG-I | -0.0386067 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0379299 |
| ANXA1 | annexin A1 | -0.0373354 |
| TXNRD1 | thioredoxin reductase 1 | -0.0372322 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0368238 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | -0.03682 |
| MT2A | metallothionein 2A | -0.0364838 |
| MYADM | myeloid-associated differentiation marker | -0.0363781 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0345752 |
| CCNL1 | cyclin L1 | -0.0341017 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0336294 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0334508 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0324096 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0322481 |
| SEC24A | SEC24 family member A | -0.0316247 |
| TP63 | tumor protein p63 | -0.0315294 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0307636 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | -0.0306528 |
| SYAP1 | synapse associated protein 1 | -0.0303595 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.0302245 |
| PLSCR1 | phospholipid scramblase 1 | -0.0298963 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0297063 |
| BRD2 | bromodomain containing 2 | -0.0294254 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0292488 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.028961 |
| TFRC | transferrin receptor | -0.0273483 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0273405 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0272463 |
| JUN | jun proto-oncogene | -0.0270888 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0270463 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0269638 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0266478 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0266136 |
| CFAP299 | cilia and flagella associated protein 299 | -0.0262348 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.026152 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0260723 |
| PODXL | podocalyxin-like | -0.0259643 |
| BSG | basigin (Ok blood group) | -0.0257574 |
| TOP1 | topoisomerase (DNA) I | -0.0256656 |
| EZR | ezrin | -0.0251584 |
| PMP22 | peripheral myelin protein 22 | -0.0250534 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0246699 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.024375 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0242714 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0240324 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0239446 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0238041 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0237804 |
| RBM25 | RNA binding motif protein 25 | -0.0235783 |
| ATN1 | atrophin 1 | -0.0231624 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.022925 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0227226 |
| JMJD1C | jumonji domain containing 1C | -0.0226768 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0225953 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0225522 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0225399 |
| ARF4 | ADP-ribosylation factor 4 | -0.0216591 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | -0.0215808 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | -0.0211365 |
| EPHA4 | EPH receptor A4 | -0.0210709 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0209458 |
| HM13 | histocompatibility (minor) 13 | -0.0204848 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0203634 |
| CCDC190 | coiled-coil domain containing 190 | -0.0201425 |
| WDR43 | WD repeat domain 43 | -0.0200467 |
| PFN1 | profilin 1 | -0.0197493 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0197348 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0194847 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0193694 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0193166 |
| NUCB2 | nucleobindin 2 | -0.0192578 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0192236 |
| CADM2 | cell adhesion molecule 2 | -0.0192142 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0186041 |
| PCBP2 | poly(rC) binding protein 2 | -0.0180948 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0180723 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0180124 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0176693 |
| DEK | DEK proto-oncogene | -0.0176611 |
| SP100 | SP100 nuclear antigen | -0.0175837 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | -0.0174203 |
