| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lucanthone perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lucanthone_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.0869877 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0435125 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0325906 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0309943 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.030973 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0307578 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0306562 |
| CCNL1 | cyclin L1 | 0.0288609 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0287217 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0279393 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0274185 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0265891 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.025938 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0252089 |
| UVRAG | UV radiation resistance associated | 0.0249005 |
| SUCO | SUN domain containing ossification factor | 0.024657 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0244677 |
| DENND4A | DENN/MADD domain containing 4A | 0.0242672 |
| RBM39 | RNA binding motif protein 39 | 0.0242203 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.023508 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0232725 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0230833 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0227374 |
| CUL3 | cullin 3 | 0.0226231 |
| RUNX1 | runt-related transcription factor 1 | 0.0224234 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0223523 |
| NDE1 | nudE neurodevelopment protein 1 | 0.0218571 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.021846 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0216638 |
| RNF145 | ring finger protein 145 | 0.0212472 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0211331 |
| KIAA1217 | KIAA1217 | 0.021014 |
| NCKAP1 | NCK-associated protein 1 | 0.0191791 |
| MYO5B | myosin VB | 0.0189915 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0189384 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0188174 |
| KMT5B | lysine methyltransferase 5B | 0.0184596 |
| FRY | furry homolog (Drosophila) | 0.0180468 |
| MATR3 | matrin 3 | 0.0179644 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0177019 |
| PTEN | phosphatase and tensin homolog | 0.017473 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.01739 |
| FNIP1 | folliculin interacting protein 1 | 0.017381 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0173702 |
| RNF169 | ring finger protein 169 | 0.0172342 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0172018 |
| ZNF292 | zinc finger protein 292 | 0.0170938 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0167227 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0166854 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.016168 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0161535 |
| ABI1 | abl-interactor 1 | 0.0160625 |
| NGLY1 | N-glycanase 1 | 0.0158316 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0157273 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0157057 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0156408 |
| PLEC | plectin | 0.0154203 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.0153506 |
| TPD52 | tumor protein D52 | 0.0153221 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.015301 |
| R3HCC1L | R3H domain and coiled-coil containing 1-like | 0.0149888 |
| ECD | ecdysoneless homolog (Drosophila) | 0.0146839 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.014519 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0144349 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0143105 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0142967 |
| TES | testin LIM domain protein | 0.0141655 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0141293 |
| USP47 | ubiquitin specific peptidase 47 | 0.0139089 |
| RTN4 | reticulon 4 | 0.0138383 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0138157 |
| SON | SON DNA binding protein | 0.0137388 |
| TMEM165 | transmembrane protein 165 | 0.0137371 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0135386 |
| EZR | ezrin | 0.0135344 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0134654 |
| RPL4 | ribosomal protein L4 | 0.0134577 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0134552 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0133113 |
| UPF2 | UPF2 regulator of nonsense transcripts homolog (yeast) | 0.0131862 |
| GPBP1L1 | GC-rich promoter binding protein 1-like 1 | 0.0131178 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0130628 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0129669 |
| SNX9 | sorting nexin 9 | 0.0128638 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0128481 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0127736 |
| TBK1 | TANK-binding kinase 1 | 0.0127133 |
| ZNF148 | zinc finger protein 148 | 0.0125808 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0125506 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0125038 |
| MREG | melanoregulin | 0.0124483 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0123173 |
| PNN | pinin, desmosome associated protein | 0.0123144 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0122894 |
| RC3H1 | ring finger and CCCH-type domains 1 | 0.0122664 |
| ABCC1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | 0.0122322 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0121941 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0121093 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.012099 |
| USP15 | ubiquitin specific peptidase 15 | 0.011821 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.404501 |
| NDRG1 | N-myc downstream regulated 1 | -0.114634 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.114419 |
| TMSB10 | thymosin beta 10 | -0.108465 |
| EGFR | epidermal growth factor receptor | -0.0907769 |
| PTMA | prothymosin, alpha | -0.0877565 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.087688 |
| PKM | pyruvate kinase, muscle | -0.0800273 |
| MT2A | metallothionein 2A | -0.0774137 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0754281 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0724537 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0718018 |
| ACTG1 | actin gamma 1 | -0.0702847 |
| S100A10 | S100 calcium binding protein A10 | -0.069417 |
| ENO1 | enolase 1, (alpha) | -0.063385 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0591138 |
| ASPH | aspartate beta-hydroxylase | -0.0587119 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0581189 |
| FTL | ferritin, light polypeptide | -0.0572094 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0554552 |
| CES1 | carboxylesterase 1 | -0.0524342 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0518885 |
| SEC61G | Sec61 gamma subunit | -0.0509489 |
| RPLP1 | ribosomal protein, large, P1 | -0.050464 |
| LDHA | lactate dehydrogenase A | -0.0502032 |
| CST3 | cystatin C | -0.0500639 |
| RPL35A | ribosomal protein L35a | -0.0498114 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0475546 |
| ANXA2 | annexin A2 | -0.0467756 |
| EGR1 | early growth response 1 | -0.0448689 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0442933 |
| RPS24 | ribosomal protein S24 | -0.0433004 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0431595 |
| RPS25 | ribosomal protein S25 | -0.0426651 |
| MCL1 | myeloid cell leukemia 1 | -0.0422899 |
| INTS6 | integrator complex subunit 6 | -0.040851 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0384743 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.037999 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0367333 |
| EFNA5 | ephrin-A5 | -0.0358236 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0347552 |
| STC1 | stanniocalcin 1 | -0.0339776 |
| RPS3 | ribosomal protein S3 | -0.0339296 |
| RPL34 | ribosomal protein L34 | -0.0338461 |
| RPS27A | ribosomal protein S27a | -0.0321451 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | -0.032087 |
| CAV2 | caveolin 2 | -0.0319626 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.031017 |
| RPS29 | ribosomal protein S29 | -0.0306627 |
| FOXP1 | forkhead box P1 | -0.0306133 |
| CANX | calnexin | -0.0305739 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0301427 |
| RPL37A | ribosomal protein L37a | -0.0300675 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0300316 |
| RPS6 | ribosomal protein S6 | -0.0296885 |
| LAMC2 | laminin, gamma 2 | -0.0291082 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0289003 |
| CDCP1 | CUB domain containing protein 1 | -0.0285864 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0282022 |
| RPL11 | ribosomal protein L11 | -0.0281105 |
| RPL31 | ribosomal protein L31 | -0.0273356 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0271001 |
| KRT7 | keratin 7, type II | -0.0269567 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0266013 |
| WASF2 | WAS protein family, member 2 | -0.0265607 |
| RPLP0 | ribosomal protein, large, P0 | -0.0265376 |
| TMEM45B | transmembrane protein 45B | -0.0263763 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0261129 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0258988 |
| HLA-B | major histocompatibility complex, class I, B | -0.0257223 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0256988 |
| CIB1 | calcium and integrin binding 1 (calmyrin) | -0.0255974 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.025382 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0253521 |
| OFD1 | oral-facial-digital syndrome 1 | -0.0253235 |
| CCND1 | cyclin D1 | -0.0248552 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.024827 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0245988 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0244562 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0244306 |
| S100P | S100 calcium binding protein P | -0.0244137 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0241995 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0241802 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0240083 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0238894 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0238684 |
| RPLP2 | ribosomal protein, large, P2 | -0.0238645 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0238092 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0232794 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0232581 |
| ANXA1 | annexin A1 | -0.0231438 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0231188 |
| AREG | amphiregulin | -0.0227352 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0225347 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0223885 |
| RPL8 | ribosomal protein L8 | -0.0221202 |
| RPS23 | ribosomal protein S23 | -0.0217625 |
| RIN2 | Ras and Rab interactor 2 | -0.0215941 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0215341 |
| RPS8 | ribosomal protein S8 | -0.0209656 |
