Lumateperone (tosylate)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Lumateperone (tosylate) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Lumateperone (tosylate)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.149047
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0893319
ERRFI1 ERBB receptor feedback inhibitor 1 0.0870944
WSB1 WD repeat and SOCS box containing 1 0.0811219
KDM3A lysine (K)-specific demethylase 3A 0.0780942
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0758892
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0702133
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0679348
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0672191
DTNA dystrobrevin, alpha 0.0654981
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0639713
TPT1 tumor protein, translationally-controlled 1 0.0637254
NAP1L1 nucleosome assembly protein 1-like 1 0.0605648
HSPA8 heat shock 70kDa protein 8 0.0603828
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.05431
TRIO trio Rho guanine nucleotide exchange factor 0.054151
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0531655
MYO10 myosin X 0.0514657
ASPH aspartate beta-hydroxylase 0.0488876
PTMA prothymosin, alpha 0.0472516
EFNA5 ephrin-A5 0.0470202
CORO1C coronin, actin binding protein, 1C 0.0462784
FMNL2 formin-like 2 0.0462277
RUNX1 runt-related transcription factor 1 0.0459151
PGK1 phosphoglycerate kinase 1 0.0416598
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0412462
CDH13 cadherin 13 0.0393837
HOOK2 hook microtubule-tethering protein 2 0.0393102
MYH9 myosin, heavy chain 9, non-muscle 0.0392569
ADM adrenomedullin 0.0388336
ITGA6 integrin, alpha 6 0.0388283
MAP2K1 mitogen-activated protein kinase kinase 1 0.0381343
EZR ezrin 0.0378598
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0371111
PTK2 protein tyrosine kinase 2 0.0367866
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0366867
CANX calnexin 0.0361206
AHNAK AHNAK nucleoprotein 0.0357015
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0350573
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0345532
NSD2 nuclear receptor binding SET domain protein 2 0.0341331
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0335047
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0326339
PRELID2 PRELI domain containing 2 0.0323006
ENO1 enolase 1, (alpha) 0.0322603
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0319186
HSPH1 heat shock 105kDa/110kDa protein 1 0.0316093
FGFR1 fibroblast growth factor receptor 1 0.0307189
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0306559
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0304793
MXI1 MAX interactor 1, dimerization protein 0.0303826
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0299366
ESYT2 extended synaptotagmin-like protein 2 0.0298461
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0296401
ELL2 elongation factor, RNA polymerase II, 2 0.02955
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0294438
ANXA2 annexin A2 0.0292243
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.029169
BZW1 basic leucine zipper and W2 domains 1 0.0291416
WDR45B WD repeat domain 45B 0.0288001
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0287763
USP34 ubiquitin specific peptidase 34 0.0287235
PRKCE protein kinase C, epsilon 0.0286645
JUN jun proto-oncogene 0.0284186
NGLY1 N-glycanase 1 0.0283144
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0282744
DENR density-regulated protein 0.0281602
CTBP2 C-terminal binding protein 2 0.0280808
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0280711
CALU calumenin 0.0274024
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0273921
POTEF POTE ankyrin domain family, member F 0.0270169
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0264975
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0263757
CAVIN1 caveolae associated protein 1 0.0263747
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0261754
CCDC47 coiled-coil domain containing 47 0.0258384
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0257139
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0254862
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0252868
LIMCH1 LIM and calponin homology domains 1 0.0252292
RAB1A RAB1A, member RAS oncogene family 0.0250591
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.025018
HILPDA hypoxia inducible lipid droplet-associated 0.0248448
TM4SF1 transmembrane 4 L six family member 1 0.0246884
EIF4B eukaryotic translation initiation factor 4B 0.0244308
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0237365
TTC3 tetratricopeptide repeat domain 3 0.0235026
NDRG1 N-myc downstream regulated 1 0.0233185
IRS2 insulin receptor substrate 2 0.023034
MYO9B myosin IXB 0.023026
RPL23 ribosomal protein L23 0.0225769
RPL7A ribosomal protein L7a 0.022524
RLF rearranged L-myc fusion 0.0224517
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0224213
TPM4 tropomyosin 4 0.0224072
PHACTR1 phosphatase and actin regulator 1 0.0223269
PDE8A phosphodiesterase 8A 0.0223189
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0222803
DDIT4 DNA-damage-inducible transcript 4 0.0222573

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.461301
VCL vinculin -0.111675
FRMD6 FERM domain containing 6 -0.0793878
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.076415
ADAM19 ADAM metallopeptidase domain 19 -0.0726373
EGR1 early growth response 1 -0.068958
RTN4 reticulon 4 -0.0669495
CALD1 caldesmon 1 -0.0661532
ENKUR enkurin, TRPC channel interacting protein -0.0658745
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0619076
MAML2 mastermind-like 2 (Drosophila) -0.0609733
MMP12 matrix metallopeptidase 12 -0.0586732
KYNU kynureninase -0.0572778
ANKRD28 ankyrin repeat domain 28 -0.0545034
LOC112694756 uncharaterized LOC112694756 -0.0544521
ERBIN erbb2 interacting protein -0.0534941
OSMR oncostatin M receptor -0.0484857
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0474922
GPC6 glypican 6 -0.0472697
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0466131
PTCHD4 patched domain containing 4 -0.045723
NABP1 nucleic acid binding protein 1 -0.0435568
TSC22D2 TSC22 domain family, member 2 -0.0429881
HMGA1 high mobility group AT-hook 1 -0.0424464
CD44 CD44 molecule (Indian blood group) -0.0413347
NPC1 Niemann-Pick disease, type C1 -0.041114
RAI14 retinoic acid induced 14 -0.0409874
CCN2 cellular communication network factor 2 -0.0409132
YBX3 Y box binding protein 3 -0.0392648
CDK17 cyclin-dependent kinase 17 -0.0391478
PCNX4 pecanex 4 -0.0383899
ACTN1 actinin, alpha 1 -0.0370937
NTM neurotrimin -0.0369705
HMGA2 high mobility group AT-hook 2 -0.0368877
PFN1 profilin 1 -0.0366599
HAS2 hyaluronan synthase 2 -0.0365859
HDAC9 histone deacetylase 9 -0.0360349
CD163L1 CD163 molecule-like 1 -0.0356848
WDR43 WD repeat domain 43 -0.0352807
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0351852
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0346312
TMSB10 thymosin beta 10 -0.0346309
FOXP1 forkhead box P1 -0.0345712
CD109 CD109 molecule -0.0345546
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0334388
BCAR3 breast cancer anti-estrogen resistance 3 -0.0333667
FN1 fibronectin 1 -0.0327781
NF1 neurofibromin 1 -0.0323444
MSR1 macrophage scavenger receptor 1 -0.0322501
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0312353
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0309408
MBD5 methyl-CpG binding domain protein 5 -0.0309348
VIM vimentin -0.0299935
SATB2 SATB homeobox 2 -0.0299402
NALF1 NALCN channel auxiliary factor 1 -0.0299087
FTL ferritin, light polypeptide -0.0298408
ZBTB20 zinc finger and BTB domain containing 20 -0.0296698
TXNRD1 thioredoxin reductase 1 -0.0292726
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0288987
FGF5 fibroblast growth factor 5 -0.0282123
SLC38A2 solute carrier family 38, member 2 -0.0278766
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0270101
ITGAV integrin, alpha V -0.0268773
GLMN glomulin, FKBP associated protein -0.0267932
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0263777
ZNF207 zinc finger protein 207 -0.0262385
TSC22D1 TSC22 domain family, member 1 -0.0259547
FNDC3B fibronectin type III domain containing 3B -0.0254129
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0253558
MAP1B microtubule-associated protein 1B -0.0252553
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.0247457
UGCG UDP-glucose ceramide glucosyltransferase -0.0245173
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 -0.0242337
MT2A metallothionein 2A -0.0240322
BRD2 bromodomain containing 2 -0.024026
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0238846
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0237626
JMJD1C jumonji domain containing 1C -0.0233236
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0232488
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0231475
NT5E 5'-nucleotidase, ecto (CD73) -0.0229744
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0229022
NRP2 neuropilin 2 -0.0228165
ETV6 ets variant 6 -0.0227763
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0227461
SASH1 SAM and SH3 domain containing 1 -0.0225731
VGLL3 vestigial-like family member 3 -0.0223649
WWTR1 WW domain containing transcription regulator 1 -0.0223144
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0222723
RIMS2 regulating synaptic membrane exocytosis 2 -0.0222324
ZNF804A zinc finger protein 804A -0.0220641
TRPS1 trichorhinophalangeal syndrome I -0.022032
TNNC1 troponin C type 1 (slow) -0.0220188
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -0.0219998
PTBP3 polypyrimidine tract binding protein 3 -0.021924
STAU2 staufen double-stranded RNA binding protein 2 -0.0218459
STRN3 striatin, calmodulin binding protein 3 -0.0216754
PHF14 PHD finger protein 14 -0.0213886
ALCAM activated leukocyte cell adhesion molecule -0.0213809
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0212947