| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lucanthone perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lucanthone_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.100331 |
| GOLGA4 | golgin A4 | 0.0952477 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0789374 |
| ASPH | aspartate beta-hydroxylase | 0.0760616 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0727014 |
| OGA | O-GlcNAcase | 0.071567 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0710779 |
| NDRG1 | N-myc downstream regulated 1 | 0.0680184 |
| FAM13A | family with sequence similarity 13, member A | 0.063517 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0624538 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.059596 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0593821 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0587602 |
| EFNA5 | ephrin-A5 | 0.0580686 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.056206 |
| ANO6 | anoctamin 6 | 0.0526109 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0520573 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0515928 |
| CCNL1 | cyclin L1 | 0.0502331 |
| TXNRD1 | thioredoxin reductase 1 | 0.0499006 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0495305 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0490163 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0470527 |
| VCL | vinculin | 0.0470367 |
| RPS3 | ribosomal protein S3 | 0.0460832 |
| FN1 | fibronectin 1 | 0.0457182 |
| SETD5 | SET domain containing 5 | 0.0455007 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0450451 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0447689 |
| KYNU | kynureninase | 0.0441837 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0440854 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0439201 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0426315 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0424968 |
| PRELID2 | PRELI domain containing 2 | 0.0419293 |
| GLG1 | golgi glycoprotein 1 | 0.0419288 |
| FAM168A | family with sequence similarity 168, member A | 0.0417888 |
| VEGFA | vascular endothelial growth factor A | 0.0416009 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0411884 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0408442 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0405265 |
| CD109 | CD109 molecule | 0.0401306 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0398939 |
| UGDH | UDP-glucose 6-dehydrogenase | 0.039319 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0392074 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0387529 |
| APP | amyloid beta (A4) precursor protein | 0.0386848 |
| CLTC | clathrin, heavy chain (Hc) | 0.0385885 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.0383843 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0383269 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0382898 |
| TLK1 | tousled-like kinase 1 | 0.0377153 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.03662 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0364361 |
| NGLY1 | N-glycanase 1 | 0.0363492 |
| CANX | calnexin | 0.0361337 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0357509 |
| PMM2 | phosphomannomutase 2 | 0.0354925 |
| SERINC1 | serine incorporator 1 | 0.0349848 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | 0.0346267 |
| GRAMD1B | GRAM domain containing 1B | 0.0341796 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0334279 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0329331 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0324675 |
| HELZ | helicase with zinc finger | 0.032464 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0324509 |
| HMGA2 | high mobility group AT-hook 2 | 0.0323467 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.0322363 |
| C3 | complement component 3 | 0.0322228 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0321951 |
| CALU | calumenin | 0.0321108 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0319794 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0312785 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0312291 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0309427 |
| NUP58 | nucleoporin 58 | 0.0307641 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0307624 |
| RAB10 | RAB10, member RAS oncogene family | 0.0306679 |
| RNF145 | ring finger protein 145 | 0.0305938 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0303553 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0303382 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0299295 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0297598 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0296509 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0296437 |
| ZNF654 | zinc finger protein 654 | 0.0295816 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0294988 |
| SRP72 | signal recognition particle 72kDa | 0.0294808 |
| MYOF | myoferlin | 0.029296 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0290537 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0289431 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0289263 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0288366 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0286996 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.028693 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0284886 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0284055 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0282576 |
| PTK2 | protein tyrosine kinase 2 | 0.0282571 |
| ARFGEF1 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) | 0.0281999 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ATOSA | atos homolog A | -0.138613 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.13373 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.117077 |
| LAMC2 | laminin, gamma 2 | -0.115342 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.101984 |
| S100A9 | S100 calcium binding protein A9 | -0.0961439 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0942735 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0863108 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0790843 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0760241 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0757323 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0723418 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0707209 |
| MYO1E | myosin IE | -0.068863 |
| STC1 | stanniocalcin 1 | -0.0630345 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0624092 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0618833 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0604418 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0603667 |
| RAD51B | RAD51 paralog B | -0.0601689 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0594242 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0588965 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0551973 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0546403 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0524494 |
| MCL1 | myeloid cell leukemia 1 | -0.0514824 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0506891 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0491852 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0486133 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0479446 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0478533 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0478191 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0455366 |
| SVIL | supervillin | -0.045192 |
| RAI14 | retinoic acid induced 14 | -0.0447565 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0446292 |
| PRDM1 | PR domain containing 1, with ZNF domain | -0.043906 |
| TMPRSS4 | transmembrane protease, serine 4 | -0.0435156 |
| FOXP1 | forkhead box P1 | -0.0430855 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | -0.0424741 |
| RFX7 | regulatory factor X, 7 | -0.0418498 |
| OSMR | oncostatin M receptor | -0.0416172 |
| VGF | VGF nerve growth factor inducible | -0.0415686 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0415021 |
| KLF6 | Kruppel-like factor 6 | -0.0402089 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0393978 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0392935 |
| MXD1 | MAX dimerization protein 1 | -0.0389351 |
| FOXO3 | forkhead box O3 | -0.038935 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0387983 |
| MUC16 | mucin 16, cell surface associated | -0.0381488 |
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | -0.0375459 |
| KRT17 | keratin 17, type I | -0.0370864 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0369859 |
| RREB1 | ras responsive element binding protein 1 | -0.036746 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0363879 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0357634 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.035684 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0349287 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0349241 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0348651 |
| BPTF | bromodomain PHD finger transcription factor | -0.0347357 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.0346593 |
| HLA-B | major histocompatibility complex, class I, B | -0.0340744 |
| JUP | junction plakoglobin | -0.033521 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0334138 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0331041 |
| RNF149 | ring finger protein 149 | -0.0325043 |
| USP53 | ubiquitin specific peptidase 53 | -0.0324542 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.031984 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0315219 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0314672 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0312194 |
| ACTN1 | actinin, alpha 1 | -0.0309648 |
| B2M | beta-2-microglobulin | -0.0309366 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0306689 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0306686 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0305578 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0302984 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0302838 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | -0.0300674 |
| PARD3 | par-3 family cell polarity regulator | -0.0299547 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0299391 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0297821 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0297359 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -0.0296818 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0295299 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0287732 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0286835 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.028656 |
| AK1 | adenylate kinase 1 | -0.0284387 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0283371 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0282581 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0280808 |
| BTBD10 | BTB (POZ) domain containing 10 | -0.0279908 |
| NIPSNAP2 | nipsnap homolog 2 | -0.0279292 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0278855 |
| NHSL1 | NHS-like 1 | -0.027587 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0274966 |
| CDK13 | cyclin-dependent kinase 13 | -0.0274686 |
