Lopinavir_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lopinavir perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lopinavir_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.073146
RPL19 ribosomal protein L19 0.0680373
KTN1 kinectin 1 (kinesin receptor) 0.0642291
FAT1 FAT atypical cadherin 1 0.0636425
RPS3 ribosomal protein S3 0.0633989
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0622681
RPS20 ribosomal protein S20 0.0608544
NAP1L1 nucleosome assembly protein 1-like 1 0.0595416
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0593172
RPL26 ribosomal protein L26 0.0592418
PTMA prothymosin, alpha 0.0539511
GLG1 golgi glycoprotein 1 0.0527599
RPLP1 ribosomal protein, large, P1 0.0518935
PEG10 paternally expressed 10 0.05152
MSI2 musashi RNA-binding protein 2 0.0497003
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0471459
GDNF glial cell derived neurotrophic factor 0.0470144
ARRDC3 arrestin domain containing 3 0.0460967
SMC5 structural maintenance of chromosomes 5 0.0450096
RPS19 ribosomal protein S19 0.04471
RAB1A RAB1A, member RAS oncogene family 0.0436216
CTBP2 C-terminal binding protein 2 0.0420776
MYH9 myosin, heavy chain 9, non-muscle 0.042065
TPI1 triosephosphate isomerase 1 0.0419979
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0418286
SIK3 SIK family kinase 3 0.0413156
ERRFI1 ERBB receptor feedback inhibitor 1 0.0409167
DST dystonin 0.0403627
AHNAK AHNAK nucleoprotein 0.0398396
CXCL8 chemokine (C-X-C motif) ligand 8 0.0395182
NKD1 naked cuticle homolog 1 (Drosophila) 0.0393628
SET SET nuclear proto-oncogene 0.0392203
VIM vimentin 0.0390114
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0382311
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0381908
FNIP1 folliculin interacting protein 1 0.0379847
APLP2 amyloid beta (A4) precursor-like protein 2 0.0376218
TRIO trio Rho guanine nucleotide exchange factor 0.0375876
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0371169
RPS24 ribosomal protein S24 0.0365168
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0364026
EIF4A1 eukaryotic translation initiation factor 4A1 0.0362669
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0359418
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0355618
RPS6 ribosomal protein S6 0.0355293
CRY1 cryptochrome circadian clock 1 0.0354409
EIF3L eukaryotic translation initiation factor 3, subunit L 0.0352896
DLG1 discs, large homolog 1 (Drosophila) 0.0349411
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0349193
AFF4 AF4/FMR2 family, member 4 0.0339954
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0329779
GGNBP2 gametogenetin binding protein 2 0.0327778
HELZ helicase with zinc finger 0.0327216
RPS27A ribosomal protein S27a 0.0326412
TFG TRK-fused gene 0.0312925
ZFR zinc finger RNA binding protein 0.0310509
MARCHF6 membrane associated ring-CH-type finger 6 0.030768
ABI1 abl-interactor 1 0.0304322
NCOA3 nuclear receptor coactivator 3 0.0302911
SEPTIN7 septin 7 0.0299749
RPL23 ribosomal protein L23 0.0299041
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0298923
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0293733
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0278525
ANKRD10 ankyrin repeat domain 10 0.0275447
PATJ PATJ crumbs cell polarity complex component 0.0271239
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0268489
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0267558
UBA6 ubiquitin-like modifier activating enzyme 6 0.0265476
CDK6 cyclin-dependent kinase 6 0.0265028
H3-3B H3.3 histone B 0.0262911
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0260299
RBM39 RNA binding motif protein 39 0.0259699
YME1L1 YME1-like 1 ATPase 0.0256136
AKAP12 A kinase (PRKA) anchor protein 12 0.0254452
ZFHX3 zinc finger homeobox 3 0.0253693
MBD5 methyl-CpG binding domain protein 5 0.0252246
RPS8 ribosomal protein S8 0.0250716
ITGA6 integrin, alpha 6 0.0245047
EEF2 eukaryotic translation elongation factor 2 0.0241729
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0240051
CANX calnexin 0.0231946
FAM13A family with sequence similarity 13, member A 0.0218845
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0214961
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.021406
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0213913
ZNF207 zinc finger protein 207 0.0213355
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0207998
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0203817
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0201823
MED13L mediator complex subunit 13-like 0.019966
BRD4 bromodomain containing 4 0.0198579
RPL35A ribosomal protein L35a 0.0193831
FNDC3B fibronectin type III domain containing 3B 0.0193115
XRN2 5'-3' exoribonuclease 2 0.0186272
TNPO1 transportin 1 0.0184518
APP amyloid beta (A4) precursor protein 0.0181738
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0179379
WDR26 WD repeat domain 26 0.0177795
RPL13A ribosomal protein L13a 0.0176541

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.346855
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.132599
NDRG1 N-myc downstream regulated 1 -0.123625
IGFBP5 insulin-like growth factor binding protein 5 -0.123241
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.113199
LRP1B low density lipoprotein receptor-related protein 1B -0.0818192
PDE4D phosphodiesterase 4D, cAMP-specific -0.0807243
MAML3 mastermind-like 3 (Drosophila) -0.078397
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0738632
PGK1 phosphoglycerate kinase 1 -0.0715179
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0713915
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0702147
NPAS2 neuronal PAS domain protein 2 -0.0674389
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0640462
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.062472
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0607119
PARD3 par-3 family cell polarity regulator -0.0593462
GPC6 glypican 6 -0.0588183
TSC22D2 TSC22 domain family, member 2 -0.0548866
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0526406
CHD9 chromodomain helicase DNA binding protein 9 -0.052481
OGA O-GlcNAcase -0.0500254
ASPH aspartate beta-hydroxylase -0.049583
SBF2 SET binding factor 2 -0.0485791
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0482409
LAMB3 laminin, beta 3 -0.0476052
FLNB filamin B, beta -0.0449479
LDHA lactate dehydrogenase A -0.0436202
GIGYF2 GRB10 interacting GYF protein 2 -0.0405273
SRPK2 SRSF protein kinase 2 -0.0387596
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0377038
MYO1E myosin IE -0.0366395
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.036021
KDM5B lysine (K)-specific demethylase 5B -0.0358606
IGFBP3 insulin-like growth factor binding protein 3 -0.0350451
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0336383
PSD3 pleckstrin and Sec7 domain containing 3 -0.0334137
OXR1 oxidation resistance 1 -0.0334055
LMO7 LIM domain 7 -0.0329287
PDLIM5 PDZ and LIM domain 5 -0.0326573
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0324026
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0320362
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0320256
SPAG9 sperm associated antigen 9 -0.0320114
KMT2E lysine (K)-specific methyltransferase 2E -0.0296396
SLC38A2 solute carrier family 38, member 2 -0.02887
EGFR epidermal growth factor receptor -0.0287404
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -0.0285455
EHBP1 EH domain binding protein 1 -0.0278903
S100A10 S100 calcium binding protein A10 -0.027771
RNF145 ring finger protein 145 -0.027687
RPL12 ribosomal protein L12 -0.0276368
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.026848
PDE10A phosphodiesterase 10A -0.026457
RAB6A RAB6A, member RAS oncogene family -0.0253622
ANXA2 annexin A2 -0.0246931
GMDS GDP-mannose 4,6-dehydratase -0.0244084
SLTM SAFB-like, transcription modulator -0.0241215
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0239732
MON2 MON2 homolog (S. cerevisiae) -0.0235588
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.022628
ACTG1 actin gamma 1 -0.022358
ZFAND3 zinc finger, AN1-type domain 3 -0.022293
JMJD1C jumonji domain containing 1C -0.0218778
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0216503
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0214487
MACF1 microtubule-actin crosslinking factor 1 -0.0212875
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0203675
DOCK5 dedicator of cytokinesis 5 -0.0195409
RBM25 RNA binding motif protein 25 -0.0190371
NIPBL Nipped-B homolog (Drosophila) -0.0189416
NPEPPS aminopeptidase puromycin sensitive -0.0189404
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0188509
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0180209
ENO1 enolase 1, (alpha) -0.0174298
MEF2A myocyte enhancer factor 2A -0.015831
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0154755
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.015462
TMSB10 thymosin beta 10 -0.0147851
COPA coatomer protein complex, subunit alpha -0.0133049
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0123029
STC1 stanniocalcin 1 -0.0122877
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0119787
ELL2 elongation factor, RNA polymerase II, 2 -0.011793
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0117463
KMT2C lysine (K)-specific methyltransferase 2C -0.0104811
RAD51B RAD51 paralog B -0.0101204
RPLP0 ribosomal protein, large, P0 -0.00963197
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0094645
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.00887434
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.00870754
ENAH enabled homolog (Drosophila) -0.00865957
BRWD1 bromodomain and WD repeat domain containing 1 -0.00829821
PRELID2 PRELI domain containing 2 -0.00805906
AKAP13 A kinase (PRKA) anchor protein 13 -0.00768138
LOC112694756 uncharaterized LOC112694756 -0.00740753
BHLHE40 basic helix-loop-helix family, member e40 -0.00734156
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.00658823
FOXO1 forkhead box O1 -0.00656868
THSD4 thrombospondin, type I, domain containing 4 -0.0054735