| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Lumateperone (tosylate) perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Lumateperone (tosylate)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.158363 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.11718 |
| FAM20C | family with sequence similarity 20, member C | 0.11347 |
| GRB10 | growth factor receptor-bound protein 10 | 0.101704 |
| HMGA2 | high mobility group AT-hook 2 | 0.0852352 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0811477 |
| FN1 | fibronectin 1 | 0.0774458 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0643731 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0624769 |
| CDH13 | cadherin 13 | 0.0612661 |
| AADAC | arylacetamide deacetylase | 0.0584601 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0562107 |
| MTSS1 | metastasis suppressor 1 | 0.0549748 |
| INTS6 | integrator complex subunit 6 | 0.0539752 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0533699 |
| NTN4 | netrin 4 | 0.0508917 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0504591 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0497574 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0490589 |
| TGFB1 | transforming growth factor, beta 1 | 0.0479004 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0477764 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0471086 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0458741 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0458028 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0438077 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0424483 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0420657 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0412204 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0408674 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0392749 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0387431 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0381637 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0376446 |
| FBN1 | fibrillin 1 | 0.0354834 |
| CTBP2 | C-terminal binding protein 2 | 0.0354256 |
| LOX | lysyl oxidase | 0.0353737 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0353609 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0348815 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0346772 |
| NRG1 | neuregulin 1 | 0.0342627 |
| SEPTIN9 | septin 9 | 0.0341454 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0329742 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0325084 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0324311 |
| ADAMTS14 | ADAM metallopeptidase with thrombospondin type 1 motif, 14 | 0.0320111 |
| NLK | nemo-like kinase | 0.0316333 |
| WLS | wntless Wnt ligand secretion mediator | 0.0315049 |
| IFI44L | interferon-induced protein 44-like | 0.0313201 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0311548 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0309905 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0304422 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0300638 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0290383 |
| GLIS3 | GLIS family zinc finger 3 | 0.0284671 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0284247 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0280956 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0276735 |
| RAI14 | retinoic acid induced 14 | 0.0275548 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | 0.0274536 |
| SYT1 | synaptotagmin I | 0.0273978 |
| PYGL | phosphorylase, glycogen, liver | 0.027386 |
| EFCAB13 | EF-hand calcium binding domain 13 | 0.0272643 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0270543 |
| GLCCI1 | glucocorticoid induced 1 | 0.0268153 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0265495 |
| OXSR1 | oxidative stress responsive 1 | 0.0263091 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0262121 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0261326 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0259383 |
| EZR | ezrin | 0.0258792 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | 0.0254792 |
| SVIL | supervillin | 0.0250787 |
| PRKCA | protein kinase C, alpha | 0.0248599 |
| NAV1 | neuron navigator 1 | 0.0238751 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0238404 |
| SP100 | SP100 nuclear antigen | 0.0235143 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.023502 |
| ADM | adrenomedullin | 0.0234678 |
| SQSTM1 | sequestosome 1 | 0.0231889 |
| CDK14 | cyclin-dependent kinase 14 | 0.0229334 |
| MYO10 | myosin X | 0.0228599 |
| RCOR1 | REST corepressor 1 | 0.0227209 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0226676 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | 0.0226024 |
| CUX1 | cut-like homeobox 1 | 0.0224861 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0224853 |
| LOXL2 | lysyl oxidase-like 2 | 0.0224814 |
| AHNAK | AHNAK nucleoprotein | 0.0224308 |
| RASAL2 | RAS protein activator like 2 | 0.0223165 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0221858 |
| GREB1L | growth regulation by estrogen in breast cancer-like | 0.0220239 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.0218385 |
| RPS8 | ribosomal protein S8 | 0.0215805 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0215776 |
| HDAC4 | histone deacetylase 4 | 0.0214922 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0214597 |
| AVIL | advillin | 0.0210359 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0208178 |
| LIPG | lipase, endothelial | 0.0204513 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0203345 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | -0.26427 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.130146 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0942107 |
| OSMR | oncostatin M receptor | -0.0909744 |
| CD44 | CD44 molecule (Indian blood group) | -0.087915 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0823772 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0792201 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0774315 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0664406 |
| CDCP1 | CUB domain containing protein 1 | -0.0664049 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0637796 |
| VIM | vimentin | -0.0634421 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0627412 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0625833 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0606246 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0595758 |
| GPC6 | glypican 6 | -0.0582305 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0526237 |
| TMSB10 | thymosin beta 10 | -0.0500194 |
| ZNF292 | zinc finger protein 292 | -0.0471482 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0456387 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.043919 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0437597 |
| GOLGA4 | golgin A4 | -0.0436475 |
| NRP1 | neuropilin 1 | -0.0432463 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0425526 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0422462 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0406164 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0403355 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0400708 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0397027 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0393893 |
| USP34 | ubiquitin specific peptidase 34 | -0.0393555 |
| EFNA5 | ephrin-A5 | -0.0390284 |
| RUNX2 | runt-related transcription factor 2 | -0.0387363 |
| PID1 | phosphotyrosine interaction domain containing 1 | -0.0382149 |
| HAS2 | hyaluronan synthase 2 | -0.0377042 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0376439 |
| RBM39 | RNA binding motif protein 39 | -0.0374527 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0369416 |
| KLF6 | Kruppel-like factor 6 | -0.0368557 |
| AHR | aryl hydrocarbon receptor | -0.0368255 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0365074 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0362568 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) | -0.0360884 |
| SBF2 | SET binding factor 2 | -0.0356358 |
| LRRC49 | leucine rich repeat containing 49 | -0.0355596 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0355172 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0344596 |
| CD109 | CD109 molecule | -0.0342518 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.0339982 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0339528 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0338539 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0337738 |
| NBAS | neuroblastoma amplified sequence | -0.0333072 |
| OGA | O-GlcNAcase | -0.0323416 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0319992 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.031457 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0314044 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0313806 |
| ATP13A3 | ATPase type 13A3 | -0.0306822 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0304684 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -0.0301485 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0294674 |
| ESCO1 | establishment of sister chromatid cohesion N-acetyltransferase 1 | -0.0292476 |
| TBK1 | TANK-binding kinase 1 | -0.0291495 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0287408 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | -0.0287257 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | -0.0286805 |
| FRMD5 | FERM domain containing 5 | -0.0283047 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.0282367 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0281414 |
| CAB39 | calcium binding protein 39 | -0.0278894 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0277557 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.027691 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0274953 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.0268483 |
| JMJD1C | jumonji domain containing 1C | -0.0268033 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0266928 |
| RTN4 | reticulon 4 | -0.0264426 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0262113 |
| RNF149 | ring finger protein 149 | -0.0260528 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0260444 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0260409 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0259077 |
| ZFR | zinc finger RNA binding protein | -0.025898 |
| PCNX1 | pecanex 1 | -0.0257298 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0256785 |
| COG5 | component of oligomeric golgi complex 5 | -0.0256701 |
| SS18 | synovial sarcoma translocation, chromosome 18 | -0.025359 |
| THOC2 | THO complex 2 | -0.0253499 |
| ETV6 | ets variant 6 | -0.0251025 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0250963 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0250476 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0246808 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0246642 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0246577 |
| PTEN | phosphatase and tensin homolog | -0.0245881 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0245597 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | -0.0241073 |
