| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lopinavir perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lopinavir_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.24138 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.23173 |
| TMEM156 | transmembrane protein 156 | 0.0949643 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.09158 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0883619 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0801718 |
| MT2A | metallothionein 2A | 0.0742616 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0617952 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0599134 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0560327 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0550224 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0479104 |
| AHR | aryl hydrocarbon receptor | 0.0464648 |
| SMAD3 | SMAD family member 3 | 0.0448997 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0419869 |
| RPL26 | ribosomal protein L26 | 0.0399326 |
| KLHL5 | kelch-like family member 5 | 0.0394185 |
| ETNK1 | ethanolamine kinase 1 | 0.0389717 |
| CANX | calnexin | 0.0389398 |
| TPI1 | triosephosphate isomerase 1 | 0.0384579 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0369282 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0366494 |
| RACK1 | receptor for activated C kinase 1 | 0.0350271 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0350187 |
| TOR1AIP2 | torsin A interacting protein 2 | 0.0346441 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.034333 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0341415 |
| SUCO | SUN domain containing ossification factor | 0.0338832 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.03378 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0337219 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.033345 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0329066 |
| CAB39 | calcium binding protein 39 | 0.0328114 |
| VMP1 | vacuole membrane protein 1 | 0.0328002 |
| TXNRD1 | thioredoxin reductase 1 | 0.0327866 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0327275 |
| EREG | epiregulin | 0.0326441 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0322844 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0321912 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.03216 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0321219 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0321144 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0321063 |
| PRRC2C | proline-rich coiled-coil 2C | 0.031919 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0317935 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0317781 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0310547 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0307244 |
| GOLGA4 | golgin A4 | 0.030547 |
| CENPF | centromere protein F, 350/400kDa | 0.0305393 |
| RO60 | Ro60, Y RNA binding protein | 0.030278 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.030264 |
| RPS12 | ribosomal protein S12 | 0.0301387 |
| SFTPA2 | surfactant protein A2 | 0.0301042 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0299774 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0297974 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0297868 |
| SCFD2 | sec1 family domain containing 2 | 0.0294734 |
| RPS19 | ribosomal protein S19 | 0.0293815 |
| RPS5 | ribosomal protein S5 | 0.0293487 |
| FAM3C | family with sequence similarity 3, member C | 0.0290267 |
| CALU | calumenin | 0.0289189 |
| WDR26 | WD repeat domain 26 | 0.0288631 |
| COG5 | component of oligomeric golgi complex 5 | 0.0287152 |
| SMOX | spermine oxidase | 0.0286362 |
| RRBP1 | ribosome binding protein 1 | 0.0284632 |
| GOLGA3 | golgin A3 | 0.0280021 |
| ARF1 | ADP-ribosylation factor 1 | 0.0279255 |
| FMN1 | formin 1 | 0.0279243 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0279033 |
| TPM3 | tropomyosin 3 | 0.027532 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0274321 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0273665 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0267533 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0267024 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0266053 |
| NEK7 | NIMA-related kinase 7 | 0.026554 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0261828 |
| FLNA | filamin A, alpha | 0.0261151 |
| RPL12 | ribosomal protein L12 | 0.0257941 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.025777 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0256223 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0253991 |
| GATAD2B | GATA zinc finger domain containing 2B | 0.0253981 |
| GOLPH3 | golgi phosphoprotein 3 (coat-protein) | 0.0250858 |
| RPL4 | ribosomal protein L4 | 0.025022 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0249322 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0247765 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | 0.0246907 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0246057 |
| RPS6 | ribosomal protein S6 | 0.0243458 |
| HDLBP | high density lipoprotein binding protein | 0.0242978 |
| SMYD3 | SET and MYND domain containing 3 | 0.024099 |
| GOLT1B | golgi transport 1B | 0.0239183 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0236245 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0234595 |
| RPL11 | ribosomal protein L11 | 0.023427 |
| GLG1 | golgi glycoprotein 1 | 0.0232875 |
| RPL23 | ribosomal protein L23 | 0.0232606 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0232577 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.189797 |
| NDRG1 | N-myc downstream regulated 1 | -0.113836 |
| NRG1 | neuregulin 1 | -0.11024 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.106994 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0847597 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0787109 |
| HMGA2 | high mobility group AT-hook 2 | -0.0666552 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0663311 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0595265 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0518627 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0506831 |
| CADM1 | cell adhesion molecule 1 | -0.0482122 |
| RAI14 | retinoic acid induced 14 | -0.0474631 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0443622 |
| ITGA1 | integrin, alpha 1 | -0.0439551 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.043763 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0433028 |
| FAM13A | family with sequence similarity 13, member A | -0.0406073 |
| PLIN2 | perilipin 2 | -0.0395803 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0361784 |
| TGFA | transforming growth factor, alpha | -0.0355639 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0345104 |
| GPC6 | glypican 6 | -0.0342911 |
| CD109 | CD109 molecule | -0.0327612 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0319503 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0315115 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0301734 |
| SYT1 | synaptotagmin I | -0.0299856 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0297943 |
| POTEF | POTE ankyrin domain family, member F | -0.0287408 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0283995 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0280463 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0274129 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0264739 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | -0.0250514 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.024789 |
| EGR1 | early growth response 1 | -0.0244862 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0238978 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | -0.0234556 |
| STC2 | stanniocalcin 2 | -0.0232498 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0231095 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | -0.022003 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0218606 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0217775 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | -0.0217096 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0215571 |
| JUN | jun proto-oncogene | -0.0215041 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0214072 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0211705 |
| FLNB | filamin B, beta | -0.0210163 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0210066 |
| FOSL1 | FOS-like antigen 1 | -0.0208846 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0208707 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0206464 |
| ACTG1 | actin gamma 1 | -0.0200625 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0199894 |
| SQSTM1 | sequestosome 1 | -0.0197961 |
| SIRT1 | sirtuin 1 | -0.019456 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0193309 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.019053 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0189576 |
| MYO1E | myosin IE | -0.0188179 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0188094 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.018521 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0184739 |
| LAMB3 | laminin, beta 3 | -0.0184723 |
| TNRC6C | trinucleotide repeat containing 6C | -0.0184579 |
| TENM4 | teneurin transmembrane protein 4 | -0.018449 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0183397 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0183144 |
| IGF2 | insulin-like growth factor 2 | -0.0181682 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0181261 |
| CUX1 | cut-like homeobox 1 | -0.0180495 |
| LOXL2 | lysyl oxidase-like 2 | -0.0179668 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0178925 |
| ZNF395 | zinc finger protein 395 | -0.0178789 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | -0.0177226 |
| LMNA | lamin A/C | -0.0176582 |
| OXR1 | oxidation resistance 1 | -0.0176089 |
| MYOF | myoferlin | -0.0173976 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0173958 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.017366 |
| RAD51B | RAD51 paralog B | -0.0172569 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0171434 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0169687 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0168383 |
| PRELID2 | PRELI domain containing 2 | -0.0165616 |
| VAC14 | Vac14 homolog (S. cerevisiae) | -0.0164139 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0164006 |
| DENND4C | DENN/MADD domain containing 4C | -0.016335 |
| MMP13 | matrix metallopeptidase 13 | -0.0159563 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0155284 |
| SPAG9 | sperm associated antigen 9 | -0.0153302 |
| NEBL | nebulette | -0.0151706 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0149533 |
| SHC3 | SHC (Src homology 2 domain containing) transforming protein 3 | -0.0148636 |
| ITGB4 | integrin, beta 4 | -0.0143986 |
| MYADM | myeloid-associated differentiation marker | -0.0143028 |
| FNDC3B | fibronectin type III domain containing 3B | -0.014159 |
| CTBP2 | C-terminal binding protein 2 | -0.0140822 |
