Lucanthone_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lucanthone perturbation in CHP-212 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Lucanthone_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HELZ helicase with zinc finger 0.0542205
DSCAM Down syndrome cell adhesion molecule 0.0317195
NAMPT nicotinamide phosphoribosyltransferase 0.0283804
PUM2 pumilio RNA-binding family member 2 0.027193
NUP58 nucleoporin 58 0.026652
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0240356
FAM13A family with sequence similarity 13, member A 0.0228648
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0227962
XPO1 exportin 1 0.022775
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.02191
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.021499
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0209809
CDC27 cell division cycle 27 0.0199809
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0197558
ZNF292 zinc finger protein 292 0.0197504
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0195965
ITPRID2 ITPR interacting domain containing 2 0.0192033
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0183263
CHD1 chromodomain helicase DNA binding protein 1 0.0183161
NPEPPS aminopeptidase puromycin sensitive 0.0181558
MED13L mediator complex subunit 13-like 0.0180001
RSRC2 arginine/serine-rich coiled-coil 2 0.0179232
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0173081
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0172582
CCNY cyclin Y 0.0172473
MAP1B microtubule-associated protein 1B 0.0171143
QKI QKI, KH domain containing, RNA binding 0.0169464
ARHGAP5 Rho GTPase activating protein 5 0.0168194
KCTD3 potassium channel tetramerization domain containing 3 0.0163001
SEPTIN9 septin 9 0.0162381
CASC3 cancer susceptibility candidate 3 0.0159782
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0158858
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0155771
CENPF centromere protein F, 350/400kDa 0.0154807
KMT2C lysine (K)-specific methyltransferase 2C 0.0154272
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0153801
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0153287
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0150624
SH3RF1 SH3 domain containing ring finger 1 0.0149935
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0144214
TM9SF3 transmembrane 9 superfamily member 3 0.0143561
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0143433
OLA1 Obg-like ATPase 1 0.014083
GLS2 glutaminase 2 (liver, mitochondrial) 0.0139796
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.013967
MSMO1 methylsterol monooxygenase 1 0.0138466
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0138393
SUCO SUN domain containing ossification factor 0.0138182
HMGB2 high mobility group box 2 0.013501
SSBP2 single-stranded DNA binding protein 2 0.0133965
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0133877
GOLGA4 golgin A4 0.0132519
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0132252
LCORL ligand dependent nuclear receptor corepressor-like 0.0132239
TNRC6A trinucleotide repeat containing 6A 0.0129987
SETD2 SET domain containing 2 0.0129682
MARCHF6 membrane associated ring-CH-type finger 6 0.012934
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0129033
MBNL2 muscleblind-like splicing regulator 2 0.0128177
HMBOX1 homeobox containing 1 0.0128089
BRWD1 bromodomain and WD repeat domain containing 1 0.0128045
MEMO1 mediator of cell motility 1 0.0126774
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0125653
LPIN1 lipin 1 0.012526
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) 0.0124944
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0124649
TXNDC11 thioredoxin domain containing 11 0.0124092
TOP2B topoisomerase (DNA) II beta 180kDa 0.0123657
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0123524
FAM13B family with sequence similarity 13, member B 0.0121602
BIRC6 baculoviral IAP repeat containing 6 0.0121536
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0121488
PCM1 pericentriolar material 1 0.0120509
TET2 tet methylcytosine dioxygenase 2 0.0119564
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.0119468
TP53BP1 tumor protein p53 binding protein 1 0.0118897
FIP1L1 factor interacting with PAPOLA and CPSF1 0.0118544
NUP54 nucleoporin 54kDa 0.0118264
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 0.0117359
FOXO3 forkhead box O3 0.0117118
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0117106
OSBPL8 oxysterol binding protein-like 8 0.0116792
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 0.0116439
XPR1 xenotropic and polytropic retrovirus receptor 1 0.0116319
RNF145 ring finger protein 145 0.0115582
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.0114674
ADAM9 ADAM metallopeptidase domain 9 0.0114247
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0114244
EGLN1 egl-9 family hypoxia-inducible factor 1 0.011278
USP15 ubiquitin specific peptidase 15 0.0112535
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.0112495
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0112471
TJP2 tight junction protein 2 0.011234
NCKAP1 NCK-associated protein 1 0.0112145
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0111751
MINDY3 MINDY lysine 48 deubiquitinase 3 0.0111628
USP3 ubiquitin specific peptidase 3 0.0111605
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0110915
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 0.0110355
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0110339

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.345091
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.155346
AKAP12 A kinase (PRKA) anchor protein 12 -0.142343
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.13203
LSAMP limbic system-associated membrane protein -0.11742
ACTG1 actin gamma 1 -0.113491
NRG1 neuregulin 1 -0.10399
VIM vimentin -0.101221
RPS6 ribosomal protein S6 -0.0938311
PTMA prothymosin, alpha -0.0936727
NALF1 NALCN channel auxiliary factor 1 -0.0866145
VCL vinculin -0.0793695
RPL35A ribosomal protein L35a -0.0701628
EXT1 exostosin glycosyltransferase 1 -0.0697469
TPT1 tumor protein, translationally-controlled 1 -0.0664592
PTPRD protein tyrosine phosphatase, receptor type, D -0.060951
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0600539
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0584855
RPLP1 ribosomal protein, large, P1 -0.0569501
RPS24 ribosomal protein S24 -0.0564774
RPL34 ribosomal protein L34 -0.0553812
ZBTB20 zinc finger and BTB domain containing 20 -0.0534347
RPL11 ribosomal protein L11 -0.0533414
THSD4 thrombospondin, type I, domain containing 4 -0.0528837
RPL23 ribosomal protein L23 -0.0527858
IER3 immediate early response 3 -0.0520517
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0520388
RPS8 ribosomal protein S8 -0.0512977
TMSB10 thymosin beta 10 -0.050594
RPL19 ribosomal protein L19 -0.0500522
BCAS3 breast carcinoma amplified sequence 3 -0.0487074
RPLP0 ribosomal protein, large, P0 -0.0484593
RPL38 ribosomal protein L38 -0.0480477
COL1A1 collagen, type I, alpha 1 -0.0470612
RPS25 ribosomal protein S25 -0.0447764
BPTF bromodomain PHD finger transcription factor -0.0444458
SYT1 synaptotagmin I -0.0441498
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0425822
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0424242
EFNA5 ephrin-A5 -0.0414784
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0410111
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0404918
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0403849
RPS16 ribosomal protein S16 -0.0385306
TRIO trio Rho guanine nucleotide exchange factor -0.0384506
ENO1 enolase 1, (alpha) -0.0380649
RPL12 ribosomal protein L12 -0.0378997
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0372298
RPS27 ribosomal protein S27 -0.0366432
RPS12 ribosomal protein S12 -0.0362818
MACF1 microtubule-actin crosslinking factor 1 -0.0361495
NPAS2 neuronal PAS domain protein 2 -0.035979
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0358794
RPL37A ribosomal protein L37a -0.0357371
S100A6 S100 calcium binding protein A6 -0.035668
RPS23 ribosomal protein S23 -0.0353718
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0353361
NDRG1 N-myc downstream regulated 1 -0.0353057
RPS19 ribosomal protein S19 -0.0346383
TIMP3 TIMP metallopeptidase inhibitor 3 -0.034477
RPL31 ribosomal protein L31 -0.0341717
RPL26 ribosomal protein L26 -0.0330926
CUX1 cut-like homeobox 1 -0.03305
RPL7A ribosomal protein L7a -0.0327567
RPS29 ribosomal protein S29 -0.0326656
RPTOR regulatory associated protein of MTOR, complex 1 -0.0320915
SLIT2 slit homolog 2 (Drosophila) -0.0319423
RPL28 ribosomal protein L28 -0.0318271
MAPK10 mitogen-activated protein kinase 10 -0.0316608
SP100 SP100 nuclear antigen -0.0314521
RPS11 ribosomal protein S11 -0.0312711
EIF1 eukaryotic translation initiation factor 1 -0.0312131
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0311403
BICD1 bicaudal D homolog 1 (Drosophila) -0.0311342
ZNF804A zinc finger protein 804A -0.0305393
RPL36A ribosomal protein L36a -0.0304932
RPS14 ribosomal protein S14 -0.0300537
ASPH aspartate beta-hydroxylase -0.029956
EGR1 early growth response 1 -0.029915
CRH corticotropin releasing hormone -0.0295972
FTL ferritin, light polypeptide -0.0295209
DIAPH2 diaphanous-related formin 2 -0.029439
RPL9 ribosomal protein L9 -0.0294119
KPNB1 karyopherin (importin) beta 1 -0.0292278
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0292196
NREP neuronal regeneration related protein -0.0288992
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0287855
RPS27A ribosomal protein S27a -0.0283099
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0281585
RPL32 ribosomal protein L32 -0.0280892
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0279859
SLC38A2 solute carrier family 38, member 2 -0.02776
COL4A5 collagen, type IV, alpha 5 -0.027672
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0275628
GCC2 GRIP and coiled-coil domain containing 2 -0.0268806
KLHL13 kelch-like family member 13 -0.0268261
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0267647
RPL30 ribosomal protein L30 -0.0264603
RIGI RNA sensor RIG-I -0.026412
RPL37 ribosomal protein L37 -0.0264017