| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lumateperone (tosylate) perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lumateperone (tosylate)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.147047 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.133744 |
| FNDC3B | fibronectin type III domain containing 3B | 0.100444 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0883218 |
| CD44 | CD44 molecule (Indian blood group) | 0.08692 |
| PLAT | plasminogen activator, tissue | 0.0779772 |
| PRELID2 | PRELI domain containing 2 | 0.0643531 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0526306 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0526074 |
| EFNA5 | ephrin-A5 | 0.0522718 |
| POTEF | POTE ankyrin domain family, member F | 0.0501539 |
| STC1 | stanniocalcin 1 | 0.0498792 |
| SEPTIN9 | septin 9 | 0.0497203 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0490089 |
| LOX | lysyl oxidase | 0.0478552 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0450542 |
| ASPH | aspartate beta-hydroxylase | 0.044292 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0442158 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0430707 |
| RUNX1 | runt-related transcription factor 1 | 0.0427721 |
| MB21D2 | Mab-21 domain containing 2 | 0.0427438 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0425791 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0421617 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0420563 |
| UBC | ubiquitin C | 0.0407659 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0378021 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0367975 |
| GLIS3 | GLIS family zinc finger 3 | 0.0367691 |
| HDAC9 | histone deacetylase 9 | 0.0361015 |
| DNMBP | dynamin binding protein | 0.0359045 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0356511 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0356493 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0350696 |
| SMAD3 | SMAD family member 3 | 0.0335906 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0334533 |
| FLNB | filamin B, beta | 0.0333198 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0332896 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0329829 |
| SMYD3 | SET and MYND domain containing 3 | 0.0316304 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0313161 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0310662 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0308913 |
| VEGFC | vascular endothelial growth factor C | 0.0308441 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | 0.0299374 |
| DST | dystonin | 0.0296993 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0293618 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0291456 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0285767 |
| INTS6 | integrator complex subunit 6 | 0.0281733 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | 0.0280761 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0279686 |
| PODXL | podocalyxin-like | 0.0279625 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0268535 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0268415 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0263539 |
| NEK7 | NIMA-related kinase 7 | 0.0262649 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0261889 |
| MT1X | metallothionein 1X | 0.0256452 |
| VMP1 | vacuole membrane protein 1 | 0.0255832 |
| MYOF | myoferlin | 0.0248257 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0247934 |
| C1D | C1D nuclear receptor corepressor | 0.0247515 |
| CDH13 | cadherin 13 | 0.0246056 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0244 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0242911 |
| EZR | ezrin | 0.0238982 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0238974 |
| TRPC1 | transient receptor potential cation channel, subfamily C, member 1 | 0.0238886 |
| SFTPA2 | surfactant protein A2 | 0.0231596 |
| DGKG | diacylglycerol kinase, gamma 90kDa | 0.0229994 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0228987 |
| SQSTM1 | sequestosome 1 | 0.0227265 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0226864 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0221728 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0221579 |
| NOTCH2 | notch 2 | 0.0219299 |
| XKR6 | XK, Kell blood group complex subunit-related family, member 6 | 0.0217759 |
| FAT1 | FAT atypical cadherin 1 | 0.0217079 |
| SVIL | supervillin | 0.0217032 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.021597 |
| MT2A | metallothionein 2A | 0.0215508 |
| ANO6 | anoctamin 6 | 0.0214177 |
| MCL1 | myeloid cell leukemia 1 | 0.021142 |
| KATNAL1 | katanin p60 subunit A-like 1 | 0.0207685 |
| TXNRD1 | thioredoxin reductase 1 | 0.0207495 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0207165 |
| TPM3 | tropomyosin 3 | 0.02062 |
| VCL | vinculin | 0.0206154 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0205456 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0204289 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0203762 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0203493 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0202821 |
| PRKCE | protein kinase C, epsilon | 0.0200544 |
| LNPEP | leucyl/cystinyl aminopeptidase | 0.0198375 |
| ADD1 | adducin 1 (alpha) | 0.0196819 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.0196231 |
| ATXN1 | ataxin 1 | 0.0195715 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0192165 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0191107 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.210535 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.208467 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.187672 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.159655 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.155348 |
| FN1 | fibronectin 1 | -0.117788 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.117074 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.113227 |
| SUCNR1 | succinate receptor 1 | -0.0781472 |
| TPM4 | tropomyosin 4 | -0.0759464 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0745111 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0711569 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0681717 |
| MEIS2 | Meis homeobox 2 | -0.0660011 |
| MAP1B | microtubule-associated protein 1B | -0.0639334 |
| CANX | calnexin | -0.0581824 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0563976 |
| LMNA | lamin A/C | -0.0556944 |
| AHNAK | AHNAK nucleoprotein | -0.054429 |
| COL1A2 | collagen, type I, alpha 2 | -0.0542322 |
| COL5A1 | collagen, type V, alpha 1 | -0.0539048 |
| PTMA | prothymosin, alpha | -0.0514797 |
| MX2 | MX dynamin-like GTPase 2 | -0.0511123 |
| CSTB | cystatin B (stefin B) | -0.0494803 |
| LOXL2 | lysyl oxidase-like 2 | -0.0493015 |
| CD109 | CD109 molecule | -0.0472825 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0465937 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0465677 |
| S100A6 | S100 calcium binding protein A6 | -0.0464763 |
| HLA-B | major histocompatibility complex, class I, B | -0.0454776 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0417684 |
| GOLGA4 | golgin A4 | -0.0416326 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0414349 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0412585 |
| TNS3 | tensin 3 | -0.0411321 |
| MSI2 | musashi RNA-binding protein 2 | -0.0405066 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0403166 |
| HLA-C | major histocompatibility complex, class I, C | -0.0400145 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0399065 |
| CALR | calreticulin | -0.039756 |
| TPM1 | tropomyosin 1 (alpha) | -0.038756 |
| PRSS23 | protease, serine, 23 | -0.0364907 |
| IL7R | interleukin 7 receptor | -0.0354449 |
| COL1A1 | collagen, type I, alpha 1 | -0.0354259 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0328937 |
| CCND1 | cyclin D1 | -0.0325737 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0319548 |
| CAVIN1 | caveolae associated protein 1 | -0.0302607 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0298286 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.0292454 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0280294 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0274237 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.027305 |
| SLFN5 | schlafen family member 5 | -0.0264545 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0262452 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0261353 |
| TMSB4X | thymosin beta 4, X-linked | -0.0259916 |
| FSTL1 | follistatin-like 1 | -0.0256894 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.025646 |
| COL5A2 | collagen, type V, alpha 2 | -0.0255751 |
| TAGLN2 | transgelin 2 | -0.0255145 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | -0.0250522 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0250175 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -0.0250125 |
| FGF13 | fibroblast growth factor 13 | -0.0249174 |
| KRT81 | keratin 81, type II | -0.024777 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0243528 |
| S100A11 | S100 calcium binding protein A11 | -0.0242953 |
| ULK1 | unc-51 like autophagy activating kinase 1 | -0.0239302 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0237551 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0236062 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0233484 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0232562 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0231395 |
| UBXN4 | UBX domain protein 4 | -0.0231217 |
| PGK1 | phosphoglycerate kinase 1 | -0.0229089 |
| TUBB6 | tubulin, beta 6 class V | -0.0226504 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0224817 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0224802 |
| SAR1A | secretion associated, Ras related GTPase 1A | -0.022328 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0222975 |
| FBN1 | fibrillin 1 | -0.0222631 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.022234 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0220703 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0219123 |
| ACTG1 | actin gamma 1 | -0.0219046 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0218581 |
| IGFBP6 | insulin-like growth factor binding protein 6 | -0.0216126 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0215584 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0213116 |
| SYT1 | synaptotagmin I | -0.0208351 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0208149 |
| TUBB | tubulin, beta class I | -0.0203714 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.0202088 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | -0.0201074 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0197071 |
| LRRC17 | leucine rich repeat containing 17 | -0.0196846 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0194202 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.0192896 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0190883 |
