Lucanthone_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lucanthone perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lucanthone_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0715806
GOLGA4 golgin A4 0.061988
CCNL1 cyclin L1 0.0571891
POTEF POTE ankyrin domain family, member F 0.0570703
PRRC2C proline-rich coiled-coil 2C 0.0536046
SPAG9 sperm associated antigen 9 0.0511569
ANKRD11 ankyrin repeat domain 11 0.0506654
RUNX1 runt-related transcription factor 1 0.0491905
RAB7A RAB7A, member RAS oncogene family 0.0470609
DST dystonin 0.0464824
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0458086
KMT2C lysine (K)-specific methyltransferase 2C 0.0429424
RTN4 reticulon 4 0.0424889
WAC WW domain containing adaptor with coiled-coil 0.0422243
RAD23B RAD23 homolog B (S. cerevisiae) 0.0414288
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.040699
BIRC3 baculoviral IAP repeat containing 3 0.0399997
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0396873
ZFAND3 zinc finger, AN1-type domain 3 0.0383896
SET SET nuclear proto-oncogene 0.0383328
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0380982
DTNA dystrobrevin, alpha 0.0379587
MATR3 matrin 3 0.0376767
SPTBN1 spectrin, beta, non-erythrocytic 1 0.036994
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0368838
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0367067
RBM39 RNA binding motif protein 39 0.0362914
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0362772
B2M beta-2-microglobulin 0.0357457
ANXA1 annexin A1 0.0348397
NUP58 nucleoporin 58 0.0348083
KIF5B kinesin family member 5B 0.034619
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.034527
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0344947
RPS3 ribosomal protein S3 0.0342419
RASAL2 RAS protein activator like 2 0.0340998
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0338994
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0337434
MBNL1 muscleblind-like splicing regulator 1 0.0337053
OGA O-GlcNAcase 0.0329314
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0323848
MPRIP myosin phosphatase Rho interacting protein 0.0320456
SAMD4A sterile alpha motif domain containing 4A 0.0316145
FXR1 fragile X mental retardation, autosomal homolog 1 0.0308688
KDM2A lysine (K)-specific demethylase 2A 0.0307701
RPL23 ribosomal protein L23 0.0305051
CASC3 cancer susceptibility candidate 3 0.0302392
SEC23A Sec23 homolog A (S. cerevisiae) 0.030226
PTMA prothymosin, alpha 0.0301773
PKM pyruvate kinase, muscle 0.0301594
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0296647
DGKD diacylglycerol kinase, delta 130kDa 0.029641
SRPK2 SRSF protein kinase 2 0.0295528
EEF1G eukaryotic translation elongation factor 1 gamma 0.0292889
TPM3 tropomyosin 3 0.0288395
RB1CC1 RB1-inducible coiled-coil 1 0.0285499
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0283272
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0282753
TXNRD1 thioredoxin reductase 1 0.028225
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0281635
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0278507
MYH9 myosin, heavy chain 9, non-muscle 0.0276482
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0275949
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0275312
PTBP2 polypyrimidine tract binding protein 2 0.027436
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0273827
STK24 serine/threonine kinase 24 0.0273137
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0272586
SEC24A SEC24 family member A 0.0272014
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0271384
RPL26 ribosomal protein L26 0.0269767
TOP1 topoisomerase (DNA) I 0.0268968
LMO7 LIM domain 7 0.0264483
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 0.0262992
QKI QKI, KH domain containing, RNA binding 0.0261277
TAOK1 TAO kinase 1 0.0259122
GORASP2 golgi reassembly stacking protein 2, 55kDa 0.0258998
SNX1 sorting nexin 1 0.0258174
IWS1 IWS1 homolog (S. cerevisiae) 0.0257841
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0257485
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0255282
SRRM1 serine/arginine repetitive matrix 1 0.0254861
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0254162
COPA coatomer protein complex, subunit alpha 0.0253879
BBX bobby sox homolog (Drosophila) 0.0252518
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0252424
EEF2 eukaryotic translation elongation factor 2 0.0252359
SAFB2 scaffold attachment factor B2 0.0251472
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0251118
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0250745
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.0249406
CALR calreticulin 0.0248691
NKTR natural killer cell triggering receptor 0.024791
SMAP1 small ArfGAP 1 0.0247387
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0246499
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0245982
SLTM SAFB-like, transcription modulator 0.0245054
UBE3A ubiquitin protein ligase E3A 0.0244537
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0244292
TPX2 TPX2, microtubule-associated 0.0243997

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.31036
LDHA lactate dehydrogenase A -0.0676207
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0659572
IGFBP3 insulin-like growth factor binding protein 3 -0.0642377
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0574824
SMYD3 SET and MYND domain containing 3 -0.0493062
TPT1 tumor protein, translationally-controlled 1 -0.0484309
OSMR oncostatin M receptor -0.0484084
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0481124
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.044492
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0438303
LOC112694756 uncharaterized LOC112694756 -0.0429204
NT5E 5'-nucleotidase, ecto (CD73) -0.0389658
DNER delta/notch-like EGF repeat containing -0.0383586
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0372774
TM4SF1 transmembrane 4 L six family member 1 -0.036492
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0360237
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0353231
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0352878
BASP1 brain abundant, membrane attached signal protein 1 -0.0348669
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.03465
VIM vimentin -0.0345909
GNAS GNAS complex locus -0.0341008
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0335791
CENPP centromere protein P -0.0324444
ATM ATM serine/threonine kinase -0.0320967
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0318371
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0310007
TMSB10 thymosin beta 10 -0.0291139
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0290477
NIPBL Nipped-B homolog (Drosophila) -0.0288377
PDE8A phosphodiesterase 8A -0.0284687
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.0281105
TTC28 tetratricopeptide repeat domain 28 -0.0276049
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0275936
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0274007
CLASP2 cytoplasmic linker associated protein 2 -0.027373
NCEH1 neutral cholesterol ester hydrolase 1 -0.0272397
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0271149
PRH1 proline-rich protein HaeIII subfamily 1 -0.0268926
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0268751
UTRN utrophin -0.0267755
PGK1 phosphoglycerate kinase 1 -0.0266007
DSCAM Down syndrome cell adhesion molecule -0.0256977
TCF25 transcription factor 25 (basic helix-loop-helix) -0.0254648
BIRC2 baculoviral IAP repeat containing 2 -0.0251924
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.025191
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0247902
TMEM123 transmembrane protein 123 -0.0247366
LRRC49 leucine rich repeat containing 49 -0.0245568
ZBTB44 zinc finger and BTB domain containing 44 -0.0245492
IFIH1 interferon induced with helicase C domain 1 -0.0243437
BPTF bromodomain PHD finger transcription factor -0.024322
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0241308
SH3KBP1 SH3-domain kinase binding protein 1 -0.0238854
TBC1D5 TBC1 domain family, member 5 -0.0236181
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0235708
BRCA1 breast cancer 1, early onset -0.0235433
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0233646
BSG basigin (Ok blood group) -0.0232491
ADGRG6 adhesion G protein-coupled receptor G6 -0.0232341
SLC30A9 solute carrier family 30 (zinc transporter), member 9 -0.0232185
H3-3B H3.3 histone B -0.0229797
IGF2 insulin-like growth factor 2 -0.0229726
TAPBP TAP binding protein (tapasin) -0.0227503
FBXL7 F-box and leucine-rich repeat protein 7 -0.0226341
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0225968
ETV1 ets variant 1 -0.0222708
EFNA5 ephrin-A5 -0.0222499
FLNB filamin B, beta -0.0222191
IL1RAP interleukin 1 receptor accessory protein -0.0221121
DEK DEK proto-oncogene -0.0220026
NDRG1 N-myc downstream regulated 1 -0.0219101
PCLO piccolo presynaptic cytomatrix protein -0.0218315
EPN2 epsin 2 -0.0217339
AVL9 AVL9 homolog (S. cerevisiase) -0.0216747
NALCN sodium leak channel, non selective -0.0216547
FAF2 Fas associated factor family member 2 -0.0214933
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.021468
RIGI RNA sensor RIG-I -0.0213009
FMNL2 formin-like 2 -0.021023
FER fer (fps/fes related) tyrosine kinase -0.02092
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0208992
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0208856
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.020846
SMAD3 SMAD family member 3 -0.0207073
RPL30 ribosomal protein L30 -0.0206499
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0204215
FKBP10 FK506 binding protein 10, 65 kDa -0.0203507
PRELID2 PRELI domain containing 2 -0.0202532
STX8 syntaxin 8 -0.020219
AEBP2 AE binding protein 2 -0.0201953
PDE4D phosphodiesterase 4D, cAMP-specific -0.020116
CLIP1 CAP-GLY domain containing linker protein 1 -0.0201067
FBXL2 F-box and leucine-rich repeat protein 2 -0.0198653
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0198276
RPL6 ribosomal protein L6 -0.0198259
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0198035
PYGL phosphorylase, glycogen, liver -0.0197696
GPC6 glypican 6 -0.0197041