| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lopinavir perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lopinavir_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.215057 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0936165 |
| TXNRD1 | thioredoxin reductase 1 | 0.0863554 |
| GRAMD1B | GRAM domain containing 1B | 0.082378 |
| TPI1 | triosephosphate isomerase 1 | 0.0512805 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0389731 |
| KRT18 | keratin 18, type I | 0.0382829 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0336709 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0310121 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0304226 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0298822 |
| MMP12 | matrix metallopeptidase 12 | 0.0295818 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0283132 |
| RPL3 | ribosomal protein L3 | 0.0241671 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0225863 |
| PGK1 | phosphoglycerate kinase 1 | 0.0218319 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0214992 |
| LATS2 | large tumor suppressor kinase 2 | 0.0205914 |
| ACTN1 | actinin, alpha 1 | 0.0202143 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0198531 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0198066 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0196654 |
| CTTN | cortactin | 0.0195257 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0190921 |
| MYL12B | myosin, light chain 12B, regulatory | 0.0188137 |
| ATP13A3 | ATPase type 13A3 | 0.0181464 |
| CDCP1 | CUB domain containing protein 1 | 0.0178622 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.0177765 |
| FKBP4 | FK506 binding protein 4, 59kDa | 0.0177175 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0168235 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0166587 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0166394 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0166173 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0163972 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0160626 |
| XPO1 | exportin 1 | 0.0158191 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.015415 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0154052 |
| SMAD3 | SMAD family member 3 | 0.0153668 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0150767 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0149864 |
| ATP11A | ATPase, class VI, type 11A | 0.014884 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0146865 |
| KRT8 | keratin 8, type II | 0.0145162 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0144953 |
| PLEC | plectin | 0.0144907 |
| KLF6 | Kruppel-like factor 6 | 0.0143299 |
| CTTNBP2NL | CTTNBP2 N-terminal like | 0.0143234 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0143068 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0140375 |
| SNX9 | sorting nexin 9 | 0.013577 |
| RTN4 | reticulon 4 | 0.0133671 |
| CALD1 | caldesmon 1 | 0.0133417 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | 0.0132004 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0131616 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0129549 |
| CCND2 | cyclin D2 | 0.0128946 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0127588 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0127554 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0126167 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0126086 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0124959 |
| RAI1 | retinoic acid induced 1 | 0.012405 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0123677 |
| CAPRIN2 | caprin family member 2 | 0.0120991 |
| ANXA5 | annexin A5 | 0.0119695 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.011965 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0118955 |
| CDK17 | cyclin-dependent kinase 17 | 0.0118658 |
| ENO1 | enolase 1, (alpha) | 0.0117928 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0117357 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0116891 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0116119 |
| RPL4 | ribosomal protein L4 | 0.0115468 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0114668 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0114392 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0114371 |
| MSN | moesin | 0.0112645 |
| TCIM | transcriptional and immune response regulator | 0.0112529 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.0112495 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0111943 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0111555 |
| STC1 | stanniocalcin 1 | 0.0111257 |
| LUZP1 | leucine zipper protein 1 | 0.0107762 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0107684 |
| TMSB10 | thymosin beta 10 | 0.01073 |
| RPS18 | ribosomal protein S18 | 0.0107212 |
| STMN1 | stathmin 1 | 0.0106693 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0105219 |
| PALS1 | protein associated with LIN7 1, MAGUK p55 family member | 0.0104191 |
| RFX7 | regulatory factor X, 7 | 0.0102196 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0102137 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.010185 |
| ITGB5 | integrin, beta 5 | 0.0100609 |
| C1QBP | complement component 1, q subcomponent binding protein | 0.0100227 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.00985061 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.00980482 |
| COL5A2 | collagen, type V, alpha 2 | 0.00977685 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0097539 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 0.009719 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0954299 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0840878 |
| EGR1 | early growth response 1 | -0.0670085 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0528764 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0442123 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.042779 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.041985 |
| AEBP2 | AE binding protein 2 | -0.0365785 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0358718 |
| RBM39 | RNA binding motif protein 39 | -0.0353175 |
| MORF4L2 | mortality factor 4 like 2 | -0.0328258 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0317695 |
| INTS6 | integrator complex subunit 6 | -0.0315375 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0288049 |
| RSF1 | remodeling and spacing factor 1 | -0.0279362 |
| MCL1 | myeloid cell leukemia 1 | -0.0266598 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0265674 |
| CANX | calnexin | -0.0256731 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0253315 |
| COPA | coatomer protein complex, subunit alpha | -0.0249537 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0247688 |
| BRD2 | bromodomain containing 2 | -0.0247497 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0242877 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | -0.0242267 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0241093 |
| FBXO11 | F-box protein 11 | -0.0234391 |
| CALR | calreticulin | -0.0229153 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0228576 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0223977 |
| ATXN1 | ataxin 1 | -0.0223254 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0222402 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.022188 |
| GOLGB1 | golgin B1 | -0.021794 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0217263 |
| ZNF207 | zinc finger protein 207 | -0.0214335 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0211968 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0209554 |
| ATF6 | activating transcription factor 6 | -0.020397 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.020372 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0203691 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0200355 |
| LRRC23 | leucine rich repeat containing 23 | -0.0195692 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0194599 |
| SMYD3 | SET and MYND domain containing 3 | -0.0194576 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0191926 |
| CCNL1 | cyclin L1 | -0.0191734 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.018585 |
| USP34 | ubiquitin specific peptidase 34 | -0.0181367 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0181252 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0180817 |
| NABP1 | nucleic acid binding protein 1 | -0.0179777 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0178406 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0178148 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0177926 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0177766 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0174737 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0174327 |
| SRP54 | signal recognition particle 54kDa | -0.0173011 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0172918 |
| C6ORF62 | chromosome 6 open reading frame 62 | -0.0171879 |
| PCBP2 | poly(rC) binding protein 2 | -0.0168985 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0168237 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0167931 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0167674 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0167608 |
| TAOK1 | TAO kinase 1 | -0.0165456 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0164062 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.0163341 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0163067 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0162429 |
| NEK10 | NIMA-related kinase 10 | -0.0161497 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0160311 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0159162 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0159007 |
| PRELID2 | PRELI domain containing 2 | -0.0158228 |
| GOLGA4 | golgin A4 | -0.0157938 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0151683 |
| RPL5 | ribosomal protein L5 | -0.0151214 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0151098 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0150765 |
| YBX1 | Y box binding protein 1 | -0.0150509 |
| SCFD1 | sec1 family domain containing 1 | -0.0150363 |
| FNDC3B | fibronectin type III domain containing 3B | -0.015016 |
| DCAF10 | DDB1 and CUL4 associated factor 10 | -0.0148892 |
| FUS | FUS RNA binding protein | -0.0148204 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0147979 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.014746 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.014719 |
| WWOX | WW domain containing oxidoreductase | -0.0147153 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0146118 |
| GPATCH2L | G patch domain containing 2-like | -0.0144869 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0144004 |
| ARF4 | ADP-ribosylation factor 4 | -0.0143989 |
| JMJD1C | jumonji domain containing 1C | -0.0143894 |
| RPLP1 | ribosomal protein, large, P1 | -0.0143762 |
| CREBBP | CREB binding protein | -0.0142945 |
| PRKCE | protein kinase C, epsilon | -0.0142794 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | -0.0142206 |
| BBX | bobby sox homolog (Drosophila) | -0.0141557 |
| ZMYM4 | zinc finger, MYM-type 4 | -0.014082 |
