| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lopinavir perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lopinavir_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.171007 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.157717 |
| MT2A | metallothionein 2A | 0.13553 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.100069 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0941172 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.093239 |
| TMSB10 | thymosin beta 10 | 0.0869895 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0815758 |
| ATP13A3 | ATPase type 13A3 | 0.0661209 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0622156 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.057793 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0567586 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0546513 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0504628 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0451891 |
| PTMA | prothymosin, alpha | 0.0451407 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0447219 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0440881 |
| ADM | adrenomedullin | 0.043922 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0403595 |
| FAM13A | family with sequence similarity 13, member A | 0.0402114 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0397661 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0391051 |
| ARRDC3 | arrestin domain containing 3 | 0.0388965 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0385443 |
| PGK1 | phosphoglycerate kinase 1 | 0.036236 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0361942 |
| MATR3 | matrin 3 | 0.0358158 |
| TFG | TRK-fused gene | 0.035282 |
| CLINT1 | clathrin interactor 1 | 0.0351546 |
| TPI1 | triosephosphate isomerase 1 | 0.0350545 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0340704 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0338728 |
| SDC4 | syndecan 4 | 0.0329234 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0328352 |
| XPO1 | exportin 1 | 0.0325929 |
| RLF | rearranged L-myc fusion | 0.0321486 |
| RBM39 | RNA binding motif protein 39 | 0.0292821 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0290255 |
| PDE10A | phosphodiesterase 10A | 0.0275312 |
| HMGB2 | high mobility group box 2 | 0.0271345 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0268236 |
| HELZ | helicase with zinc finger | 0.0267122 |
| COG5 | component of oligomeric golgi complex 5 | 0.0264831 |
| IGF2R | insulin-like growth factor 2 receptor | 0.0264364 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.026174 |
| MYOF | myoferlin | 0.0260811 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0260689 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0257213 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0256532 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0253973 |
| CDK7 | cyclin-dependent kinase 7 | 0.0253801 |
| TPM2 | tropomyosin 2 (beta) | 0.0253722 |
| LMNA | lamin A/C | 0.0253493 |
| TXNIP | thioredoxin interacting protein | 0.0249779 |
| MT1X | metallothionein 1X | 0.0248573 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0248364 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0247205 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0246954 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0246708 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0245587 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0245337 |
| ANXA2 | annexin A2 | 0.0243287 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0242303 |
| SKP1 | S-phase kinase-associated protein 1 | 0.0241426 |
| ACTN4 | actinin, alpha 4 | 0.0236642 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0236559 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0236514 |
| ENO1 | enolase 1, (alpha) | 0.0236275 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0235424 |
| APP | amyloid beta (A4) precursor protein | 0.023373 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0233058 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0231394 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0226704 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0225649 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0225524 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0222879 |
| LOXL2 | lysyl oxidase-like 2 | 0.0222853 |
| GOLGA4 | golgin A4 | 0.0222706 |
| HDLBP | high density lipoprotein binding protein | 0.0220788 |
| FTL | ferritin, light polypeptide | 0.0220501 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0219005 |
| PRRC1 | proline-rich coiled-coil 1 | 0.0218205 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0215734 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.021356 |
| COPA | coatomer protein complex, subunit alpha | 0.0210217 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0207728 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0207433 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0207079 |
| GNAS | GNAS complex locus | 0.0207073 |
| TPR | translocated promoter region, nuclear basket protein | 0.0206677 |
| EMP1 | epithelial membrane protein 1 | 0.0206444 |
| QKI | QKI, KH domain containing, RNA binding | 0.0206358 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0206007 |
| RINT1 | RAD50 interactor 1 | 0.0205089 |
| TMEM39A | transmembrane protein 39A | 0.0204803 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.020397 |
| RPL36 | ribosomal protein L36 | 0.020161 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.020155 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | 0.0201508 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.309571 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.191746 |
| FN1 | fibronectin 1 | -0.12918 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.122723 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.109615 |
| POTEF | POTE ankyrin domain family, member F | -0.0806525 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0757959 |
| HMGA2 | high mobility group AT-hook 2 | -0.0685476 |
| VCL | vinculin | -0.0680465 |
| TNS3 | tensin 3 | -0.0667277 |
| CDH13 | cadherin 13 | -0.0633131 |
| IL6 | interleukin 6 | -0.0615964 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0597331 |
| COL5A1 | collagen, type V, alpha 1 | -0.0583758 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0579362 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0563854 |
| CDK6 | cyclin-dependent kinase 6 | -0.0562351 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.05314 |
| VEGFC | vascular endothelial growth factor C | -0.0511385 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0502691 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0488827 |
| VEGFA | vascular endothelial growth factor A | -0.0486835 |
| COL6A1 | collagen, type VI, alpha 1 | -0.048046 |
| HLA-B | major histocompatibility complex, class I, B | -0.0477235 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0471603 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0456602 |
| KYNU | kynureninase | -0.0437204 |
| RUNX1 | runt-related transcription factor 1 | -0.0436252 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0434055 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0423485 |
| CALD1 | caldesmon 1 | -0.0418845 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0399791 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0395023 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0386531 |
| KAZN | kazrin, periplakin interacting protein | -0.0383523 |
| FNIP1 | folliculin interacting protein 1 | -0.0383308 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0373967 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0370805 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0357602 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0347938 |
| PRKCA | protein kinase C, alpha | -0.0342676 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0337024 |
| MAP1B | microtubule-associated protein 1B | -0.0334892 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0326451 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0324785 |
| LOX | lysyl oxidase | -0.0324769 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0311965 |
| TAOK1 | TAO kinase 1 | -0.0311567 |
| EXOC4 | exocyst complex component 4 | -0.0310517 |
| CDK13 | cyclin-dependent kinase 13 | -0.03105 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0308182 |
| DST | dystonin | -0.030594 |
| MSN | moesin | -0.0303365 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0300206 |
| ATXN1 | ataxin 1 | -0.0298316 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0296696 |
| ATG7 | autophagy related 7 | -0.0295336 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0288113 |
| ACTG1 | actin gamma 1 | -0.0287962 |
| TANK | TRAF family member-associated NFKB activator | -0.0283297 |
| TPM1 | tropomyosin 1 (alpha) | -0.0281186 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0278433 |
| PTK2 | protein tyrosine kinase 2 | -0.0275636 |
| C1D | C1D nuclear receptor corepressor | -0.0270625 |
| RASAL2 | RAS protein activator like 2 | -0.0260775 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0257074 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0256656 |
| CUX1 | cut-like homeobox 1 | -0.0254777 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0251185 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0250821 |
| MYLK | myosin light chain kinase | -0.0250141 |
| NRP1 | neuropilin 1 | -0.0248473 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0246454 |
| MAP4 | microtubule-associated protein 4 | -0.0244927 |
| EXOC6B | exocyst complex component 6B | -0.0243865 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0240407 |
| CANX | calnexin | -0.0238641 |
| NRXN3 | neurexin 3 | -0.0237979 |
| PRELID2 | PRELI domain containing 2 | -0.023661 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0236034 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0235023 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0232748 |
| CACNA1C | calcium channel, voltage-dependent, L type, alpha 1C subunit | -0.0229642 |
| MED13L | mediator complex subunit 13-like | -0.0228759 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0227923 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0226629 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.02264 |
| NECTIN3 | nectin cell adhesion molecule 3 | -0.0225565 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0224988 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0221504 |
| TPM4 | tropomyosin 4 | -0.0220259 |
| HM13 | histocompatibility (minor) 13 | -0.0218876 |
| SRPK2 | SRSF protein kinase 2 | -0.021849 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0217728 |
| TNPO1 | transportin 1 | -0.0216846 |
| FOSL1 | FOS-like antigen 1 | -0.0215118 |
| ZNF644 | zinc finger protein 644 | -0.0212868 |
| DNAH11 | dynein, axonemal, heavy chain 11 | -0.0212382 |
| ARHGAP24 | Rho GTPase activating protein 24 | -0.0211796 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0211695 |
