Lopinavir_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lopinavir perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lopinavir_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein 0.175175
TMSB4X thymosin beta 4, X-linked 0.142562
VCL vinculin 0.126806
PTMA prothymosin, alpha 0.120669
TPT1 tumor protein, translationally-controlled 1 0.114927
SSBP2 single-stranded DNA binding protein 2 0.108722
KDM3A lysine (K)-specific demethylase 3A 0.0881202
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0823755
RPL3 ribosomal protein L3 0.0755209
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0744333
ANK2 ankyrin 2, neuronal 0.0724115
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0712938
PYGB phosphorylase, glycogen; brain 0.0691818
RPL4 ribosomal protein L4 0.068065
EIF4A2 eukaryotic translation initiation factor 4A2 0.0673729
NAMPT nicotinamide phosphoribosyltransferase 0.0651384
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.064192
RPL26 ribosomal protein L26 0.0640892
SAMD4A sterile alpha motif domain containing 4A 0.0599472
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0597101
KMT2E lysine (K)-specific methyltransferase 2E 0.0595978
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0594702
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0590979
ADAM10 ADAM metallopeptidase domain 10 0.054194
HSPA8 heat shock 70kDa protein 8 0.054066
PGK1 phosphoglycerate kinase 1 0.0521904
RPL11 ribosomal protein L11 0.0513639
RHEB Ras homolog enriched in brain 0.0511258
CAMTA1 calmodulin binding transcription activator 1 0.0500934
EPS8 epidermal growth factor receptor pathway substrate 8 0.0495547
BMP10 bone morphogenetic protein 10 0.0491269
RPS8 ribosomal protein S8 0.0491
RPLP1 ribosomal protein, large, P1 0.049036
RPL31 ribosomal protein L31 0.0485801
MKI67 marker of proliferation Ki-67 0.0484712
ZEB1 zinc finger E-box binding homeobox 1 0.047726
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0441811
NAP1L1 nucleosome assembly protein 1-like 1 0.0438104
H1-4 H1.4 linker histone, cluster member 0.0435099
RPL7A ribosomal protein L7a 0.0425123
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0423449
ADAM9 ADAM metallopeptidase domain 9 0.041871
RPSA ribosomal protein SA 0.0418331
MYL12B myosin, light chain 12B, regulatory 0.0417457
FHIT fragile histidine triad 0.0412305
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0410136
TM4SF1 transmembrane 4 L six family member 1 0.0404185
CORO1C coronin, actin binding protein, 1C 0.0404071
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0403837
RPL34 ribosomal protein L34 0.0403309
RPL10A ribosomal protein L10a 0.0400769
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0400715
GARS1 glycyl-tRNA synthetase 1 0.0399814
RAD21 RAD21 homolog (S. pombe) 0.0391494
EIF4A1 eukaryotic translation initiation factor 4A1 0.0387271
LOC112694756 uncharaterized LOC112694756 0.0387208
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0384532
EIF1 eukaryotic translation initiation factor 1 0.0383946
AMOTL2 angiomotin like 2 0.0382329
RPL12 ribosomal protein L12 0.0378532
CDC73 cell division cycle 73 0.0377712
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.037313
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0372883
FNDC3B fibronectin type III domain containing 3B 0.0372301
SOX6 SRY (sex determining region Y)-box 6 0.0370242
WSB1 WD repeat and SOCS box containing 1 0.0369554
RPL5 ribosomal protein L5 0.0365612
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0365239
FBLN2 fibulin 2 0.0362964
CENPF centromere protein F, 350/400kDa 0.0357946
EBNA1BP2 EBNA1 binding protein 2 0.0353474
FAR1 fatty acyl CoA reductase 1 0.035249
ENO1 enolase 1, (alpha) 0.0349535
ANKRD11 ankyrin repeat domain 11 0.0347088
PKM pyruvate kinase, muscle 0.0346076
MEF2A myocyte enhancer factor 2A 0.034554
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0339659
GSK3B glycogen synthase kinase 3 beta 0.033745
KPNB1 karyopherin (importin) beta 1 0.0333636
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0331849
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0324355
NAV2 neuron navigator 2 0.032435
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0323721
RPS17 ribosomal protein S17 0.0321751
RPS18 ribosomal protein S18 0.0321027
TPI1 triosephosphate isomerase 1 0.0320041
DIAPH3 diaphanous-related formin 3 0.0319846
SFTPA2 surfactant protein A2 0.0318275
RPS2 ribosomal protein S2 0.0318244
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0317102
CAMKMT calmodulin-lysine N-methyltransferase 0.0317094
RPS5 ribosomal protein S5 0.0316985
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0315104
NCKAP1 NCK-associated protein 1 0.0314705
RPL35 ribosomal protein L35 0.0313579
TCEA1 transcription elongation factor A (SII), 1 0.0311033
RPS12 ribosomal protein S12 0.0309835
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0307705
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0296056
EVI5 ecotropic viral integration site 5 0.0295909

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.1136
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0910421
TTC3 tetratricopeptide repeat domain 3 -0.0740783
GOLGA4 golgin A4 -0.0720313
NPAS2 neuronal PAS domain protein 2 -0.0696349
ENO2 enolase 2 (gamma, neuronal) -0.063832
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0617431
DPYD dihydropyrimidine dehydrogenase -0.0585344
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0520965
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0520149
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.047927
CPED1 cadherin-like and PC-esterase domain containing 1 -0.046661
NBEA neurobeachin -0.0460015
EGFR epidermal growth factor receptor -0.0448649
BRD2 bromodomain containing 2 -0.0433725
HMGA1 high mobility group AT-hook 1 -0.0424643
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0413217
LATS2 large tumor suppressor kinase 2 -0.0401391
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0369906
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0364199
AKAP9 A kinase (PRKA) anchor protein 9 -0.0359783
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0357864
SEC31A SEC31 homolog A (S. cerevisiae) -0.0353962
RNMT RNA (guanine-7-) methyltransferase -0.0351117
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0349186
MON2 MON2 homolog (S. cerevisiae) -0.034856
DSCAM Down syndrome cell adhesion molecule -0.0346942
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0345859
EXT1 exostosin glycosyltransferase 1 -0.0343346
SMYD3 SET and MYND domain containing 3 -0.0343057
CSNK1A1 casein kinase 1, alpha 1 -0.0342445
SEC24A SEC24 family member A -0.0342091
SMC5 structural maintenance of chromosomes 5 -0.0341767
EFNA5 ephrin-A5 -0.033897
CCND1 cyclin D1 -0.0336349
RAB7A RAB7A, member RAS oncogene family -0.0335788
ZNF638 zinc finger protein 638 -0.0325878
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0317534
POTEF POTE ankyrin domain family, member F -0.0312473
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0311367
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0309892
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0306268
SLC38A2 solute carrier family 38, member 2 -0.0306268
PDIA3 protein disulfide isomerase family A, member 3 -0.0303027
TAS2R14 taste receptor, type 2, member 14 -0.0297651
ZBTB20 zinc finger and BTB domain containing 20 -0.0296053
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0294237
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0292645
NBEAL1 neurobeachin-like 1 -0.0292571
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0292551
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0291626
GPATCH2L G patch domain containing 2-like -0.0291049
ACBD3 acyl-CoA binding domain containing 3 -0.0277352
ADNP activity-dependent neuroprotector homeobox -0.0276947
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.0274937
RTN4 reticulon 4 -0.0274115
BPTF bromodomain PHD finger transcription factor -0.0273284
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -0.0261825
PDE4B phosphodiesterase 4B, cAMP-specific -0.0261611
PARD3 par-3 family cell polarity regulator -0.0261156
TBC1D5 TBC1 domain family, member 5 -0.0259913
MTDH metadherin -0.0258585
NOCT nocturnin -0.0258378
AHI1 Abelson helper integration site 1 -0.0257413
TASOR2 transcription activation suppressor family member 2 -0.0256396
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0255105
PHF14 PHD finger protein 14 -0.0249254
FBXO11 F-box protein 11 -0.0246989
TBK1 TANK-binding kinase 1 -0.0246461
AFF4 AF4/FMR2 family, member 4 -0.0243247
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0239967
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -0.0237188
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0236753
PKN2 protein kinase N2 -0.0233311
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) -0.0233009
SUCO SUN domain containing ossification factor -0.0232898
ASXL2 additional sex combs like transcriptional regulator 2 -0.0230226
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0229219
SETD5 SET domain containing 5 -0.0228387
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0228109
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0227506
INTS6 integrator complex subunit 6 -0.0227129
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0225359
ANKRD17 ankyrin repeat domain 17 -0.0223873
COG6 component of oligomeric golgi complex 6 -0.0223141
FAM13A family with sequence similarity 13, member A -0.022296
SP100 SP100 nuclear antigen -0.0222584
TMF1 TATA element modulatory factor 1 -0.0219896
DHFR dihydrofolate reductase -0.0218346
CORIN corin, serine peptidase -0.0217004
FAM193A family with sequence similarity 193, member A -0.0216181
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0216095
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0213997
CCDC88A coiled-coil domain containing 88A -0.021109
PDS5A PDS5 cohesin associated factor A -0.0208989
DLG1 discs, large homolog 1 (Drosophila) -0.0208814
PFN1 profilin 1 -0.0208773
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0208192
SRSF11 serine/arginine-rich splicing factor 11 -0.020813
ATM ATM serine/threonine kinase -0.0207557