Lucanthone_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lucanthone perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lucanthone_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0808575
TMSB4X thymosin beta 4, X-linked 0.0567017
TXNRD1 thioredoxin reductase 1 0.0547373
DST dystonin 0.0453949
MACF1 microtubule-actin crosslinking factor 1 0.0401934
RPL4 ribosomal protein L4 0.0324431
LOXL2 lysyl oxidase-like 2 0.0320203
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0313487
AHNAK AHNAK nucleoprotein 0.0288175
TRIO trio Rho guanine nucleotide exchange factor 0.0285275
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0266831
PDE10A phosphodiesterase 10A 0.0257564
MYOF myoferlin 0.0253969
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0252488
CSMD3 CUB and Sushi multiple domains 3 0.0244368
EFNA5 ephrin-A5 0.0243525
TTC3 tetratricopeptide repeat domain 3 0.0233796
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0233532
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0233394
HDLBP high density lipoprotein binding protein 0.0225789
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0221457
DENND1A DENN/MADD domain containing 1A 0.0211288
EHBP1 EH domain binding protein 1 0.0209762
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0201221
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0198224
BZW1 basic leucine zipper and W2 domains 1 0.0195056
EIF4A2 eukaryotic translation initiation factor 4A2 0.0192584
SAMD4A sterile alpha motif domain containing 4A 0.0185782
ZSWIM6 zinc finger, SWIM-type containing 6 0.0184575
LRRC49 leucine rich repeat containing 49 0.0177765
CANX calnexin 0.0172404
EGFR epidermal growth factor receptor 0.0166159
PYGL phosphorylase, glycogen, liver 0.0166128
TNS3 tensin 3 0.0165891
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0165801
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0164236
TBC1D22A TBC1 domain family, member 22A 0.0163777
HSPA8 heat shock 70kDa protein 8 0.0162717
HOMER1 homer scaffolding protein 1 0.0162445
SDK1 sidekick cell adhesion molecule 1 0.0157621
RPL37A ribosomal protein L37a 0.0157322
GOLGA3 golgin A3 0.0157266
NPAS2 neuronal PAS domain protein 2 0.0155596
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0154409
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0151096
SQSTM1 sequestosome 1 0.0146246
NEK10 NIMA-related kinase 10 0.0146033
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0144254
INTS6 integrator complex subunit 6 0.0142663
HOOK2 hook microtubule-tethering protein 2 0.0141929
KRT18 keratin 18, type I 0.0140288
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0139814
CXCL8 chemokine (C-X-C motif) ligand 8 0.0137693
CAPRIN2 caprin family member 2 0.0133711
SND1 staphylococcal nuclease and tudor domain containing 1 0.0133633
ARFGEF3 ARFGEF family member 3 0.0133251
SERINC1 serine incorporator 1 0.0132972
SOD2 superoxide dismutase 2, mitochondrial 0.0131627
ADARB1 adenosine deaminase, RNA-specific, B1 0.013078
ZNF146 zinc finger protein 146 0.0130118
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0129225
RPL3 ribosomal protein L3 0.012769
MNMIP1 manchette microtubule inner protein 1 0.0125585
PGM3 phosphoglucomutase 3 0.0124334
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0124226
EIF4H eukaryotic translation initiation factor 4H 0.0123363
RPS17 ribosomal protein S17 0.0122211
RCAN1 regulator of calcineurin 1 0.0120958
CLIP2 CAP-GLY domain containing linker protein 2 0.0118899
RPL37 ribosomal protein L37 0.0117665
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0116895
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0116505
KDM4C lysine (K)-specific demethylase 4C 0.0116112
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0114688
RPL26 ribosomal protein L26 0.011464
MCL1 myeloid cell leukemia 1 0.0112518
MYH9 myosin, heavy chain 9, non-muscle 0.0112167
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0111732
RPL38 ribosomal protein L38 0.0109535
ZNF841 zinc finger protein 841 0.0109162
GOLGB1 golgin B1 0.0108561
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.010721
EHBP1L1 EH domain binding protein 1-like 1 0.0105937
PLEC plectin 0.0105409
GPATCH2L G patch domain containing 2-like 0.010537
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0104133
SKI SKI proto-oncogene 0.0103158
ANXA1 annexin A1 0.010208
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0101995
LARP1B La ribonucleoprotein domain family, member 1B 0.0101319
SAFB2 scaffold attachment factor B2 0.0100787
RPN1 ribophorin I 0.0100559
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0100382
EEF1G eukaryotic translation elongation factor 1 gamma 0.00995254
WDR43 WD repeat domain 43 0.0099449
PDIA5 protein disulfide isomerase family A, member 5 0.00992396
CAMTA1 calmodulin binding transcription activator 1 0.00986943
CAVIN1 caveolae associated protein 1 0.00985364
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.00985011
APOLD1 apolipoprotein L domain containing 1 0.00978065

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.461283
VIM vimentin -0.262341
MT2A metallothionein 2A -0.172621
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.14555
PTMA prothymosin, alpha -0.129742
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0981278
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0933131
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0787497
FTL ferritin, light polypeptide -0.0716441
TXNIP thioredoxin interacting protein -0.0694645
TMSB10 thymosin beta 10 -0.0690645
SLC38A2 solute carrier family 38, member 2 -0.0660455
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0631903
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0599212
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0584217
ADGRG6 adhesion G protein-coupled receptor G6 -0.0549446
MT1X metallothionein 1X -0.0541009
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0516813
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0495718
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0491781
KMT2E lysine (K)-specific methyltransferase 2E -0.0491035
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0485828
XPO1 exportin 1 -0.0467131
HMGA1 high mobility group AT-hook 1 -0.0465596
WARS1 tryptophanyl-tRNA synthetase 1 -0.0460509
POTEF POTE ankyrin domain family, member F -0.0452405
WSB1 WD repeat and SOCS box containing 1 -0.0447208
CD44 CD44 molecule (Indian blood group) -0.0438737
SMC4 structural maintenance of chromosomes 4 -0.0428223
MT1E metallothionein 1E -0.0413979
KLF6 Kruppel-like factor 6 -0.0398823
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0382099
PCBP2 poly(rC) binding protein 2 -0.0381645
ACTG1 actin gamma 1 -0.0378758
BRWD1 bromodomain and WD repeat domain containing 1 -0.0373429
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.037148
SEPTIN7 septin 7 -0.0371237
RIGI RNA sensor RIG-I -0.0370966
DLG1 discs, large homolog 1 (Drosophila) -0.0368007
RAB7A RAB7A, member RAS oncogene family -0.0367903
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.0356712
TPI1 triosephosphate isomerase 1 -0.0354726
SRPK2 SRSF protein kinase 2 -0.0352294
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0348497
KMT2C lysine (K)-specific methyltransferase 2C -0.034599
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0340425
JMJD1C jumonji domain containing 1C -0.0339305
FMNL2 formin-like 2 -0.0335149
PRRC2C proline-rich coiled-coil 2C -0.0331289
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.032702
GCLM glutamate-cysteine ligase, modifier subunit -0.0323919
NCOR1 nuclear receptor corepressor 1 -0.0322457
TOP1 topoisomerase (DNA) I -0.0321994
PFN1 profilin 1 -0.0319635
PDIA3 protein disulfide isomerase family A, member 3 -0.0316295
RPS6 ribosomal protein S6 -0.0314154
NPEPPS aminopeptidase puromycin sensitive -0.0305226
FOSL1 FOS-like antigen 1 -0.0303867
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0303248
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0302527
CENPF centromere protein F, 350/400kDa -0.0300868
PHIP pleckstrin homology domain interacting protein -0.0300127
PKM pyruvate kinase, muscle -0.029279
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0292516
ADAR adenosine deaminase, RNA-specific -0.0291811
IFITM1 interferon induced transmembrane protein 1 -0.0288736
BIRC6 baculoviral IAP repeat containing 6 -0.0285237
H1-0 H1.0 linker histone -0.0285007
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0282155
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0281664
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0281643
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0280974
CCDC88A coiled-coil domain containing 88A -0.0279791
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0279447
ADAM17 ADAM metallopeptidase domain 17 -0.0279068
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0278878
PTK2 protein tyrosine kinase 2 -0.0278668
CELF1 CUGBP, Elav-like family member 1 -0.0275626
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0274181
WDR45B WD repeat domain 45B -0.0269379
ZMYND8 zinc finger, MYND-type containing 8 -0.0268679
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0265629
KCMF1 potassium channel modulatory factor 1 -0.0260724
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0260355
RPL35A ribosomal protein L35a -0.0260238
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0259415
RLF rearranged L-myc fusion -0.025858
PGAP1 post-GPI attachment to proteins 1 -0.025692
SPAG9 sperm associated antigen 9 -0.0255445
WNK1 WNK lysine deficient protein kinase 1 -0.0254887
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0254323
LOC112694756 uncharaterized LOC112694756 -0.0253218
RAB27B RAB27B, member RAS oncogene family -0.0253059
GARS1 glycyl-tRNA synthetase 1 -0.0252051
MKI67 marker of proliferation Ki-67 -0.0251242
VDAC1 voltage-dependent anion channel 1 -0.0250383
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0249509
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0246943
RPS23 ribosomal protein S23 -0.0246183
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0245306