| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lumateperone (tosylate) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lumateperone (tosylate)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.179223 |
| COL6A3 | collagen, type VI, alpha 3 | 0.162372 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.12409 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.067719 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0632083 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0483518 |
| LOX | lysyl oxidase | 0.040251 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0389114 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0373784 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0350848 |
| ATP13A3 | ATPase type 13A3 | 0.0336148 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.030802 |
| STC1 | stanniocalcin 1 | 0.0307915 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0295448 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0292466 |
| COL3A1 | collagen, type III, alpha 1 | 0.0287518 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0275152 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0264565 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0259731 |
| ARRDC3 | arrestin domain containing 3 | 0.0256721 |
| ANXA2 | annexin A2 | 0.0251074 |
| AMOTL1 | angiomotin like 1 | 0.0235842 |
| FBN1 | fibrillin 1 | 0.0229605 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0229412 |
| DST | dystonin | 0.0218258 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0216467 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0216271 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0215695 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.0215686 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0212547 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0208839 |
| POSTN | periostin, osteoblast specific factor | 0.0207653 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0204809 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0192868 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0192462 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0187464 |
| ANO6 | anoctamin 6 | 0.0185584 |
| RPL3 | ribosomal protein L3 | 0.0185085 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0182775 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0182132 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0178933 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0178478 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0172452 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0169018 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0163471 |
| CD44 | CD44 molecule (Indian blood group) | 0.0163372 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0161758 |
| SMAD3 | SMAD family member 3 | 0.0159262 |
| HYOU1 | hypoxia up-regulated 1 | 0.0159245 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0157672 |
| TBX3 | T-box 3 | 0.0155959 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.0154159 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | 0.0152096 |
| MYO10 | myosin X | 0.0147301 |
| CA12 | carbonic anhydrase XII | 0.0147144 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0144402 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0140207 |
| APP | amyloid beta (A4) precursor protein | 0.0136707 |
| SFTPA2 | surfactant protein A2 | 0.0136254 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.0135769 |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.0135667 |
| SERINC1 | serine incorporator 1 | 0.0133814 |
| PLEC | plectin | 0.0133491 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0131558 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.013019 |
| DHFR | dihydrofolate reductase | 0.0128621 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 0.0128276 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0127824 |
| NUCB1 | nucleobindin 1 | 0.012742 |
| SCARB2 | scavenger receptor class B, member 2 | 0.0125386 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0124944 |
| PLXNA1 | plexin A1 | 0.0122851 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0122719 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | 0.0121975 |
| HLA-C | major histocompatibility complex, class I, C | 0.0121193 |
| FRMD6 | FERM domain containing 6 | 0.0119699 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0119102 |
| NAV2 | neuron navigator 2 | 0.011583 |
| LOXL2 | lysyl oxidase-like 2 | 0.0113078 |
| TLN1 | talin 1 | 0.0112264 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0111569 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | 0.0110972 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0110564 |
| FAT1 | FAT atypical cadherin 1 | 0.0110252 |
| JAG1 | jagged 1 | 0.0108779 |
| DNAJC10 | DnaJ (Hsp40) homolog, subfamily C, member 10 | 0.010824 |
| TAOK1 | TAO kinase 1 | 0.0108074 |
| MYOF | myoferlin | 0.0107382 |
| DSPP | dentin sialophosphoprotein | 0.010731 |
| HMGA2 | high mobility group AT-hook 2 | 0.0106925 |
| DNMBP | dynamin binding protein | 0.0105583 |
| TPX2 | TPX2, microtubule-associated | 0.0104726 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.010401 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0103795 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.010356 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.010352 |
| TMEM167A | transmembrane protein 167A | 0.0103081 |
| PFKP | phosphofructokinase, platelet | 0.0102206 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.0101972 |
| OSMR | oncostatin M receptor | 0.0100904 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL1A1 | collagen, type I, alpha 1 | -0.299718 |
| VIM | vimentin | -0.234393 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.192351 |
| TMSB10 | thymosin beta 10 | -0.12623 |
| NDRG1 | N-myc downstream regulated 1 | -0.117998 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.110285 |
| COL1A2 | collagen, type I, alpha 2 | -0.0930144 |
| PTMA | prothymosin, alpha | -0.0927877 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0862972 |
| IER3 | immediate early response 3 | -0.0846259 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0792262 |
| FTL | ferritin, light polypeptide | -0.0788998 |
| TPM4 | tropomyosin 4 | -0.0693109 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0691921 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0661583 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0659198 |
| MT2A | metallothionein 2A | -0.0649728 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0644523 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0638749 |
| MTDH | metadherin | -0.0570463 |
| HLA-B | major histocompatibility complex, class I, B | -0.0569329 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0563546 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0547389 |
| CDH13 | cadherin 13 | -0.0545347 |
| RPS8 | ribosomal protein S8 | -0.0542992 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0531666 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0527489 |
| COL5A1 | collagen, type V, alpha 1 | -0.0513339 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0512581 |
| ACTG1 | actin gamma 1 | -0.0507813 |
| RPL35A | ribosomal protein L35a | -0.0498468 |
| RRBP1 | ribosome binding protein 1 | -0.0488196 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0481973 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0481879 |
| RPS6 | ribosomal protein S6 | -0.047171 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0466397 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0464757 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0444604 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0442864 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0428547 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0405443 |
| CALR | calreticulin | -0.0393622 |
| SBF2 | SET binding factor 2 | -0.0391893 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0391506 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0390371 |
| GOLGB1 | golgin B1 | -0.0378089 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0376935 |
| CADM1 | cell adhesion molecule 1 | -0.0371864 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0366896 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0364711 |
| EGR1 | early growth response 1 | -0.03631 |
| GOLGA4 | golgin A4 | -0.0362523 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0360878 |
| TMEM165 | transmembrane protein 165 | -0.0356961 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0350123 |
| CALD1 | caldesmon 1 | -0.034555 |
| RPS19 | ribosomal protein S19 | -0.0330578 |
| INHBA | inhibin, beta A | -0.0328326 |
| RPL8 | ribosomal protein L8 | -0.0325819 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0323072 |
| PTK2 | protein tyrosine kinase 2 | -0.0322948 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0322488 |
| ADM | adrenomedullin | -0.0316649 |
| FOXP1 | forkhead box P1 | -0.0315805 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0310361 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0307224 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0303799 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0302347 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0301253 |
| CMIP | c-Maf inducing protein | -0.030081 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.029976 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0293984 |
| RPL37A | ribosomal protein L37a | -0.0293792 |
| CANX | calnexin | -0.0292285 |
| S100A6 | S100 calcium binding protein A6 | -0.028806 |
| MYO9B | myosin IXB | -0.0286688 |
| BBX | bobby sox homolog (Drosophila) | -0.0285456 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.028532 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0283854 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0282839 |
| GNAS | GNAS complex locus | -0.0280815 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0279357 |
| SETD5 | SET domain containing 5 | -0.0276283 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0274031 |
| ATXN1 | ataxin 1 | -0.027365 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0273232 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0271547 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0262662 |
| SEC61G | Sec61 gamma subunit | -0.0261952 |
| RPS27A | ribosomal protein S27a | -0.025941 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0258613 |
| CCDC80 | coiled-coil domain containing 80 | -0.0258582 |
| IL6 | interleukin 6 | -0.0258374 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.025811 |
| RPL9 | ribosomal protein L9 | -0.0257557 |
| RPL28 | ribosomal protein L28 | -0.0254888 |
| RPL36 | ribosomal protein L36 | -0.0253561 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0252728 |
| CNTN5 | contactin 5 | -0.0250907 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0250786 |
