| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lumateperone (tosylate) perturbation in AsPC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lumateperone (tosylate)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.188935 |
| ASPH | aspartate beta-hydroxylase | 0.0876291 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0719647 |
| EZR | ezrin | 0.0614733 |
| AHNAK | AHNAK nucleoprotein | 0.0549217 |
| SMAD3 | SMAD family member 3 | 0.0548604 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0515114 |
| EFNA5 | ephrin-A5 | 0.0511597 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0485816 |
| ITGA6 | integrin, alpha 6 | 0.0484848 |
| DSPP | dentin sialophosphoprotein | 0.0439391 |
| EGFR | epidermal growth factor receptor | 0.0433801 |
| OGA | O-GlcNAcase | 0.0433036 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0423326 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0400468 |
| LAMC2 | laminin, gamma 2 | 0.039488 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0375307 |
| MYOF | myoferlin | 0.0374296 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0350388 |
| DST | dystonin | 0.0350272 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0345494 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0344956 |
| LAMA4 | laminin, alpha 4 | 0.0335844 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0327744 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0326718 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0313008 |
| SDC4 | syndecan 4 | 0.0311466 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0308286 |
| CORO1C | coronin, actin binding protein, 1C | 0.0302457 |
| VCL | vinculin | 0.0294689 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0284185 |
| KLF6 | Kruppel-like factor 6 | 0.0277079 |
| DNTTIP1 | deoxynucleotidyltransferase, terminal, interacting protein 1 | 0.0275031 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0271371 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0264019 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0263253 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.025876 |
| KIF5B | kinesin family member 5B | 0.0251857 |
| CD9 | CD9 molecule | 0.025155 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0245481 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0241157 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0240256 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0238812 |
| BCL2L1 | BCL2-like 1 | 0.0237598 |
| SERINC1 | serine incorporator 1 | 0.0235317 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0230426 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.02298 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0227478 |
| SERINC3 | serine incorporator 3 | 0.0226393 |
| PRELID2 | PRELI domain containing 2 | 0.0225244 |
| ANLN | anillin, actin binding protein | 0.022446 |
| PLEC | plectin | 0.0223348 |
| RAD21 | RAD21 homolog (S. pombe) | 0.02211 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.021677 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0214341 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0213069 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.021154 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0207355 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0206826 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0205149 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0204478 |
| GNE | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | 0.0204317 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0201721 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0200924 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0200475 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | 0.0200192 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.019469 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0193848 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0193395 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0192283 |
| ANXA11 | annexin A11 | 0.019222 |
| EPCAM | epithelial cell adhesion molecule | 0.0190197 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | 0.0188157 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0187521 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0186903 |
| RALB | v-ral simian leukemia viral oncogene homolog B | 0.0186289 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0186267 |
| CAB39 | calcium binding protein 39 | 0.0185962 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0185382 |
| APP | amyloid beta (A4) precursor protein | 0.018451 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0184452 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.018442 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.018351 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0182362 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0181613 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0179799 |
| ATP9A | ATPase, class II, type 9A | 0.0178959 |
| PON2 | paraoxonase 2 | 0.0178895 |
| MKI67 | marker of proliferation Ki-67 | 0.0178493 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0178469 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0178253 |
| SLTM | SAFB-like, transcription modulator | 0.0177527 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0176232 |
| ANO6 | anoctamin 6 | 0.0174529 |
| HMGB2 | high mobility group box 2 | 0.0174264 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0173479 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.0171313 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0169863 |
| EMP1 | epithelial membrane protein 1 | 0.0169778 |
| FAT1 | FAT atypical cadherin 1 | 0.0169384 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | -0.21855 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.177722 |
| NDRG1 | N-myc downstream regulated 1 | -0.150427 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.143772 |
| HMGA1 | high mobility group AT-hook 1 | -0.137443 |
| TMSB10 | thymosin beta 10 | -0.122027 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.121663 |
| EGR1 | early growth response 1 | -0.118868 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.118459 |
| MUC17 | mucin 17, cell surface associated | -0.109842 |
| KLK10 | kallikrein-related peptidase 10 | -0.100296 |
| MXD1 | MAX dimerization protein 1 | -0.0964346 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0892983 |
| RIOK3 | RIO kinase 3 | -0.0818675 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.0814664 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0788463 |
| LMTK2 | lemur tyrosine kinase 2 | -0.0787314 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0763831 |
| FTL | ferritin, light polypeptide | -0.0740262 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0690219 |
| SMC3 | structural maintenance of chromosomes 3 | -0.0675708 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0668205 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0656487 |
| FOSL1 | FOS-like antigen 1 | -0.0654105 |
| TXNIP | thioredoxin interacting protein | -0.0637739 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0632288 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0618471 |
| PARD3 | par-3 family cell polarity regulator | -0.0599721 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0594893 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0574847 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0558846 |
| UBC | ubiquitin C | -0.0557189 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0549875 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0548106 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0546848 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0517378 |
| LAMB3 | laminin, beta 3 | -0.050353 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0503203 |
| RPL35A | ribosomal protein L35a | -0.0502909 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0499927 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.047435 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0469664 |
| CLMP | CXADR-like membrane protein | -0.0462177 |
| ARPC1A | actin related protein 2/3 complex, subunit 1A, 41kDa | -0.0444927 |
| B2M | beta-2-microglobulin | -0.0442438 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.044242 |
| UPP1 | uridine phosphorylase 1 | -0.0440629 |
| RPL8 | ribosomal protein L8 | -0.0415218 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0406496 |
| GNAS | GNAS complex locus | -0.0403108 |
| SKAP2 | src kinase associated phosphoprotein 2 | -0.0402465 |
| FA2H | fatty acid 2-hydroxylase | -0.039875 |
| PNPLA8 | patatin-like phospholipase domain containing 8 | -0.0385761 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0365013 |
| FAM107B | family with sequence similarity 107, member B | -0.0363995 |
| FAM3C | family with sequence similarity 3, member C | -0.0363 |
| NOP58 | NOP58 ribonucleoprotein | -0.0360963 |
| RPS21 | ribosomal protein S21 | -0.0353497 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0352892 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0352872 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0352816 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0352419 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0349766 |
| RPS11 | ribosomal protein S11 | -0.0348025 |
| CALU | calumenin | -0.0347555 |
| SEC24A | SEC24 family member A | -0.0346427 |
| PKM | pyruvate kinase, muscle | -0.0342417 |
| MCL1 | myeloid cell leukemia 1 | -0.0342104 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0341492 |
| HM13 | histocompatibility (minor) 13 | -0.0339414 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0336553 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0334678 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0333726 |
| TRRAP | transformation/transcription domain-associated protein | -0.0333598 |
| SP100 | SP100 nuclear antigen | -0.0331673 |
| RPS2 | ribosomal protein S2 | -0.0327368 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0326124 |
| RPLP1 | ribosomal protein, large, P1 | -0.0325562 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0323685 |
| RAB2A | RAB2A, member RAS oncogene family | -0.032239 |
| ARF4 | ADP-ribosylation factor 4 | -0.0320666 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0320432 |
| RPL30 | ribosomal protein L30 | -0.03203 |
| MORF4L2 | mortality factor 4 like 2 | -0.0318065 |
| RPS13 | ribosomal protein S13 | -0.0316467 |
| RPS14 | ribosomal protein S14 | -0.0313806 |
| GOLGA4 | golgin A4 | -0.0312161 |
| FBXO11 | F-box protein 11 | -0.0310377 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.030798 |
| RPS8 | ribosomal protein S8 | -0.0305117 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0302368 |
| ZNF207 | zinc finger protein 207 | -0.0301741 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | -0.0295698 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0294631 |
| RBM39 | RNA binding motif protein 39 | -0.0294548 |
| WASF2 | WAS protein family, member 2 | -0.029399 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0291699 |
| S100A11 | S100 calcium binding protein A11 | -0.0289907 |
| SRP54 | signal recognition particle 54kDa | -0.028961 |
| SPAG9 | sperm associated antigen 9 | -0.0288331 |
