| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lumateperone (tosylate) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lumateperone (tosylate)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.166136 |
| KYNU | kynureninase | 0.112727 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.107045 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.103332 |
| EXT1 | exostosin glycosyltransferase 1 | 0.100653 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0918215 |
| ANXA2 | annexin A2 | 0.0842777 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0828702 |
| SMAD3 | SMAD family member 3 | 0.0820359 |
| STC1 | stanniocalcin 1 | 0.0749013 |
| ASPH | aspartate beta-hydroxylase | 0.0692102 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0682831 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0681255 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0654604 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0632514 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0590198 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0576147 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0561381 |
| ACTG1 | actin gamma 1 | 0.0560245 |
| PDE10A | phosphodiesterase 10A | 0.054938 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0528709 |
| SP100 | SP100 nuclear antigen | 0.048921 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.047006 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0459704 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0445076 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0431318 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0427933 |
| DOCK5 | dedicator of cytokinesis 5 | 0.042708 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0424262 |
| RHCG | Rh family, C glycoprotein | 0.0404923 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0394808 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0394806 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0394577 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0392079 |
| RIGI | RNA sensor RIG-I | 0.0388859 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0387049 |
| KANK1 | KN motif and ankyrin repeat domains 1 | 0.0377974 |
| RNF213 | ring finger protein 213 | 0.0368773 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0356747 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0352831 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0352766 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0348272 |
| PRKCE | protein kinase C, epsilon | 0.0344977 |
| MYO1E | myosin IE | 0.0340146 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.033188 |
| ST6GAL2 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 | 0.0331848 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.032731 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0322921 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0320746 |
| BMP6 | bone morphogenetic protein 6 | 0.0319355 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0317504 |
| DST | dystonin | 0.0315775 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0310337 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0308909 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0307645 |
| PRELID2 | PRELI domain containing 2 | 0.0305013 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0304704 |
| ANXA1 | annexin A1 | 0.0304526 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0300396 |
| DUSP16 | dual specificity phosphatase 16 | 0.0299349 |
| AHNAK | AHNAK nucleoprotein | 0.0299235 |
| VMP1 | vacuole membrane protein 1 | 0.0298737 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0298612 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0297917 |
| SQSTM1 | sequestosome 1 | 0.0296017 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0294919 |
| TDRD7 | tudor domain containing 7 | 0.0287175 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.0284678 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0283509 |
| RND3 | Rho family GTPase 3 | 0.0282483 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0281767 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0272808 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0272615 |
| WWOX | WW domain containing oxidoreductase | 0.0270202 |
| VCL | vinculin | 0.0268935 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0266321 |
| UBC | ubiquitin C | 0.0262156 |
| RAB10 | RAB10, member RAS oncogene family | 0.025672 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0255941 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0253531 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0253396 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0253322 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.025245 |
| DSPP | dentin sialophosphoprotein | 0.0251792 |
| ADM | adrenomedullin | 0.0243307 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0243155 |
| PDLIM5 | PDZ and LIM domain 5 | 0.024259 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0240136 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0239607 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | 0.0238416 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0233854 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0227216 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0222522 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.021901 |
| EXOC4 | exocyst complex component 4 | 0.0218688 |
| PGK1 | phosphoglycerate kinase 1 | 0.021743 |
| RSPO3 | R-spondin 3 | 0.0216452 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0215938 |
| LMO7 | LIM domain 7 | 0.0215038 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0215011 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0686658 |
| MT2A | metallothionein 2A | -0.0625762 |
| NDRG1 | N-myc downstream regulated 1 | -0.0538034 |
| MAP1B | microtubule-associated protein 1B | -0.0514376 |
| MT1X | metallothionein 1X | -0.0507334 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0478776 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0458042 |
| LAMA5 | laminin, alpha 5 | -0.0419096 |
| USP3 | ubiquitin specific peptidase 3 | -0.0413704 |
| NBAS | neuroblastoma amplified sequence | -0.0411155 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0407464 |
| SBF2 | SET binding factor 2 | -0.0407325 |
| GOLGA4 | golgin A4 | -0.0401079 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0384544 |
| FLNB | filamin B, beta | -0.0383816 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0361082 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0341019 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0330446 |
| RPS19 | ribosomal protein S19 | -0.03297 |
| EGFR | epidermal growth factor receptor | -0.0328077 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0325581 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0321698 |
| HELZ | helicase with zinc finger | -0.0310923 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0310047 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0300869 |
| WDR43 | WD repeat domain 43 | -0.0294321 |
| TNS3 | tensin 3 | -0.0293502 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0283985 |
| RASA2 | RAS p21 protein activator 2 | -0.0280904 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0279394 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.027787 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0277485 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0272512 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0257495 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0257131 |
| WASF2 | WAS protein family, member 2 | -0.0249316 |
| HMGA1 | high mobility group AT-hook 1 | -0.0240491 |
| MYADM | myeloid-associated differentiation marker | -0.023649 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.023584 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0235516 |
| PFN1 | profilin 1 | -0.0232543 |
| AGRN | agrin | -0.0231735 |
| DENND4A | DENN/MADD domain containing 4A | -0.022757 |
| CD44 | CD44 molecule (Indian blood group) | -0.0227535 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0225963 |
| CTBP2 | C-terminal binding protein 2 | -0.0222874 |
| ZNF292 | zinc finger protein 292 | -0.0221666 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0219439 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | -0.0218426 |
| ITSN2 | intersectin 2 | -0.0218172 |
| LAMC2 | laminin, gamma 2 | -0.0214627 |
| SUCO | SUN domain containing ossification factor | -0.0213694 |
| SPAG9 | sperm associated antigen 9 | -0.0211367 |
| MEF2A | myocyte enhancer factor 2A | -0.0210058 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0207462 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0206302 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0206262 |
| KLC1 | kinesin light chain 1 | -0.0205223 |
| NAV2 | neuron navigator 2 | -0.0204412 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | -0.020308 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0202621 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0202078 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0201115 |
| LTBP4 | latent transforming growth factor beta binding protein 4 | -0.0199782 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.019966 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0194447 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0194163 |
| AXL | AXL receptor tyrosine kinase | -0.0192305 |
| EP400 | E1A binding protein p400 | -0.0190997 |
| NUP214 | nucleoporin 214kDa | -0.0190356 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.0189916 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0188717 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | -0.018807 |
| COG5 | component of oligomeric golgi complex 5 | -0.0187341 |
| RIN2 | Ras and Rab interactor 2 | -0.0187169 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0186373 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0186319 |
| ANXA4 | annexin A4 | -0.018574 |
| NUP58 | nucleoporin 58 | -0.0185643 |
| EGR1 | early growth response 1 | -0.0183984 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.018359 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | -0.0182607 |
| URI1 | URI1, prefoldin-like chaperone | -0.0181931 |
| MTCL1 | microtubule crosslinking factor 1 | -0.018101 |
| ERLEC1 | endoplasmic reticulum lectin 1 | -0.0180477 |
| BTBD10 | BTB (POZ) domain containing 10 | -0.0179863 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.017836 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.0178288 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0175704 |
| TJP1 | tight junction protein 1 | -0.017396 |
| CLINT1 | clathrin interactor 1 | -0.0173554 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0173455 |
| POM121C | POM121 transmembrane nucleoporin C | -0.0172009 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | -0.0170153 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0170087 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0169622 |
| COPA | coatomer protein complex, subunit alpha | -0.0169031 |
| MAP2K4 | mitogen-activated protein kinase kinase 4 | -0.016878 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.016688 |
| RTN4 | reticulon 4 | -0.0166708 |
