| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lumateperone (tosylate) perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lumateperone (tosylate)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ASPH | aspartate beta-hydroxylase | 0.0935612 |
| LMO7 | LIM domain 7 | 0.0924037 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0823191 |
| FAT1 | FAT atypical cadherin 1 | 0.0808314 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0737393 |
| LAMA4 | laminin, alpha 4 | 0.0662674 |
| VCL | vinculin | 0.0568894 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0560498 |
| MT2A | metallothionein 2A | 0.052712 |
| AREG | amphiregulin | 0.0514697 |
| EZR | ezrin | 0.0509368 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0494539 |
| LDHA | lactate dehydrogenase A | 0.049154 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0475383 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0467135 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0446376 |
| ECT2 | epithelial cell transforming 2 | 0.043385 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0422432 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0415168 |
| PRELID2 | PRELI domain containing 2 | 0.041446 |
| DSPP | dentin sialophosphoprotein | 0.0394799 |
| LAMC2 | laminin, gamma 2 | 0.0387794 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0384877 |
| CENPF | centromere protein F, 350/400kDa | 0.0373854 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0369776 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0368525 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.036531 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0358225 |
| MYO5B | myosin VB | 0.0352036 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0350728 |
| HMGB2 | high mobility group box 2 | 0.033107 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0329889 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0324496 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0311686 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0284449 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | 0.0283434 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0282375 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0276134 |
| POF1B | premature ovarian failure, 1B | 0.0274725 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0272543 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0267749 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0263937 |
| CLCN3 | chloride channel, voltage-sensitive 3 | 0.0262143 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | 0.025793 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0255801 |
| MUC13 | mucin 13, cell surface associated | 0.0253981 |
| POTEF | POTE ankyrin domain family, member F | 0.0253368 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0250903 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0244287 |
| ANXA1 | annexin A1 | 0.0241955 |
| ACTG1 | actin gamma 1 | 0.0238535 |
| KRT18 | keratin 18, type I | 0.0238275 |
| RPS12 | ribosomal protein S12 | 0.0236924 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0235007 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0234394 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0232828 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.023281 |
| SMAD3 | SMAD family member 3 | 0.0231828 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0229288 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0227433 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0225114 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0225023 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0222643 |
| PGK1 | phosphoglycerate kinase 1 | 0.0221224 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0220098 |
| RRM2 | ribonucleotide reductase M2 | 0.0219124 |
| EFNB2 | ephrin-B2 | 0.0217668 |
| KRT19 | keratin 19, type I | 0.0217662 |
| MYOF | myoferlin | 0.0217458 |
| PRR5L | proline rich 5 like | 0.0216939 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0216776 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0216238 |
| RPS3 | ribosomal protein S3 | 0.0215583 |
| USP53 | ubiquitin specific peptidase 53 | 0.021151 |
| TPR | translocated promoter region, nuclear basket protein | 0.0211248 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.021035 |
| ENO1 | enolase 1, (alpha) | 0.0210044 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0208355 |
| TUBB4B | tubulin, beta 4B class IVb | 0.0207727 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0204092 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.020162 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0200186 |
| MT1E | metallothionein 1E | 0.0200041 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.0192648 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0192602 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0192461 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.019243 |
| PLEKHA6 | pleckstrin homology domain containing, family A member 6 | 0.0192101 |
| EGFR | epidermal growth factor receptor | 0.0191478 |
| SVIL | supervillin | 0.0189684 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0188966 |
| DIAPH3 | diaphanous-related formin 3 | 0.0182668 |
| INTS6 | integrator complex subunit 6 | 0.0182612 |
| FTL | ferritin, light polypeptide | 0.0181952 |
| EPHA4 | EPH receptor A4 | 0.0180608 |
| ANLN | anillin, actin binding protein | 0.0180237 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0177445 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0177042 |
| PDZD8 | PDZ domain containing 8 | 0.0176602 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0174968 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.189533 |
| NPSR1 | neuropeptide S receptor 1 | -0.157965 |
| GPHN | gephyrin | -0.121214 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.117988 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.117453 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.111499 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.106993 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.101484 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0976262 |
| PTMA | prothymosin, alpha | -0.0910324 |
| RPS6 | ribosomal protein S6 | -0.0904304 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0871117 |
| GOLGA4 | golgin A4 | -0.0868015 |
| PIGR | polymeric immunoglobulin receptor | -0.0833526 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0745257 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0659706 |
| TMSB10 | thymosin beta 10 | -0.0620207 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.060758 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0561767 |
| PRSS3 | protease, serine, 3 | -0.0537741 |
| RREB1 | ras responsive element binding protein 1 | -0.0526509 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0517744 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0517488 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0517115 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0502377 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0501903 |
| MUC17 | mucin 17, cell surface associated | -0.0486718 |
| ITGB4 | integrin, beta 4 | -0.0483518 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0482101 |
| CALB1 | calbindin 1, 28kDa | -0.0465624 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0463923 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0457949 |
| TFF3 | trefoil factor 3 (intestinal) | -0.0446992 |
| MED13L | mediator complex subunit 13-like | -0.0444329 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0443085 |
| NFIA | nuclear factor I/A | -0.0442764 |
| S100A6 | S100 calcium binding protein A6 | -0.0439535 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0436462 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0435967 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0429848 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0428747 |
| ABHD2 | abhydrolase domain containing 2 | -0.0423503 |
| FLNB | filamin B, beta | -0.0415443 |
| HMGA1 | high mobility group AT-hook 1 | -0.0414615 |
| FAM13A | family with sequence similarity 13, member A | -0.0412703 |
| PTEN | phosphatase and tensin homolog | -0.0402877 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0398798 |
| RPL34 | ribosomal protein L34 | -0.0397296 |
| VEGFA | vascular endothelial growth factor A | -0.0394877 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | -0.039318 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0392693 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0390266 |
| NDRG1 | N-myc downstream regulated 1 | -0.0389344 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0387245 |
| TNS4 | tensin 4 | -0.0372739 |
| SBF2 | SET binding factor 2 | -0.0365848 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0364978 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0351029 |
| RNF43 | ring finger protein 43 | -0.034741 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0346115 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0345127 |
| FOXP1 | forkhead box P1 | -0.0341895 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0339812 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.033939 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0337137 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0332322 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0330983 |
| COG5 | component of oligomeric golgi complex 5 | -0.033006 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | -0.0329162 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0328646 |
| MSI2 | musashi RNA-binding protein 2 | -0.0328334 |
| AGR2 | anterior gradient 2 | -0.0327693 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0324799 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0324052 |
| SETD5 | SET domain containing 5 | -0.0320987 |
| RPS23 | ribosomal protein S23 | -0.031898 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | -0.0314181 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0313629 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0313358 |
| USP3 | ubiquitin specific peptidase 3 | -0.031288 |
| FNBP1L | formin binding protein 1-like | -0.0309082 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -0.0309001 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0308311 |
| DNM2 | dynamin 2 | -0.0307148 |
| RPL5 | ribosomal protein L5 | -0.0306207 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.0306166 |
| TFF1 | trefoil factor 1 | -0.0301948 |
| GDF15 | growth differentiation factor 15 | -0.0299111 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0298432 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0297566 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0296515 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0292409 |
| INSIG1 | insulin induced gene 1 | -0.0292377 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.029215 |
| MAP4 | microtubule-associated protein 4 | -0.0292015 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0290478 |
| ZNF292 | zinc finger protein 292 | -0.0288058 |
| RPS24 | ribosomal protein S24 | -0.0287365 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0285583 |
| PKM | pyruvate kinase, muscle | -0.0285129 |
