Lucanthone_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lucanthone perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

190 genes differentially expressed following the Lucanthone_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.190425
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.132687
VIM vimentin 0.127922
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.122016
EIF1 eukaryotic translation initiation factor 1 0.105276
RPL19 ribosomal protein L19 0.0994503
IGFBP3 insulin-like growth factor binding protein 3 0.0942503
SND1 staphylococcal nuclease and tudor domain containing 1 0.0929683
CANX calnexin 0.0919041
FTH1 ferritin, heavy polypeptide 1 0.0883046
RPL11 ribosomal protein L11 0.085988
RPL35A ribosomal protein L35a 0.0845311
JMJD1C jumonji domain containing 1C 0.0833345
NKD1 naked cuticle homolog 1 (Drosophila) 0.0733453
B2M beta-2-microglobulin 0.0732335
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0702554
ATP13A3 ATPase type 13A3 0.0693485
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.062763
PTMA prothymosin, alpha 0.0596791
FNDC3B fibronectin type III domain containing 3B 0.0587708
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0567216
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0558063
KMT2E lysine (K)-specific methyltransferase 2E 0.0550622
NDRG1 N-myc downstream regulated 1 0.0542038
RPS6 ribosomal protein S6 0.0528542
ZMYM2 zinc finger, MYM-type 2 0.0515891
FTL ferritin, light polypeptide 0.050842
DSCAM Down syndrome cell adhesion molecule 0.0491906
ERRFI1 ERBB receptor feedback inhibitor 1 0.047181
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0466822
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0466545
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0446762
LDHA lactate dehydrogenase A 0.0435198
MCL1 myeloid cell leukemia 1 0.042137
TPT1 tumor protein, translationally-controlled 1 0.0406583
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0373155
EXT1 exostosin glycosyltransferase 1 0.0360028
TPM4 tropomyosin 4 0.034967
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0346628
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0340403
TMSB10 thymosin beta 10 0.0332233
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0331029
ELL2 elongation factor, RNA polymerase II, 2 0.0330862
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.032997
NF1 neurofibromin 1 0.0327666
MYO1E myosin IE 0.0324994
MACC1 metastasis associated in colon cancer 1 0.0317453
RUNX1 runt-related transcription factor 1 0.0311751
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0306379
SPAG9 sperm associated antigen 9 0.0294426
PRKCA protein kinase C, alpha 0.0293275
RNF145 ring finger protein 145 0.0292233
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0289397
NCOR1 nuclear receptor corepressor 1 0.0286895
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0285236
TXNRD1 thioredoxin reductase 1 0.0276015
SLC38A1 solute carrier family 38, member 1 0.0274803
MT2A metallothionein 2A 0.0245635
RPLP2 ribosomal protein, large, P2 0.0238673
DLG1 discs, large homolog 1 (Drosophila) 0.0234934
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0231729
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0231164
PRRC2B proline-rich coiled-coil 2B 0.0214921
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0205117
EEF2 eukaryotic translation elongation factor 2 0.0202187
MACF1 microtubule-actin crosslinking factor 1 0.0195754
OLA1 Obg-like ATPase 1 0.0185023
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0183394
RBM39 RNA binding motif protein 39 0.0179093
SMAD3 SMAD family member 3 0.0168256
RPS12 ribosomal protein S12 0.0162014
GLS2 glutaminase 2 (liver, mitochondrial) 0.0143751
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0137701
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0130679
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0129899
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0126333
ZMYND8 zinc finger, MYND-type containing 8 0.012103
RPL37A ribosomal protein L37a 0.0117313
AKAP13 A kinase (PRKA) anchor protein 13 0.0104456
TTC17 tetratricopeptide repeat domain 17 0.0104338
RPL31 ribosomal protein L31 0.0102669
RPS8 ribosomal protein S8 0.0100913
LMAN1 lectin, mannose-binding, 1 0.00983956
RIOK3 RIO kinase 3 0.00952125
TRIO trio Rho guanine nucleotide exchange factor 0.00921873
TXNIP thioredoxin interacting protein 0.00907895
PGK1 phosphoglycerate kinase 1 0.00886582
CTNND1 catenin (cadherin-associated protein), delta 1 0.00803488
VCL vinculin 0.00741074
NAMPT nicotinamide phosphoribosyltransferase 0.00717626
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.00636422
LMO7 LIM domain 7 0.00594564
FMN1 formin 1 0.00590633
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.00503603
PRRC2C proline-rich coiled-coil 2C 0.00412722
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.00377022
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.00259958
ZBTB20 zinc finger and BTB domain containing 20 0.00185877
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.00178845
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.00152157

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.128364
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.107281
PSD3 pleckstrin and Sec7 domain containing 3 -0.0958766
PDE10A phosphodiesterase 10A -0.0958402
FN1 fibronectin 1 -0.0943002
ALCAM activated leukocyte cell adhesion molecule -0.0922561
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0914816
SMYD3 SET and MYND domain containing 3 -0.0876322
DOCK4 dedicator of cytokinesis 4 -0.0838231
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0831131
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0784278
ITCH itchy E3 ubiquitin protein ligase -0.0740389
NUP58 nucleoporin 58 -0.0721989
FLNB filamin B, beta -0.0695997
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0689319
FNDC3A fibronectin type III domain containing 3A -0.0665171
TBC1D5 TBC1 domain family, member 5 -0.0629732
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0596958
ADAM10 ADAM metallopeptidase domain 10 -0.0581499
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0538996
RTN4 reticulon 4 -0.0489447
UBC ubiquitin C -0.0480984
RLF rearranged L-myc fusion -0.0475491
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0463303
PTK2 protein tyrosine kinase 2 -0.0457417
MYO6 myosin VI -0.0453464
ANXA2 annexin A2 -0.0444514
PKM pyruvate kinase, muscle -0.0440702
NIPBL Nipped-B homolog (Drosophila) -0.0432351
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0391016
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.0390626
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0384438
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0380559
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.0371559
ACTN4 actinin, alpha 4 -0.0360141
ZNF292 zinc finger protein 292 -0.035242
MED13L mediator complex subunit 13-like -0.0346512
GPHN gephyrin -0.034093
MAP4 microtubule-associated protein 4 -0.0320942
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0318626
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0313896
DST dystonin -0.0310151
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0305823
ASPH aspartate beta-hydroxylase -0.0303777
ZFAND3 zinc finger, AN1-type domain 3 -0.0295543
KDM3A lysine (K)-specific demethylase 3A -0.0287289
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0283826
GPC6 glypican 6 -0.0283151
RPS3 ribosomal protein S3 -0.0276649
RNF213 ring finger protein 213 -0.0272892
WAC WW domain containing adaptor with coiled-coil -0.0272612
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0267898
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0267609
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0267534
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0261731
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0259691
GSK3B glycogen synthase kinase 3 beta -0.0254891
CCNI cyclin I -0.0252022
MAML2 mastermind-like 2 (Drosophila) -0.025172
COG5 component of oligomeric golgi complex 5 -0.0238151
ADAM9 ADAM metallopeptidase domain 9 -0.0236175
SETD5 SET domain containing 5 -0.0218087
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0216774
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0213471
KLF6 Kruppel-like factor 6 -0.0211508
MYH9 myosin, heavy chain 9, non-muscle -0.0168601
RPS27A ribosomal protein S27a -0.0165965
TPI1 triosephosphate isomerase 1 -0.0163722
EFNA5 ephrin-A5 -0.0144766
RPL23 ribosomal protein L23 -0.0138767
ACTG1 actin gamma 1 -0.0128498
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0116331
ENO1 enolase 1, (alpha) -0.0116203
MARCHF6 membrane associated ring-CH-type finger 6 -0.0110323
NAP1L1 nucleosome assembly protein 1-like 1 -0.0103608
PARD3 par-3 family cell polarity regulator -0.00961736
RAB7A RAB7A, member RAS oncogene family -0.00840522
KMT2C lysine (K)-specific methyltransferase 2C -0.00756186
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.00679035
BIRC6 baculoviral IAP repeat containing 6 -0.0066007
SRPK2 SRSF protein kinase 2 -0.00611592
PDE4D phosphodiesterase 4D, cAMP-specific -0.00432787
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.00362584
HOOK2 hook microtubule-tethering protein 2 -0.00309672
TRA2A transformer 2 alpha homolog (Drosophila) -0.0030563
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.00304989
NBAS neuroblastoma amplified sequence -0.00239955
GOLGA4 golgin A4 -0.00223121
RBM25 RNA binding motif protein 25 -0.00101277
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -2.15086E-4