Lopinavir_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lopinavir perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lopinavir_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.12927
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0441439
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0438858
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.041617
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0379703
TPX2 TPX2, microtubule-associated 0.0343641
SET SET nuclear proto-oncogene 0.0336483
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0336251
NUP58 nucleoporin 58 0.0308741
MYH9 myosin, heavy chain 9, non-muscle 0.0304706
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0300468
TXNRD1 thioredoxin reductase 1 0.0292219
EEF2 eukaryotic translation elongation factor 2 0.0283077
CXCL8 chemokine (C-X-C motif) ligand 8 0.0280063
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0246723
RPL4 ribosomal protein L4 0.0245677
HSPA8 heat shock 70kDa protein 8 0.0230196
NUMA1 nuclear mitotic apparatus protein 1 0.0222035
EIF4A1 eukaryotic translation initiation factor 4A1 0.0213402
GOLT1B golgi transport 1B 0.0206291
DIAPH3 diaphanous-related formin 3 0.020487
NAP1L1 nucleosome assembly protein 1-like 1 0.0202287
EIF1 eukaryotic translation initiation factor 1 0.0201471
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0199141
CENPF centromere protein F, 350/400kDa 0.0195937
COPB1 coatomer protein complex, subunit beta 1 0.0194035
IARS1 isoleucyl-tRNA synthetase 1 0.0194014
AURKA aurora kinase A 0.0192347
MMP1 matrix metallopeptidase 1 0.0191085
CANX calnexin 0.0188542
MKI67 marker of proliferation Ki-67 0.0188485
RPL3 ribosomal protein L3 0.0187235
CKAP2 cytoskeleton associated protein 2 0.017705
HYOU1 hypoxia up-regulated 1 0.017673
ANLN anillin, actin binding protein 0.0176624
CALR calreticulin 0.0175608
SGO2 shugoshin 2 0.0174763
RPL7A ribosomal protein L7a 0.0173987
MIS18BP1 MIS18 binding protein 1 0.0173689
IPO7 importin 7 0.0173218
RPL12 ribosomal protein L12 0.0172573
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.016986
CKAP5 cytoskeleton associated protein 5 0.0167668
RPS2 ribosomal protein S2 0.0166016
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0165494
KIF5B kinesin family member 5B 0.0163278
PABPC1 poly(A) binding protein, cytoplasmic 1 0.016156
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.016065
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0159165
HMGB2 high mobility group box 2 0.0152713
RPL26 ribosomal protein L26 0.015227
ELP2 elongator acetyltransferase complex subunit 2 0.0152253
PHIP pleckstrin homology domain interacting protein 0.0151519
GOLGA2 golgin A2 0.0151311
TFG TRK-fused gene 0.014892
CEP70 centrosomal protein 70kDa 0.0148584
TTK TTK protein kinase 0.0148283
TUBB tubulin, beta class I 0.0147952
KIF23 kinesin family member 23 0.014769
SLC31A1 solute carrier family 31 (copper transporter), member 1 0.0147334
KIAA1958 KIAA1958 0.0145711
COPA coatomer protein complex, subunit alpha 0.014475
SRP54 signal recognition particle 54kDa 0.0144594
MAP1B microtubule-associated protein 1B 0.0144563
TPR translocated promoter region, nuclear basket protein 0.0142945
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 0.0142805
TMED2 transmembrane emp24 domain trafficking protein 2 0.0142444
LDHB lactate dehydrogenase B 0.0139658
RPL23 ribosomal protein L23 0.0138096
BIRC2 baculoviral IAP repeat containing 2 0.0137445
CKAP2L cytoskeleton associated protein 2-like 0.0136514
TPM3 tropomyosin 3 0.0135256
H1-2 H1.2 linker histone, cluster member 0.013507
TOP2B topoisomerase (DNA) II beta 180kDa 0.0134852
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0134352
RPLP0 ribosomal protein, large, P0 0.0133914
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0133631
CENPE centromere protein E, 312kDa 0.0132735
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0132371
H1-4 H1.4 linker histone, cluster member 0.0131556
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.013001
ECT2 epithelial cell transforming 2 0.0129927
HILPDA hypoxia inducible lipid droplet-associated 0.0129379
SETD5 SET domain containing 5 0.0128396
WAC WW domain containing adaptor with coiled-coil 0.012799
ATXN2L ataxin 2-like 0.0127952
RARS1 arginyl-tRNA synthetase 1 0.0126821
ZC3H15 zinc finger CCCH-type containing 15 0.0126282
GARS1 glycyl-tRNA synthetase 1 0.0126032
BRD2 bromodomain containing 2 0.0125842
SEC24A SEC24 family member A 0.012539
CCDC47 coiled-coil domain containing 47 0.0125333
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0125265
SMC4 structural maintenance of chromosomes 4 0.0125264
HJURP Holliday junction recognition protein 0.0124782
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0124465
SEC23A Sec23 homolog A (S. cerevisiae) 0.0123919
NCAPD2 non-SMC condensin I complex, subunit D2 0.0123713
CLTC clathrin, heavy chain (Hc) 0.012361
PRR11 proline rich 11 0.0123548

decreased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B -0.169389
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.165089
CD44 CD44 molecule (Indian blood group) -0.0795931
HMGA2 high mobility group AT-hook 2 -0.0787232
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0749793
SMYD3 SET and MYND domain containing 3 -0.0733249
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0720613
FMNL2 formin-like 2 -0.0647669
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0647341
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0640818
RAD51B RAD51 paralog B -0.0640535
ZBTB20 zinc finger and BTB domain containing 20 -0.0624825
DST dystonin -0.0608472
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0602053
TMSB10 thymosin beta 10 -0.0535525
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0534323
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0529221
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0516131
NDRG1 N-myc downstream regulated 1 -0.049913
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0498059
ATXN1 ataxin 1 -0.0487333
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0474033
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0466627
SVIL supervillin -0.046322
IGF2 insulin-like growth factor 2 -0.0438631
SAMD4A sterile alpha motif domain containing 4A -0.0434491
TRIO trio Rho guanine nucleotide exchange factor -0.043209
TAS2R14 taste receptor, type 2, member 14 -0.0427923
MACF1 microtubule-actin crosslinking factor 1 -0.0419377
PRKCA protein kinase C, alpha -0.04123
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0409407
ZMYND8 zinc finger, MYND-type containing 8 -0.0394948
RIGI RNA sensor RIG-I -0.0393326
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0391321
INTS6 integrator complex subunit 6 -0.0390759
AHNAK AHNAK nucleoprotein -0.0387467
IGFBP3 insulin-like growth factor binding protein 3 -0.0382982
ANO6 anoctamin 6 -0.0382725
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0380769
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0378991
BASP1 brain abundant, membrane attached signal protein 1 -0.0376318
RAI14 retinoic acid induced 14 -0.0374915
DPYD dihydropyrimidine dehydrogenase -0.0374474
FLNB filamin B, beta -0.0367414
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0362734
ATM ATM serine/threonine kinase -0.035989
VCL vinculin -0.0359359
SH3KBP1 SH3-domain kinase binding protein 1 -0.0355031
FMN1 formin 1 -0.0353402
ANXA2 annexin A2 -0.0351997
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0351767
OSMR oncostatin M receptor -0.034986
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0343463
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0336532
SLC38A2 solute carrier family 38, member 2 -0.0334972
GPC6 glypican 6 -0.0333886
FTH1 ferritin, heavy polypeptide 1 -0.0330761
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0327701
POTEF POTE ankyrin domain family, member F -0.0327561
AKAP13 A kinase (PRKA) anchor protein 13 -0.0324966
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0323839
NALCN sodium leak channel, non selective -0.0322818
DNER delta/notch-like EGF repeat containing -0.031643
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0315802
IL1RAP interleukin 1 receptor accessory protein -0.031259
EXT1 exostosin glycosyltransferase 1 -0.0308801
PRR16 proline rich 16 -0.0304896
PRSS23 protease, serine, 23 -0.0302557
NAV2 neuron navigator 2 -0.03006
PCED1B PC-esterase domain containing 1B -0.0300586
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0299901
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0294277
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.029377
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0289932
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0289581
VIM vimentin -0.0288512
ATG7 autophagy related 7 -0.0287174
SCAPER S-phase cyclin A-associated protein in the ER -0.0286935
EGFR epidermal growth factor receptor -0.0281629
NT5E 5'-nucleotidase, ecto (CD73) -0.0281373
PCNX4 pecanex 4 -0.0277689
ELL2 elongation factor, RNA polymerase II, 2 -0.0272334
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0271766
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0270244
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0267016
EGR1 early growth response 1 -0.0260608
PARD3 par-3 family cell polarity regulator -0.0259587
ANGPTL4 angiopoietin-like 4 -0.0259348
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.025355
LDHA lactate dehydrogenase A -0.0253196
BICD1 bicaudal D homolog 1 (Drosophila) -0.0251537
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0250413
EFNA5 ephrin-A5 -0.0249002
SMAD3 SMAD family member 3 -0.0248594
MYOF myoferlin -0.0246319
BPTF bromodomain PHD finger transcription factor -0.0244894
LPP LIM domain containing preferred translocation partner in lipoma -0.0244285
ENO2 enolase 2 (gamma, neuronal) -0.0243418
PTK2 protein tyrosine kinase 2 -0.023849
FNDC3A fibronectin type III domain containing 3A -0.0238036