| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lumateperone (tosylate) perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lumateperone (tosylate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.180047 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.152758 |
| PRELID2 | PRELI domain containing 2 | 0.136215 |
| MT2A | metallothionein 2A | 0.128 |
| ASPH | aspartate beta-hydroxylase | 0.110013 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0715623 |
| RAD51B | RAD51 paralog B | 0.0674998 |
| CANX | calnexin | 0.0583275 |
| LAMC2 | laminin, gamma 2 | 0.0547605 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0537948 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0528064 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0521283 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0510288 |
| ATXN1 | ataxin 1 | 0.0505737 |
| EZR | ezrin | 0.0499532 |
| TPM4 | tropomyosin 4 | 0.0498719 |
| LAMB3 | laminin, beta 3 | 0.0491139 |
| FHIT | fragile histidine triad | 0.0487546 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0486158 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0486146 |
| INTS6 | integrator complex subunit 6 | 0.0474246 |
| NDRG1 | N-myc downstream regulated 1 | 0.046419 |
| CALR | calreticulin | 0.0452184 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0441802 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0441553 |
| FNIP1 | folliculin interacting protein 1 | 0.0419243 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0415746 |
| ANXA1 | annexin A1 | 0.0409107 |
| SMAD3 | SMAD family member 3 | 0.0393904 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0391099 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0387945 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0387106 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0380801 |
| GOLGB1 | golgin B1 | 0.0373973 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0367843 |
| PDIA5 | protein disulfide isomerase family A, member 5 | 0.0366879 |
| LARS1 | leucyl-tRNA synthetase 1 | 0.0366623 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0363083 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0357679 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0354209 |
| DIAPH3 | diaphanous-related formin 3 | 0.0349102 |
| CDK13 | cyclin-dependent kinase 13 | 0.0345114 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0339882 |
| FLNB | filamin B, beta | 0.0337357 |
| SETX | senataxin | 0.0336446 |
| ECT2 | epithelial cell transforming 2 | 0.0335597 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.033373 |
| EXOC4 | exocyst complex component 4 | 0.0331838 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0325747 |
| ENO1 | enolase 1, (alpha) | 0.0324418 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0317749 |
| WWOX | WW domain containing oxidoreductase | 0.0315899 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0313513 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0312492 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0312149 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0308979 |
| OGA | O-GlcNAcase | 0.030715 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.030567 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.030455 |
| HKDC1 | hexokinase domain containing 1 | 0.0303847 |
| SCFD1 | sec1 family domain containing 1 | 0.0302697 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0301416 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0297512 |
| RUNX1 | runt-related transcription factor 1 | 0.0296558 |
| ANXA3 | annexin A3 | 0.0294354 |
| MYO1E | myosin IE | 0.0293928 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0293107 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.029278 |
| LARP1B | La ribonucleoprotein domain family, member 1B | 0.0291482 |
| LAMA4 | laminin, alpha 4 | 0.0287508 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.028748 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0284862 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0283221 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0283021 |
| LDHA | lactate dehydrogenase A | 0.0279919 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0277729 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0276881 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0275369 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0275024 |
| CARD11 | caspase recruitment domain family, member 11 | 0.0273564 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.026994 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0268388 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0267092 |
| ERBIN | erbb2 interacting protein | 0.0266267 |
| RNF213 | ring finger protein 213 | 0.0263232 |
| ATF4 | activating transcription factor 4 | 0.0260612 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0255738 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.02556 |
| CMIP | c-Maf inducing protein | 0.0254102 |
| MYOF | myoferlin | 0.0252305 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0248294 |
| PLEC | plectin | 0.0246749 |
| HM13 | histocompatibility (minor) 13 | 0.0245849 |
| NFX1 | nuclear transcription factor, X-box binding 1 | 0.0244473 |
| CEP128 | centrosomal protein 128kDa | 0.0243803 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0243611 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0240516 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0237992 |
| LRRC23 | leucine rich repeat containing 23 | 0.0236684 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0235918 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.216847 |
| ZNF292 | zinc finger protein 292 | -0.0962529 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0900241 |
| MATR3 | matrin 3 | -0.0838675 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0800381 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.073547 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0619946 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0599262 |
| HMGA1 | high mobility group AT-hook 1 | -0.058242 |
| SNX9 | sorting nexin 9 | -0.0566819 |
| CCNL1 | cyclin L1 | -0.0552898 |
| RPS6 | ribosomal protein S6 | -0.0551343 |
| CCND1 | cyclin D1 | -0.053552 |
| TCERG1 | transcription elongation regulator 1 | -0.0526885 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0523755 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0515658 |
| RNF145 | ring finger protein 145 | -0.0508315 |
| ITGB8 | integrin, beta 8 | -0.050249 |
| PKM | pyruvate kinase, muscle | -0.0482466 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0474554 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | -0.0459562 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0449969 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0441082 |
| WDR43 | WD repeat domain 43 | -0.0439509 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | -0.0432364 |
| RPS19 | ribosomal protein S19 | -0.0431257 |
| RPL35A | ribosomal protein L35a | -0.0429322 |
| KRT7 | keratin 7, type II | -0.0425075 |
| RACK1 | receptor for activated C kinase 1 | -0.0424782 |
| PUM2 | pumilio RNA-binding family member 2 | -0.042065 |
| SBF2 | SET binding factor 2 | -0.040668 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0405225 |
| PTBP2 | polypyrimidine tract binding protein 2 | -0.0374458 |
| TMSB10 | thymosin beta 10 | -0.0371464 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0367784 |
| B2M | beta-2-microglobulin | -0.0364023 |
| RPL32 | ribosomal protein L32 | -0.0361279 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0360743 |
| RPS24 | ribosomal protein S24 | -0.0360619 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | -0.0359454 |
| RHOA | ras homolog family member A | -0.035483 |
| NCKAP1 | NCK-associated protein 1 | -0.0352335 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0352195 |
| H1-0 | H1.0 linker histone | -0.0350348 |
| RPL34 | ribosomal protein L34 | -0.0343385 |
| RPS5 | ribosomal protein S5 | -0.0342629 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0342351 |
| RPS8 | ribosomal protein S8 | -0.0342282 |
| PARD3 | par-3 family cell polarity regulator | -0.0333084 |
| ZNF148 | zinc finger protein 148 | -0.0332269 |
| RPS2 | ribosomal protein S2 | -0.0329317 |
| USP3 | ubiquitin specific peptidase 3 | -0.0328903 |
| WWC1 | WW and C2 domain containing 1 | -0.032792 |
| RFX7 | regulatory factor X, 7 | -0.0326127 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0324754 |
| RPL5 | ribosomal protein L5 | -0.0322147 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0320234 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.031963 |
| RPL23 | ribosomal protein L23 | -0.0318743 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0316567 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0315467 |
| OLA1 | Obg-like ATPase 1 | -0.0309876 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0305958 |
| RTN4 | reticulon 4 | -0.0303727 |
| YBX1 | Y box binding protein 1 | -0.0303497 |
| ANKRD17 | ankyrin repeat domain 17 | -0.02988 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0298559 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0298544 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | -0.0297824 |
| FTL | ferritin, light polypeptide | -0.0297354 |
| PFN1 | profilin 1 | -0.0296875 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0296268 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.029535 |
| PTMA | prothymosin, alpha | -0.0294931 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0293364 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.0292631 |
| FAM168B | family with sequence similarity 168, member B | -0.0292207 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.028971 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0288712 |
| RLF | rearranged L-myc fusion | -0.0288354 |
| NAA50 | N(alpha)-acetyltransferase 50, NatE catalytic subunit | -0.0287489 |
| PUM1 | pumilio RNA-binding family member 1 | -0.028702 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0285905 |
| GNAS | GNAS complex locus | -0.0285114 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.028314 |
| MEF2A | myocyte enhancer factor 2A | -0.0283119 |
| APP | amyloid beta (A4) precursor protein | -0.0282545 |
| RPS23 | ribosomal protein S23 | -0.0281557 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0279738 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0277301 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0276529 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0276041 |
| UBE3A | ubiquitin protein ligase E3A | -0.0275798 |
| NUP54 | nucleoporin 54kDa | -0.027313 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0272225 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0271948 |
| UBP1 | upstream binding protein 1 (LBP-1a) | -0.0271521 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.027124 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0268899 |
| NOP58 | NOP58 ribonucleoprotein | -0.0267758 |
