| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lopinavir perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lopinavir_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.108919 |
| THBS1 | thrombospondin 1 | 0.0657727 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0506913 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0448792 |
| AHNAK | AHNAK nucleoprotein | 0.0443293 |
| XPO1 | exportin 1 | 0.0440439 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0429525 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0365665 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0361517 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0337923 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0336945 |
| TPM3 | tropomyosin 3 | 0.0333286 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0320882 |
| H1-4 | H1.4 linker histone, cluster member | 0.0316525 |
| RPL3 | ribosomal protein L3 | 0.0312145 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0307617 |
| H1-5 | H1.5 linker histone, cluster member | 0.0301348 |
| CDC73 | cell division cycle 73 | 0.0296432 |
| SET | SET nuclear proto-oncogene | 0.0292199 |
| GPC4 | glypican 4 | 0.0284533 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0277741 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0272403 |
| MEMO1 | mediator of cell motility 1 | 0.0269032 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0268312 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0260986 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0260899 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0254603 |
| NCKAP1 | NCK-associated protein 1 | 0.0253666 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0241402 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.0239656 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0239185 |
| ENAH | enabled homolog (Drosophila) | 0.0237954 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0232655 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0230711 |
| H1-2 | H1.2 linker histone, cluster member | 0.02301 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0228587 |
| RIGI | RNA sensor RIG-I | 0.0228001 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0226143 |
| NUP58 | nucleoporin 58 | 0.0224975 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | 0.0219143 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0213612 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0208977 |
| MED13L | mediator complex subunit 13-like | 0.0208293 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0207387 |
| KMT2A | lysine (K)-specific methyltransferase 2A | 0.0206337 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0206024 |
| NUDC | nudC nuclear distribution protein | 0.0203075 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0201405 |
| MYO10 | myosin X | 0.0201237 |
| TPM1 | tropomyosin 1 (alpha) | 0.0196893 |
| CCNY | cyclin Y | 0.0193203 |
| RPSA | ribosomal protein SA | 0.0192869 |
| UBC | ubiquitin C | 0.0190699 |
| SUCO | SUN domain containing ossification factor | 0.0187834 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0186805 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0186222 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0183224 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.018305 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0182294 |
| ZNF462 | zinc finger protein 462 | 0.0180522 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0179297 |
| FOXP2 | forkhead box P2 | 0.0178884 |
| YAP1 | Yes-associated protein 1 | 0.0178659 |
| MKI67 | marker of proliferation Ki-67 | 0.0178219 |
| TARDBP | TAR DNA binding protein | 0.0177684 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | 0.0174709 |
| UPP1 | uridine phosphorylase 1 | 0.017394 |
| EMC1 | ER membrane protein complex subunit 1 | 0.0173017 |
| FRY | furry homolog (Drosophila) | 0.0172542 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0169967 |
| PER1 | period circadian clock 1 | 0.0168732 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0166546 |
| SHROOM3 | shroom family member 3 | 0.0163397 |
| NOTCH2 | notch 2 | 0.0163147 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0161785 |
| PAFAH1B2 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) | 0.0161031 |
| BMPR1A | bone morphogenetic protein receptor, type IA | 0.0160861 |
| UBP1 | upstream binding protein 1 (LBP-1a) | 0.0159741 |
| VIRMA | vir like m6A methyltransferase associated | 0.0158926 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0157878 |
| CERT1 | ceramide transporter 1 | 0.015769 |
| CYTH3 | cytohesin 3 | 0.0157411 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0156705 |
| TAB3 | TGF-beta activated kinase 1/MAP3K7 binding protein 3 | 0.0156127 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0156015 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0156007 |
| PEG10 | paternally expressed 10 | 0.0155428 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0154226 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0154169 |
| SSBP3 | single stranded DNA binding protein 3 | 0.0153834 |
| ZFP30 | ZFP30 zinc finger protein | 0.015309 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0152091 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.015055 |
| PRKCI | protein kinase C, iota | 0.0150284 |
| ACER3 | alkaline ceramidase 3 | 0.0149876 |
| SYDE2 | synapse defective 1, Rho GTPase, homolog 2 (C. elegans) | 0.0149806 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0149483 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.0148639 |
| ACVR1 | activin A receptor, type I | 0.0148563 |
| RHOA | ras homolog family member A | 0.014841 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.161245 |
| TMSB10 | thymosin beta 10 | -0.140379 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.112472 |
| DST | dystonin | -0.08495 |
| PTMA | prothymosin, alpha | -0.0798374 |
| RPLP1 | ribosomal protein, large, P1 | -0.0766871 |
| RPS16 | ribosomal protein S16 | -0.0751 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0720678 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0708067 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0647926 |
| RPL35A | ribosomal protein L35a | -0.0557049 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0497173 |
| RPS8 | ribosomal protein S8 | -0.0488422 |
| RPS6 | ribosomal protein S6 | -0.0477457 |
| RPS19 | ribosomal protein S19 | -0.0470317 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0461171 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0452076 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0451666 |
| GNAS | GNAS complex locus | -0.0435616 |
| CADM2 | cell adhesion molecule 2 | -0.0422099 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0415826 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0406442 |
| SRP54 | signal recognition particle 54kDa | -0.0405674 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0404481 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0396228 |
| PHIP | pleckstrin homology domain interacting protein | -0.0394997 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0388784 |
| SFRP4 | secreted frizzled-related protein 4 | -0.0386359 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0383317 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0377314 |
| TUBA1B | tubulin, alpha 1b | -0.0373795 |
| SNX6 | sorting nexin 6 | -0.0366853 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0362055 |
| RPLP2 | ribosomal protein, large, P2 | -0.0361381 |
| FBXO11 | F-box protein 11 | -0.0360204 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0359392 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0358313 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0357787 |
| RPL11 | ribosomal protein L11 | -0.0357673 |
| TMSB4X | thymosin beta 4, X-linked | -0.0356918 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0348508 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.034059 |
| RPL38 | ribosomal protein L38 | -0.0338841 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.033199 |
| RAB31 | RAB31, member RAS oncogene family | -0.0325335 |
| RPL37A | ribosomal protein L37a | -0.0325114 |
| MT2A | metallothionein 2A | -0.0316618 |
| ACTG1 | actin gamma 1 | -0.0315618 |
| RPLP0 | ribosomal protein, large, P0 | -0.0315279 |
| RPL30 | ribosomal protein L30 | -0.031344 |
| RPS21 | ribosomal protein S21 | -0.0313247 |
| HMGB1 | high mobility group box 1 | -0.0311524 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0311331 |
| RPL36 | ribosomal protein L36 | -0.0306963 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.030436 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0303604 |
| PGK1 | phosphoglycerate kinase 1 | -0.0296212 |
| RPS4X | ribosomal protein S4, X-linked | -0.0293979 |
| NTM | neurotrimin | -0.0290503 |
| RPL36A | ribosomal protein L36a | -0.0288939 |
| PFN1 | profilin 1 | -0.0285289 |
| KIF20B | kinesin family member 20B | -0.0284161 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0283908 |
| NOP58 | NOP58 ribonucleoprotein | -0.0283588 |
| SYT1 | synaptotagmin I | -0.0279342 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0278424 |
| CENPF | centromere protein F, 350/400kDa | -0.0278414 |
| RPS3 | ribosomal protein S3 | -0.0277864 |
| JMJD1C | jumonji domain containing 1C | -0.027671 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0276663 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0275742 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0275586 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0274933 |
| RPS29 | ribosomal protein S29 | -0.0273641 |
| RPL34 | ribosomal protein L34 | -0.0272405 |
| RPS27A | ribosomal protein S27a | -0.0272186 |
| SEPTIN7 | septin 7 | -0.027099 |
| S100A9 | S100 calcium binding protein A9 | -0.026962 |
| RPL9 | ribosomal protein L9 | -0.0266226 |
| RPS20 | ribosomal protein S20 | -0.0266092 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0265469 |
| RDX | radixin | -0.026314 |
| COL11A1 | collagen, type XI, alpha 1 | -0.0262363 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0262056 |
| DEK | DEK proto-oncogene | -0.0261593 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0260951 |
| MORF4L2 | mortality factor 4 like 2 | -0.025953 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0258941 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.025769 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0257668 |
| CENPE | centromere protein E, 312kDa | -0.025683 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0256783 |
| FSCN1 | fascin actin-bundling protein 1 | -0.0254392 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0253179 |
| SMYD3 | SET and MYND domain containing 3 | -0.0253035 |
| ANK2 | ankyrin 2, neuronal | -0.0252205 |
| RPL28 | ribosomal protein L28 | -0.0251989 |
| RPL19 | ribosomal protein L19 | -0.0251854 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0247542 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.0246288 |
