| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/11658860 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in Lorcaserin relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TIGD1 | tigger transposable element derived 1 | 1.12 |
| PTMA | prothymosin, alpha | 0.92 |
| ZNF428 | zinc finger protein 428 | 0.85 |
| TSR2 | TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) | 0.72 |
| RWDD1 | RWD domain containing 1 | 0.71 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.69 |
| TNNC2 | troponin C type 2 (fast) | 0.69 |
| RCN2 | reticulocalbin 2, EF-hand calcium binding domain | 0.68 |
| METTL22 | methyltransferase like 22 | 0.66 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.64 |
| RPLP1 | ribosomal protein, large, P1 | 0.61 |
| BSDC1 | BSD domain containing 1 | 0.61 |
| SKIL | SKI-like proto-oncogene | 0.61 |
| CLNS1A | chloride channel, nucleotide-sensitive, 1A | 0.59 |
| MT-ND5 | NADH dehydrogenase, subunit 5 (complex I) | 0.59 |
| PTMS | parathymosin | 0.59 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.57 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.56 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.55 |
| GCSH | glycine cleavage system protein H (aminomethyl carrier) | 0.51 |
| MTUS2 | microtubule associated tumor suppressor candidate 2 | 0.5 |
| POLR2J | polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa | 0.5 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.49 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.49 |
| CSRNP2 | cysteine-serine-rich nuclear protein 2 | 0.48 |
| COX10 | COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor | 0.47 |
| ZNF267 | zinc finger protein 267 | 0.47 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | 0.47 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.46 |
| CHCHD4 | coiled-coil-helix-coiled-coil-helix domain containing 4 | 0.45 |
| CLTA | clathrin, light chain A | 0.45 |
| TLE5 | TLE family member 5, transcriptional modulator | 0.44 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | 0.44 |
| TSPAN3 | tetraspanin 3 | 0.44 |
| ASB1 | ankyrin repeat and SOCS box containing 1 | 0.42 |
| FGFR2 | fibroblast growth factor receptor 2 | 0.41 |
| NUCB1 | nucleobindin 1 | 0.41 |
| ZDHHC2 | zinc finger, DHHC-type containing 2 | 0.41 |
| AURKAIP1 | aurora kinase A interacting protein 1 | 0.4 |
| RPLP2 | ribosomal protein, large, P2 | 0.39 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.38 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 0.38 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.38 |
| SYAP1 | synapse associated protein 1 | 0.38 |
| PAIP2 | poly(A) binding protein interacting protein 2 | 0.38 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 0.36 |
| CDC34 | cell division cycle 34 | 0.36 |
| RPL37A | ribosomal protein L37a | 0.36 |
| TPM2 | tropomyosin 2 (beta) | 0.36 |
| JMJD4 | jumonji domain containing 4 | 0.36 |
| CCDC97 | coiled-coil domain containing 97 | 0.35 |
| ARL2BP | ADP-ribosylation factor-like 2 binding protein | 0.35 |
| PEX1 | peroxisomal biogenesis factor 1 | 0.35 |
| MEST | mesoderm specific transcript | 0.35 |
| NASP | nuclear autoantigenic sperm protein (histone-binding) | 0.35 |
| SET | SET nuclear proto-oncogene | 0.35 |
| ZNF385B | zinc finger protein 385B | 0.35 |
| LIME1 | Lck interacting transmembrane adaptor 1 | 0.34 |
| PIGH | phosphatidylinositol glycan anchor biosynthesis, class H | 0.34 |
| KMT5C | lysine methyltransferase 5C | 0.34 |
| CDC25B | cell division cycle 25B | 0.34 |
| PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) | 0.33 |
| ATXN1L | ataxin 1-like | 0.33 |
| GABPB1 | GA binding protein transcription factor, beta subunit 1 | 0.33 |
| ADAP2 | ArfGAP with dual PH domains 2 | 0.33 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.32 |
| TMEM222 | transmembrane protein 222 | 0.32 |
| FKBP1A | FK506 binding protein 1A, 12kDa | 0.32 |
| RNF126 | ring finger protein 126 | 0.32 |
| TPM3 | tropomyosin 3 | 0.32 |
| AAGAB | alpha- and gamma-adaptin binding protein | 0.32 |
| NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa | 0.31 |
| WASHC3 | WASH complex subunit 3 | 0.31 |
| HNF4A | hepatocyte nuclear factor 4, alpha | 0.31 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.31 |
| TXN2 | thioredoxin 2 | 0.31 |
| SDF2 | stromal cell-derived factor 2 | 0.31 |
| BSG | basigin (Ok blood group) | 0.31 |
| NFU1 | NFU1 iron-sulfur cluster scaffold | 0.31 |
| CCDC9 | coiled-coil domain containing 9 | 0.31 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.31 |
| LRRK1 | leucine-rich repeat kinase 1 | 0.31 |
| HTT | huntingtin | 0.31 |
| GATD1 | glutamine amidotransferase class 1 domain containing 1 | 0.3 |
| SLC10A4 | solute carrier family 10, member 4 | 0.3 |
| FAM241A | family with sequence similarity 241 member A | 0.3 |
| POLE4 | polymerase (DNA-directed), epsilon 4, accessory subunit | 0.3 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | 0.3 |
| C12ORF66 | chromosome 12 open reading frame 66 | 0.3 |
| GMCL2 | germ cell-less 2, spermatogenesis associated | 0.3 |
| PRG4 | proteoglycan 4 | 0.3 |
| NPM3 | nucleophosmin/nucleoplasmin 3 | 0.29 |
| FAM177A1 | family with sequence similarity 177, member A1 | 0.28 |
| PHLPP2 | PH domain and leucine rich repeat protein phosphatase 2 | 0.28 |
| DCAF16 | DDB1 and CUL4 associated factor 16 | 0.28 |
| CIAO2B | cytosolic iron-sulfur assembly component 2B | 0.28 |
| SKP1 | S-phase kinase-associated protein 1 | 0.28 |
| FXN | frataxin | 0.28 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DIPK1B | divergent protein kinase domain 1B | -1.74 |
| KIF27 | kinesin family member 27 | -1.36 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -1.16 |
| DES | desmin | -1.12 |
| TENM2 | teneurin transmembrane protein 2 | -1.1 |
| PEX12 | peroxisomal biogenesis factor 12 | -1.08 |
| SEPTIN4 | septin 4 | -0.87 |
| PREX1 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 | -0.82 |
| OTC | ornithine carbamoyltransferase | -0.64 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -0.59 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.57 |
| TRIM29 | tripartite motif containing 29 | -0.56 |
| TSPAN33 | tetraspanin 33 | -0.55 |
| PPP1R14C | protein phosphatase 1, regulatory (inhibitor) subunit 14C | -0.54 |
| FN3K | fructosamine 3 kinase | -0.5 |
| AKNA | AT-hook transcription factor | -0.5 |
| ZBTB44 | zinc finger and BTB domain containing 44 | -0.49 |
| SH3YL1 | SH3 and SYLF domain containing 1 | -0.49 |
| ABLIM3 | actin binding LIM protein family, member 3 | -0.47 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | -0.47 |
| TULP4 | tubby like protein 4 | -0.45 |
| MFGE8 | milk fat globule-EGF factor 8 protein | -0.42 |
| BAIAP2 | BAI1-associated protein 2 | -0.42 |
| H2AZ1 | H2A.Z variant histone 1 | -0.42 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -0.42 |
| C15ORF61 | chromosome 15 open reading frame 61 | -0.42 |
| SLC30A6 | solute carrier family 30 (zinc transporter), member 6 | -0.42 |
| MT1L | metallothionein 1L (gene/pseudogene) | -0.41 |
| REX1BD | required for excision 1-B domain containing | -0.41 |
| GINM1 | glycoprotein integral membrane 1 | -0.41 |
| DMGDH | dimethylglycine dehydrogenase | -0.41 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -0.41 |
| ATP7B | ATPase, Cu++ transporting, beta polypeptide | -0.4 |
| ALKBH7 | alkB, alkylation repair homolog 7 (E. coli) | -0.4 |
| TDRD9 | tudor domain containing 9 | -0.39 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 | -0.39 |
| WDR90 | WD repeat domain 90 | -0.39 |
| ADGRE2 | adhesion G protein-coupled receptor E2 | -0.38 |
| ZNF276 | zinc finger protein 276 | -0.37 |
| TM2D3 | TM2 domain containing 3 | -0.37 |
| PIP5K1C | phosphatidylinositol-4-phosphate 5-kinase, type I, gamma | -0.37 |
| NAAA | N-acylethanolamine acid amidase | -0.37 |
| LARP6 | La ribonucleoprotein domain family, member 6 | -0.36 |
| PACRGL | PARK2 co-regulated-like | -0.36 |
| RIOX1 | ribosomal oxygenase 1 | -0.36 |
| SPPL3 | signal peptide peptidase like 3 | -0.36 |
| PRDX1 | peroxiredoxin 1 | -0.36 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | -0.35 |
| SS18L1 | synovial sarcoma translocation gene on chromosome 18-like 1 | -0.35 |
| CASZ1 | castor zinc finger 1 | -0.35 |
| TMEM179B | transmembrane protein 179B | -0.35 |
| CETN1 | centrin, EF-hand protein, 1 | -0.34 |
| JAK2 | Janus kinase 2 | -0.34 |
| KIAA1324L | KIAA1324-like | -0.33 |
| MLH3 | mutL homolog 3 | -0.33 |
| ELOVL6 | ELOVL fatty acid elongase 6 | -0.33 |
| PARK7 | parkinson protein 7 | -0.33 |
| ZNF888 | zinc finger protein 888 | -0.33 |
| MYH7B | myosin, heavy chain 7B, cardiac muscle, beta | -0.32 |
| BDH2 | 3-hydroxybutyrate dehydrogenase, type 2 | -0.32 |
| SPIDR | scaffolding protein involved in DNA repair | -0.31 |
| PLA2G12A | phospholipase A2, group XIIA | -0.31 |
| SMOX | spermine oxidase | -0.31 |
| ANAPC11 | anaphase promoting complex subunit 11 | -0.3 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.3 |
| IER3IP1 | immediate early response 3 interacting protein 1 | -0.3 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.3 |
| EPHX4 | epoxide hydrolase 4 | -0.3 |
| RFT1 | RFT1 homolog (S. cerevisiae) | -0.29 |
| SPCS3 | signal peptidase complex subunit 3 homolog (S. cerevisiae) | -0.29 |
| VWA5A | von Willebrand factor A domain containing 5A | -0.29 |
| MAZ | MYC-associated zinc finger protein (purine-binding transcription factor) | -0.28 |
| CDC26 | cell division cycle 26 | -0.28 |
| LRIG3 | leucine-rich repeats and immunoglobulin-like domains 3 | -0.28 |
| SPICE1 | spindle and centriole associated protein 1 | -0.28 |
| COPS7B | COP9 signalosome subunit 7B | -0.28 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | -0.28 |
| S100A10 | S100 calcium binding protein A10 | -0.28 |
| DEF8 | differentially expressed in FDCP 8 homolog (mouse) | -0.28 |
| CEP290 | centrosomal protein 290kDa | -0.28 |
| TMSB10 | thymosin beta 10 | -0.27 |
| FTL | ferritin, light polypeptide | -0.27 |
| GRAMD2B | GRAM domain containing 2B | -0.27 |
| BTBD7 | BTB (POZ) domain containing 7 | -0.27 |
| LAMC2 | laminin, gamma 2 | -0.27 |
| PAQR4 | progestin and adipoQ receptor family member IV | -0.27 |
| MED19 | mediator complex subunit 19 | -0.27 |
| CETN2 | centrin, EF-hand protein, 2 | -0.27 |
| ELF4 | E74-like factor 4 (ets domain transcription factor) | -0.27 |
| ZBTB8A | zinc finger and BTB domain containing 8A | -0.27 |
| PFDN1 | prefoldin subunit 1 | -0.27 |
| HRAS | Harvey rat sarcoma viral oncogene homolog | -0.27 |
| MT1X | metallothionein 1X | -0.26 |
| SUMO2 | small ubiquitin-like modifier 2 | -0.26 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | -0.26 |
| TYK2 | tyrosine kinase 2 | -0.26 |
| ZNF76 | zinc finger protein 76 | -0.26 |
| FAM241B | family with sequence similarity 241 member B | -0.25 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.25 |
| COX5B | cytochrome c oxidase subunit Vb | -0.25 |
