| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lumateperone (tosylate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Lumateperone (tosylate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GRAMD1B | GRAM domain containing 1B | 0.165453 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.140841 |
| SLTM | SAFB-like, transcription modulator | 0.13642 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.114675 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.102638 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0984954 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0892249 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0853267 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0762763 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0736417 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0666239 |
| SMAD3 | SMAD family member 3 | 0.0661318 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0646117 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0631298 |
| SPAG9 | sperm associated antigen 9 | 0.0615146 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0609579 |
| TOP1 | topoisomerase (DNA) I | 0.0581661 |
| MYOF | myoferlin | 0.0544866 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0530863 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0518608 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0507075 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0498436 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0481489 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0477863 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0473177 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0460318 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.045452 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0452884 |
| RUNX1 | runt-related transcription factor 1 | 0.0450868 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0444607 |
| GSK3B | glycogen synthase kinase 3 beta | 0.043416 |
| FAM13A | family with sequence similarity 13, member A | 0.0418102 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0410785 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0407397 |
| ENO1 | enolase 1, (alpha) | 0.0401923 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0391603 |
| BMP6 | bone morphogenetic protein 6 | 0.0390533 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0380995 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0367916 |
| MCL1 | myeloid cell leukemia 1 | 0.0364536 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0347081 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0345267 |
| VMP1 | vacuole membrane protein 1 | 0.0341673 |
| JMJD1C | jumonji domain containing 1C | 0.0340764 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0340684 |
| CPE | carboxypeptidase E | 0.0335658 |
| TES | testin LIM domain protein | 0.0329403 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0328926 |
| VEGFC | vascular endothelial growth factor C | 0.0322392 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0322291 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0318764 |
| VCL | vinculin | 0.0317361 |
| ATP13A3 | ATPase type 13A3 | 0.0316739 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.03095 |
| MAP7 | microtubule-associated protein 7 | 0.0309273 |
| SIK3 | SIK family kinase 3 | 0.0308824 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0300401 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0298774 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0298161 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0296032 |
| KYNU | kynureninase | 0.0295844 |
| SMYD3 | SET and MYND domain containing 3 | 0.0295577 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0292447 |
| MSN | moesin | 0.0292389 |
| CES1 | carboxylesterase 1 | 0.028392 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0283639 |
| STC1 | stanniocalcin 1 | 0.0283477 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0280323 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0277487 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0277347 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0275457 |
| EZR | ezrin | 0.0273954 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0272154 |
| HOMER1 | homer scaffolding protein 1 | 0.0270138 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.026373 |
| MT2A | metallothionein 2A | 0.0261315 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0260214 |
| HELZ | helicase with zinc finger | 0.0258981 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0255313 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0252974 |
| RTN4 | reticulon 4 | 0.025095 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0246634 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.024616 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0245087 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0243836 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0241325 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0236057 |
| GPHN | gephyrin | 0.0233788 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0233438 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0231748 |
| CUL3 | cullin 3 | 0.0226162 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0226075 |
| WWOX | WW domain containing oxidoreductase | 0.0225412 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0224624 |
| DST | dystonin | 0.0222398 |
| HBP1 | HMG-box transcription factor 1 | 0.022189 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0221005 |
| RNF145 | ring finger protein 145 | 0.0219017 |
| POTEF | POTE ankyrin domain family, member F | 0.0218155 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0217402 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | -0.251214 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.181304 |
| TMSB10 | thymosin beta 10 | -0.135637 |
| NDRG1 | N-myc downstream regulated 1 | -0.109553 |
| ACTG1 | actin gamma 1 | -0.0964637 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0704527 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0667437 |
| PTMA | prothymosin, alpha | -0.0660513 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0644356 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0625501 |
| EGR1 | early growth response 1 | -0.0611769 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0572552 |
| CST3 | cystatin C | -0.0559005 |
| S100A10 | S100 calcium binding protein A10 | -0.0556383 |
| AHNAK | AHNAK nucleoprotein | -0.0536764 |
| HDLBP | high density lipoprotein binding protein | -0.0524449 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0514855 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0472479 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0454932 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0447971 |
| HLA-B | major histocompatibility complex, class I, B | -0.0432798 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0431548 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0421563 |
| AGR2 | anterior gradient 2 | -0.0418629 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0409892 |
| WASF2 | WAS protein family, member 2 | -0.0396817 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0389034 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0388668 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0388494 |
| LMO7 | LIM domain 7 | -0.0386119 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0376556 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0376528 |
| CCND1 | cyclin D1 | -0.0369949 |
| RPL35A | ribosomal protein L35a | -0.0367124 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0366464 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0338255 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0335057 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0333629 |
| S100A6 | S100 calcium binding protein A6 | -0.0331642 |
| RIN2 | Ras and Rab interactor 2 | -0.0331254 |
| TNS3 | tensin 3 | -0.033061 |
| GOLGB1 | golgin B1 | -0.0329764 |
| HM13 | histocompatibility (minor) 13 | -0.0327878 |
| TXNRD1 | thioredoxin reductase 1 | -0.0323927 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0321467 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0321163 |
| RPL34 | ribosomal protein L34 | -0.0319532 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0314625 |
| S100A11 | S100 calcium binding protein A11 | -0.0312456 |
| KRT7 | keratin 7, type II | -0.0311015 |
| PKM | pyruvate kinase, muscle | -0.0307957 |
| PERP | PERP, TP53 apoptosis effector | -0.0304902 |
| TRIM56 | tripartite motif containing 56 | -0.0301411 |
| MYO1D | myosin ID | -0.0296135 |
| CUX1 | cut-like homeobox 1 | -0.0295309 |
| FTL | ferritin, light polypeptide | -0.0289811 |
| HMGA1 | high mobility group AT-hook 1 | -0.0287745 |
| RPS25 | ribosomal protein S25 | -0.0286899 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.0285566 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0284933 |
| SMIM14 | small integral membrane protein 14 | -0.0283342 |
| RPL31 | ribosomal protein L31 | -0.0282542 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0280423 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0276509 |
| TMEM165 | transmembrane protein 165 | -0.0273277 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0271223 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0270926 |
| MGAT4C | MGAT4 family, member C | -0.026977 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0266589 |
| CANX | calnexin | -0.0262235 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0260273 |
| SCEL | sciellin | -0.0258128 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.0254026 |
| B2M | beta-2-microglobulin | -0.0253433 |
| RPS24 | ribosomal protein S24 | -0.0251231 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0245995 |
| KRT8 | keratin 8, type II | -0.0238045 |
| LAMB3 | laminin, beta 3 | -0.0225279 |
| KRT18 | keratin 18, type I | -0.0224525 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0224358 |
| KRT19 | keratin 19, type I | -0.0224062 |
| DSG2 | desmoglein 2 | -0.0222991 |
| RIOK3 | RIO kinase 3 | -0.0221331 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0219777 |
| S100A9 | S100 calcium binding protein A9 | -0.0218711 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.021261 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0211323 |
| RPS29 | ribosomal protein S29 | -0.021051 |
| RPL37A | ribosomal protein L37a | -0.0208899 |
| RPL11 | ribosomal protein L11 | -0.0205577 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0202359 |
| CP | ceruloplasmin (ferroxidase) | -0.0201824 |
| SH3D19 | SH3 domain containing 19 | -0.0200218 |
| GOLGA3 | golgin A3 | -0.0200031 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0199759 |
| CD99 | CD99 molecule | -0.0199413 |
| ATG7 | autophagy related 7 | -0.0198432 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0198384 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0197306 |
| GM2A | GM2 ganglioside activator | -0.0196503 |
