| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lumateperone (tosylate) perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lumateperone (tosylate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.172747 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0873721 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0769633 |
| PRELID2 | PRELI domain containing 2 | 0.0628589 |
| TXNRD1 | thioredoxin reductase 1 | 0.0584433 |
| EZR | ezrin | 0.052997 |
| INTS6 | integrator complex subunit 6 | 0.0504448 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0499783 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0455885 |
| MT2A | metallothionein 2A | 0.0440094 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0415687 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.041252 |
| CALR | calreticulin | 0.0396947 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0387581 |
| OGA | O-GlcNAcase | 0.0376149 |
| SQSTM1 | sequestosome 1 | 0.0370382 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0354034 |
| PCM1 | pericentriolar material 1 | 0.0340958 |
| RRM2 | ribonucleotide reductase M2 | 0.0329306 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0328324 |
| SEC24D | SEC24 family member D | 0.0323124 |
| LRRC23 | leucine rich repeat containing 23 | 0.0319514 |
| PCBP2 | poly(rC) binding protein 2 | 0.0318575 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0300935 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0297362 |
| HDLBP | high density lipoprotein binding protein | 0.029572 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0294077 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0291163 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0289638 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.028802 |
| HMGB2 | high mobility group box 2 | 0.0281466 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0274131 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0272964 |
| MORF4L2 | mortality factor 4 like 2 | 0.0270245 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0268153 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0266835 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0266479 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0265104 |
| COG6 | component of oligomeric golgi complex 6 | 0.0261645 |
| SON | SON DNA binding protein | 0.026037 |
| HYOU1 | hypoxia up-regulated 1 | 0.025868 |
| SKP1 | S-phase kinase-associated protein 1 | 0.0256357 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0248858 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | 0.0248314 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0245187 |
| PCNT | pericentrin | 0.0241604 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0241089 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0239875 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0237971 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0235021 |
| SRP54 | signal recognition particle 54kDa | 0.0234998 |
| KIAA1217 | KIAA1217 | 0.0233362 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0231228 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0230895 |
| HOMER1 | homer scaffolding protein 1 | 0.0229801 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0228595 |
| PER1 | period circadian clock 1 | 0.0227963 |
| GTF2B | general transcription factor IIB | 0.0225384 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.0224982 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0224178 |
| ATF3 | activating transcription factor 3 | 0.0223716 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0223162 |
| NASP | nuclear autoantigenic sperm protein (histone-binding) | 0.0221914 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.0220886 |
| YTHDC1 | YTH domain containing 1 | 0.0220409 |
| RUNX1 | runt-related transcription factor 1 | 0.0216385 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 0.0211955 |
| SGMS2 | sphingomyelin synthase 2 | 0.0209959 |
| CANX | calnexin | 0.0209906 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 0.0205408 |
| MLEC | malectin | 0.0205272 |
| TPI1 | triosephosphate isomerase 1 | 0.0204023 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.020122 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0200412 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.020012 |
| ADD3 | adducin 3 (gamma) | 0.0199914 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0197776 |
| SUCO | SUN domain containing ossification factor | 0.0196919 |
| IGF2R | insulin-like growth factor 2 receptor | 0.019661 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0196065 |
| JUN | jun proto-oncogene | 0.0195959 |
| RBM39 | RNA binding motif protein 39 | 0.0195057 |
| SLC10A7 | solute carrier family 10, member 7 | 0.0194796 |
| XRN1 | 5'-3' exoribonuclease 1 | 0.0193881 |
| WDR26 | WD repeat domain 26 | 0.0192943 |
| CHD8 | chromodomain helicase DNA binding protein 8 | 0.0192473 |
| LNPK | lunapark, ER junction formation factor | 0.0191849 |
| SEPTIN2 | septin 2 | 0.0191652 |
| PAXBP1 | PAX3 and PAX7 binding protein 1 | 0.0190676 |
| GOLGB1 | golgin B1 | 0.0190672 |
| DIAPH3 | diaphanous-related formin 3 | 0.018976 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0189349 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0187558 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0187165 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0186832 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | 0.0186511 |
| TPR | translocated promoter region, nuclear basket protein | 0.0186451 |
| UBXN4 | UBX domain protein 4 | 0.01863 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0185961 |
| TMEM263 | transmembrane protein 263 | 0.0185718 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | -0.190834 |
| FAT1 | FAT atypical cadherin 1 | -0.167147 |
| AHNAK | AHNAK nucleoprotein | -0.156151 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0938011 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0906961 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0831713 |
| TPM4 | tropomyosin 4 | -0.0777313 |
| RPS6 | ribosomal protein S6 | -0.0751235 |
| PKM | pyruvate kinase, muscle | -0.0739626 |
| EGR1 | early growth response 1 | -0.0720802 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0719452 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0711431 |
| RPS8 | ribosomal protein S8 | -0.0707048 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0700166 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0666834 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0585474 |
| SERINC5 | serine incorporator 5 | -0.0580421 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0570303 |
| PTMA | prothymosin, alpha | -0.0555907 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0540933 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0531724 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0507739 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0494973 |
| RPL34 | ribosomal protein L34 | -0.0488031 |
| CCND1 | cyclin D1 | -0.0485367 |
| MED13L | mediator complex subunit 13-like | -0.0484141 |
| TCF12 | transcription factor 12 | -0.0483235 |
| ITGB4 | integrin, beta 4 | -0.0458023 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0456069 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0454173 |
| RPS2 | ribosomal protein S2 | -0.0444699 |
| NF1 | neurofibromin 1 | -0.0437843 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | -0.0435801 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0430542 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0424398 |
| RPL19 | ribosomal protein L19 | -0.0406301 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0403795 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0401084 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0397374 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.039367 |
| RPS25 | ribosomal protein S25 | -0.0393146 |
| S100A10 | S100 calcium binding protein A10 | -0.0392793 |
| KRT18 | keratin 18, type I | -0.0389243 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0386942 |
| CUX1 | cut-like homeobox 1 | -0.0383939 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0376081 |
| RPL5 | ribosomal protein L5 | -0.0374043 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0370657 |
| HMGA2 | high mobility group AT-hook 2 | -0.0370581 |
| RHOA | ras homolog family member A | -0.0368789 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.036694 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0365689 |
| WWC2 | WW and C2 domain containing 2 | -0.0365497 |
| CADPS | Ca++-dependent secretion activator | -0.0364854 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0354926 |
| PALD1 | phosphatase domain containing, paladin 1 | -0.0353017 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | -0.0345478 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0341609 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0340357 |
| RPL26 | ribosomal protein L26 | -0.0336003 |
| S100A6 | S100 calcium binding protein A6 | -0.0333957 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0331333 |
| RPS13 | ribosomal protein S13 | -0.0330733 |
| PCDH7 | protocadherin 7 | -0.0328905 |
| VEGFA | vascular endothelial growth factor A | -0.0325678 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0325426 |
| CDCP1 | CUB domain containing protein 1 | -0.0324015 |
| ENO1 | enolase 1, (alpha) | -0.0322287 |
| MYO1D | myosin ID | -0.0321465 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0318063 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0316137 |
| RPL31 | ribosomal protein L31 | -0.0312471 |
| RPL37A | ribosomal protein L37a | -0.0310153 |
| RPL4 | ribosomal protein L4 | -0.0309864 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0304317 |
| WWC1 | WW and C2 domain containing 1 | -0.0303913 |
| HMGA1 | high mobility group AT-hook 1 | -0.029912 |
| RPS19 | ribosomal protein S19 | -0.0298432 |
| RPL37 | ribosomal protein L37 | -0.0298285 |
| USP34 | ubiquitin specific peptidase 34 | -0.0296078 |
| RPL30 | ribosomal protein L30 | -0.0294252 |
| MSI2 | musashi RNA-binding protein 2 | -0.029398 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0293843 |
| RPS3 | ribosomal protein S3 | -0.029262 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.029258 |
| ASPH | aspartate beta-hydroxylase | -0.0292506 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0291347 |
| SNX14 | sorting nexin 14 | -0.0287054 |
| BPTF | bromodomain PHD finger transcription factor | -0.0285876 |
| SRSF4 | serine/arginine-rich splicing factor 4 | -0.028571 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.0283886 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0282982 |
| RPL32 | ribosomal protein L32 | -0.0282801 |
| UBC | ubiquitin C | -0.0282761 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.027833 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0278124 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -0.0277392 |
| FLNB | filamin B, beta | -0.0274953 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.0274903 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0274274 |
