| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lumateperone (tosylate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lumateperone (tosylate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.136007 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.105861 |
| APOB | apolipoprotein B | 0.0792606 |
| VCL | vinculin | 0.0791215 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0725137 |
| SDC4 | syndecan 4 | 0.0663638 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0658402 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0655296 |
| BCL2L1 | BCL2-like 1 | 0.0561427 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0537591 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.053274 |
| DSPP | dentin sialophosphoprotein | 0.0531141 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0521315 |
| SVIL | supervillin | 0.0510567 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0492657 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0473566 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.045353 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.045075 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0444514 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0441898 |
| PTCHD4 | patched domain containing 4 | 0.0436772 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0429109 |
| FOXP1 | forkhead box P1 | 0.0417957 |
| USP34 | ubiquitin specific peptidase 34 | 0.0413135 |
| VMP1 | vacuole membrane protein 1 | 0.0411316 |
| ATXN1 | ataxin 1 | 0.0407638 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0395638 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.038242 |
| STAU1 | staufen double-stranded RNA binding protein 1 | 0.03762 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0369275 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0360798 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0355401 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0347484 |
| ITGAV | integrin, alpha V | 0.0342159 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0339264 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0328189 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0327576 |
| MYO1E | myosin IE | 0.0320331 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.031557 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0312642 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0309362 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0307212 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0301887 |
| FAM107B | family with sequence similarity 107, member B | 0.0299147 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0297392 |
| ZNF644 | zinc finger protein 644 | 0.0294598 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0293538 |
| INTS6 | integrator complex subunit 6 | 0.029142 |
| CLIC4 | chloride intracellular channel 4 | 0.0286578 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0286261 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0285895 |
| CORO1C | coronin, actin binding protein, 1C | 0.028402 |
| CFB | complement factor B | 0.0278291 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0277736 |
| RPL11 | ribosomal protein L11 | 0.0277633 |
| RBM39 | RNA binding motif protein 39 | 0.027347 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0268552 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0265205 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0264181 |
| PCBP2 | poly(rC) binding protein 2 | 0.0260826 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0260221 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0258979 |
| A2M | alpha-2-macroglobulin | 0.0258394 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0258058 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0257652 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0256641 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | 0.0254068 |
| AHNAK | AHNAK nucleoprotein | 0.0252635 |
| CANX | calnexin | 0.0252 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0250162 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0249885 |
| DIAPH1 | diaphanous-related formin 1 | 0.0248632 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0246424 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0245911 |
| MCL1 | myeloid cell leukemia 1 | 0.0244101 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.024406 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0242556 |
| MRTFA | myocardin related transcription factor A | 0.0242188 |
| DENND4A | DENN/MADD domain containing 4A | 0.0241927 |
| AFDN | afadin, adherens junction formation factor | 0.0240424 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0239679 |
| FRMD5 | FERM domain containing 5 | 0.0239613 |
| TOP1 | topoisomerase (DNA) I | 0.0238267 |
| PEG3 | paternally expressed 3 | 0.0238105 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0237626 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.023693 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0236389 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | 0.0235781 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0233588 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0231526 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0229965 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0228253 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0227557 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0224415 |
| SEPTIN9 | septin 9 | 0.0224412 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0224064 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0223231 |
| UBQLN1 | ubiquilin 1 | 0.022273 |
| ARHGEF18 | Rho/Rac guanine nucleotide exchange factor (GEF) 18 | 0.022266 |
| DNAH17 | dynein, axonemal, heavy chain 17 | 0.0220925 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.388482 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.172851 |
| IGF2 | insulin-like growth factor 2 | -0.163517 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.141266 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.122287 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.112489 |
| MT2A | metallothionein 2A | -0.101956 |
| ENO1 | enolase 1, (alpha) | -0.081661 |
| CP | ceruloplasmin (ferroxidase) | -0.0757639 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0528585 |
| FTL | ferritin, light polypeptide | -0.0496723 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0491554 |
| C3 | complement component 3 | -0.0490405 |
| PLIN2 | perilipin 2 | -0.0472722 |
| AHSG | alpha-2-HS-glycoprotein | -0.0443133 |
| TMSB10 | thymosin beta 10 | -0.0430255 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0408199 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0398168 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0394997 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0385987 |
| NDRG1 | N-myc downstream regulated 1 | -0.037373 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0363667 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0337082 |
| RPL37A | ribosomal protein L37a | -0.0331588 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0331104 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0326676 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0325327 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0322341 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0321694 |
| OSMR | oncostatin M receptor | -0.0286763 |
| RNASET2 | ribonuclease T2 | -0.0282545 |
| GDF15 | growth differentiation factor 15 | -0.0281332 |
| RPS12 | ribosomal protein S12 | -0.0277915 |
| PERP | PERP, TP53 apoptosis effector | -0.0276108 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0274683 |
| TMEM51 | transmembrane protein 51 | -0.0271378 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0268015 |
| APOA1 | apolipoprotein A-I | -0.0267373 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.026132 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0260689 |
| GSE1 | Gse1 coiled-coil protein | -0.0248173 |
| ARFGEF3 | ARFGEF family member 3 | -0.0246572 |
| LDHA | lactate dehydrogenase A | -0.0242909 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0239666 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0227498 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0227033 |
| APOE | apolipoprotein E | -0.0226593 |
| PHYHIPL | phytanoyl-CoA 2-hydroxylase interacting protein-like | -0.0224191 |
| APOA2 | apolipoprotein A-II | -0.0223662 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0220553 |
| ATP10A | ATPase, class V, type 10A | -0.0218594 |
| ARHGAP18 | Rho GTPase activating protein 18 | -0.0218377 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | -0.0212694 |
| CALD1 | caldesmon 1 | -0.0212283 |
| WDR45B | WD repeat domain 45B | -0.0209261 |
| TMEM45B | transmembrane protein 45B | -0.0203984 |
| SQSTM1 | sequestosome 1 | -0.0201249 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0200714 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0200272 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0198901 |
| RPL28 | ribosomal protein L28 | -0.0198507 |
| GLRX | glutaredoxin (thioltransferase) | -0.0194978 |
| IFITM2 | interferon induced transmembrane protein 2 | -0.019341 |
| ITGA1 | integrin, alpha 1 | -0.0189967 |
| GNAS | GNAS complex locus | -0.0188139 |
| TXNIP | thioredoxin interacting protein | -0.0187578 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0187262 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | -0.0185133 |
| MBNL3 | muscleblind-like splicing regulator 3 | -0.0185056 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0182995 |
| PRXL2A | peroxiredoxin like 2A | -0.0181696 |
| CRLS1 | cardiolipin synthase 1 | -0.018055 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0180107 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0175928 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0173426 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0172277 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | -0.0172004 |
| TPI1 | triosephosphate isomerase 1 | -0.016978 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0169549 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | -0.0167354 |
| FERMT1 | fermitin family member 1 | -0.016695 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0165053 |
| HMGA1 | high mobility group AT-hook 1 | -0.0163206 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0162433 |
| RPL37 | ribosomal protein L37 | -0.0161747 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0161643 |
| RSF1 | remodeling and spacing factor 1 | -0.0160481 |
| DSG2 | desmoglein 2 | -0.0159725 |
| PIAS2 | protein inhibitor of activated STAT, 2 | -0.0159619 |
| MAPK14 | mitogen-activated protein kinase 14 | -0.0159214 |
| CCDC146 | coiled-coil domain containing 146 | -0.0158723 |
| WWC1 | WW and C2 domain containing 1 | -0.0155824 |
| RPL30 | ribosomal protein L30 | -0.0154281 |
| MATN3 | matrilin 3 | -0.0153965 |
| HLA-A | major histocompatibility complex, class I, A | -0.0153097 |
| INSIG2 | insulin induced gene 2 | -0.0152065 |
| HLA-E | major histocompatibility complex, class I, E | -0.0151402 |
| PKM | pyruvate kinase, muscle | -0.0151291 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0149322 |
| PCBP1 | poly(rC) binding protein 1 | -0.0148941 |
