Lopinavir_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lopinavir perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lopinavir_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA8 heat shock 70kDa protein 8 0.0915946
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0853045
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0850795
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0837771
ERRFI1 ERBB receptor feedback inhibitor 1 0.080943
MYH9 myosin, heavy chain 9, non-muscle 0.0808774
RPL4 ribosomal protein L4 0.07896
ELL2 elongation factor, RNA polymerase II, 2 0.0710239
FMNL2 formin-like 2 0.0699055
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0697924
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0654193
LPP LIM domain containing preferred translocation partner in lipoma 0.0651585
APP amyloid beta (A4) precursor protein 0.0645616
SMOC1 SPARC related modular calcium binding 1 0.0643099
ZFAND3 zinc finger, AN1-type domain 3 0.06359
AKAP12 A kinase (PRKA) anchor protein 12 0.0614159
SAMD4A sterile alpha motif domain containing 4A 0.0605892
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0605038
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0587867
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0586004
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0577705
KDM3A lysine (K)-specific demethylase 3A 0.0576625
RPL3 ribosomal protein L3 0.0573616
COPA coatomer protein complex, subunit alpha 0.0557587
PDLIM5 PDZ and LIM domain 5 0.0540143
EIF1 eukaryotic translation initiation factor 1 0.0515462
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0509581
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0495961
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0491543
TRIO trio Rho guanine nucleotide exchange factor 0.0490113
ANKRD11 ankyrin repeat domain 11 0.0490013
EIF4A1 eukaryotic translation initiation factor 4A1 0.0486134
AKAP13 A kinase (PRKA) anchor protein 13 0.0475057
ASPH aspartate beta-hydroxylase 0.0455692
AHNAK AHNAK nucleoprotein 0.0454367
EXT1 exostosin glycosyltransferase 1 0.0454142
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0448284
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0443163
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0436973
UBASH3B ubiquitin associated and SH3 domain containing B 0.0434072
FLNB filamin B, beta 0.043267
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0432662
DSCAM Down syndrome cell adhesion molecule 0.0423544
RAD21 RAD21 homolog (S. pombe) 0.0410839
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0402321
TPM3 tropomyosin 3 0.0393974
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0391301
FLNA filamin A, alpha 0.038405
PFDN2 prefoldin subunit 2 0.0384007
THSD4 thrombospondin, type I, domain containing 4 0.0380807
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0378176
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0375736
CXCL8 chemokine (C-X-C motif) ligand 8 0.0355418
RICTOR RPTOR independent companion of MTOR, complex 2 0.0349858
TPD52 tumor protein D52 0.0347789
MACF1 microtubule-actin crosslinking factor 1 0.0342677
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0342626
CYTH1 cytohesin 1 0.0342294
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0340695
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.03398
PLEC plectin 0.0332585
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.032816
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0324059
ASXL1 additional sex combs like transcriptional regulator 1 0.031838
HDLBP high density lipoprotein binding protein 0.0318334
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0317377
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0316899
SLC38A2 solute carrier family 38, member 2 0.0312261
ARHGAP26 Rho GTPase activating protein 26 0.0312077
SMAD2 SMAD family member 2 0.0300585
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0300064
GON4L gon-4-like (C. elegans) 0.0297328
CTNND1 catenin (cadherin-associated protein), delta 1 0.029562
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0295154
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0293855
FAM107B family with sequence similarity 107, member B 0.0291317
ACTG1 actin gamma 1 0.028904
PTK2 protein tyrosine kinase 2 0.0288217
NACA nascent polypeptide-associated complex alpha subunit 0.028747
NCKAP1 NCK-associated protein 1 0.0285496
TPI1 triosephosphate isomerase 1 0.0285391
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0272385
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0271931
PYGL phosphorylase, glycogen, liver 0.027061
NUMB numb homolog (Drosophila) 0.0267428
FDPS farnesyl diphosphate synthase 0.0267339
KLC1 kinesin light chain 1 0.0263456
SBF2 SET binding factor 2 0.0262153
NAP1L1 nucleosome assembly protein 1-like 1 0.0260802
HYOU1 hypoxia up-regulated 1 0.0260005
H1-4 H1.4 linker histone, cluster member 0.0259812
MARS1 methionyl-tRNA synthetase 1 0.0258955
ACTN1 actinin, alpha 1 0.0257057
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0256266
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0253674
BRD2 bromodomain containing 2 0.0251624
TARS1 threonyl-tRNA synthetase 1 0.0249136
RASAL2 RAS protein activator like 2 0.0248035
EGFR epidermal growth factor receptor 0.0247573
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0245308

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.238307
MT2A metallothionein 2A -0.215926
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.19622
IGF2 insulin-like growth factor 2 -0.141019
FTH1 ferritin, heavy polypeptide 1 -0.13336
FTL ferritin, light polypeptide -0.112283
PM20D1 peptidase M20 domain containing 1 -0.106933
POTEF POTE ankyrin domain family, member F -0.0797708
FGB fibrinogen beta chain -0.079673
VIM vimentin -0.0750209
PFN1 profilin 1 -0.0556116
EGR1 early growth response 1 -0.0547798
TFPI2 tissue factor pathway inhibitor 2 -0.0532582
BIRC3 baculoviral IAP repeat containing 3 -0.0528116
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0520526
HMGA1 high mobility group AT-hook 1 -0.0512533
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0450124
WWOX WW domain containing oxidoreductase -0.0448508
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0434313
OSMR oncostatin M receptor -0.0432741
TOP2A topoisomerase (DNA) II alpha 170kDa -0.042308
BICC1 BicC family RNA binding protein 1 -0.042107
TM4SF1 transmembrane 4 L six family member 1 -0.038381
TAGLN2 transgelin 2 -0.0375386
TXNRD1 thioredoxin reductase 1 -0.0371761
RPLP1 ribosomal protein, large, P1 -0.0369394
ANXA2 annexin A2 -0.0361845
BABAM2 BRISC and BRCA1 A complex member 2 -0.0352226
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0332594
B2M beta-2-microglobulin -0.0323445
EFNA5 ephrin-A5 -0.0310659
SVIL supervillin -0.0306438
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0305833
PDE8A phosphodiesterase 8A -0.0303531
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0293427
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0284669
RPS21 ribosomal protein S21 -0.0280641
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.027902
NNMT nicotinamide N-methyltransferase -0.0274979
RBM25 RNA binding motif protein 25 -0.0273831
RPS8 ribosomal protein S8 -0.0272505
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0267085
PDE4D phosphodiesterase 4D, cAMP-specific -0.026684
IGFBP4 insulin-like growth factor binding protein 4 -0.0264236
YBX1 Y box binding protein 1 -0.026278
S100A11 S100 calcium binding protein A11 -0.0262705
ANKRD28 ankyrin repeat domain 28 -0.0262495
ATP5F1B ATP synthase F1 subunit beta -0.0261174
RSPO3 R-spondin 3 -0.0258899
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0256465
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0256092
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0255547
FGG fibrinogen gamma chain -0.0255386
FOSL1 FOS-like antigen 1 -0.0254062
RIGI RNA sensor RIG-I -0.0247615
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0247607
SRGN serglycin -0.0237055
CENPF centromere protein F, 350/400kDa -0.0236299
ANKRD12 ankyrin repeat domain 12 -0.0233405
HMGB1 high mobility group box 1 -0.0233261
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0231717
NRG1 neuregulin 1 -0.0228396
RPL35A ribosomal protein L35a -0.022792
ATP5F1E ATP synthase F1 subunit epsilon -0.022743
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0226968
TUBA1B tubulin, alpha 1b -0.0226837
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0226647
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0226344
FGA fibrinogen alpha chain -0.0224763
RPL9 ribosomal protein L9 -0.0217643
CCT3 chaperonin containing TCP1, subunit 3 (gamma) -0.0216719
CCNL1 cyclin L1 -0.0211959
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0210688
LDHB lactate dehydrogenase B -0.0209543
GSTP1 glutathione S-transferase pi 1 -0.0207529
GRAMD1B GRAM domain containing 1B -0.0207346
TUBB tubulin, beta class I -0.0206559
LAMB1 laminin, beta 1 -0.0206091
CYB5R3 cytochrome b5 reductase 3 -0.0201742
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0201079
CNRIP1 cannabinoid receptor interacting protein 1 -0.0195983
TBCK TBC1 domain containing kinase -0.0194703
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.0194295
LAMA5 laminin, alpha 5 -0.0193342
RPL28 ribosomal protein L28 -0.0191981
KMT2E lysine (K)-specific methyltransferase 2E -0.0190206
UFM1 ubiquitin-fold modifier 1 -0.0185842
RPLP0 ribosomal protein, large, P0 -0.0184304
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0184066
S100A9 S100 calcium binding protein A9 -0.0182378
MKI67 marker of proliferation Ki-67 -0.0181735
SSH1 slingshot protein phosphatase 1 -0.0181
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0179222
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0178722
BCLAF1 BCL2-associated transcription factor 1 -0.0178291
AK1 adenylate kinase 1 -0.0177669
MYADM myeloid-associated differentiation marker -0.0177392
PNISR PNN-interacting serine/arginine-rich protein -0.0174426
ITGB5 integrin, beta 5 -0.0173121
RPS6 ribosomal protein S6 -0.0172954