Losartan Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position (Chemical Entities of Biological Interest Ontology, CHEBI_6541)
External Link http://ctdbase.org/detail.go?type=chem&acc=D019808
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Genes

79 genes/proteins interacting with the chemical Losartan from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ACE2 angiotensin I converting enzyme 2
ADRB2 adrenoceptor beta 2, surface
AGER advanced glycosylation end product-specific receptor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
ALOX15 arachidonate 15-lipoxygenase
ALOX5 arachidonate 5-lipoxygenase
AMBP alpha-1-microglobulin/bikunin precursor
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAT catalase
CCL2 chemokine (C-C motif) ligand 2
CCL3 chemokine (C-C motif) ligand 3
CCL5 chemokine (C-C motif) ligand 5
COL3A1 collagen, type III, alpha 1
CREB1 cAMP responsive element binding protein 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYCS cytochrome c, somatic
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
EDN1 endothelin 1
ENG endoglin
F3 coagulation factor III (thromboplastin, tissue factor)
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GJA1 gap junction protein, alpha 1, 43kDa
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IL1A interleukin 1, alpha
IL6 interleukin 6
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA6 integrin, alpha 6
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MMP2 matrix metallopeptidase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH6 myosin, heavy chain 6, cardiac muscle, alpha
MYH7 myosin, heavy chain 7, cardiac muscle, beta
MYLK myosin light chain kinase
NCF1 neutrophil cytosolic factor 1
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPA natriuretic peptide A
NPR1 natriuretic peptide receptor 1
PDGFB platelet-derived growth factor beta polypeptide
PRKCB protein kinase C, beta
PRL prolactin
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTH1R parathyroid hormone 1 receptor
PTHLH parathyroid hormone-like hormone
REN renin
SDC2 syndecan 2
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SFRP2 secreted frizzled-related protein 2
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12
SLC22A9 solute carrier family 22 (organic anion transporter), member 9
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SOD2 superoxide dismutase 2, mitochondrial
SOD3 superoxide dismutase 3, extracellular
SREBF1 sterol regulatory element binding transcription factor 1
TGFB1 transforming growth factor, beta 1
TJP1 tight junction protein 1
TNF tumor necrosis factor
TP53 tumor protein p53
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A