| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lumateperone (tosylate) perturbation in C32 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lumateperone (tosylate)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.105945 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0934222 |
| FMNL2 | formin-like 2 | 0.0808573 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0742541 |
| DST | dystonin | 0.073549 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0729154 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0726493 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0696133 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0638406 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0614106 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.057173 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0564089 |
| CD109 | CD109 molecule | 0.0530156 |
| MACROD2 | MACRO domain containing 2 | 0.0521808 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0516732 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.05011 |
| ANXA2 | annexin A2 | 0.0491951 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.049181 |
| COPA | coatomer protein complex, subunit alpha | 0.0472905 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0472107 |
| VCL | vinculin | 0.0470699 |
| ASPH | aspartate beta-hydroxylase | 0.0461777 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0459191 |
| INSIG1 | insulin induced gene 1 | 0.045748 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0441717 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0434081 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0420368 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0408762 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0407007 |
| SFTPA2 | surfactant protein A2 | 0.0406724 |
| LDHA | lactate dehydrogenase A | 0.0401139 |
| MYOF | myoferlin | 0.0399825 |
| VIM | vimentin | 0.0399798 |
| JUN | jun proto-oncogene | 0.0390555 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0389779 |
| TLE4 | transducin-like enhancer of split 4 | 0.0387674 |
| ZYX | zyxin | 0.0383018 |
| ENO1 | enolase 1, (alpha) | 0.0380302 |
| HBP1 | HMG-box transcription factor 1 | 0.0371503 |
| PHF21A | PHD finger protein 21A | 0.0371005 |
| CDC73 | cell division cycle 73 | 0.036913 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0358933 |
| PGK1 | phosphoglycerate kinase 1 | 0.0357562 |
| CADM1 | cell adhesion molecule 1 | 0.0353942 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | 0.0353912 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0347496 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0347397 |
| PRKD1 | protein kinase D1 | 0.0345381 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0343143 |
| CTTNBP2 | cortactin binding protein 2 | 0.0340914 |
| RLF | rearranged L-myc fusion | 0.0338524 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0333759 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0332692 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0328535 |
| CALR | calreticulin | 0.0326113 |
| PLIN2 | perilipin 2 | 0.0323854 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0319117 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0312607 |
| ADM | adrenomedullin | 0.0311645 |
| RYBP | RING1 and YY1 binding protein | 0.0311311 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0307448 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0304802 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0302289 |
| NPR2 | natriuretic peptide receptor 2 | 0.029751 |
| RBM39 | RNA binding motif protein 39 | 0.0297263 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.0295559 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0295013 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0294709 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.029409 |
| UTRN | utrophin | 0.0293704 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.029249 |
| TMEM178B | transmembrane protein 178B | 0.0291907 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 0.0288362 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0287046 |
| RNF213 | ring finger protein 213 | 0.0286814 |
| NLGN1 | neuroligin 1 | 0.0286624 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0281421 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.027979 |
| CABIN1 | calcineurin binding protein 1 | 0.0279636 |
| MCL1 | myeloid cell leukemia 1 | 0.0272741 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0270286 |
| SETBP1 | SET binding protein 1 | 0.0270209 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0267286 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0264318 |
| PLAT | plasminogen activator, tissue | 0.0262515 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0261872 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0260017 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0257687 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0257673 |
| FBXO7 | F-box protein 7 | 0.0256875 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0254993 |
| SDC2 | syndecan 2 | 0.0253232 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0251892 |
| LRRC23 | leucine rich repeat containing 23 | 0.0251145 |
| SMAD3 | SMAD family member 3 | 0.0250434 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0250133 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0250012 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0248526 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0245504 |
| EXT1 | exostosin glycosyltransferase 1 | 0.024516 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.473672 |
| MT2A | metallothionein 2A | -0.174872 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.143763 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0922483 |
| ACTG1 | actin gamma 1 | -0.0693733 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0658662 |
| NAV2 | neuron navigator 2 | -0.0646331 |
| COL19A1 | collagen, type XIX, alpha 1 | -0.0536506 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0530988 |
| GPC6 | glypican 6 | -0.0522684 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | -0.0517491 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0478828 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.047237 |
| SCFD2 | sec1 family domain containing 2 | -0.0424985 |
| SBF2 | SET binding factor 2 | -0.0424045 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | -0.0423586 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0414912 |
| CUX1 | cut-like homeobox 1 | -0.0380793 |
| RUNX1 | runt-related transcription factor 1 | -0.037619 |
| HLA-B | major histocompatibility complex, class I, B | -0.0357637 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0357236 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0355786 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0346146 |
| CENPF | centromere protein F, 350/400kDa | -0.033908 |
| RPS19 | ribosomal protein S19 | -0.0334499 |
| SRPK2 | SRSF protein kinase 2 | -0.0330374 |
| RPL19 | ribosomal protein L19 | -0.0319809 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0313099 |
| MT1X | metallothionein 1X | -0.0305599 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0305564 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0287213 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0278705 |
| RPLP1 | ribosomal protein, large, P1 | -0.0278355 |
| RO60 | Ro60, Y RNA binding protein | -0.0268996 |
| RPL30 | ribosomal protein L30 | -0.0262176 |
| MKI67 | marker of proliferation Ki-67 | -0.0260306 |
| SEPTIN7 | septin 7 | -0.0259766 |
| PKM | pyruvate kinase, muscle | -0.0255314 |
| POM121 | POM121 transmembrane nucleoporin | -0.0253192 |
| RPLP2 | ribosomal protein, large, P2 | -0.0252639 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0251573 |
| TNPO3 | transportin 3 | -0.0250697 |
| SGO2 | shugoshin 2 | -0.0248062 |
| RPS8 | ribosomal protein S8 | -0.0244763 |
| RPL34 | ribosomal protein L34 | -0.0241766 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0240267 |
| RPS23 | ribosomal protein S23 | -0.0238587 |
| CBFB | core-binding factor, beta subunit | -0.0237803 |
| UHMK1 | U2AF homology motif (UHM) kinase 1 | -0.023769 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0233597 |
| TMEM123 | transmembrane protein 123 | -0.0232498 |
| CCDC91 | coiled-coil domain containing 91 | -0.0231373 |
| MTDH | metadherin | -0.0226725 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0225903 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0220571 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0220272 |
| POM121C | POM121 transmembrane nucleoporin C | -0.0218027 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0217623 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0216929 |
| RPL36 | ribosomal protein L36 | -0.021678 |
| ITGB8 | integrin, beta 8 | -0.021591 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0215313 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0214022 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0213738 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0208075 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0205972 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0201994 |
| OSMR | oncostatin M receptor | -0.02018 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | -0.0199505 |
| TAPBP | TAP binding protein (tapasin) | -0.0198022 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0195521 |
| RPS24 | ribosomal protein S24 | -0.0193699 |
| CTSD | cathepsin D | -0.019297 |
| SNX14 | sorting nexin 14 | -0.0191752 |
| CDK14 | cyclin-dependent kinase 14 | -0.0190469 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0190348 |
| RPL32 | ribosomal protein L32 | -0.0189844 |
| HMGA1 | high mobility group AT-hook 1 | -0.0189036 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | -0.0188829 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0187277 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0184275 |
| UBE3C | ubiquitin protein ligase E3C | -0.0184176 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0183647 |
| SSH1 | slingshot protein phosphatase 1 | -0.018267 |
| IL6ST | interleukin 6 signal transducer | -0.0182356 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0182286 |
| RPS13 | ribosomal protein S13 | -0.0179456 |
| AHCYL2 | adenosylhomocysteinase-like 2 | -0.0178605 |
| PPP1R12B | protein phosphatase 1, regulatory subunit 12B | -0.0178402 |
| NHSL1 | NHS-like 1 | -0.0178163 |
| GRID1 | glutamate receptor, ionotropic, delta 1 | -0.0177803 |
| FOSL1 | FOS-like antigen 1 | -0.0177075 |
| RPL9 | ribosomal protein L9 | -0.0176096 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | -0.0175644 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0175282 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0175121 |
| ZFR | zinc finger RNA binding protein | -0.0174956 |
| ZNF704 | zinc finger protein 704 | -0.017416 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0172797 |
| ACTN4 | actinin, alpha 4 | -0.0171598 |
