Lucanthone_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lucanthone perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lucanthone_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
C3 complement component 3 0.0764542
NKD1 naked cuticle homolog 1 (Drosophila) 0.0722513
SAMD4A sterile alpha motif domain containing 4A 0.0553915
LRMDA leucine rich melanocyte differentiation associated 0.0552597
FNDC3B fibronectin type III domain containing 3B 0.0474806
DST dystonin 0.0377163
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0369098
VEGFA vascular endothelial growth factor A 0.0361149
FAT1 FAT atypical cadherin 1 0.0358974
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.035124
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0313564
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0307109
MYH9 myosin, heavy chain 9, non-muscle 0.0275003
VMP1 vacuole membrane protein 1 0.0262655
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0261661
EEF2 eukaryotic translation elongation factor 2 0.0256913
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0256481
RBM39 RNA binding motif protein 39 0.0250629
ARHGAP9 Rho GTPase activating protein 9 0.0248567
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0242535
PTPRM protein tyrosine phosphatase, receptor type, M 0.0230223
CCNL1 cyclin L1 0.0224808
TNS1 tensin 1 0.0220272
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0213091
MACF1 microtubule-actin crosslinking factor 1 0.0212496
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0211148
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0208581
TNS3 tensin 3 0.020632
EIF4B eukaryotic translation initiation factor 4B 0.0204268
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0200764
RPL3 ribosomal protein L3 0.0200089
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0199669
MAML2 mastermind-like 2 (Drosophila) 0.019342
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0192833
TRIO trio Rho guanine nucleotide exchange factor 0.0192174
DSPP dentin sialophosphoprotein 0.0189145
YAP1 Yes-associated protein 1 0.0186664
FBF1 Fas (TNFRSF6) binding factor 1 0.0182576
TXNRD1 thioredoxin reductase 1 0.0181191
LMCD1 LIM and cysteine-rich domains 1 0.01794
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0178022
JAG1 jagged 1 0.0175905
ZFAND3 zinc finger, AN1-type domain 3 0.0175285
NRIP1 nuclear receptor interacting protein 1 0.0175021
SHB Src homology 2 domain containing adaptor protein B 0.0170985
ITGAV integrin, alpha V 0.0170556
DSCAM Down syndrome cell adhesion molecule 0.0170052
VCL vinculin 0.0168906
PICALM phosphatidylinositol binding clathrin assembly protein 0.0166585
MRTFA myocardin related transcription factor A 0.016616
CRY1 cryptochrome circadian clock 1 0.0166149
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0165894
ANXA5 annexin A5 0.0165669
PCBP2 poly(rC) binding protein 2 0.016559
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0164339
CCNY cyclin Y 0.0163806
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0162342
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.016145
APLP2 amyloid beta (A4) precursor-like protein 2 0.0159939
SESTD1 SEC14 and spectrin domains 1 0.0157375
SMAD3 SMAD family member 3 0.0154268
SIK3 SIK family kinase 3 0.015359
LCOR ligand dependent nuclear receptor corepressor 0.0153243
DIAPH1 diaphanous-related formin 1 0.0150989
BCL2L1 BCL2-like 1 0.0149642
ADAM9 ADAM metallopeptidase domain 9 0.0148298
LPP LIM domain containing preferred translocation partner in lipoma 0.0148236
FAM107B family with sequence similarity 107, member B 0.0148156
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0147793
SEPTIN9 septin 9 0.0146005
WDR43 WD repeat domain 43 0.0145439
ZNF644 zinc finger protein 644 0.0145383
PLEC plectin 0.0145382
DNAH17 dynein, axonemal, heavy chain 17 0.0142374
MAPK8 mitogen-activated protein kinase 8 0.0141611
SOD2 superoxide dismutase 2, mitochondrial 0.0141515
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0141394
DOCK4 dedicator of cytokinesis 4 0.0138453
SFPQ splicing factor proline/glutamine-rich 0.0137916
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0136422
JMJD1C jumonji domain containing 1C 0.0134121
CORO1C coronin, actin binding protein, 1C 0.013185
TTC28 tetratricopeptide repeat domain 28 0.0131374
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0131184
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0130894
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0128914
RAD23B RAD23 homolog B (S. cerevisiae) 0.0127113
CUL3 cullin 3 0.0124613
CEMIP2 cell migration inducing hyaluronidase 2 0.012171
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0121327
ACTN4 actinin, alpha 4 0.0120727
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0119528
LMO7 LIM domain 7 0.0119233
STK24 serine/threonine kinase 24 0.0118251
LARP4 La ribonucleoprotein domain family, member 4 0.0116184
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0115962
EPHA2 EPH receptor A2 0.0115863
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0115735
MTMR3 myotubularin related protein 3 0.0115215
ZMIZ1 zinc finger, MIZ-type containing 1 0.0114795

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.482979
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.128459
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.116212
MT2A metallothionein 2A -0.11002
TPT1 tumor protein, translationally-controlled 1 -0.102854
AKAP12 A kinase (PRKA) anchor protein 12 -0.0944217
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0927624
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0749531
APOA2 apolipoprotein A-II -0.0725023
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.068071
ENO1 enolase 1, (alpha) -0.06256
GPC3 glypican 3 -0.0592639
FTL ferritin, light polypeptide -0.0576629
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0551225
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0506939
TM4SF1 transmembrane 4 L six family member 1 -0.0504264
RPS24 ribosomal protein S24 -0.0493327
RPLP1 ribosomal protein, large, P1 -0.0476829
RPS8 ribosomal protein S8 -0.0465957
AHSG alpha-2-HS-glycoprotein -0.0442294
RPS6 ribosomal protein S6 -0.0434335
CP ceruloplasmin (ferroxidase) -0.0410681
ZMYND8 zinc finger, MYND-type containing 8 -0.0383273
RPL34 ribosomal protein L34 -0.037995
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0377843
RPL11 ribosomal protein L11 -0.0375209
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0365517
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0358404
RPLP0 ribosomal protein, large, P0 -0.0356079
RPL35A ribosomal protein L35a -0.033914
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0333874
SLC38A2 solute carrier family 38, member 2 -0.0329595
H1-0 H1.0 linker histone -0.0328728
RPL12 ribosomal protein L12 -0.0320607
NDRG1 N-myc downstream regulated 1 -0.0317635
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0315789
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0315267
KDM3A lysine (K)-specific demethylase 3A -0.0306507
DDIT4 DNA-damage-inducible transcript 4 -0.0302603
APOE apolipoprotein E -0.030234
IGFBP1 insulin-like growth factor binding protein 1 -0.0300734
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0280504
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.027998
RPS19 ribosomal protein S19 -0.0277867
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0277213
RPS29 ribosomal protein S29 -0.0269425
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0269297
RPLP2 ribosomal protein, large, P2 -0.0268463
APOB apolipoprotein B -0.0266693
RPL32 ribosomal protein L32 -0.0258158
RPS23 ribosomal protein S23 -0.024803
RRBP1 ribosome binding protein 1 -0.0246225
WDR45B WD repeat domain 45B -0.0243426
STAU1 staufen double-stranded RNA binding protein 1 -0.0239565
GDF15 growth differentiation factor 15 -0.0238688
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0236635
TMSB10 thymosin beta 10 -0.0236085
GNAS GNAS complex locus -0.0235049
PERP PERP, TP53 apoptosis effector -0.0234767
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0228839
PDIA3 protein disulfide isomerase family A, member 3 -0.0228126
FN1 fibronectin 1 -0.0227837
RPS27A ribosomal protein S27a -0.0216769
AMBP alpha-1-microglobulin/bikunin precursor -0.0212613
PTPRF protein tyrosine phosphatase, receptor type, F -0.0208968
IER3 immediate early response 3 -0.020663
RPS11 ribosomal protein S11 -0.020595
HMGA1 high mobility group AT-hook 1 -0.0202877
FRMD5 FERM domain containing 5 -0.0202008
PLIN2 perilipin 2 -0.0196538
RPL31 ribosomal protein L31 -0.0186699
LOC112694756 uncharaterized LOC112694756 -0.0185055
GK glycerol kinase -0.0181308
ANGPTL8 angiopoietin like 8 -0.0180126
NAP1L1 nucleosome assembly protein 1-like 1 -0.0177799
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0175043
A2M alpha-2-macroglobulin -0.0174612
LMAN1 lectin, mannose-binding, 1 -0.0171082
S100A10 S100 calcium binding protein A10 -0.0169941
RPL5 ribosomal protein L5 -0.0167856
SLC38A1 solute carrier family 38, member 1 -0.0166693
GCC2 GRIP and coiled-coil domain containing 2 -0.0166567
RPS16 ribosomal protein S16 -0.016633
FMNL2 formin-like 2 -0.0166066
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0164522
RPS5 ribosomal protein S5 -0.0160847
S100A9 S100 calcium binding protein A9 -0.0160806
PGK1 phosphoglycerate kinase 1 -0.015907
WSB1 WD repeat and SOCS box containing 1 -0.0157913
RPS10 ribosomal protein S10 -0.0157391
NPEPPS aminopeptidase puromycin sensitive -0.0157205
APOC1 apolipoprotein C-I -0.015628
RPS13 ribosomal protein S13 -0.0155562
RPL9 ribosomal protein L9 -0.0153087
RPL7A ribosomal protein L7a -0.0151996
RPL19 ribosomal protein L19 -0.0151735
CTSB cathepsin B -0.0150984
RACK1 receptor for activated C kinase 1 -0.015051
UGP2 UDP-glucose pyrophosphorylase 2 -0.0149893
RPL27A ribosomal protein L27a -0.0149038