| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lumateperone (tosylate) perturbation in CFPAC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lumateperone (tosylate)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.165203 |
| ASPH | aspartate beta-hydroxylase | 0.125432 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.121303 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.115549 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0881594 |
| APOL1 | apolipoprotein L, 1 | 0.0739919 |
| SMAD3 | SMAD family member 3 | 0.0709903 |
| EFNA5 | ephrin-A5 | 0.063586 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0631327 |
| MYOF | myoferlin | 0.0493475 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0483884 |
| AREG | amphiregulin | 0.0481342 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0447533 |
| TGM2 | transglutaminase 2 | 0.0441732 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0428673 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.042338 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0423309 |
| KYNU | kynureninase | 0.0417653 |
| CANX | calnexin | 0.0384683 |
| BICC1 | BicC family RNA binding protein 1 | 0.0362991 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0356584 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0348976 |
| TXNIP | thioredoxin interacting protein | 0.0339259 |
| VMP1 | vacuole membrane protein 1 | 0.033074 |
| FAM3C | family with sequence similarity 3, member C | 0.0317654 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0311513 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0308551 |
| PRELID2 | PRELI domain containing 2 | 0.0303315 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0300187 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0298326 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0297698 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0293492 |
| MX1 | MX dynamin-like GTPase 1 | 0.02895 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0284402 |
| RNF213 | ring finger protein 213 | 0.0281841 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0276751 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0274604 |
| EHF | ets homologous factor | 0.0274461 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0272539 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0271149 |
| CD2AP | CD2-associated protein | 0.0269917 |
| JAK1 | Janus kinase 1 | 0.0269278 |
| PHF3 | PHD finger protein 3 | 0.0265316 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0258186 |
| RIGI | RNA sensor RIG-I | 0.0249764 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.024802 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0247632 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0244948 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0240152 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0235469 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.02338 |
| OGA | O-GlcNAcase | 0.023236 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0232077 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0228966 |
| SEPTIN2 | septin 2 | 0.0228229 |
| CALR | calreticulin | 0.0226632 |
| DYNC2H1 | dynein, cytoplasmic 2, heavy chain 1 | 0.0226624 |
| TMEM51 | transmembrane protein 51 | 0.0226494 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0224797 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0224787 |
| ANO6 | anoctamin 6 | 0.0222821 |
| RBM39 | RNA binding motif protein 39 | 0.0221206 |
| SP100 | SP100 nuclear antigen | 0.0219877 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.02155 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0215452 |
| RIMKLB | ribosomal modification protein rimK-like family member B | 0.0213247 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.0212789 |
| HKDC1 | hexokinase domain containing 1 | 0.0209528 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0208591 |
| INSIG2 | insulin induced gene 2 | 0.0207459 |
| DNMBP | dynamin binding protein | 0.0206835 |
| SGMS2 | sphingomyelin synthase 2 | 0.0206204 |
| ENO1 | enolase 1, (alpha) | 0.0201961 |
| ANXA1 | annexin A1 | 0.0196773 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.019621 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0194759 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0193965 |
| PCBP2 | poly(rC) binding protein 2 | 0.0192047 |
| MT1X | metallothionein 1X | 0.0191019 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0189606 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0189156 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0189062 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0188873 |
| SERINC3 | serine incorporator 3 | 0.0188824 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0188678 |
| TGFB2 | transforming growth factor, beta 2 | 0.0188379 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0187939 |
| CCNL1 | cyclin L1 | 0.0187894 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0187636 |
| DST | dystonin | 0.0187047 |
| UGDH | UDP-glucose 6-dehydrogenase | 0.0186682 |
| NTN4 | netrin 4 | 0.0184878 |
| LOX | lysyl oxidase | 0.0181815 |
| TES | testin LIM domain protein | 0.0181756 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0179979 |
| EREG | epiregulin | 0.0178682 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0177792 |
| STAU1 | staufen double-stranded RNA binding protein 1 | 0.0177385 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0174378 |
| HPCAL1 | hippocalcin-like 1 | 0.0173704 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DTNA | dystrobrevin, alpha | -0.136616 |
| TMSB10 | thymosin beta 10 | -0.115313 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.103498 |
| B2M | beta-2-microglobulin | -0.101717 |
| LAMB3 | laminin, beta 3 | -0.100577 |
| HLA-B | major histocompatibility complex, class I, B | -0.0971669 |
| HLA-A | major histocompatibility complex, class I, A | -0.0781303 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0750369 |
| HMGA1 | high mobility group AT-hook 1 | -0.07493 |
| PARD3 | par-3 family cell polarity regulator | -0.0741563 |
| S100A6 | S100 calcium binding protein A6 | -0.0616436 |
| LAMC2 | laminin, gamma 2 | -0.0605643 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0578593 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0576487 |
| CP | ceruloplasmin (ferroxidase) | -0.0568827 |
| KRT19 | keratin 19, type I | -0.0555596 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0555512 |
| RCOR1 | REST corepressor 1 | -0.0533788 |
| TMEM165 | transmembrane protein 165 | -0.0506788 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0500404 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0483749 |
| ITGA6 | integrin, alpha 6 | -0.0465057 |
| PTMA | prothymosin, alpha | -0.046297 |
| JUP | junction plakoglobin | -0.046123 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.04569 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0450996 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0448008 |
| RPL35A | ribosomal protein L35a | -0.0436424 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0430327 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0423397 |
| EGR1 | early growth response 1 | -0.0422105 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0409984 |
| MMP7 | matrix metallopeptidase 7 | -0.0408464 |
| FLNB | filamin B, beta | -0.0407188 |
| PLAT | plasminogen activator, tissue | -0.0398399 |
| AGRN | agrin | -0.0393008 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0388514 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0381942 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0376973 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0359751 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | -0.035593 |
| MT2A | metallothionein 2A | -0.0355581 |
| HLA-E | major histocompatibility complex, class I, E | -0.0355251 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0350964 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0345955 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0342428 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0338927 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0335822 |
| ITGB4 | integrin, beta 4 | -0.033491 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.032186 |
| PLS3 | plastin 3 | -0.0321704 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0321329 |
| MCU | mitochondrial calcium uniporter | -0.0318485 |
| PRKCA | protein kinase C, alpha | -0.0317861 |
| LAMA5 | laminin, alpha 5 | -0.0314326 |
| SPAG9 | sperm associated antigen 9 | -0.0313261 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.0308331 |
| RANBP17 | RAN binding protein 17 | -0.0302756 |
| CDC42BPB | CDC42 binding protein kinase beta (DMPK-like) | -0.0301004 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0300276 |
| PADI1 | peptidyl arginine deiminase, type I | -0.028781 |
| NCKAP5 | NCK-associated protein 5 | -0.0287624 |
| TAPBP | TAP binding protein (tapasin) | -0.0287435 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0287121 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0285738 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0284531 |
| FOXO3 | forkhead box O3 | -0.0284008 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0283708 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0283465 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0283464 |
| RPLP1 | ribosomal protein, large, P1 | -0.028328 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0280927 |
| RREB1 | ras responsive element binding protein 1 | -0.0279281 |
| SQSTM1 | sequestosome 1 | -0.027722 |
| SLK | STE20-like kinase | -0.0276745 |
| VIM | vimentin | -0.0276631 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | -0.0276108 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0276009 |
| RPS8 | ribosomal protein S8 | -0.0271342 |
| CSTB | cystatin B (stefin B) | -0.0271111 |
| LMO7 | LIM domain 7 | -0.0268943 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0268337 |
| RPS14 | ribosomal protein S14 | -0.0266874 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0261822 |
| PLEC | plectin | -0.02613 |
| RPS25 | ribosomal protein S25 | -0.0261287 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0260622 |
| KLC1 | kinesin light chain 1 | -0.0260581 |
| ITSN2 | intersectin 2 | -0.0259892 |
| DSG2 | desmoglein 2 | -0.0258687 |
| RPS29 | ribosomal protein S29 | -0.025768 |
| GNAS | GNAS complex locus | -0.0256831 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | -0.02544 |
| JMJD1C | jumonji domain containing 1C | -0.0253783 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0253255 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | -0.0253058 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0252598 |
| TPM4 | tropomyosin 4 | -0.0249858 |
| RPL31 | ribosomal protein L31 | -0.0247811 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0246114 |
