Lucanthone_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lucanthone perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lucanthone_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.161792
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.128978
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.104356
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0931611
TMSB4X thymosin beta 4, X-linked 0.0894756
CCNL1 cyclin L1 0.0857692
ASPH aspartate beta-hydroxylase 0.0778037
FNDC3B fibronectin type III domain containing 3B 0.0776346
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0775445
MYH9 myosin, heavy chain 9, non-muscle 0.0731098
NAMPT nicotinamide phosphoribosyltransferase 0.0700337
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0671121
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0649445
BHLHE40 basic helix-loop-helix family, member e40 0.0606788
TPM3 tropomyosin 3 0.0586506
VEGFA vascular endothelial growth factor A 0.057872
FXR1 fragile X mental retardation, autosomal homolog 1 0.0575848
MATR3 matrin 3 0.0560557
RAD21 RAD21 homolog (S. pombe) 0.0548253
TRIO trio Rho guanine nucleotide exchange factor 0.0545942
TFG TRK-fused gene 0.0533448
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0529637
RPL4 ribosomal protein L4 0.0528316
KMT2E lysine (K)-specific methyltransferase 2E 0.0512806
EEF2 eukaryotic translation elongation factor 2 0.0510282
MARCHF6 membrane associated ring-CH-type finger 6 0.0493745
ADAM9 ADAM metallopeptidase domain 9 0.0481732
TXNRD1 thioredoxin reductase 1 0.0479357
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0478976
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0454996
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0453882
ZNF292 zinc finger protein 292 0.0451374
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0442053
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0427263
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0421261
SEC23A Sec23 homolog A (S. cerevisiae) 0.041947
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0418064
DSCAM Down syndrome cell adhesion molecule 0.0408292
RSRC2 arginine/serine-rich coiled-coil 2 0.0402042
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0397381
SPAG9 sperm associated antigen 9 0.0378394
IQGAP1 IQ motif containing GTPase activating protein 1 0.0377895
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0373618
PTK2 protein tyrosine kinase 2 0.0366116
KDM3A lysine (K)-specific demethylase 3A 0.0364754
USP3 ubiquitin specific peptidase 3 0.0361374
CANX calnexin 0.0359803
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0359726
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0359678
KDM6A lysine (K)-specific demethylase 6A 0.0358213
NUP58 nucleoporin 58 0.0357861
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0355223
USP9X ubiquitin specific peptidase 9, X-linked 0.0353966
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0352005
GRB10 growth factor receptor-bound protein 10 0.0349808
APP amyloid beta (A4) precursor protein 0.0349501
TNIP1 TNFAIP3 interacting protein 1 0.0346399
HSPA8 heat shock 70kDa protein 8 0.0344317
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0344138
RBM39 RNA binding motif protein 39 0.0342614
NCKAP1 NCK-associated protein 1 0.0341658
FAM13A family with sequence similarity 13, member A 0.0340656
CDC73 cell division cycle 73 0.0340537
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0340218
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0339384
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0337846
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0337473
CSDE1 cold shock domain containing E1, RNA-binding 0.0335375
QKI QKI, KH domain containing, RNA binding 0.033385
TMF1 TATA element modulatory factor 1 0.0333436
ZFAND3 zinc finger, AN1-type domain 3 0.0333418
ECT2 epithelial cell transforming 2 0.0333006
GARS1 glycyl-tRNA synthetase 1 0.0327885
GOLGA4 golgin A4 0.0323923
EEF1G eukaryotic translation elongation factor 1 gamma 0.032268
MSN moesin 0.0321628
DSPP dentin sialophosphoprotein 0.0320074
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0319048
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0318315
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0317787
PLAU plasminogen activator, urokinase 0.0317237
RNF145 ring finger protein 145 0.031636
YTHDC1 YTH domain containing 1 0.0315891
PAPOLA poly(A) polymerase alpha 0.0314673
IRF6 interferon regulatory factor 6 0.0314149
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0313859
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0306969
SET SET nuclear proto-oncogene 0.0306728
LYN LYN proto-oncogene, Src family tyrosine kinase 0.0305345
LMO7 LIM domain 7 0.0305053
CLINT1 clathrin interactor 1 0.0304823
PGK1 phosphoglycerate kinase 1 0.0301563
EIF4A2 eukaryotic translation initiation factor 4A2 0.0300594
RLF rearranged L-myc fusion 0.02994
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0298175
KRT18 keratin 18, type I 0.0297562
YME1L1 YME1-like 1 ATPase 0.0297203
RYK receptor-like tyrosine kinase 0.0296664
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0295993
WDR43 WD repeat domain 43 0.0292613

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.365497
FTL ferritin, light polypeptide -0.232875
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.214811
TMSB10 thymosin beta 10 -0.13102
ACTG1 actin gamma 1 -0.119438
MT2A metallothionein 2A -0.0980619
SAMD4A sterile alpha motif domain containing 4A -0.0923211
NDRG1 N-myc downstream regulated 1 -0.0920791
IFI27 interferon, alpha-inducible protein 27 -0.0782105
LPP LIM domain containing preferred translocation partner in lipoma -0.0626994
ZSWIM6 zinc finger, SWIM-type containing 6 -0.059685
WSB1 WD repeat and SOCS box containing 1 -0.0568059
HMGA1 high mobility group AT-hook 1 -0.0526732
EXT1 exostosin glycosyltransferase 1 -0.0514509
RPLP1 ribosomal protein, large, P1 -0.0496686
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0479325
RPL35A ribosomal protein L35a -0.045256
RPS19 ribosomal protein S19 -0.0443432
IFI6 interferon, alpha-inducible protein 6 -0.0442928
RPS29 ribosomal protein S29 -0.0422253
LIMCH1 LIM and calponin homology domains 1 -0.0421116
EFNA5 ephrin-A5 -0.0419381
FBXO32 F-box protein 32 -0.0412468
IFI16 interferon, gamma-inducible protein 16 -0.0404205
IGFBP3 insulin-like growth factor binding protein 3 -0.0402861
IFITM3 interferon induced transmembrane protein 3 -0.0402495
IFITM1 interferon induced transmembrane protein 1 -0.0397028
RPLP2 ribosomal protein, large, P2 -0.0381163
RPL8 ribosomal protein L8 -0.0378273
S100A10 S100 calcium binding protein A10 -0.0377815
RPL34 ribosomal protein L34 -0.0374676
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0364053
ZBTB20 zinc finger and BTB domain containing 20 -0.0355052
TXNIP thioredoxin interacting protein -0.0354361
MX2 MX dynamin-like GTPase 2 -0.0348888
S100A6 S100 calcium binding protein A6 -0.0343633
TPT1 tumor protein, translationally-controlled 1 -0.0340714
LY6E lymphocyte antigen 6 complex, locus E -0.0340261
TUBB4B tubulin, beta 4B class IVb -0.0333538
RPS23 ribosomal protein S23 -0.0322037
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0312102
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0305029
GNAS GNAS complex locus -0.030403
RIGI RNA sensor RIG-I -0.030368
RPL28 ribosomal protein L28 -0.0297844
CLDN4 claudin 4 -0.0293576
RPL37A ribosomal protein L37a -0.0293411
RPS13 ribosomal protein S13 -0.0292171
EIF1 eukaryotic translation initiation factor 1 -0.0290926
RPS6 ribosomal protein S6 -0.0290807
GOLGB1 golgin B1 -0.0288936
LOC112694756 uncharaterized LOC112694756 -0.0281463
RPL32 ribosomal protein L32 -0.0279696
CSTB cystatin B (stefin B) -0.0276772
ATXN1 ataxin 1 -0.0274955
RPS25 ribosomal protein S25 -0.0270405
RNF213 ring finger protein 213 -0.0267563
ISG15 ISG15 ubiquitin-like modifier -0.0265198
RPL19 ribosomal protein L19 -0.0261378
MYO1E myosin IE -0.0260319
RPL9 ribosomal protein L9 -0.0258895
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0258111
SOX4 SRY (sex determining region Y)-box 4 -0.0258105
EGR1 early growth response 1 -0.0257959
ARHGAP20 Rho GTPase activating protein 20 -0.0255618
RPS27 ribosomal protein S27 -0.0250905
KRT19 keratin 19, type I -0.0249567
ETV6 ets variant 6 -0.0248978
HSPB1 heat shock 27kDa protein 1 -0.0248964
ATP11A ATPase, class VI, type 11A -0.0248104
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0247584
S100A9 S100 calcium binding protein A9 -0.0247239
RPS16 ribosomal protein S16 -0.0246823
RBM47 RNA binding motif protein 47 -0.0243504
TIMP2 TIMP metallopeptidase inhibitor 2 -0.024176
NPC2 Niemann-Pick disease, type C2 -0.0241369
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0239545
BBX bobby sox homolog (Drosophila) -0.0235372
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0235258
PKM pyruvate kinase, muscle -0.0234556
NAV2 neuron navigator 2 -0.0230758
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0229289
TM4SF1 transmembrane 4 L six family member 1 -0.022672
MDK midkine (neurite growth-promoting factor 2) -0.0226621
INTS6 integrator complex subunit 6 -0.022589
S100A11 S100 calcium binding protein A11 -0.0223713
RPS10 ribosomal protein S10 -0.0222658
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0221969
RPL15 ribosomal protein L15 -0.0221396
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.0217201
RPS15 ribosomal protein S15 -0.0216336
RPL37 ribosomal protein L37 -0.0216056
RPS11 ribosomal protein S11 -0.0214525
FBXO34 F-box protein 34 -0.0212991
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0212742
RPL36 ribosomal protein L36 -0.0212293
PGBD5 piggyBac transposable element derived 5 -0.0211078
RAB7A RAB7A, member RAS oncogene family -0.020977
ANKRD37 ankyrin repeat domain 37 -0.0209222
PALLD palladin, cytoskeletal associated protein -0.0207553