Lumateperone (tosylate)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lumateperone (tosylate) perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lumateperone (tosylate)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.167951
FGFR1 fibroblast growth factor receptor 1 0.0693389
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0677769
USP9X ubiquitin specific peptidase 9, X-linked 0.0628721
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0547397
ZNF608 zinc finger protein 608 0.0451746
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0437643
TOP2B topoisomerase (DNA) II beta 180kDa 0.0424799
RPL3 ribosomal protein L3 0.0417742
PDE10A phosphodiesterase 10A 0.0416316
PRELID2 PRELI domain containing 2 0.041263
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0409704
TMSB4X thymosin beta 4, X-linked 0.0401341
FTH1 ferritin, heavy polypeptide 1 0.039716
OGA O-GlcNAcase 0.0358862
EIF4H eukaryotic translation initiation factor 4H 0.035515
HSPA8 heat shock 70kDa protein 8 0.0322495
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0318051
QKI QKI, KH domain containing, RNA binding 0.0311756
CCNG2 cyclin G2 0.0309771
BTBD3 BTB (POZ) domain containing 3 0.0295828
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0291586
ARHGAP21 Rho GTPase activating protein 21 0.0291327
PDE4B phosphodiesterase 4B, cAMP-specific 0.0286632
ZFAND3 zinc finger, AN1-type domain 3 0.0285068
RPS18 ribosomal protein S18 0.0282695
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0272897
SPTBN1 spectrin, beta, non-erythrocytic 1 0.02484
HMGB2 high mobility group box 2 0.0247245
HOXA3 homeobox A3 0.0245133
SOD2 superoxide dismutase 2, mitochondrial 0.0244774
PHF3 PHD finger protein 3 0.0242747
FGFR2 fibroblast growth factor receptor 2 0.0241004
ANO6 anoctamin 6 0.0229964
BOC BOC cell adhesion associated, oncogene regulated 0.0227978
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0225669
BCOR BCL6 corepressor 0.0224261
SFTPA2 surfactant protein A2 0.021642
KANK1 KN motif and ankyrin repeat domains 1 0.0215328
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0209769
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0207488
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0207377
GSK3B glycogen synthase kinase 3 beta 0.0200426
PANK3 pantothenate kinase 3 0.0198764
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0198122
ARHGAP5 Rho GTPase activating protein 5 0.0197621
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0197559
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.0195215
SCAF8 SR-related CTD-associated factor 8 0.0192163
MACF1 microtubule-actin crosslinking factor 1 0.0185879
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0185466
DBN1 drebrin 1 0.0183834
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0183726
GSE1 Gse1 coiled-coil protein 0.0183522
SERINC1 serine incorporator 1 0.0182822
MYH9 myosin, heavy chain 9, non-muscle 0.0182579
RAB14 RAB14, member RAS oncogene family 0.018256
PCDH7 protocadherin 7 0.01815
LARS1 leucyl-tRNA synthetase 1 0.018039
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0179732
FAM120B family with sequence similarity 120B 0.0179348
LOC112694756 uncharaterized LOC112694756 0.0176576
PAPOLA poly(A) polymerase alpha 0.0175858
KDM3A lysine (K)-specific demethylase 3A 0.0175477
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0174827
EIF4B eukaryotic translation initiation factor 4B 0.0173585
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0172164
ZNF678 zinc finger protein 678 0.017215
PCNX1 pecanex 1 0.0171785
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0170934
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0170154
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0169178
ADGRA3 adhesion G protein-coupled receptor A3 0.0168997
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 0.0168285
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0167705
PHF21A PHD finger protein 21A 0.016483
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0163911
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0162705
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0160739
YTHDC1 YTH domain containing 1 0.015982
NGLY1 N-glycanase 1 0.0159094
ENAH enabled homolog (Drosophila) 0.0158589
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 0.0157841
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.015779
ARRDC3 arrestin domain containing 3 0.0157025
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0156669
VWA8 von Willebrand factor A domain containing 8 0.0156368
TNIP1 TNFAIP3 interacting protein 1 0.0156275
RPS2 ribosomal protein S2 0.0155744
CCDC6 coiled-coil domain containing 6 0.015491
TIAM2 T-cell lymphoma invasion and metastasis 2 0.0154798
CKAP5 cytoskeleton associated protein 5 0.0154271
TXNRD1 thioredoxin reductase 1 0.0154079
KIF11 kinesin family member 11 0.0153725
MDN1 MDN1, midasin homolog (yeast) 0.0153721
RPS7 ribosomal protein S7 0.0153355
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.015308
KDM6A lysine (K)-specific demethylase 6A 0.0152916
ARL15 ADP-ribosylation factor-like 15 0.0152708
SOX6 SRY (sex determining region Y)-box 6 0.0152668

decreased expression

Symbol Name Standardized Value
CADM2 cell adhesion molecule 2 -0.180133
VIM vimentin -0.16579
PTMA prothymosin, alpha -0.148774
MGP matrix Gla protein -0.141975
PRKG1 protein kinase, cGMP-dependent, type I -0.133503
RPS6 ribosomal protein S6 -0.106629
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.100494
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0881223
TMSB10 thymosin beta 10 -0.0868015
RPL34 ribosomal protein L34 -0.0726673
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0700029
RPS8 ribosomal protein S8 -0.0683325
RPS23 ribosomal protein S23 -0.0679126
RPLP2 ribosomal protein, large, P2 -0.0634471
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0629848
RPLP1 ribosomal protein, large, P1 -0.0628836
HMGA1 high mobility group AT-hook 1 -0.0606155
ACTG1 actin gamma 1 -0.0593664
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0584123
PEG10 paternally expressed 10 -0.0569249
RPL35A ribosomal protein L35a -0.0554784
RPS19 ribosomal protein S19 -0.0552803
RPL31 ribosomal protein L31 -0.0546158
SOX4 SRY (sex determining region Y)-box 4 -0.0544401
RPS11 ribosomal protein S11 -0.0519505
CENPF centromere protein F, 350/400kDa -0.0512169
RPS10 ribosomal protein S10 -0.0495998
HMGB1 high mobility group box 1 -0.0489509
S100A9 S100 calcium binding protein A9 -0.0482985
FTL ferritin, light polypeptide -0.047876
RPS14 ribosomal protein S14 -0.0478328
RPL23 ribosomal protein L23 -0.0475582
RPS21 ribosomal protein S21 -0.0459065
RBM25 RNA binding motif protein 25 -0.0454357
RPS13 ribosomal protein S13 -0.0440899
RPL8 ribosomal protein L8 -0.0438275
RPS25 ribosomal protein S25 -0.0438188
TPT1 tumor protein, translationally-controlled 1 -0.0435461
DLG1 discs, large homolog 1 (Drosophila) -0.0426056
RPL37A ribosomal protein L37a -0.0423561
CALD1 caldesmon 1 -0.0417585
RPS24 ribosomal protein S24 -0.0417328
MT2A metallothionein 2A -0.0406604
COL1A2 collagen, type I, alpha 2 -0.0392486
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0390451
DEK DEK proto-oncogene -0.0390239
CBX3 chromobox homolog 3 -0.0367138
RPL28 ribosomal protein L28 -0.0367074
KTN1 kinectin 1 (kinesin receptor) -0.0363719
RPS29 ribosomal protein S29 -0.0359688
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0355586
PFN1 profilin 1 -0.0355514
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0340915
RPS5 ribosomal protein S5 -0.0336048
KPNB1 karyopherin (importin) beta 1 -0.0332936
PDIA3 protein disulfide isomerase family A, member 3 -0.0332113
RPS15 ribosomal protein S15 -0.0322796
SBF2 SET binding factor 2 -0.0320521
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0319795
MAML2 mastermind-like 2 (Drosophila) -0.0317796
IGF2 insulin-like growth factor 2 -0.0317264
RPL18 ribosomal protein L18 -0.031426
PRRC2C proline-rich coiled-coil 2C -0.0307336
HSPB1 heat shock 27kDa protein 1 -0.0306449
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0306195
YBX1 Y box binding protein 1 -0.0300875
RPL5 ribosomal protein L5 -0.0300713
MED13L mediator complex subunit 13-like -0.0300351
NFIB nuclear factor I/B -0.0300114
RAB7A RAB7A, member RAS oncogene family -0.0298559
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0298554
DIAPH3 diaphanous-related formin 3 -0.0297328
MEIS2 Meis homeobox 2 -0.0292518
RPS17 ribosomal protein S17 -0.0290995
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0290834
BRD4 bromodomain containing 4 -0.0287963
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 -0.0282503
LOC102724023 ES1 protein homolog, mitochondrial -0.028088
MEST mesoderm specific transcript -0.0278314
PNISR PNN-interacting serine/arginine-rich protein -0.0277938
RPL32 ribosomal protein L32 -0.0274368
NDUFA4 NDUFA4, mitochondrial complex associated -0.0274321
RPL19 ribosomal protein L19 -0.0273735
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0272422
TTC3 tetratricopeptide repeat domain 3 -0.0262939
RPL11 ribosomal protein L11 -0.0257175
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0256427
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0252957
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.0251964
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -0.0251624
RPL9 ribosomal protein L9 -0.025143
EGR1 early growth response 1 -0.0250424
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0250127
NOP58 NOP58 ribonucleoprotein -0.0249956
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0249279
SLC38A2 solute carrier family 38, member 2 -0.0249081
RPS3 ribosomal protein S3 -0.0248538
RPL12 ribosomal protein L12 -0.0248098
RPS16 ribosomal protein S16 -0.024361
BSG basigin (Ok blood group) -0.0242918