Lumateperone (tosylate)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lumateperone (tosylate) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lumateperone (tosylate)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.0950976
ASPH aspartate beta-hydroxylase 0.0612564
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0589142
KYNU kynureninase 0.0513524
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0506186
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0482894
PRELID2 PRELI domain containing 2 0.0415741
ZSWIM6 zinc finger, SWIM-type containing 6 0.0380281
GRB10 growth factor receptor-bound protein 10 0.0331068
INTS6 integrator complex subunit 6 0.0329631
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0328291
PTPRD protein tyrosine phosphatase, receptor type, D 0.0306932
AKAP12 A kinase (PRKA) anchor protein 12 0.0296758
RIGI RNA sensor RIG-I 0.0293845
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0269626
NFE2L1 nuclear factor, erythroid 2-like 1 0.0260029
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0258547
VEGFC vascular endothelial growth factor C 0.0258111
PDLIM5 PDZ and LIM domain 5 0.0244795
GLIS3 GLIS family zinc finger 3 0.0244607
HSPA8 heat shock 70kDa protein 8 0.0241392
DSCAM Down syndrome cell adhesion molecule 0.0236275
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.0207671
VCL vinculin 0.0206377
MYH9 myosin, heavy chain 9, non-muscle 0.020517
ERRFI1 ERBB receptor feedback inhibitor 1 0.0196832
SDK1 sidekick cell adhesion molecule 1 0.0190293
MBNL1 muscleblind-like splicing regulator 1 0.0189035
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0187201
ANKRD36 ankyrin repeat domain 36 0.0183309
HYOU1 hypoxia up-regulated 1 0.0181468
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 0.0179578
MACF1 microtubule-actin crosslinking factor 1 0.0179268
RNF144A ring finger protein 144A 0.0177325
WWTR1 WW domain containing transcription regulator 1 0.0172175
HOMER1 homer scaffolding protein 1 0.0170225
NAV2 neuron navigator 2 0.0169383
DOCK5 dedicator of cytokinesis 5 0.0168257
EGFR epidermal growth factor receptor 0.0165765
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0163354
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0159888
SUMF1 sulfatase modifying factor 1 0.0155126
SMAD3 SMAD family member 3 0.0154866
SETX senataxin 0.0153286
GRAMD1B GRAM domain containing 1B 0.0152227
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0151308
AEBP2 AE binding protein 2 0.0149492
HDAC4 histone deacetylase 4 0.0149062
WWOX WW domain containing oxidoreductase 0.0148321
STXBP1 syntaxin binding protein 1 0.014738
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0147327
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0143508
RUNX1 runt-related transcription factor 1 0.014346
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0142207
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0141334
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0140214
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.0139525
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0137537
PHF3 PHD finger protein 3 0.0136048
LNPEP leucyl/cystinyl aminopeptidase 0.013545
ANO6 anoctamin 6 0.0134758
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0131526
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0126001
RAD51B RAD51 paralog B 0.0125472
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.0123714
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.012149
NUMA1 nuclear mitotic apparatus protein 1 0.0121108
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0120763
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0120676
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0120246
MACROD2 MACRO domain containing 2 0.0119477
FNDC3A fibronectin type III domain containing 3A 0.0119345
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0117176
MYLK myosin light chain kinase 0.0116438
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0116098
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0114676
MYO10 myosin X 0.0114225
RRM2 ribonucleotide reductase M2 0.0113537
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0113523
MAST4 microtubule associated serine/threonine kinase family member 4 0.0113514
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0113455
ZC3H12B zinc finger CCCH-type containing 12B 0.0112824
RIMS2 regulating synaptic membrane exocytosis 2 0.0112405
CEP128 centrosomal protein 128kDa 0.011162
FLRT2 fibronectin leucine rich transmembrane protein 2 0.0111186
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 0.0111016
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.01103
KIF21A kinesin family member 21A 0.0109683
ELL2 elongation factor, RNA polymerase II, 2 0.0109153
SETBP1 SET binding protein 1 0.0108559
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0107512
PCBP3 poly(rC) binding protein 3 0.0106746
SPDYA speedy/RINGO cell cycle regulator family member A 0.0104535
TLE4 transducin-like enhancer of split 4 0.010452
CFAP161 cilia and flagella associated protein 161 0.010284
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0102687
CRYBG3 beta-gamma crystallin domain containing 3 0.0102542
TOP1 topoisomerase (DNA) I 0.010163
ZBTB38 zinc finger and BTB domain containing 38 0.0100911
ARHGAP22 Rho GTPase activating protein 22 0.0100835

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.293021
VIM vimentin -0.150499
TMSB10 thymosin beta 10 -0.144668
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.143926
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.136757
IGFBP3 insulin-like growth factor binding protein 3 -0.128477
FTL ferritin, light polypeptide -0.123158
MT2A metallothionein 2A -0.114423
TPM4 tropomyosin 4 -0.0907087
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0892316
PTMA prothymosin, alpha -0.0878479
FN1 fibronectin 1 -0.082403
RPS6 ribosomal protein S6 -0.0750755
NDRG1 N-myc downstream regulated 1 -0.0690497
HLA-B major histocompatibility complex, class I, B -0.0690404
RPS8 ribosomal protein S8 -0.0689862
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0617819
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0615407
PDIA3 protein disulfide isomerase family A, member 3 -0.0614178
TPT1 tumor protein, translationally-controlled 1 -0.0586012
B2M beta-2-microglobulin -0.0584694
RPL35A ribosomal protein L35a -0.0553966
GARS1 glycyl-tRNA synthetase 1 -0.0538479
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0525085
HLA-A major histocompatibility complex, class I, A -0.0510578
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0495214
CANX calnexin -0.0492164
GOLGA4 golgin A4 -0.0489662
SBF2 SET binding factor 2 -0.0476348
GNAS GNAS complex locus -0.0473331
EIF1 eukaryotic translation initiation factor 1 -0.0472959
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0465089
RTN4 reticulon 4 -0.0463372
PKM pyruvate kinase, muscle -0.0446566
LMAN1 lectin, mannose-binding, 1 -0.0440268
RPLP1 ribosomal protein, large, P1 -0.0438139
AHNAK AHNAK nucleoprotein -0.0436702
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0433057
CALR calreticulin -0.0418731
TGFBI transforming growth factor, beta-induced, 68kDa -0.03994
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0399149
HILPDA hypoxia inducible lipid droplet-associated -0.0396635
RPL34 ribosomal protein L34 -0.0387548
IGF2 insulin-like growth factor 2 -0.0385105
RPS13 ribosomal protein S13 -0.0384601
RPS19 ribosomal protein S19 -0.0373472
RPL37A ribosomal protein L37a -0.0373305
RPLP2 ribosomal protein, large, P2 -0.0370332
MAP1B microtubule-associated protein 1B -0.0368854
RPL28 ribosomal protein L28 -0.035787
NAMPT nicotinamide phosphoribosyltransferase -0.0343371
RNF216 ring finger protein 216 -0.034025
IGFBP5 insulin-like growth factor binding protein 5 -0.0337345
PRRC2C proline-rich coiled-coil 2C -0.0337327
S100A6 S100 calcium binding protein A6 -0.0337289
PGK1 phosphoglycerate kinase 1 -0.0333677
RAB1A RAB1A, member RAS oncogene family -0.0325221
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0324828
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0320283
SEC61G Sec61 gamma subunit -0.0319635
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0318855
S100A10 S100 calcium binding protein A10 -0.0313912
GOLGB1 golgin B1 -0.0306259
KPNB1 karyopherin (importin) beta 1 -0.0305933
RAB7A RAB7A, member RAS oncogene family -0.0305726
CD99 CD99 molecule -0.0303776
SEPTIN7 septin 7 -0.0301945
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0301588
FAM13A family with sequence similarity 13, member A -0.0301582
INHBA inhibin, beta A -0.0297546
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -0.0294371
ANKRD11 ankyrin repeat domain 11 -0.0294195
TTC3 tetratricopeptide repeat domain 3 -0.0294091
CKAP4 cytoskeleton-associated protein 4 -0.0293936
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0292376
COPB1 coatomer protein complex, subunit beta 1 -0.0288445
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0286858
ENO1 enolase 1, (alpha) -0.0286351
MORF4L2 mortality factor 4 like 2 -0.028588
RACK1 receptor for activated C kinase 1 -0.0282777
LDHA lactate dehydrogenase A -0.0279577
NF1 neurofibromin 1 -0.0271686
CBX3 chromobox homolog 3 -0.0271198
HIP1 huntingtin interacting protein 1 -0.0270931
CADM1 cell adhesion molecule 1 -0.0268182
CLMP CXADR-like membrane protein -0.0265769
NOP58 NOP58 ribonucleoprotein -0.0262539
SRP54 signal recognition particle 54kDa -0.0261942
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0257266
SETD5 SET domain containing 5 -0.0257211
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0256686
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.025619
GLG1 golgi glycoprotein 1 -0.0255452
RRBP1 ribosome binding protein 1 -0.0254732
RPL37 ribosomal protein L37 -0.0254096
USP36 ubiquitin specific peptidase 36 -0.0252763
UBE2K ubiquitin-conjugating enzyme E2K -0.0252298
RPL31 ribosomal protein L31 -0.0252248
CALU calumenin -0.0251104
S100A9 S100 calcium binding protein A9 -0.0250189