| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lumateperone (tosylate) perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lumateperone (tosylate)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.178157 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.122114 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.119716 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0918171 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0812737 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0667782 |
| LMO7 | LIM domain 7 | 0.0632003 |
| MLPH | melanophilin | 0.0563913 |
| STS | steroid sulfatase (microsomal), isozyme S | 0.055796 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0544016 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0526898 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0517149 |
| INTS6 | integrator complex subunit 6 | 0.0493392 |
| KYNU | kynureninase | 0.0490281 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.046545 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0464468 |
| VMP1 | vacuole membrane protein 1 | 0.04638 |
| RBM47 | RNA binding motif protein 47 | 0.0461975 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0459212 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0451165 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0443509 |
| SMAD3 | SMAD family member 3 | 0.0442912 |
| LCN2 | lipocalin 2 | 0.0433565 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0428398 |
| POTEF | POTE ankyrin domain family, member F | 0.0428027 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0419807 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0418369 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0405805 |
| FAT1 | FAT atypical cadherin 1 | 0.0403857 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0402999 |
| TOX3 | TOX high mobility group box family member 3 | 0.0402674 |
| ASPH | aspartate beta-hydroxylase | 0.0397206 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.039701 |
| TMC5 | transmembrane channel-like 5 | 0.0391317 |
| FNIP1 | folliculin interacting protein 1 | 0.0386874 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.038679 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0380434 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0378734 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0372083 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0369608 |
| DPP4 | dipeptidyl-peptidase 4 | 0.0362395 |
| CTBP2 | C-terminal binding protein 2 | 0.0346956 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0337889 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0336326 |
| YAP1 | Yes-associated protein 1 | 0.0335051 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.032905 |
| PDZD8 | PDZ domain containing 8 | 0.0328152 |
| EZR | ezrin | 0.0325179 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0320349 |
| UBAP1 | ubiquitin associated protein 1 | 0.0320216 |
| CMIP | c-Maf inducing protein | 0.0319702 |
| MYO10 | myosin X | 0.0315434 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0314466 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0312306 |
| BCL2L1 | BCL2-like 1 | 0.0310194 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0308705 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0308508 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0307124 |
| FTL | ferritin, light polypeptide | 0.0302111 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0291669 |
| RNF149 | ring finger protein 149 | 0.0290125 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0289515 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0287264 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0285239 |
| ABHD2 | abhydrolase domain containing 2 | 0.0282749 |
| PADI1 | peptidyl arginine deiminase, type I | 0.0279579 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0278761 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.027826 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0273476 |
| ADM | adrenomedullin | 0.0270612 |
| ABHD17C | abhydrolase domain containing 17C | 0.026971 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0268886 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.026883 |
| FRMD5 | FERM domain containing 5 | 0.0268178 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0267373 |
| MYO1E | myosin IE | 0.0264401 |
| CDHR2 | cadherin-related family member 2 | 0.0263896 |
| PKM | pyruvate kinase, muscle | 0.0259327 |
| SEPTIN9 | septin 9 | 0.0255805 |
| UBC | ubiquitin C | 0.0250463 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0248533 |
| ENO1 | enolase 1, (alpha) | 0.0247281 |
| PCBP2 | poly(rC) binding protein 2 | 0.0244715 |
| MT2A | metallothionein 2A | 0.0243546 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0242229 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.0241471 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0235619 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0233764 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0233265 |
| DST | dystonin | 0.0230577 |
| ATP9A | ATPase, class II, type 9A | 0.0230183 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0229609 |
| DUSP10 | dual specificity phosphatase 10 | 0.0228786 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0226234 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0222929 |
| TMEM65 | transmembrane protein 65 | 0.0221341 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0221334 |
| SFTPA2 | surfactant protein A2 | 0.0219524 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | 0.0218655 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0213856 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.17478 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.1633 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.115703 |
| HLA-B | major histocompatibility complex, class I, B | -0.0954358 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0895489 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0841825 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0833892 |
| LYZ | lysozyme | -0.0829433 |
| PTMA | prothymosin, alpha | -0.0822299 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0729288 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0691075 |
| NPSR1 | neuropeptide S receptor 1 | -0.0656046 |
| SP100 | SP100 nuclear antigen | -0.0620676 |
| RPL35A | ribosomal protein L35a | -0.0619009 |
| H1-0 | H1.0 linker histone | -0.0609782 |
| RRBP1 | ribosome binding protein 1 | -0.0606345 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0602887 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0583353 |
| GOLGB1 | golgin B1 | -0.0579823 |
| PLSCR1 | phospholipid scramblase 1 | -0.0574242 |
| NF1 | neurofibromin 1 | -0.055074 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0546695 |
| MX2 | MX dynamin-like GTPase 2 | -0.0531499 |
| PMP22 | peripheral myelin protein 22 | -0.0516072 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0515397 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0497457 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0493986 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0480014 |
| RPL34 | ribosomal protein L34 | -0.0461946 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.046165 |
| RIGI | RNA sensor RIG-I | -0.0453442 |
| XAF1 | XIAP associated factor 1 | -0.0449618 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0449063 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0447739 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0438071 |
| AHI1 | Abelson helper integration site 1 | -0.0431645 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0422664 |
| CANX | calnexin | -0.0419618 |
| LAP3 | leucine aminopeptidase 3 | -0.0418967 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0416556 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0405577 |
| PHF3 | PHD finger protein 3 | -0.0400578 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.039807 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0397601 |
| MECOM | MDS1 and EVI1 complex locus | -0.0396915 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0396721 |
| RPS6 | ribosomal protein S6 | -0.0393474 |
| HLA-C | major histocompatibility complex, class I, C | -0.0388387 |
| SBF2 | SET binding factor 2 | -0.0386215 |
| XRN1 | 5'-3' exoribonuclease 1 | -0.0384471 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0378556 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.03781 |
| THOC2 | THO complex 2 | -0.037292 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0371957 |
| MX1 | MX dynamin-like GTPase 1 | -0.036642 |
| DIAPH3 | diaphanous-related formin 3 | -0.0365072 |
| RUNX1 | runt-related transcription factor 1 | -0.0362991 |
| HMGB1 | high mobility group box 1 | -0.036269 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0360763 |
| APOL6 | apolipoprotein L, 6 | -0.0358843 |
| TMSB10 | thymosin beta 10 | -0.0357195 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0354561 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0353283 |
| RNF213 | ring finger protein 213 | -0.0351765 |
| RBM39 | RNA binding motif protein 39 | -0.0351719 |
| ZC3H13 | zinc finger CCCH-type containing 13 | -0.0349987 |
| NUP214 | nucleoporin 214kDa | -0.0344387 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0343413 |
| PRELID2 | PRELI domain containing 2 | -0.0341086 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0337148 |
| RBM25 | RNA binding motif protein 25 | -0.0337051 |
| BRCA2 | breast cancer 2, early onset | -0.033658 |
| ANXA4 | annexin A4 | -0.0332727 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0330518 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.033001 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0326181 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0318839 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0318697 |
| ZDHHC20 | zinc finger, DHHC-type containing 20 | -0.0317347 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0316742 |
| SPATA13 | spermatogenesis associated 13 | -0.0315756 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0315176 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0314043 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.031217 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0312048 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0306027 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0305275 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0305099 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0304893 |
| RBBP6 | retinoblastoma binding protein 6 | -0.0304654 |
| RAD51B | RAD51 paralog B | -0.029974 |
| CHD6 | chromodomain helicase DNA binding protein 6 | -0.0298618 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0296023 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0295767 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.029477 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0294077 |
| MPHOSPH8 | M-phase phosphoprotein 8 | -0.0292305 |
| SQSTM1 | sequestosome 1 | -0.0289191 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.028674 |
| RPS24 | ribosomal protein S24 | -0.0286042 |
