Lumateperone (tosylate)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lumateperone (tosylate) perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lumateperone (tosylate)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.152536
POTEF POTE ankyrin domain family, member F 0.108583
NAV2 neuron navigator 2 0.0956469
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0804278
CENPF centromere protein F, 350/400kDa 0.0726876
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.072118
ERBIN erbb2 interacting protein 0.0658568
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0628641
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0625411
EXT1 exostosin glycosyltransferase 1 0.061105
ZNF841 zinc finger protein 841 0.0598249
PRELID2 PRELI domain containing 2 0.0595096
LDHA lactate dehydrogenase A 0.0570183
CALD1 caldesmon 1 0.0514822
VCL vinculin 0.0507611
INTS6 integrator complex subunit 6 0.0502871
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0485359
WWOX WW domain containing oxidoreductase 0.0476754
ZSWIM6 zinc finger, SWIM-type containing 6 0.0470667
SMAD3 SMAD family member 3 0.0433711
SMC4 structural maintenance of chromosomes 4 0.0430236
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0426549
DST dystonin 0.0420514
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0420146
TLE4 transducin-like enhancer of split 4 0.0411308
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0403961
PICALM phosphatidylinositol binding clathrin assembly protein 0.0400993
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0385208
PCLO piccolo presynaptic cytomatrix protein 0.0374468
MBNL1 muscleblind-like splicing regulator 1 0.0372216
PLSCR1 phospholipid scramblase 1 0.0365117
LPP LIM domain containing preferred translocation partner in lipoma 0.0363151
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0360411
MYH9 myosin, heavy chain 9, non-muscle 0.0357415
PDLIM5 PDZ and LIM domain 5 0.0354638
SETX senataxin 0.0341146
FHIT fragile histidine triad 0.0340878
GLIPR1 GLI pathogenesis-related 1 0.0339325
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0333109
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0332783
MSN moesin 0.0330123
BCAR3 breast cancer anti-estrogen resistance 3 0.0325759
ACTN1 actinin, alpha 1 0.0321843
SH3RF1 SH3 domain containing ring finger 1 0.0315618
PLK2 polo-like kinase 2 0.0314444
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0292796
ATXN1 ataxin 1 0.0288657
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0282392
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0279092
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0278543
C6ORF62 chromosome 6 open reading frame 62 0.0274883
CORO1C coronin, actin binding protein, 1C 0.0274306
FHL2 four and a half LIM domains 2 0.0271349
SLIT2 slit homolog 2 (Drosophila) 0.0266695
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0265626
SON SON DNA binding protein 0.0262142
ANO6 anoctamin 6 0.0260601
HSPH1 heat shock 105kDa/110kDa protein 1 0.0258625
NEK7 NIMA-related kinase 7 0.0253424
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0250726
ACTN4 actinin, alpha 4 0.025051
MYOF myoferlin 0.0249895
RIGI RNA sensor RIG-I 0.0249733
RRM2 ribonucleotide reductase M2 0.0248985
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0246101
APLP2 amyloid beta (A4) precursor-like protein 2 0.0243915
TPX2 TPX2, microtubule-associated 0.0241197
MACF1 microtubule-actin crosslinking factor 1 0.0239024
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0238705
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0236329
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0236016
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.023462
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0231598
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0230667
SET SET nuclear proto-oncogene 0.0229065
UTRN utrophin 0.0228225
SMC1A structural maintenance of chromosomes 1A 0.0227307
SAMD9 sterile alpha motif domain containing 9 0.0225283
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0224771
FLNA filamin A, alpha 0.0224029
VEGFC vascular endothelial growth factor C 0.022402
SCFD1 sec1 family domain containing 1 0.0223764
SRRM2 serine/arginine repetitive matrix 2 0.0221199
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0219886
ASPH aspartate beta-hydroxylase 0.0218412
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0217097
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0215969
TLN1 talin 1 0.021596
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0214749
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0213909
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0213287
STARD13 StAR-related lipid transfer (START) domain containing 13 0.0211786
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0211084
KLF12 Kruppel-like factor 12 0.0210136
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0209699
NRIP1 nuclear receptor interacting protein 1 0.0209319
SFPQ splicing factor proline/glutamine-rich 0.0208203
PODXL podocalyxin-like 0.0204683
SPIDR scaffolding protein involved in DNA repair 0.0203941
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.0200429

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.325015
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.195169
IGFBP3 insulin-like growth factor binding protein 3 -0.167702
HLA-B major histocompatibility complex, class I, B -0.158506
ABI3BP ABI family, member 3 (NESH) binding protein -0.146487
NALF1 NALCN channel auxiliary factor 1 -0.119624
PHACTR1 phosphatase and actin regulator 1 -0.0935566
SLC12A8 solute carrier family 12, member 8 -0.0908385
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0838603
UGCG UDP-glucose ceramide glucosyltransferase -0.0816746
NDRG1 N-myc downstream regulated 1 -0.0786968
ATP13A3 ATPase type 13A3 -0.0784249
NAMPT nicotinamide phosphoribosyltransferase -0.0769347
FTL ferritin, light polypeptide -0.073739
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0727404
DLG1 discs, large homolog 1 (Drosophila) -0.0725312
SOD2 superoxide dismutase 2, mitochondrial -0.0677778
MT2A metallothionein 2A -0.0633653
RPS6 ribosomal protein S6 -0.063213
PTMA prothymosin, alpha -0.0625425
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0602727
AHNAK AHNAK nucleoprotein -0.0538576
DTNA dystrobrevin, alpha -0.0531507
CXCL8 chemokine (C-X-C motif) ligand 8 -0.052294
RPL35A ribosomal protein L35a -0.0510776
OSMR oncostatin M receptor -0.0500176
IGFBP5 insulin-like growth factor binding protein 5 -0.0481729
TPT1 tumor protein, translationally-controlled 1 -0.0467062
CCBE1 collagen and calcium binding EGF domains 1 -0.0454808
DEK DEK proto-oncogene -0.0431546
PDIA3 protein disulfide isomerase family A, member 3 -0.0427214
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0416694
CANX calnexin -0.0412039
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0400937
EIF1 eukaryotic translation initiation factor 1 -0.0399272
RPL37 ribosomal protein L37 -0.0393419
TMSB4X thymosin beta 4, X-linked -0.0388403
GLIS3 GLIS family zinc finger 3 -0.0387861
RPLP2 ribosomal protein, large, P2 -0.0387465
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0381611
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.037875
MMP12 matrix metallopeptidase 12 -0.0375079
PKM pyruvate kinase, muscle -0.0357804
CAVIN1 caveolae associated protein 1 -0.0352913
FTH1 ferritin, heavy polypeptide 1 -0.0349456
NUP58 nucleoporin 58 -0.0343604
RPS13 ribosomal protein S13 -0.0343313
RPLP1 ribosomal protein, large, P1 -0.0336309
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0328759
MAP4 microtubule-associated protein 4 -0.032667
FOXP1 forkhead box P1 -0.0320671
GOLGA4 golgin A4 -0.0319681
KPNB1 karyopherin (importin) beta 1 -0.0317777
CCND1 cyclin D1 -0.0311468
TMEM165 transmembrane protein 165 -0.0298935
S100A6 S100 calcium binding protein A6 -0.0298026
RPS8 ribosomal protein S8 -0.0293857
POSTN periostin, osteoblast specific factor -0.0291889
HLA-E major histocompatibility complex, class I, E -0.0285686
GNAS GNAS complex locus -0.0285615
PACS1 phosphofurin acidic cluster sorting protein 1 -0.028524
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0285086
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0284971
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0284547
PTBP3 polypyrimidine tract binding protein 3 -0.0283429
SULF1 sulfatase 1 -0.0279244
RIOK3 RIO kinase 3 -0.0276009
AFAP1 actin filament associated protein 1 -0.0274361
RAI14 retinoic acid induced 14 -0.027414
ZMYND8 zinc finger, MYND-type containing 8 -0.0273805
KMT2C lysine (K)-specific methyltransferase 2C -0.027372
ZFR zinc finger RNA binding protein -0.027222
PLCB4 phospholipase C, beta 4 -0.0271966
ANXA2 annexin A2 -0.0269735
RPS20 ribosomal protein S20 -0.0268564
NPEPPS aminopeptidase puromycin sensitive -0.0267183
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0265444
S100A10 S100 calcium binding protein A10 -0.0263829
RHOA ras homolog family member A -0.0262641
HLA-A major histocompatibility complex, class I, A -0.0262607
ACTG1 actin gamma 1 -0.0262282
WSB1 WD repeat and SOCS box containing 1 -0.0260529
CUX1 cut-like homeobox 1 -0.0255927
PDE10A phosphodiesterase 10A -0.0255239
RPS24 ribosomal protein S24 -0.0253996
SBF2 SET binding factor 2 -0.0250925
ZNF804A zinc finger protein 804A -0.0248376
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0247731
AKAP12 A kinase (PRKA) anchor protein 12 -0.0245515
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0244422
LCORL ligand dependent nuclear receptor corepressor-like -0.0244194
FLNB filamin B, beta -0.0241084
RPL26 ribosomal protein L26 -0.024079
COL5A2 collagen, type V, alpha 2 -0.0240192
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0236611
RLF rearranged L-myc fusion -0.0236437
PTX3 pentraxin 3, long -0.0236114
RPL7A ribosomal protein L7a -0.023582
CTSD cathepsin D -0.0235163
RPL34 ribosomal protein L34 -0.0234807