| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lucanthone perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lucanthone_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.0553017 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0505864 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0344592 |
| RPL4 | ribosomal protein L4 | 0.0314318 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0310705 |
| WDR43 | WD repeat domain 43 | 0.0300626 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0286863 |
| FGB | fibrinogen beta chain | 0.0278574 |
| FAM168A | family with sequence similarity 168, member A | 0.0273504 |
| RTN4 | reticulon 4 | 0.0262765 |
| YBX3 | Y box binding protein 3 | 0.0248549 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0245127 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0222816 |
| TFG | TRK-fused gene | 0.0221346 |
| YBX1 | Y box binding protein 1 | 0.0216615 |
| MKI67 | marker of proliferation Ki-67 | 0.0206677 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0206255 |
| CCNL1 | cyclin L1 | 0.0205803 |
| RPS12 | ribosomal protein S12 | 0.020208 |
| PM20D1 | peptidase M20 domain containing 1 | 0.019869 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0197184 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0191357 |
| DENND4A | DENN/MADD domain containing 4A | 0.0188487 |
| PFDN2 | prefoldin subunit 2 | 0.0187278 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0182555 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0179015 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0178832 |
| PNN | pinin, desmosome associated protein | 0.0177327 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0175185 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.017247 |
| SDC4 | syndecan 4 | 0.0170214 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0165942 |
| TPM3 | tropomyosin 3 | 0.016537 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0165076 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0162283 |
| RBM8A | RNA binding motif protein 8A | 0.0159642 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0157675 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0156665 |
| THBS1 | thrombospondin 1 | 0.0156496 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0152337 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0152196 |
| KLF6 | Kruppel-like factor 6 | 0.0152163 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0151771 |
| RPL26 | ribosomal protein L26 | 0.0151527 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0150093 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0149152 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0145577 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0145222 |
| RRM2 | ribonucleotide reductase M2 | 0.0141703 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0141461 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0141068 |
| JAK1 | Janus kinase 1 | 0.0140834 |
| RPL3 | ribosomal protein L3 | 0.0137252 |
| AREG | amphiregulin | 0.0136823 |
| CENPF | centromere protein F, 350/400kDa | 0.0135736 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0130671 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0130467 |
| RPS7 | ribosomal protein S7 | 0.0129279 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0127365 |
| SIN3A | SIN3 transcription regulator family member A | 0.0126923 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0124885 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | 0.0124871 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0124548 |
| HBS1L | HBS1-like translational GTPase | 0.0124502 |
| UPP1 | uridine phosphorylase 1 | 0.0124161 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0121629 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0121359 |
| RPL23 | ribosomal protein L23 | 0.0118862 |
| ILF2 | interleukin enhancer binding factor 2 | 0.0118862 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0117668 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0115741 |
| RPL41 | ribosomal protein L41 | 0.0115537 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0115267 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0114186 |
| MTPN | myotrophin | 0.011386 |
| ELOC | elongin C | 0.0113623 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 0.01136 |
| ENY2 | enhancer of yellow 2 homolog (Drosophila) | 0.0113268 |
| TMEM123 | transmembrane protein 123 | 0.0112729 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0112665 |
| FGG | fibrinogen gamma chain | 0.0112113 |
| RPL5 | ribosomal protein L5 | 0.0111652 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0110459 |
| CCL2 | chemokine (C-C motif) ligand 2 | 0.0110404 |
| SET | SET nuclear proto-oncogene | 0.0107957 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0106587 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.0105677 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0105535 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.0104529 |
| WBP11 | WW domain binding protein 11 | 0.0103977 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.010394 |
| RAB11A | RAB11A, member RAS oncogene family | 0.0103546 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.0103252 |
| RPS18 | ribosomal protein S18 | 0.0103192 |
| DUT | deoxyuridine triphosphatase | 0.0102529 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | 0.0101916 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0100681 |
| DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56 | 0.0100612 |
| NOCT | nocturnin | 0.00992981 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.00980641 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.189692 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.164061 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.130375 |
| MT2A | metallothionein 2A | -0.123422 |
| DOCK4 | dedicator of cytokinesis 4 | -0.116417 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.102572 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0919304 |
| VIM | vimentin | -0.0888484 |
| FMNL2 | formin-like 2 | -0.0765843 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0714646 |
| FTL | ferritin, light polypeptide | -0.071325 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0698707 |
| CMIP | c-Maf inducing protein | -0.0679802 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0678542 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0668885 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0654054 |
| FLNB | filamin B, beta | -0.0637232 |
| PARD3 | par-3 family cell polarity regulator | -0.062184 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0600572 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0593803 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.058404 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0581254 |
| SVIL | supervillin | -0.0580712 |
| ACTG1 | actin gamma 1 | -0.0549493 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0536967 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0521415 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0518655 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0503673 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0483842 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0474238 |
| PKM | pyruvate kinase, muscle | -0.0463534 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0452221 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0443633 |
| COPA | coatomer protein complex, subunit alpha | -0.0442543 |
| DOCK5 | dedicator of cytokinesis 5 | -0.043685 |
| EFNA5 | ephrin-A5 | -0.0430045 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0426382 |
| ZFHX3 | zinc finger homeobox 3 | -0.042442 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0423328 |
| UTRN | utrophin | -0.0422353 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0416558 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0400373 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.039693 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0393814 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0393027 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0390812 |
| IGF2 | insulin-like growth factor 2 | -0.038529 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0384164 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0383295 |
| DST | dystonin | -0.0376541 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0374813 |
| ERBIN | erbb2 interacting protein | -0.0367093 |
| CFDP1 | craniofacial development protein 1 | -0.0366924 |
| NEBL | nebulette | -0.036327 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0363184 |
| PTK2 | protein tyrosine kinase 2 | -0.0362342 |
| BICC1 | BicC family RNA binding protein 1 | -0.0361967 |
| PYGL | phosphorylase, glycogen, liver | -0.0356771 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0356413 |
| EGFR | epidermal growth factor receptor | -0.0355113 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0353557 |
| ATXN1 | ataxin 1 | -0.0351752 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0349267 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0347125 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0346532 |
| TMSB10 | thymosin beta 10 | -0.0346267 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0345984 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0339886 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0339717 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0339538 |
| JMJD1C | jumonji domain containing 1C | -0.0338483 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0338312 |
| GLG1 | golgi glycoprotein 1 | -0.0333607 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0332832 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0330448 |
| NF1 | neurofibromin 1 | -0.032996 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0326031 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0322392 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0321055 |
| CUX1 | cut-like homeobox 1 | -0.0320892 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0317795 |
| ACTN1 | actinin, alpha 1 | -0.0317622 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0316976 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0314709 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.031001 |
| NUMB | numb homolog (Drosophila) | -0.0308337 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0307248 |
| SBF2 | SET binding factor 2 | -0.0307021 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0306851 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0306729 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0306133 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0303378 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0302507 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0298497 |
| SNX14 | sorting nexin 14 | -0.029847 |
| NDRG1 | N-myc downstream regulated 1 | -0.0298383 |
| NHSL1 | NHS-like 1 | -0.0296635 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0294455 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.028677 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0282433 |
