| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lopinavir perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lopinavir_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.162994 |
| GDA | guanine deaminase | 0.15543 |
| GRAMD1B | GRAM domain containing 1B | 0.10413 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0934085 |
| TXNRD1 | thioredoxin reductase 1 | 0.0898702 |
| ASPH | aspartate beta-hydroxylase | 0.0824222 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.074033 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0710513 |
| NRCAM | neuronal cell adhesion molecule | 0.0692957 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0633549 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0628008 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0490709 |
| EFNA5 | ephrin-A5 | 0.0456573 |
| PCBP3 | poly(rC) binding protein 3 | 0.0447996 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0442635 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0441162 |
| NEK7 | NIMA-related kinase 7 | 0.042886 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0424803 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0388615 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.037943 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0365107 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0359271 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0342047 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0339085 |
| MFF | mitochondrial fission factor | 0.0338732 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0323695 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0316915 |
| CD109 | CD109 molecule | 0.0311246 |
| TNPO1 | transportin 1 | 0.0309938 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0305516 |
| COL5A2 | collagen, type V, alpha 2 | 0.0302456 |
| ENAH | enabled homolog (Drosophila) | 0.029847 |
| MYOF | myoferlin | 0.0297377 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0296404 |
| PTGR1 | prostaglandin reductase 1 | 0.0278769 |
| CTSC | cathepsin C | 0.0275541 |
| RAB3B | RAB3B, member RAS oncogene family | 0.0272927 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0272044 |
| MKI67 | marker of proliferation Ki-67 | 0.0268223 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0268142 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0266939 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0266243 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0265075 |
| CENPF | centromere protein F, 350/400kDa | 0.0264327 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0258928 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.025346 |
| BMERB1 | bMERB domain containing 1 | 0.0251481 |
| TBXT | T-box transcription factor T | 0.0249396 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0249048 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0247998 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | 0.024088 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0238734 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.023834 |
| COL4A6 | collagen, type IV, alpha 6 | 0.0236491 |
| KYNU | kynureninase | 0.0236412 |
| PGK1 | phosphoglycerate kinase 1 | 0.0227546 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0225516 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0224255 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0222082 |
| OGA | O-GlcNAcase | 0.0220795 |
| ALPK2 | alpha-kinase 2 | 0.0217578 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0215842 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | 0.0211081 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0202686 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0198597 |
| RTN4 | reticulon 4 | 0.0196742 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0187863 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0187253 |
| TMSB4X | thymosin beta 4, X-linked | 0.0183391 |
| MALT1 | MALT1 paracaspase | 0.017881 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.017677 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.0176626 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0176267 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | 0.0176186 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0175784 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0174359 |
| RGS2 | regulator of G-protein signaling 2 | 0.0173637 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0172119 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | 0.0171951 |
| AHNAK | AHNAK nucleoprotein | 0.0170378 |
| TUSC3 | tumor suppressor candidate 3 | 0.0166867 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0166799 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0166252 |
| TMX4 | thioredoxin-related transmembrane protein 4 | 0.0160784 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.016051 |
| GLIS3 | GLIS family zinc finger 3 | 0.0160279 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0158119 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0158023 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0157976 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.015636 |
| IGF2R | insulin-like growth factor 2 receptor | 0.0154954 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.0154542 |
| FLNB | filamin B, beta | 0.0154019 |
| RLIM | ring finger protein, LIM domain interacting | 0.0152791 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0152677 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0152565 |
| SEPTIN10 | septin 10 | 0.0152165 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0151958 |
| SUB1 | SUB1 homolog (S. cerevisiae) | 0.015118 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0151129 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.279571 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.274047 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.169556 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.130788 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.109909 |
| FN1 | fibronectin 1 | -0.0973478 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0782333 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0724766 |
| CDH13 | cadherin 13 | -0.067468 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.066303 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0642298 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.058626 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0562877 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0559648 |
| VIM | vimentin | -0.0546541 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0543412 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0528486 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0526662 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0522631 |
| VCL | vinculin | -0.0505949 |
| AUTS2 | autism susceptibility candidate 2 | -0.0505314 |
| LSAMP | limbic system-associated membrane protein | -0.0483669 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0472933 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0437234 |
| NDRG1 | N-myc downstream regulated 1 | -0.0417278 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.041565 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0414022 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0403932 |
| PTMA | prothymosin, alpha | -0.0385208 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0377036 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0376607 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0375336 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.0361023 |
| INTS6 | integrator complex subunit 6 | -0.0360612 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0359121 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0356613 |
| CUX1 | cut-like homeobox 1 | -0.0355699 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.035419 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0343803 |
| SMAD2 | SMAD family member 2 | -0.0338981 |
| DENND1A | DENN/MADD domain containing 1A | -0.0336253 |
| RPS6 | ribosomal protein S6 | -0.0334415 |
| XYLT1 | xylosyltransferase I | -0.0333736 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0329028 |
| CADM2 | cell adhesion molecule 2 | -0.0324037 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0324031 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0321876 |
| SQSTM1 | sequestosome 1 | -0.0319538 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0310515 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | -0.0308409 |
| GLRX | glutaredoxin (thioltransferase) | -0.0303672 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0300829 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0297798 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0297474 |
| CTBP2 | C-terminal binding protein 2 | -0.029741 |
| FTL | ferritin, light polypeptide | -0.0296467 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | -0.0290505 |
| EZR | ezrin | -0.0290033 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0287465 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0286252 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0285364 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0282 |
| CANX | calnexin | -0.0278269 |
| SPAG9 | sperm associated antigen 9 | -0.0275384 |
| EGR1 | early growth response 1 | -0.0274144 |
| PCBP2 | poly(rC) binding protein 2 | -0.0273682 |
| PCDH15 | protocadherin-related 15 | -0.0273508 |
| RAD51B | RAD51 paralog B | -0.0273223 |
| CHL1 | cell adhesion molecule L1-like | -0.0272925 |
| NCKAP5 | NCK-associated protein 5 | -0.0267651 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0264315 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0263849 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.0259364 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | -0.0259042 |
| CALR | calreticulin | -0.0256625 |
| MARCHF1 | membrane associated ring-CH-type finger 1 | -0.0255989 |
| YBX3 | Y box binding protein 3 | -0.0247466 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0245312 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0242249 |
| RPS8 | ribosomal protein S8 | -0.0239668 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0234983 |
| MAP7 | microtubule-associated protein 7 | -0.0234222 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0233896 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0232759 |
| LAMA5 | laminin, alpha 5 | -0.0228783 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0228232 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0228124 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0228038 |
| OXSR1 | oxidative stress responsive 1 | -0.0225334 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0225271 |
| PKM | pyruvate kinase, muscle | -0.0224359 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0222374 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0219021 |
| NBEAL1 | neurobeachin-like 1 | -0.0217436 |
| ANXA2 | annexin A2 | -0.0217191 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0215353 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0213795 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.021323 |
| STC1 | stanniocalcin 1 | -0.0213206 |
| MORF4L2 | mortality factor 4 like 2 | -0.0211962 |
