Lumateperone (tosylate)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lumateperone (tosylate) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lumateperone (tosylate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.163998
ASPH aspartate beta-hydroxylase 0.162049
CXCL8 chemokine (C-X-C motif) ligand 8 0.135024
SOD2 superoxide dismutase 2, mitochondrial 0.101498
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.100903
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0798151
RNF213 ring finger protein 213 0.0783713
CCL2 chemokine (C-C motif) ligand 2 0.0734265
VCAM1 vascular cell adhesion molecule 1 0.0717825
ZFP36L1 ZFP36 ring finger protein-like 1 0.0702337
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0670998
CA12 carbonic anhydrase XII 0.0616293
CSF1 colony stimulating factor 1 (macrophage) 0.0616193
ADAM9 ADAM metallopeptidase domain 9 0.058784
TRIO trio Rho guanine nucleotide exchange factor 0.058137
IGFBP3 insulin-like growth factor binding protein 3 0.0568218
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0559967
MYOF myoferlin 0.0524526
ICAM1 intercellular adhesion molecule 1 0.0467336
GLIS3 GLIS family zinc finger 3 0.0465808
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.04432
EPS8 epidermal growth factor receptor pathway substrate 8 0.0440938
RIGI RNA sensor RIG-I 0.0440913
IFI44L interferon-induced protein 44-like 0.0435605
TSHZ2 teashirt zinc finger homeobox 2 0.0432145
ADAM10 ADAM metallopeptidase domain 10 0.0431219
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0430321
RAD23B RAD23 homolog B (S. cerevisiae) 0.0424039
CANX calnexin 0.0423573
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0414785
PBX1 pre-B-cell leukemia homeobox 1 0.0412068
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0407171
PDIA4 protein disulfide isomerase family A, member 4 0.040574
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0403661
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.04018
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0400577
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0387738
TKT transketolase 0.038409
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0381294
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0379663
ITGAV integrin, alpha V 0.0371338
APOL1 apolipoprotein L, 1 0.0367243
BIRC3 baculoviral IAP repeat containing 3 0.036557
FMNL2 formin-like 2 0.0363815
NDRG1 N-myc downstream regulated 1 0.036052
CTBP2 C-terminal binding protein 2 0.0341336
OSBPL3 oxysterol binding protein-like 3 0.0335282
COL4A1 collagen, type IV, alpha 1 0.0333983
COPA coatomer protein complex, subunit alpha 0.0321935
MX1 MX dynamin-like GTPase 1 0.0316134
GDF15 growth differentiation factor 15 0.0312164
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0312114
UBC ubiquitin C 0.0310559
FAM13A family with sequence similarity 13, member A 0.0310388
IRF1 interferon regulatory factor 1 0.0308401
PCBP2 poly(rC) binding protein 2 0.0307034
SP100 SP100 nuclear antigen 0.0298692
GLS2 glutaminase 2 (liver, mitochondrial) 0.0297293
CXXC1 CXXC finger protein 1 0.0292221
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.029086
FBXO32 F-box protein 32 0.0285424
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0284913
FNDC3B fibronectin type III domain containing 3B 0.0283041
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0273586
CXCL3 chemokine (C-X-C motif) ligand 3 0.0272987
HDAC9 histone deacetylase 9 0.0272781
SPATS2L spermatogenesis associated, serine-rich 2-like 0.026226
ANKRD10 ankyrin repeat domain 10 0.0261331
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0257893
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0256088
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0255206
SCARB2 scavenger receptor class B, member 2 0.0252375
CALR calreticulin 0.0251257
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0250867
MARCHF6 membrane associated ring-CH-type finger 6 0.024893
ECT2 epithelial cell transforming 2 0.0248707
UBE2H ubiquitin-conjugating enzyme E2H 0.024594
MBNL2 muscleblind-like splicing regulator 2 0.0244804
PAX8 paired box 8 0.0243349
TMEM123 transmembrane protein 123 0.0242858
ADAM17 ADAM metallopeptidase domain 17 0.0242436
ESYT2 extended synaptotagmin-like protein 2 0.0242429
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0242136
DPYSL3 dihydropyrimidinase-like 3 0.0241828
NFE2L1 nuclear factor, erythroid 2-like 1 0.0236688
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0236058
HBP1 HMG-box transcription factor 1 0.0233673
ANXA2 annexin A2 0.0232359
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0231521
PFN1 profilin 1 0.0231247
UGDH UDP-glucose 6-dehydrogenase 0.0230815
USP3 ubiquitin specific peptidase 3 0.0230017
BNC2 basonuclin 2 0.0226313
MLEC malectin 0.0226095
PDIA6 protein disulfide isomerase family A, member 6 0.0225546
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0224903
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0224371
ARHGAP26 Rho GTPase activating protein 26 0.0222116
INSIG1 insulin induced gene 1 0.0220869
FNIP2 folliculin interacting protein 2 0.0220393

decreased expression

Symbol Name Standardized Value
RPS2 ribosomal protein S2 -0.10954
MT2A metallothionein 2A -0.10426
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0830197
CENPF centromere protein F, 350/400kDa -0.0760074
TMSB10 thymosin beta 10 -0.0753463
NAMPT nicotinamide phosphoribosyltransferase -0.0703267
RPS6 ribosomal protein S6 -0.0636735
RPL37A ribosomal protein L37a -0.0601727
CD44 CD44 molecule (Indian blood group) -0.0580296
RAI14 retinoic acid induced 14 -0.054401
RPL26 ribosomal protein L26 -0.0539542
FRMD4A FERM domain containing 4A -0.0516215
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0511393
GCC2 GRIP and coiled-coil domain containing 2 -0.0501004
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.049636
VIM vimentin -0.0487235
PRRC2C proline-rich coiled-coil 2C -0.0481689
CDCP1 CUB domain containing protein 1 -0.0472275
PTMA prothymosin, alpha -0.0471961
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0470845
AKAP9 A kinase (PRKA) anchor protein 9 -0.0468418
RPS8 ribosomal protein S8 -0.0463794
RPL7 ribosomal protein L7 -0.0461209
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0458144
LOXL2 lysyl oxidase-like 2 -0.0433439
CLTC clathrin, heavy chain (Hc) -0.0427969
MTDH metadherin -0.0425791
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.042428
FAM107B family with sequence similarity 107, member B -0.0420187
RPS13 ribosomal protein S13 -0.0416768
TXNRD1 thioredoxin reductase 1 -0.0406793
EIF1 eukaryotic translation initiation factor 1 -0.0406015
RPL38 ribosomal protein L38 -0.0403388
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0397343
RPL19 ribosomal protein L19 -0.039091
NUP214 nucleoporin 214kDa -0.0390478
GOLT1B golgi transport 1B -0.0389013
RPL9 ribosomal protein L9 -0.0379191
VCL vinculin -0.037656
RPL31 ribosomal protein L31 -0.0374305
RPS19 ribosomal protein S19 -0.0366572
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0363393
RPS27A ribosomal protein S27a -0.0360748
NLGN1 neuroligin 1 -0.0355347
CENPE centromere protein E, 312kDa -0.0354917
RRBP1 ribosome binding protein 1 -0.0354832
NAV2 neuron navigator 2 -0.0352799
CEP350 centrosomal protein 350kDa -0.0348411
RPS17 ribosomal protein S17 -0.0342809
ANKRD17 ankyrin repeat domain 17 -0.0340352
MKI67 marker of proliferation Ki-67 -0.0338919
USP47 ubiquitin specific peptidase 47 -0.0337132
GOLGA4 golgin A4 -0.0334663
CALD1 caldesmon 1 -0.0333137
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0331201
RPLP2 ribosomal protein, large, P2 -0.0325812
RPLP1 ribosomal protein, large, P1 -0.0324553
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0321044
ALCAM activated leukocyte cell adhesion molecule -0.0318906
SUB1 SUB1 homolog (S. cerevisiae) -0.0310007
RPL34 ribosomal protein L34 -0.0309394
RPL5 ribosomal protein L5 -0.0306071
TUBB4B tubulin, beta 4B class IVb -0.0305273
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0305183
PRDX1 peroxiredoxin 1 -0.0297994
LMNA lamin A/C -0.029153
TPT1 tumor protein, translationally-controlled 1 -0.0291441
LIMA1 LIM domain and actin binding 1 -0.0289417
NACA nascent polypeptide-associated complex alpha subunit -0.0287506
SAA2 serum amyloid A2 -0.0287352
WDR43 WD repeat domain 43 -0.0286967
RPS24 ribosomal protein S24 -0.0286508
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0285555
MON2 MON2 homolog (S. cerevisiae) -0.0284381
VCAN versican -0.0284305
RPS12 ribosomal protein S12 -0.0283884
SET SET nuclear proto-oncogene -0.0283642
NUP98 nucleoporin 98kDa -0.0282684
UBXN4 UBX domain protein 4 -0.0280301
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0277065
TUSC3 tumor suppressor candidate 3 -0.0274044
HM13 histocompatibility (minor) 13 -0.0273906
RB1CC1 RB1-inducible coiled-coil 1 -0.0271521
ANKHD1 ankyrin repeat and KH domain containing 1 -0.027128
SCFD2 sec1 family domain containing 2 -0.0269175
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0268508
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0265136
TMEM165 transmembrane protein 165 -0.0262422
DSTN destrin (actin depolymerizing factor) -0.0261563
SRGN serglycin -0.0260555
MAP1B microtubule-associated protein 1B -0.0259588
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.025877
ACTG1 actin gamma 1 -0.0258186
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0255896
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0251703
B2M beta-2-microglobulin -0.0250719
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0249251
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0249151
ZNF706 zinc finger protein 706 -0.0247338
TBCA tubulin folding cofactor A -0.0244225