Lucanthone_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lucanthone perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lucanthone_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.0421653
VEGFA vascular endothelial growth factor A 0.0292116
CEMIP cell migration inducing protein, hyaluronan binding 0.0256184
TMSB4X thymosin beta 4, X-linked 0.0247642
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0242596
MPRIP myosin phosphatase Rho interacting protein 0.0231159
LPP LIM domain containing preferred translocation partner in lipoma 0.0223081
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0208221
FAT1 FAT atypical cadherin 1 0.0199327
KRT8 keratin 8, type II 0.018486
CCNL1 cyclin L1 0.0183909
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0178141
ZFAND3 zinc finger, AN1-type domain 3 0.0177433
MYH9 myosin, heavy chain 9, non-muscle 0.017653
CTBP2 C-terminal binding protein 2 0.0173141
SLC35F3 solute carrier family 35, member F3 0.017143
PRELID2 PRELI domain containing 2 0.0166298
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0163523
PLEC plectin 0.0162378
SHB Src homology 2 domain containing adaptor protein B 0.0156545
ANXA11 annexin A11 0.0153672
OSBPL10 oxysterol binding protein-like 10 0.0152378
EIF4B eukaryotic translation initiation factor 4B 0.0146446
MYO5B myosin VB 0.0146313
LAMB3 laminin, beta 3 0.0142065
PRSS3 protease, serine, 3 0.0141185
NALF1 NALCN channel auxiliary factor 1 0.013772
SAMD4A sterile alpha motif domain containing 4A 0.0133629
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0133022
ANKRD11 ankyrin repeat domain 11 0.0132577
PTK2 protein tyrosine kinase 2 0.0128178
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0127712
MYOF myoferlin 0.0126111
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0124934
FLNB filamin B, beta 0.0123739
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0120646
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0118483
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0114597
NUMA1 nuclear mitotic apparatus protein 1 0.0113176
PCDHB16 protocadherin beta 16 0.0112715
HSPA8 heat shock 70kDa protein 8 0.0112261
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0110699
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0106597
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0105605
EWSR1 EWS RNA-binding protein 1 0.0105253
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0104591
MYO18A myosin XVIIIA 0.0101528
PTPRK protein tyrosine phosphatase, receptor type, K 0.0100286
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0100261
SND1 staphylococcal nuclease and tudor domain containing 1 0.00995918
EHBP1 EH domain binding protein 1 0.00994919
EIF3A eukaryotic translation initiation factor 3, subunit A 0.00980556
MINK1 misshapen-like kinase 1 0.00979186
ARHGAP29 Rho GTPase activating protein 29 0.00978199
ZFC3H1 zinc finger, C3H1-type containing 0.00976705
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.00964021
GAK cyclin G associated kinase 0.00958071
SNX13 sorting nexin 13 0.00944092
NCKAP1 NCK-associated protein 1 0.00938245
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.00929191
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.00929047
TRIO trio Rho guanine nucleotide exchange factor 0.00927002
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.00913338
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.00912186
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.00902934
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.00897916
AXIN2 axin 2 0.00895467
AUH AU RNA binding protein/enoyl-CoA hydratase 0.00888644
ONECUT3 one cut homeobox 3 0.00879888
EXT1 exostosin glycosyltransferase 1 0.00874784
SHROOM3 shroom family member 3 0.00865939
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.00859583
LHFPL2 lipoma HMGIC fusion partner-like 2 0.00859567
NCOR2 nuclear receptor corepressor 2 0.00856649
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.00856321
OSBPL3 oxysterol binding protein-like 3 0.00854689
MSI2 musashi RNA-binding protein 2 0.00850028
NKD1 naked cuticle homolog 1 (Drosophila) 0.00842772
GSK3B glycogen synthase kinase 3 beta 0.00841818
LAMA4 laminin, alpha 4 0.00840744
SMAD3 SMAD family member 3 0.0083762
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.00836816
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.00826816
NIBAN2 niban apoptosis regulator 2 0.00820744
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.00819225
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.00818354
AFDN afadin, adherens junction formation factor 0.00811112
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.00806484
PSME4 proteasome (prosome, macropain) activator subunit 4 0.00804554
ANKRD10 ankyrin repeat domain 10 0.00797705
STK24 serine/threonine kinase 24 0.00797262
KMT2C lysine (K)-specific methyltransferase 2C 0.00788164
DSCAM Down syndrome cell adhesion molecule 0.00788097
CDYL chromodomain protein, Y-like 0.00784802
TBC1D22A TBC1 domain family, member 22A 0.00775708
FGD4 FYVE, RhoGEF and PH domain containing 4 0.00773788
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 0.00771602
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.00768101
SMAD2 SMAD family member 2 0.00764192
ABHD17C abhydrolase domain containing 17C 0.00757617

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.40974
PTMA prothymosin, alpha -0.274372
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.22395
TMSB10 thymosin beta 10 -0.141175
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.132008
RPS6 ribosomal protein S6 -0.113812
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.108613
TPT1 tumor protein, translationally-controlled 1 -0.0907898
FTL ferritin, light polypeptide -0.0771069
TXNIP thioredoxin interacting protein -0.0768947
RPS8 ribosomal protein S8 -0.0767472
ENO1 enolase 1, (alpha) -0.0761156
RPLP1 ribosomal protein, large, P1 -0.0743594
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.073926
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0724079
RPS19 ribosomal protein S19 -0.0684737
NDRG1 N-myc downstream regulated 1 -0.0682595
LDHA lactate dehydrogenase A -0.0677848
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0662217
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0660954
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0650674
RPL12 ribosomal protein L12 -0.0641325
RPS27A ribosomal protein S27a -0.0618777
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0611166
RPL23 ribosomal protein L23 -0.0585371
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0585233
PKM pyruvate kinase, muscle -0.0585017
RPL35A ribosomal protein L35a -0.0570097
RPLP2 ribosomal protein, large, P2 -0.0558024
RPS12 ribosomal protein S12 -0.0555326
PDIA3 protein disulfide isomerase family A, member 3 -0.0533881
RPL9 ribosomal protein L9 -0.0525628
RPL34 ribosomal protein L34 -0.0514506
RPS3 ribosomal protein S3 -0.0510642
RPLP0 ribosomal protein, large, P0 -0.0510372
CALR calreticulin -0.0508058
RPL19 ribosomal protein L19 -0.0501264
UBC ubiquitin C -0.0499027
EIF1 eukaryotic translation initiation factor 1 -0.0494934
S100A6 S100 calcium binding protein A6 -0.0486153
RPL11 ribosomal protein L11 -0.0472412
RPL26 ribosomal protein L26 -0.0459151
RPL36 ribosomal protein L36 -0.0458515
PGK1 phosphoglycerate kinase 1 -0.0449907
AREG amphiregulin -0.0449253
MT2A metallothionein 2A -0.0439403
RPL8 ribosomal protein L8 -0.043117
RPL31 ribosomal protein L31 -0.0429363
RPL37A ribosomal protein L37a -0.0414419
LOC112694756 uncharaterized LOC112694756 -0.0410844
RPS13 ribosomal protein S13 -0.0410465
RPS25 ribosomal protein S25 -0.041041
ACTG1 actin gamma 1 -0.0410097
RPL5 ribosomal protein L5 -0.0409664
RPS23 ribosomal protein S23 -0.0409237
ANXA2 annexin A2 -0.0407856
EEF2 eukaryotic translation elongation factor 2 -0.040169
RPL32 ribosomal protein L32 -0.0401381
HMGA1 high mobility group AT-hook 1 -0.0401342
S100A9 S100 calcium binding protein A9 -0.0396746
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0385745
PERP PERP, TP53 apoptosis effector -0.038001
S100A10 S100 calcium binding protein A10 -0.0379784
S100P S100 calcium binding protein P -0.0375823
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0373837
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0366642
RPS29 ribosomal protein S29 -0.0364959
CANX calnexin -0.0363607
EPCAM epithelial cell adhesion molecule -0.0363391
RPS14 ribosomal protein S14 -0.0357964
RPL7A ribosomal protein L7a -0.0351837
AGR2 anterior gradient 2 -0.0346986
RPS24 ribosomal protein S24 -0.0341149
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0339981
PDIA4 protein disulfide isomerase family A, member 4 -0.0339863
RPL7 ribosomal protein L7 -0.0327496
RPL18 ribosomal protein L18 -0.0326479
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0323793
GOLGA4 golgin A4 -0.0323305
RPS27 ribosomal protein S27 -0.0314357
RPS11 ribosomal protein S11 -0.0311016
RPL27A ribosomal protein L27a -0.0310313
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0306298
ITGA6 integrin, alpha 6 -0.0301174
KIF5B kinesin family member 5B -0.0299516
RPS16 ribosomal protein S16 -0.0291062
RACK1 receptor for activated C kinase 1 -0.0289363
ASPH aspartate beta-hydroxylase -0.0288973
RPL28 ribosomal protein L28 -0.028728
TPI1 triosephosphate isomerase 1 -0.0285942
B2M beta-2-microglobulin -0.0284536
NAP1L1 nucleosome assembly protein 1-like 1 -0.0283703
RPL15 ribosomal protein L15 -0.0281294
TPM4 tropomyosin 4 -0.02808
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0278544
RPL10A ribosomal protein L10a -0.027561
EZR ezrin -0.0275589
VDAC1 voltage-dependent anion channel 1 -0.0267478
DDIT4 DNA-damage-inducible transcript 4 -0.0264681
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0264487