| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lumateperone (tosylate) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lumateperone (tosylate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.083459 |
| HMGA2 | high mobility group AT-hook 2 | 0.0672659 |
| YAP1 | Yes-associated protein 1 | 0.0641896 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0639945 |
| POTEF | POTE ankyrin domain family, member F | 0.0587647 |
| INTS6 | integrator complex subunit 6 | 0.0584736 |
| RRM2 | ribonucleotide reductase M2 | 0.0506802 |
| DST | dystonin | 0.049405 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0467117 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0439499 |
| ADIPOR2 | adiponectin receptor 2 | 0.0436677 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0424111 |
| PCDH9 | protocadherin 9 | 0.0422039 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0418636 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0405496 |
| WWOX | WW domain containing oxidoreductase | 0.0399464 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0397499 |
| PCBP2 | poly(rC) binding protein 2 | 0.0374372 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0372678 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0367051 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0352536 |
| SETD5 | SET domain containing 5 | 0.0349271 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0321286 |
| DENND5A | DENN/MADD domain containing 5A | 0.0316542 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0315338 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0311915 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0309119 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0308014 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0307439 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0304376 |
| BBX | bobby sox homolog (Drosophila) | 0.0303667 |
| ETV6 | ets variant 6 | 0.0303266 |
| PRELID2 | PRELI domain containing 2 | 0.0302474 |
| PCM1 | pericentriolar material 1 | 0.030225 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0299309 |
| TAOK1 | TAO kinase 1 | 0.0289933 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0269103 |
| EHBP1 | EH domain binding protein 1 | 0.0268055 |
| CALR | calreticulin | 0.0267981 |
| PRIM2 | primase, DNA, polypeptide 2 (58kDa) | 0.0265321 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 0.0261784 |
| MMP16 | matrix metallopeptidase 16 (membrane-inserted) | 0.0261278 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0256813 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.025625 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.024573 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0238198 |
| ANK2 | ankyrin 2, neuronal | 0.0237393 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0236861 |
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | 0.0235975 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0235372 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0235132 |
| MMS22L | MMS22-like, DNA repair protein | 0.0232024 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0231981 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 0.0231628 |
| RCOR1 | REST corepressor 1 | 0.0230484 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0228805 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0228405 |
| RUNX1 | runt-related transcription factor 1 | 0.0227397 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0227075 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0226862 |
| NFIB | nuclear factor I/B | 0.0225768 |
| ERBIN | erbb2 interacting protein | 0.0224597 |
| HOMER1 | homer scaffolding protein 1 | 0.0224119 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.022181 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0221562 |
| STAU1 | staufen double-stranded RNA binding protein 1 | 0.0218418 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0217686 |
| AHRR | aryl-hydrocarbon receptor repressor | 0.0216214 |
| FAT1 | FAT atypical cadherin 1 | 0.0215206 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.0209783 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0208069 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0207962 |
| FAM168A | family with sequence similarity 168, member A | 0.0207151 |
| CPNE1 | copine I | 0.0204086 |
| GREB1L | growth regulation by estrogen in breast cancer-like | 0.0204041 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.020302 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.020265 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0202238 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0201906 |
| STAG2 | stromal antigen 2 | 0.0201636 |
| NEK1 | NIMA-related kinase 1 | 0.0199714 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0199511 |
| RNF213 | ring finger protein 213 | 0.0198529 |
| DENND1A | DENN/MADD domain containing 1A | 0.0197721 |
| PHACTR4 | phosphatase and actin regulator 4 | 0.0197628 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0196312 |
| CAMSAP2 | calmodulin regulated spectrin-associated protein family, member 2 | 0.0195067 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.0194936 |
| FHIT | fragile histidine triad | 0.0194107 |
| EXOC4 | exocyst complex component 4 | 0.0193833 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0192556 |
| PRKCE | protein kinase C, epsilon | 0.0191097 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.018952 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0188142 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0187005 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0186085 |
| ANO6 | anoctamin 6 | 0.0185293 |
| EFNA5 | ephrin-A5 | 0.0185238 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0182465 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0182186 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.206339 |
| VIM | vimentin | -0.194199 |
| AREG | amphiregulin | -0.144711 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.137583 |
| TMSB10 | thymosin beta 10 | -0.0959474 |
| MGAT4C | MGAT4 family, member C | -0.090858 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0791873 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0775292 |
| TMEM41B | transmembrane protein 41B | -0.0766582 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0745881 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0643059 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0621965 |
| BCHE | butyrylcholinesterase | -0.0602146 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0602055 |
| TXNRD1 | thioredoxin reductase 1 | -0.0582349 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.056004 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0490307 |
| LMO7 | LIM domain 7 | -0.0476659 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0468737 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0464478 |
| RPL26 | ribosomal protein L26 | -0.0457223 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0447265 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0442131 |
| RPS2 | ribosomal protein S2 | -0.043974 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.043532 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0433316 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0414498 |
| RPL34 | ribosomal protein L34 | -0.0401483 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0399442 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0397722 |
| RPL5 | ribosomal protein L5 | -0.0390962 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.0374704 |
| MATR3 | matrin 3 | -0.0374658 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0374158 |
| WDR43 | WD repeat domain 43 | -0.0370701 |
| RPS24 | ribosomal protein S24 | -0.0366723 |
| CLDN1 | claudin 1 | -0.0361148 |
| RPL35A | ribosomal protein L35a | -0.0357918 |
| TMEM123 | transmembrane protein 123 | -0.0357541 |
| NEK7 | NIMA-related kinase 7 | -0.0354979 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0354078 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0340133 |
| KLF6 | Kruppel-like factor 6 | -0.0338633 |
| RPS8 | ribosomal protein S8 | -0.0336639 |
| KLHL24 | kelch-like family member 24 | -0.0331473 |
| ACTG1 | actin gamma 1 | -0.0329564 |
| RPL4 | ribosomal protein L4 | -0.0328388 |
| RPL37A | ribosomal protein L37a | -0.0326049 |
| TENM3 | teneurin transmembrane protein 3 | -0.0320763 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0319576 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0319452 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0318446 |
| RACK1 | receptor for activated C kinase 1 | -0.0314655 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.031293 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0312066 |
| GASK1B | golgi associated kinase 1B | -0.030961 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0299906 |
| SEC62 | SEC62 homolog (S. cerevisiae) | -0.0297487 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0296239 |
| RPLP1 | ribosomal protein, large, P1 | -0.0292842 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0292198 |
| HLA-A | major histocompatibility complex, class I, A | -0.0291105 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0290082 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.0289403 |
| AHNAK | AHNAK nucleoprotein | -0.0288453 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0288159 |
| RPL11 | ribosomal protein L11 | -0.0286145 |
| SLC25A3 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 | -0.0285979 |
| RPS15 | ribosomal protein S15 | -0.0285268 |
| NCOA6 | nuclear receptor coactivator 6 | -0.028491 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0284729 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0283972 |
| AXIN2 | axin 2 | -0.0283368 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.0283011 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0279425 |
| WDR45B | WD repeat domain 45B | -0.0277432 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0275546 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0274163 |
| RPLP2 | ribosomal protein, large, P2 | -0.0272813 |
| TIGAR | TP53 induced glycolysis regulatory phosphatase | -0.0271634 |
| KIF5B | kinesin family member 5B | -0.0271183 |
| CCND1 | cyclin D1 | -0.0270351 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0269963 |
| GNAS | GNAS complex locus | -0.0269226 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0269012 |
| BTG3 | BTG family, member 3 | -0.0268755 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0268499 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0266535 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0260288 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | -0.0259235 |
| TWSG1 | twisted gastrulation BMP signaling modulator 1 | -0.0257145 |
| RPL37 | ribosomal protein L37 | -0.0254195 |
| RPS21 | ribosomal protein S21 | -0.0252624 |
| ZFR | zinc finger RNA binding protein | -0.0251949 |
| RHOA | ras homolog family member A | -0.0251631 |
| NLN | neurolysin (metallopeptidase M3 family) | -0.0251042 |
| YBX1 | Y box binding protein 1 | -0.0249769 |
| FUS | FUS RNA binding protein | -0.0247 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0246259 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0244044 |
